| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Simchon, A Weizman, M Rehav. The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 10. 2010-12-22. PMID:20493667. |
juvenile shr rats exhibited low dopamine transporter (dat) density, low vesicular monoamine transporter 2 (vmat2) density and lower unstimulated dopamine (da) release in comparison to their corresponding wky controls. |
2010-12-22 |
2023-08-12 |
rat |
| Y Simchon, A Weizman, M Rehav. The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 10. 2010-12-22. PMID:20493667. |
chronic methylphenidate treatment of the young shr rats was associated with lower dat density and lower unstimulated basal dopamine release but with enhanced potassium- and amphetamine-induced dopamine release. |
2010-12-22 |
2023-08-12 |
rat |
| Morten Ziebell, Signe Holm-Hansen, Gerda Thomsen, Aase Wagner, Peter Jensen, Lars H Pinborg, Gitte Moos Knudse. Serotonin transporters in dopamine transporter imaging: a head-to-head comparison of dopamine transporter SPECT radioligands 123I-FP-CIT and 123I-PE2I. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51. issue 12. 2010-12-22. PMID:21078806. |
current spect radioligands available for in vivo imaging of the dopamine transporter (dat) also show affinity for monoamine transporters other than dat, especially the serotonin transporter (sert). |
2010-12-22 |
2023-08-12 |
Not clear |
| Pingyuan Gong, Anyun Zheng, Kejin Zhang, Xu Lei, Fengchao Li, Dongmei Chen, Wanyu Chi, Xueli Tong, Zijian Zheng, Xiaocai Gao, Fuchang Zhan. Association analysis between 12 genetic variants of ten genes and personality traits in a young chinese Han population. Journal of molecular neuroscience : MN. vol 42. issue 1. 2010-12-20. PMID:20464528. |
in the study, we selected some functional variations in ten candidate genes (comt, dbh, drd(2), drd(3), dat, maoa, grm(1), grin2b, 5-th(2a), and 5-th(6)) encoding components in dopamine, glutamate, and 5-hydroxytryptamine pathways. |
2010-12-20 |
2023-08-12 |
human |
| Roberto Cilia, Ji Hyun Ko, Sang Soo Cho, Thilo van Eimeren, Giorgio Marotta, Giovanna Pellecchia, Gianni Pezzoli, Angelo Antonini, Antonio P Strafell. Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling. Neurobiology of disease. vol 39. issue 1. 2010-12-14. PMID:20338240. |
using striatal dopamine transporter (dat) with single photon emission tomography we assessed presynaptic dopaminergic function in 8 pd patients with pg, 21 matched pd control subjects, and 14 healthy subjects. |
2010-12-14 |
2023-08-12 |
human |
| A Knapman, J-M Heinzmann, F Holsboer, R Landgraf, C Toum. Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice. Neurobiology of learning and memory. vol 94. issue 2. 2010-12-13. PMID:20451634. |
furthermore, as the dopaminergic system is involved in both li and reversal learning, the dopamine 1 receptor (d1r), dopamine 2 receptor (d2r) and dopamine transporter (dat) mrna expression levels were assessed in relevant brain areas of these animals. |
2010-12-13 |
2023-08-12 |
mouse |
| Weimin C Hong, Susan G Amar. Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding. The Journal of biological chemistry. vol 285. issue 42. 2010-12-07. PMID:20688912. |
clearance of synaptically released dopamine is regulated by the plasmalemmal dopamine transporter (dat), an integral membrane protein that resides within a complex lipid milieu. |
2010-12-07 |
2023-08-12 |
Not clear |
| Katy M Webb, Michael Y Aksenov, Charles F Mactutus, Rosemarie M Booz. Evidence for developmental dopaminergic alterations in the human immunodeficiency virus-1 transgenic rat. Journal of neurovirology. vol 16. issue 2. 2010-12-02. PMID:20337512. |
findings from our model of choice, the hiv-1 transgenic rat, reveal a significant increase in phosphorylated tyrosine hydroxylase protein expression and a decrease in dopamine transporter mrna, without changes in tyrosine hydroxylase (th) or dopamine transporter (dat) protein or in more general markers of protein and gene expression levels in the hiv-1 transgenic rat midbrain. |
2010-12-02 |
2023-08-12 |
human |
| Hong Liu, Feng Dong, Zhaowei Meng, Benshu Zhang, Jian Tan, Yu Wan. Evaluation of Tourette's syndrome by (99m)Tc-TRODAT-1 SPECT/CT imaging. Annals of nuclear medicine. vol 24. issue 7. 2010-12-01. PMID:20544324. |
clinical evidence indicates that the tourette's syndrome (ts) is associated with hyperactivity of the dopaminergic system; however, imaging studies of dopamine transporter (dat) in ts patients remain controversial. |
2010-12-01 |
2023-08-12 |
human |
| K Ishibashi, K Kanemaru, Y Saito, S Murayama, K Oda, K Ishiwata, H Mizusawa, K Ishi. Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson's disease. Acta neurologica Scandinavica. vol 122. issue 1. 2010-11-16. PMID:20002007. |
to evaluate the association between cerebrospinal fluid (csf) homovanillic acid (hva) concentrations and nigrostriatal dopaminergic function assessed by positron emission tomography (pet) imaging with carbon-11-labeled 2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane ((11)c-cft), which can measure the dopamine transporter (dat) density, in parkinson's disease (pd). |
