| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vesna Sossi, Katherine Dinelle, Michael Schulzer, Edwin Mak, Doris J Doudet, Raúl de la Fuente-Fernánde. Levodopa and pramipexole effects on presynaptic dopamine PET markers and estimated dopamine release. European journal of nuclear medicine and molecular imaging. vol 37. issue 12. 2011-03-24. PMID:20697890. |
here we used multi-tracer positron emission tomography imaging and a unilateral 6-hydroxydopamine (6-ohda) rat model of pd to evaluate in vivo the effects of chronic levodopa and pramipexole treatments on measurements of vesicular monoamine transporter type 2 (vmat2), dopamine transporter (dat) levels, and on levodopa-induced changes in synaptic da levels [Δ(da)]. |
2011-03-24 |
2023-08-12 |
rat |
| Walter Adriani, Frederic Boyer, Damiana Leo, Rossella Canese, Franca Podo, Carla Perrone-Capano, Jean-Luc Dreyer, Giovanni Laviol. Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20085672. |
dysfunction of brain dopamine transporter (dat) has been associated with sensation seeking and impulse-control disorders. |
2011-03-18 |
2023-08-12 |
rat |
| A Del Sole, V Chiesa, G Lucignani, A Vignoli, L Giordano, M Lecchi, M P Canevin. Exploring dopaminergic activity in ring chromosome 20 syndrome: a SPECT study. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... vol 54. issue 5. 2011-03-11. PMID:20927024. |
we conducted a study looking for correlations between r(20) mosaicism, other clinical variables and both pre-synaptic dopamine transporter (dat) expression and post-synaptic d2 receptor density. |
2011-03-11 |
2023-08-12 |
Not clear |
| Massimiliano Caiazzo, Luca Colucci-D'Amato, Floriana Volpicelli, Luisa Speranza, Ciro Petrone, Lucio Pastore, Stefano Stifani, Francesco Ramirez, Gian Carlo Bellenchi, Umberto di Porzi. Krüppel-like factor 7 is required for olfactory bulb dopaminergic neuron development. Experimental cell research. vol 317. issue 4. 2011-03-08. PMID:21093432. |
in particular, the tyrosine hydroxylase (th) and dopamine transporter (dat) transcripts are strongly decreased in the olfactory bulbs and ventral midbrain at birth, compared to wild-type littermates. |
2011-03-08 |
2023-08-12 |
mouse |
| Narasimha V Hegde, Gordon L Jensen, Erica L Unge. Iron chelation down-regulates dopamine transporter expression by decreasing mRNA stability and increasing endocytosis in N2a cells. Experimental cell research. vol 317. issue 4. 2011-03-08. PMID:21147099. |
cell surface expression of the dopamine transporter (dat) is determined by the relative rates of its internalization and recycling. |
2011-03-08 |
2023-08-12 |
Not clear |
| Michael E Talkowski, Kathleen L McCann, Michael Chen, Lora McClain, Mikhil Bamne, Joel Wood, Kodavali V Chowdari, Annie Watson, Konasale M Prasad, George Kirov, Lyudmilla Georgieva, Draga Toncheva, Hader Mansour, David A Lewis, Michael Owen, Michael O'Donovan, Panagiotis Papasaikas, Patrick Sullivan, Douglas Ruderfer, Jeffrey K Yao, Sherry Leonard, Pramod Thomas, Fabio Miyajima, John Quinn, A Javier Lopez, Vishwajit L Nimgaonka. Fine-mapping reveals novel alternative splicing of the dopamine transporter. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 8. 2011-03-07. PMID:20957647. |
the dopamine transporter gene (slc6a3, dat) has been implicated in the pathogenesis of numerous psychiatric and neurodevelopmental disorders, including schizophrenia (sz). |
2011-03-07 |
2023-08-12 |
human |
| Fei Li, L Phillip Wang, Xiaoming Shen, Joe Z Tsie. Balanced dopamine is critical for pattern completion during associative memory recall. PloS one. vol 5. issue 10. 2011-03-07. PMID:21060884. |
to study the role of dopamine in memory recall, we have analyzed dopamine transporter heterozygous knockout mice (dat(+/-)), and found that while these mice possess normal learning, consolidation, and memory recall under full cue conditions, they exhibit specific deficits in pattern completion under partial cue condition. |
2011-03-07 |
2023-08-12 |
mouse |
| Santi Alvarez, Sergi Mas, Patricia Gassó, Miquel Bernardo, Eduard Parellada, Amalia Lafuent. Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes. Fundamental & clinical pharmacology. vol 24. issue 6. 2011-03-03. PMID:20041956. |
we investigated the relationship between several functional polymorphisms in genes coding for dopamine metabolism and transport enzymes (mao-a vntr; mao-a 941t>g; dat vntr; dat -67a/t; cyp2d6*3; cyp2d6*4; cyp2d6*5; cyp2d6*6) and the frequency of schizophrenia. |
2011-03-03 |
2023-08-12 |
human |
| Su-Min Li, Theresa A Kopajtic, Matthew J O'Callaghan, Gregory E Agoston, Jianjing Cao, Amy Hauck Newman, Jonathan L Kat. N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects. The Journal of pharmacology and experimental therapeutics. vol 336. issue 2. 2011-03-03. PMID:21088247. |
