| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Morten Ziebel. Evaluation of the superselective radioligand [123I]PE2I for imaging of the dopamine transporter in SPECT. Danish medical bulletin. vol 58. issue 5. 2011-10-19. PMID:21535991. |
imaging of the dopamine transporter (dat) with single photon emission computer tomography (spect) has increasingly been used as a biomarker for the integrity of presynaptic dopaminergic nerve cells in patients with movement disorders. |
2011-10-19 |
2023-08-12 |
human |
| Thi-Lien Nguyen, Yu-Hua Tian, In-Jee You, Seok-Yong Lee, Choon-Gon Jan. Modafinil-induced conditioned place preference via dopaminergic system in mice. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21157933. |
dopamine transporter (dat) binding was increased in the prefrontal cortex, the caudate putamen, and the nucleus accumbens. |
2011-10-18 |
2023-08-12 |
mouse |
| Antonio Simeone, Michela Di Salvio, Luca Giovanni Di Giovannantonio, Dario Acampora, Daniela Omodei, Carmine Tomasett. The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons. Molecular neurobiology. vol 43. issue 2. 2011-10-14. PMID:21086067. |
in particular, otx2 is prevalently excluded from neurons of the dorsal-lateral vta, which expressed girk2 and high level of the dopamine transporter (dat). |
2011-10-14 |
2023-08-12 |
mouse |
| Melissa A Stouffer, Solav Ali, Maarten E A Reith, Jyoti C Patel, Federica Sarti, Kenneth D Carr, Margaret E Ric. SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21689106. |
both effects were occluded by nomifensine (1 μm), a dopamine transporter (dat) inhibitor, suggesting that skf-83566 acted via the dat. |
2011-10-14 |
2023-08-12 |
rat |
| Alex Iranzo, Francesc Valldeoriola, Francisco Lomeña, José Luis Molinuevo, Mónica Serradell, Manel Salamero, Albert Cot, Domènec Ros, Javier Pavía, Joan Santamaria, Eduardo Tolos. Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. The Lancet. Neurology. vol 10. issue 9. 2011-10-13. PMID:21802993. |
serial dopamine transporter (dat) imaging in patients with parkinson's disease (pd) and other synucleinopathies shows progressive nigrostriatal dopaminergic dysfunction. |
2011-10-13 |
2023-08-12 |
Not clear |
| K B Reynolds, L MacGillivray, M Zettler, P I Rosebush, M F Mazure. Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons. Brain research. vol 1394. 2011-10-11. PMID:21396352. |
the dopamine transporter (dat) has been shown to play a role in the behavioural and biochemical action of neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2011-10-11 |
2023-08-12 |
rat |
| Liming Shao, Michael C Hewitt, Scott C Malcolm, Fengjiang Wang, Jianguo Ma, Una C Campbell, Nancy A Spicer, Sharon R Engel, Larry W Hardy, Zhi-Dong Jiang, Rudy Schreiber, Kerry L Spear, Mark A Varne. Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues. Journal of medicinal chemistry. vol 54. issue 15. 2011-10-07. PMID:21739935. |
the present work expands the chemical space known to offer potent inhibition of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) and discloses novel bicyclic octahydrocyclopenta[c]pyrrole and octahydro-1h-isoindole scaffolds as potent triple reuptake inhibitors (tris) for the potential treatment of depression. |
2011-10-07 |
2023-08-12 |
mouse |
| Andrea Varrone, Vladimir Stepanov, Ryuji Nakao, Miklós Tóth, Balázs Gulyás, Patrik Emond, Jean Bernard Deloye, Johnny Vercouillie, Michael G Stabin, Cathrine Jonsson, Denis Guilloteau, Christer Halldi. Imaging of the striatal and extrastriatal dopamine transporter with (18)F-LBT-999: quantification, biodistribution, and radiation dosimetry in nonhuman primates. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 52. issue 8. 2011-10-07. PMID:21764797. |
the aim of this study was to evaluate the quantification, biodistribution, and radiation dosimetry of the novel dopamine transporter (dat) radioligand (18)f-(2s,3s)-methyl 8-((e)-4-fluorobut-2-en-1-yl)-3-(p-tolyl)-8-azabicyclo[3.2.1]octane-2-carboxylate ((18)f-lbt-999) in nonhuman primates. |
2011-10-07 |
2023-08-12 |
Not clear |
| Ji Young Yun, Woong-Woo Lee, Hee Jin Kim, Ji Seon Kim, Jong-Min Kim, Han-Joon Kim, Sung Yeun Kim, Ji Yeon Kim, Sung Sup Park, Yu Kyeong Kim, Sang Eun Kim, Beom S Jeo. Relative contribution of SCA2, SCA3 and SCA17 in Korean patients with parkinsonism and ataxia. Parkinsonism & related disorders. vol 17. issue 5. 2011-09-30. PMID:21334959. |
dopamine transporter (dat) imaging was performed in a subset of ataxic or parkinsonian sca2 or sca17, all of whom showed decreased dat binding. |
2011-09-30 |
2023-08-12 |
Not clear |
| Z Y Ong, B S Muhlhausle. Maternal "junk-food" feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 7. 2011-09-28. PMID:21427213. |
mrna expression of μ-opioid receptor (mu) was 1.6-fold higher (p<0.01) and dopamine active transporter (dat) was 2-fold lower (p<0.05) in jf offspring at 6 wk of age. |
2011-09-28 |
2023-08-12 |
rat |
| Mohammad Reza Safarineja. Relationship between premature ejaculation and genetic polymorphisms of the dopamine transporter gene (SLC6A3). BJU international. vol 108. issue 2. 2011-09-20. PMID:21050355. |