2010-11-16 |
2023-08-12 |
Not clear |
| Yao-Chu Chen, Wen-Sung La. Behavioural phenotyping of dopamine transporter knockdown mice using local small interference RNA. Behavioural brain research. vol 214. issue 2. 2010-11-16. PMID:20558209. |
the objective of this study was to evaluate basic behavioural phenotypes and methamphetamine-induced hyperactivity in dopamine transporter (dat) knockdown and control mice after local injections of small interference rna into ventral tegmental area/substantia nigra once every other day for 14 days. |
2010-11-16 |
2023-08-12 |
mouse |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
the positron emission tomography (pet) tracer 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-[18f]-fluoroethyl)-nortropane ((18)f-fecnt) is a highly specific ligand for dopamine transporter (dat) that yields higher peak striatum-to-cerebellum ratios and offers more favorable kinetics than most (18)f-radiolabeled dat ligands currently available. |
2010-11-12 |
2023-08-12 |
monkey |
| Jörn Reese, Adrian Kraschewski, Ion Anghelescu, Georg Winterer, Lutz G Schmidt, Jürgen Gallinat, Franz Rüschendorf, Hans Rommelspacher, Catrin Wernick. Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics. Psychiatric genetics. vol 20. issue 4. 2010-11-04. PMID:20505557. |
the dopamine transporter (dat) and the serotonin transporter (sert) are involved in endophenotypes that are associated with these subtypes. |
2010-11-04 |
2023-08-12 |
Not clear |
| Zivjena Vucetic, Jessica Kimmel, Kathy Totoki, Emily Hollenbeck, Teresa M Reye. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology. vol 151. issue 10. 2010-11-04. PMID:20685869. |
gene expression, measured using quantitative real-time pcr, revealed a significant approximately 3- to 10-fold up-regulation of dopamine reuptake transporter (dat) in the ventral tegmental area, nucleus accumbens, and prefrontal cortex and a down-regulation of dat in the hypothalamus. |
2010-11-04 |
2023-08-12 |
mouse |
| Chiharu Sogawa, Chieko Mitsuhata, Kei Kumagai-Morioka, Norio Sogawa, Kazumi Ohyama, Katsuya Morita, Katsuyuki Kozai, Toshihiro Dohi, Shigeo Kitayam. Expression and function of variants of human catecholamine transporters lacking the fifth transmembrane region encoded by exon 6. PloS one. vol 5. issue 8. 2010-11-04. PMID:20700532. |
the transporters for dopamine (dat) and norepinephrine (net) are members of the na+- and cl--dependent neurotransmitter transporter family slc6. |
2010-11-04 |
2023-08-12 |
human |
| Joanne Clark, Elizabeth L Clore, Kangni Zheng, Anthony Adame, Eliezer Masliah, David K Simo. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808797. |
despite the transient nature of the impact of nac on brain glutathione, the loss of dopaminergic terminals at 1 year associated with snca overexpression was significantly attenuated by nac supplementation, as measured by immunoreactivity for tyrosine hydroxylase in the striatum (p = 0.007; unpaired, two-tailed t-test), with a similar but nonsignificant trend for dopamine transporter (dat) immunoreactivity. |
2010-11-04 |
2023-08-12 |
mouse |
| E N Rizos, S Chatziioannou, N Siafakas, A Douzenis, E Katsantoni, A Mandrapilia, S Bacalis, C Fotiadis, L Lykoura. Increased striatal dopamine transporter levels, as indicated by a DAT scan, induced by ziprasidone in association to improvement of tardive dyskinesia--a case report. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20460141. |
increased striatal dopamine transporter levels, as indicated by a dat scan, induced by ziprasidone in association to improvement of tardive dyskinesia--a case report. |
2010-11-02 |
2023-08-12 |
Not clear |
| Paul W Czoty, Jennifer L Martelle, F Ivy Carroll, Michael A Nade. Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates. Pharmacology, biochemistry, and behavior. vol 96. issue 3. 2010-10-28. PMID:20580733. |
drugs that inhibit brain dopamine transporters (dat) have been developed as potential agonist medications for cocaine abuse and dependence. |
2010-10-28 |
2023-08-12 |
human |
| Xiaowei Zhang, Elaine L Bearer, Benoit Boulat, F Scott Hall, George R Uhl, Russell E Jacob. Altered neurocircuitry in the dopamine transporter knockout mouse brain. PloS one. vol 5. issue 7. 2010-10-28. PMID:20634895. |
in the present work we use the unique properties of magnetic resonance imaging (mri) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (dat) ko mice. |
2010-10-28 |
2023-08-12 |
mouse |
| Camila Guindalini, Raquel Cristina Martins, Monica L Andersen, Sergio Tufi. Influence of genotype on dopamine transporter availability in human striatum and sleep architecture. Psychiatry research. vol 179. issue 2. 2010-10-26. PMID:20493539. |
genetic variants may modulate dopamine transporter (dat) availability in the brain. |
2010-10-26 |
2023-08-12 |
human |