the compounds had 5.6 to 30 nm affinities at the dopamine transporter (dat), with uniformly lower affinities at norepinephrine and serotonin transporters (from 490-4600 and 1420-7350 nm, respectively). |
2011-03-03 |
2023-08-12 |
rat |
| Thomas J Spencer, Bertha K Madras, Ali A Bonab, Darin D Dougherty, Allison Clarke, Tara Mirto, Jessica Martin, Alan J Fischma. A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride. Biological psychiatry. vol 68. issue 10. 2011-03-01. PMID:21035624. |
we investigated the hypothesis that armodafinil enhances wakefulness by modulating the activities of the dopamine transporter (dat). |
2011-03-01 |
2023-08-12 |
Not clear |
| Thomas J Spencer, Bertha K Madras, Ali A Bonab, Darin D Dougherty, Allison Clarke, Tara Mirto, Jessica Martin, Alan J Fischma. A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride. Biological psychiatry. vol 68. issue 10. 2011-03-01. PMID:21035624. |
with positron emission tomography imaging, we determined dat occupancy and changes in extracellular dopamine by armodafinil in vivo. |
2011-03-01 |
2023-08-12 |
Not clear |
| Heidi Bisgaard, M Andreas B Larsen, Sonia Mazier, Thijs Beuming, Amy Hauck Newman, Harel Weinstein, Lei Shi, Claus J Loland, Ulrik Gethe. The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. vol 60. issue 1. 2011-02-25. PMID:20816875. |
analogs of benztropines (bzts) are potent inhibitors of the dopamine transporter (dat) but are less effective than cocaine as behavioral stimulants. |
2011-02-25 |
2023-08-12 |
Not clear |
| Jared W Young, Andrew K L Goey, Arpi Minassian, William Perry, Martin P Paulus, Mark A Geye. The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administration. Pharmacology, biochemistry, and behavior. vol 96. issue 1. 2011-02-23. PMID:20363246. |
we recently presented two dopamine transporter (dat) mouse models of bd mania: genetic (dat knockdown; kd, mice) and pharmacological (the selective dat inhibitor gbr 12909). |
2011-02-23 |
2023-08-12 |
mouse |
| Jiange Zhang, Xianbo Liu, Xinsheng Lei, Lei Wang, Lihe Guo, Gang Zhao, Guoqiang Li. Discovery and synthesis of novel luteolin derivatives as DAT agonists. Bioorganic & medicinal chemistry. vol 18. issue 22. 2011-02-22. PMID:20971650. |
luteolin, 5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-4h-chromen-4-one, has been proposed and proved to be a novel dopamine transporter (dat) activator. |
2011-02-22 |
2023-08-12 |
rat |
| G Brousse, F Vorspan, K Ksouda, V Bloch, K Peoc'h, J L Laplanche, S Mouly, J Schmidt, P M Llorca, J P Lepin. Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. Medical hypotheses. vol 75. issue 6. 2011-02-18. PMID:20801583. |
several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes drd2, comt, slc6a3 (coding for the dopamine transporter dat) and dbh (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. |
2011-02-18 |
2023-08-12 |
Not clear |
| Jonas Hannestad, Jean-Dominique Gallezot, Beata Planeta-Wilson, Shu-Fei Lin, Wendol A Williams, Christopher H van Dyck, Robert T Malison, Richard E Carson, Yu-Shin Din. Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo. Biological psychiatry. vol 68. issue 9. 2011-02-15. PMID:20691429. |
in vitro, the affinity of methylphenidate for the norepinephrine transporter (net) is higher than that for the dopamine transporter (dat). |
2011-02-15 |
2023-08-12 |
Not clear |
| Ashutosh Kumar, Israr Ahmad, Smriti Shukla, Brajesh Kumar Singh, Devendra Kumar Patel, Haushila Prasad Pandey, Chetna Sing. Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats. Free radical research. vol 44. issue 8. 2011-02-14. PMID:20553223. |
altered dopamine transporter (dat) and vesicular monoamine transporter-2 (vmat-2) are also documented in pd. |
2011-02-14 |
2023-08-12 |
rat |
| Jeff A Beeler, Nathaniel Daw, Cristianne R M Frazier, Xiaoxi Zhuan. Tonic dopamine modulates exploitation of reward learning. Frontiers in behavioral neuroscience. vol 4. 2011-02-07. PMID:21120145. |
we quantitatively evaluate the role of tonic dopamine in these functions by studying the behavior of hyperdopaminergic dat knockdown mice in an instrumental task in a semi-naturalistic homecage environment. |
2011-02-07 |
2023-08-12 |
mouse |
| F Mignini, M Sabbatini, V D'Andrea, C Cavallott. Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus. European journal of histochemistry : EJH. vol 54. issue 2. 2011-02-04. PMID:20558339. |
the aim of this study was to examine rat thymus innervation using denervation techniques and to explore the related micro-anatomical localization of dopamine, d1, d2 receptors and dopamine membrane transporter (dat). |
2011-02-04 |
2023-08-12 |
rat |
| F Mignini, M Sabbatini, V D'Andrea, C Cavallott. Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus. European journal of histochemistry : EJH. vol 54. issue 2. 2011-02-04. PMID:20558339. |
no variation in dopamine and dat immune reaction was observed following total or partial parasympathectomy or phrenic nerve cutting. |
2011-02-04 |
2023-08-12 |
rat |