| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anja W Fjorback, Heidi K Müller, Jana Haase, Merete K Raarup, Ove Wibor. Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2. Biochemical and biophysical research communications. vol 406. issue 2. 2011-05-05. PMID:21295544. |
the monoamine transporters for dopamine (dat), norepinephrine (net) and serotonin (sert) facilitate the homeostatic balance of neurotransmitters in the synaptic cleft and thus, play a fundamental role in regulating neuronal activity. |
2011-05-05 |
2023-08-12 |
Not clear |
| Anja W Fjorback, Heidi K Müller, Jana Haase, Merete K Raarup, Ove Wibor. Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2. Biochemical and biophysical research communications. vol 406. issue 2. 2011-05-05. PMID:21295544. |
moreover, co-expression of dat and scamp2 results in a decrease in dat-mediated dopamine uptake caused by reduced levels of dat molecules on the cell surface. |
2011-05-05 |
2023-08-12 |
Not clear |
| I A Zimin, I O Logvinov, T A Antipova, G I Kovale. [A comparative study of hemantane and amantadine effects on dopamine transporter expression in brain of normal and MPTP-treated C57BL/6 mice]. Eksperimental'naia i klinicheskaia farmakologiia. vol 74. issue 1. 2011-05-05. PMID:21476268. |
the effects of acute and subchronic administration of antiparkinsonian drugs hemantane and amantadine on dopamine transporter (dat) content in the brain of normal and mptp-treated mice have been studied. |
2011-05-05 |
2023-08-12 |
mouse |
| Heping Zhang, Shupeng Li, Min Wang, Brian Vukusic, Zdenek B Pristupa, Fang Li. Regulation of dopamine transporter activity by carboxypeptidase E. Molecular brain. vol 2. 2011-05-02. PMID:19419578. |
regulation of dopamine transporter activity by carboxypeptidase e. the dopamine transporter (dat) plays a critical role in terminating the action of dopamine by rapid reuptake into the presynaptic neuron. |
2011-05-02 |
2023-08-12 |
Not clear |
| Leonardo Fazio, Giuseppe Blasi, Paolo Taurisano, Apostolos Papazacharias, Raffaella Romano, Barbara Gelao, Gianluca Ursini, Tiziana Quarto, Luciana Lo Bianco, Annabella Di Giorgio, Marina Mancini, Teresa Popolizio, Giuseppe Rubini, Alessandro Bertolin. D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans. NeuroImage. vol 54. issue 4. 2011-05-02. PMID:21087673. |
pre-synaptic d2 receptors regulate striatal dopamine release and dat activity, key factors for modulation of motor pathways. |
2011-05-02 |
2023-08-12 |
human |
| Leonardo Fazio, Giuseppe Blasi, Paolo Taurisano, Apostolos Papazacharias, Raffaella Romano, Barbara Gelao, Gianluca Ursini, Tiziana Quarto, Luciana Lo Bianco, Annabella Di Giorgio, Marina Mancini, Teresa Popolizio, Giuseppe Rubini, Alessandro Bertolin. D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans. NeuroImage. vol 54. issue 4. 2011-05-02. PMID:21087673. |
to further evaluate the relationship of this circuitry with dopamine signaling, we also explored the correlation between genotype based differences in motor brain activity and pre-synaptic striatal dat binding measured with [(123)i] fp-cit spect. |
2011-05-02 |
2023-08-12 |
human |
| Vivienne Ann Russel. Overview of animal models of attention deficit hyperactivity disorder (ADHD). Current protocols in neuroscience. vol Chapter 9. 2011-04-26. PMID:21207367. |
genetic models include the spontaneously hypertensive rat (shr), the naples high excitability (nhe) rat, poor performers in the 5-choice serial reaction time (5-csrt) task, the dopamine transporter (dat) knock-out mouse, the snap-25 deficient mutant coloboma mouse, mice expressing a human mutant thyroid hormone receptor, a nicotinic receptor knock-out mouse, and a tachykinin-1 (nk1) receptor knock-out mouse. |
2011-04-26 |
2023-08-12 |
mouse |
| Atsumi Nitta, Yoko Hibi, Yoshiaki Miyamoto, Toshitaka Nabeshim. [Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 45. issue 6. 2011-04-26. PMID:21387608. |
dopamine transporter (dat) internalization is a mechanism underlying the decreased dopamine reuptake caused by addictive drugs like methamphetamine (meth). |
2011-04-26 |
2023-08-12 |
mouse |
| Atsumi Nitta, Yoko Hibi, Yoshiaki Miyamoto, Toshitaka Nabeshim. [Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 45. issue 6. 2011-04-26. PMID:21387608. |
expression of piccolo c2a domain attenuated meth-induced inhibition of dopamine uptake in pc12 cells expressing human dat. |
2011-04-26 |
2023-08-12 |
mouse |
| Karl Strecker, Florian Wegner, Swen Hesse, Georg-Alexander Becker, Marianne Patt, Philipp M Meyer, Donald Lobsien, Johannes Schwarz, Osama Sabr. Preserved serotonin transporter binding in de novo Parkinson's disease: negative correlation with the dopamine transporter. Journal of neurology. vol 258. issue 1. 2011-04-25. PMID:20644949. |
since the loss of dopaminergic neurons is the pathologic hallmark of pd and sert might be associated with psychiatric co-morbidity, we further sought to correlate sert availability with the availability of dopamine transporter (dat) and depressive or motor symptoms in early pd. |
2011-04-25 |
2023-08-12 |
human |
