| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-ming Xu, En-xiang Tao, Xiao-jun Din. [Responsive changes to MPTP in rats with DAT inhibited by antisense oligonucleotides]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 25. issue 2. 2009-03-19. PMID:18393256. |
to investigate the inhibitory effect of antisense oligonucleotides (odn) on dopamine transporter (dat) in rats and observe the response of the rats to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2009-03-19 |
2023-08-12 |
rat |
| Thomas Hillemacher, Helge Frieling, Thomas Hartl, Julia Wilhelm, Johannes Kornhuber, Stefan Bleic. Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. Journal of psychiatric research. vol 43. issue 4. 2009-03-18. PMID:18504048. |
epigenetic regulation via promoter specific dna methylation of the dopamine transporter gene (dat) may influence altered dopaminergic neurotransmission in alcoholism. |
2009-03-18 |
2023-08-12 |
Not clear |
| Lynette C Daw. Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy. Pharmacology & therapeutics. vol 121. issue 1. 2009-03-18. PMID:19022290. |
biogenic amine transporters for serotonin, norepinephrine and dopamine (sert, net and dat respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. |
2009-03-18 |
2023-08-12 |
Not clear |
| Vladimir Stepanov, Jaak Jär. Kinetic mechanism of dopamine transporter interaction with 1-(2-(bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909). Neurochemistry international. vol 53. issue 6-8. 2009-03-09. PMID:18845198. |
it appears that the isomerization phenomenon previously described for pe2i is not limited to tropane-based dat inhibitors, but is, in fact, a general property of dopamine transporter protein, similar to "isomerization" process reported previously for g-protein coupled receptors. |
2009-03-09 |
2023-08-12 |
rat |
| Elisabeth M van de Giessen, Maartje M L de Win, Michael W T Tanck, Wim van den Brink, Frank Baas, Jan Booi. Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 50. issue 1. 2009-03-06. PMID:19091889. |
polymorphisms in the dopamine transporter (dat) gene slc6a3 are associated with human striatal dat expression, but the exact effects on dat expression are not clear. |
2009-03-06 |
2023-08-12 |
human |
| Cindy Casteels, Erwin Lauwers, Guy Bormans, Veerle Baekelandt, Koen Van Laer. Metabolic-dopaminergic mapping of the 6-hydroxydopamine rat model for Parkinson's disease. European journal of nuclear medicine and molecular imaging. vol 35. issue 1. 2009-03-04. PMID:17906859. |
here, we have characterized this model in vivo by multitracer imaging [glucose metabolism and dopamine transporter (dat)] in relation to behavioral and histological parameters. |
2009-03-04 |
2023-08-12 |
rat |
| Trent J Volz, Sarah J Farnsworth, Shane D Rowley, Glen R Hanson, Annette E Fleckenstei. Age-dependent differences in dopamine transporter and vesicular monoamine transporter-2 function and their implications for methamphetamine neurotoxicity. Synapse (New York, N.Y.). vol 63. issue 2. 2009-03-03. PMID:19021208. |
the initial velocities of dopamine (da) transport into, meth-induced da efflux from, and da transporter (dat) immunoreactivity in striatal suspensions are greater in pnd38-42 rats than in pnd88-92 rats. |
2009-03-03 |
2023-08-12 |
rat |
| Leonard L Howel. Nonhuman primate neuroimaging and cocaine medication development. Experimental and clinical psychopharmacology. vol 16. issue 6. 2009-03-03. PMID:19086766. |
given the important role of the dopamine transporter (dat) in the addictive properties of cocaine, the development and use of compounds that target the dat represents a reasonable approach for the pharmacological treatment of cocaine abuse. |
2009-03-03 |
2023-08-12 |
Not clear |
| Leonard L Howel. Nonhuman primate neuroimaging and cocaine medication development. Experimental and clinical psychopharmacology. vol 16. issue 6. 2009-03-03. PMID:19086766. |