• to investigate the possible relationships between premature ejaculation (pe) polymorphisms in the dopamine transporter (dat) gene (slc6a3, dat1), which has a polymorphic 40 base pair (40 bp) variable number of tandem repeats (vntr) sequence in the 3'-untranslated region (3' vntr). |
2011-09-20 |
2023-08-12 |
Not clear |
| P T Meyer, O H Winz, M Dafotakis, C J Werner, T Krohn, W M Schäfe. Improved visual [(123)I]FP-CIT SPECT interpretation for evaluation of parkinsonism by visual rating of parametric distribution volume ratio images. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... vol 55. issue 3. 2011-09-20. PMID:21532542. |
imaging of presynaptic dopamine transporters (dat) by single-photon emission computed tomography (spect) and [(123)i]fp-cit is an established method for differentiating between neurodegenerative and non-neurodegenerative parkinsonism. |
2011-09-20 |
2023-08-12 |
Not clear |
| Bastian Zimmer, Stefan Schildknecht, Philipp B Kuegler, Vivek Tanavde, Suzanne Kadereit, Marcel Leis. Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. Toxicological sciences : an official journal of the Society of Toxicology. vol 121. issue 2. 2011-09-19. PMID:21385734. |
the mixed neuronal cultures that formed within 20 days contained a small subpopulation of tyrosine hydroxylase (th)-positive neurons with specific dopaminergic functions such as dopamine transport (dat) activity. |
2011-09-19 |
2023-08-12 |
Not clear |
| Mitchell F Roitman, Seth Wescott, Jackson J Cone, Michael P McLane, Henry R Wolf. MSI-1436 reduces acute food intake without affecting dopamine transporter activity. Pharmacology, biochemistry, and behavior. vol 97. issue 1. 2011-09-15. PMID:20478327. |
many therapies designed to reduce food intake and body weight act, in part, by blocking the dopamine transporter (dat) - a protein responsible for clearing extracellular dopamine (da) after release thereby terminating its action. |
2011-09-15 |
2023-08-12 |
rat |
| Wei Sun, Kenji Sugiyama, Tetsuya Asakawa, Hiroshi Yamaguchi, Soichi Akamine, Yasuomi Ouchi, Yasuhiro Magata, Hiroki Namb. Dynamic changes of striatal dopamine D2 receptor binding at later stages after unilateral lesions of the medial forebrain bundle in Parkinsonian rat models. Neuroscience letters. vol 496. issue 3. 2011-09-07. PMID:21514359. |
in the present study, we further examined binding of d(2) receptor as well as pre-synaptic dopamine transporter (dat) at later stages (6 months after lesion) both in the striatal and mfb lesion models. |
2011-09-07 |
2023-08-12 |
rat |
| Mei Han, Xu-Feng Huang, Chao Den. Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects. The international journal of neuropsychopharmacology. vol 12. issue 7. 2011-09-06. PMID:19203411. |
aripiprazole also decreased dopamine transporter (dat) binding density in nac (for 1- and 12-wk treatment) and vta (1-wk treatment). |
2011-09-06 |
2023-08-12 |
Not clear |
| Courtney M Keller, Michael F Salvatore, Brandon S Pruett, Glenn F Guerin, Nicholas E Goeder. Biphasic dopamine regulation in mesoaccumbens pathway in response to non-contingent binge and escalating methamphetamine regimens in the Wistar rat. Psychopharmacology. vol 215. issue 3. 2011-09-01. PMID:21523347. |
methamphetamine (ma) increases extracellular dopamine (da) and at chronic high doses induces toxicity as indicated by decreased expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2011-09-01 |
2023-08-12 |
rat |
| Stacey J Sukoff Rizzo, Sarah K Leonard, Adam Gilbert, Paul Dollings, Deborah L Smith, Mei-Yi Zhang, Li Di, Brian J Platt, Sarah Neal, Jason M Dwyer, Corey N Bender, Jean Zhang, Tim Lock, Dianne Kowal, Angela Kramer, Andrew Randall, Christine Huselton, Karthick Vishwanathan, Susanna Y Tse, John Butera, Robert H Ring, Sharon Rosenzweig-Lipson, Zoë A Hughes, John Dunlo. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21508084. |
in vitro selectivity profiling of met-1 demonstrated physiologically relevant transporter binding affinity at serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net) (323, 3020, and 3410 nm, respectively); whereas the parent compound amn082 had appreciable affinity at net (1385 nm). |
2011-08-30 |
2023-08-12 |
rat |
| Alejandro Higuera-Matas, Fanny Botreau, Nuria Del Olmo, Miguel Miguéns, Oscar Olías, Gonzalo L Montoya, Carmen García-Lecumberri, Emilio Ambrosi. Periadolescent exposure to cannabinoids alters the striatal and hippocampal dopaminergic system in the adult rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 12. 2011-08-26. PMID:20655181. |
we evaluated the levels of the dopamine transporter (dat), and the d1- (d1r) and d2-type (d2r) dopaminergic receptors, as well as tyrosine hydroxylase (th) mrna in dopaminergic areas of the adult, cocaine self-administered, rat brain that had been chronically exposed to cp or vehicle (vh) during periadolescence. |
2011-08-26 |
2023-08-12 |
human |
| Noelia Granado, Sara Ares-Santos, Idaira Oliva, Esther O'Shea, Eduardo D Martin, M Isabel Colado, Rosario Moratall. Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21303698. |
methamphetamine (meth) and 3,4-methylenedioxymethamphetamine (mdma), amphetamine derivatives widely used as recreational drugs, induce similar neurotoxic effects in mice, including a marked loss of tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum. |
2011-08-23 |
2023-08-12 |
mouse |