| David B Horton, Kiran B Siripurapu, Seth D Norrholm, John P Culver, Marhaba Hojahmat, Joshua S Beckmann, Steven B Harrod, Agripina G Deaciuc, Michael T Bardo, Peter A Crooks, Linda P Dwoski. meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21177475. |
meso-transdiene (mtd), a lobeline analog, lacks nicotinic receptor affinity, retains affinity for vesicular monoamine transporter 2 (vmat2), and, surprisingly, has enhanced affinity for dopamine (da) and serotonin transporters [da transporter (dat) and serotonin transporter (sert), respectively]. |
2011-04-21 |
2023-08-12 |
rat |
| Derek Angus, Matilda Bingham, Dawn Buchanan, Neil Dunbar, Linsday Gibson, Richard Goodwin, Anders Haunsø, Andrea Houghton, Margaret Huggett, Richard Morphy, Susan Napier, Olaf Nimz, Joanna Passmore, Glenn Walke. The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain. Bioorganic & medicinal chemistry letters. vol 21. issue 1. 2011-04-14. PMID:21112782. |
hit compound 1, a selective noradrenaline re-uptake transporter (net) inhibitor was optimised to build in potency at the serotonin re-uptake transporter (sert) whilst maintaining selectivity against the dopamine re-uptake transporter (dat). |
2011-04-14 |
2023-08-12 |
mouse |
| Madhusudhan Purushotham, Anjaneyulu Sheri, Duy-Phong Pham-Huu, Bertha K Madras, Aaron Janowsky, Peter C Meltze. The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes. Bioorganic & medicinal chemistry letters. vol 21. issue 1. 2011-04-14. PMID:21146984. |
cocaine, a potent stimulant of the central nervous system, owes its reinforcing and stimulant properties to its ability to inhibit monoamine uptake systems such as the dopamine transporter (dat), and the serotonin transporter (sert) located on presynaptic neurons in the striatum. |
2011-04-14 |
2023-08-12 |
Not clear |
| Samuel D Banister, Iman A Moussa, Corinne Beinat, Aaron J Reynolds, Paolo Schiavini, William T Jorgensen, Michael Kassio. Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands. Bioorganic & medicinal chemistry letters. vol 21. issue 1. 2011-04-14. PMID:21146989. |
trishomocubane as a scaffold for the development of selective dopamine transporter (dat) ligands. |
2011-04-14 |
2023-08-12 |
Not clear |
| Samuel D Banister, Iman A Moussa, Corinne Beinat, Aaron J Reynolds, Paolo Schiavini, William T Jorgensen, Michael Kassio. Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands. Bioorganic & medicinal chemistry letters. vol 21. issue 1. 2011-04-14. PMID:21146989. |
in our continued exploration of trishomocubane derivatives with central nervous system (cns) activity, n-arylalkyl-8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes (10-13) displaying affinity for the sigma (σ) receptor were also found, in several cases, to interact with the dopamine transporter (dat). |
2011-04-14 |
2023-08-12 |
Not clear |
| James D Foster, Roxanne A Vaugha. Palmitoylation controls dopamine transporter kinetics, degradation, and protein kinase C-dependent regulation. The Journal of biological chemistry. vol 286. issue 7. 2011-04-11. PMID:21118819. |
these results identify s-palmitoylation as a major regulator of dat properties that could significantly impact acute and long term dopamine transport capacity. |
2011-04-11 |
2023-08-12 |
rat |
| Kei Yamamoto, Jori O Ruuskanen, Mario F Wullimann, Philippe Vernie. Differential expression of dopaminergic cell markers in the adult zebrafish forebrain. The Journal of comparative neurology. vol 519. issue 3. 2011-04-11. PMID:21192085. |
although the simultaneous presence of tyrosine hydroxylase (th), aromatic amino acid decarboxylase (aadc), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) is considered as a phenotypic signature of dopamine (da) neurons, it has been suggested that they are not uniformly expressed in all dopaminergic brain nuclei. |
2011-04-11 |
2023-08-12 |
zebrafish |
| Vesna Sossi, Raul de la Fuente-Fernández, Ramachandiran Nandhagopal, Michael Schulzer, Jessamyn McKenzie, Thomas J Ruth, Jan O Aasly, Matthew J Farrer, Zbigniew K Wszolek, Jon A Stoess. Dopamine turnover increases in asymptomatic LRRK2 mutations carriers. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 16. 2011-04-08. PMID:20939082. |
increase in dopamine (da) turnover was found to occur early in symptomatic parkinson's disease (pd) and to be functionally related to the dopamine transporter (dat). |
2011-04-08 |
2023-08-12 |
human |
| Maria Hadjiconstantinou, Anne-Marie Duchemin, Hailing Zhang, Norton H Nef. Enhanced dopamine transporter function in striatum during nicotine withdrawal. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20506223. |
uptake via the dopamine transporter (dat) is a key mechanism for regulating the concentrations of extracellular da. |
2011-04-01 |
2023-08-12 |
mouse |
| Claudia M Szobot, Tatiana Roman, Mara H Hutz, Júlia P Genro, Ming Chi Shih, Marcelo Q Hoexter, Neivo Júnior, Flávio Pechansky, Rodrigo A Bressan, Luis A P Rohd. Molecular imaging genetics of methylphenidate response in ADHD and substance use comorbidity. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20593420. |
methylphenidate (mph), a dopamine transporter (dat) blocker, is an effective drug for most adhd patients. |
2011-04-01 |
2023-08-12 |
Not clear |