a profile of slow rate of drug uptake in brain accompanied by a gradual increase in extracellular dopamine may account for the more limited reinforcing effectiveness of the dat inhibitors. |
2009-03-03 |
2023-08-12 |
Not clear |
| Balachandra K Gorentla, Amy E Moritz, James D Foster, Roxanne A Vaugha. Proline-directed phosphorylation of the dopamine transporter N-terminal domain. Biochemistry. vol 48. issue 5. 2009-03-03. PMID:19146407. |
phosphorylation of the dopamine transporter (dat) on n-terminal serines and unidentified threonines occurs concomitantly with protein kinase c (pkc)- and substrate-induced alterations in transporter activity, subcellular distribution, and dopamine efflux, but the residues phosphorylated and identities of protein kinases and phosphatases involved are not known. |
2009-03-03 |
2023-08-12 |
rat |
| J E de Leeuw van Weenen, L Hu, K Jansen-Van Zelm, M G de Vries, J T Tamsma, J A Romijn, H Pij. Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice. Brain research. vol 1250. 2009-02-27. PMID:19028458. |
we monitored in vivo dopamine release in the dorsomedial region of the hypothalamus, and determined hypothalamic gene expression patterns of dopamine receptors 1 and 2 (drd1 and 2), tyrosine hydroxylase (th) and the dopamine transporter (dat) in c57bl6 mice maintained on a high fat diet for 4 weeks. |
2009-02-27 |
2023-08-12 |
mouse |
| Ole Valente Mortensen, Mads Breum Larsen, Balakrishna M Prasad, Susan G Amar. Genetic complementation screen identifies a mitogen-activated protein kinase phosphatase, MKP3, as a regulator of dopamine transporter trafficking. Molecular biology of the cell. vol 19. issue 7. 2009-02-25. PMID:18434601. |
to identify molecules in pathways that regulate dopamine transporter (dat) internalization, we used a genetic complementation screen in xenopus oocytes to identify a mitogen-activated protein (map) kinase phosphatase, mkp3/pyst1/dusp6, as a molecule that inhibits protein kinase c-induced (pkc) internalization of transporters, resulting in enhanced dat activity. |
2009-02-25 |
2023-08-12 |
xenopus_laevis |
| Eriko Aoki, Ryohei Yano, Hironori Yokoyama, Hiroyuki Kato, Tsutomu Arak. Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice. Experimental and molecular pathology. vol 86. issue 1. 2009-02-25. PMID:19027004. |
densities of dat (dopamine transporter) immunoreactivity were also significantly decreased in nigral neurons of mice from 1 up to 21 days after mptp treatment. |
2009-02-25 |
2023-08-12 |
mouse |
| Tatiana Sorkina, Toni L Richards, Anjali Rao, Nancy R Zahniser, Alexander Sorki. Negative regulation of dopamine transporter endocytosis by membrane-proximal N-terminal residues. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 5. 2009-02-24. PMID:19193883. |
the plasma membrane dopamine transporter (dat) takes extracellular dopamine back up into dopaminergic neurons. |
2009-02-24 |
2023-08-12 |
human |
| Joanna S Fowler, Nora D Volkow, Jean Logan, David Alexoff, Frank Telang, Gene-Jack Wang, Christopher Wong, Yeming Ma, Aarti Kriplani, Kith Pradhan, David Schlyer, Millard Jayne, Barbara Hubbard, Pauline Carter, Donald Warner, Payton King, Colleen Shea, Youwen Xu, Lisa Muench, Karen Apelsko. Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine. NeuroImage. vol 43. issue 4. 2009-02-10. PMID:18708148. |
among individuals, those with the highest striatal (but not cerebellar) methamphetamine accumulation also had the highest dopamine transporter availability suggesting a relationship between meth exposure and dat availability. |
2009-02-10 |
2023-08-12 |
human |
| Valentina Ghisi, Amy J Ramsey, Bernard Masri, Raul R Gainetdinov, Marc G Caron, Ali Salahpou. Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. Cellular signalling. vol 21. issue 1. 2009-02-06. PMID:18929645. |
the dopamine transporter (dat) regulates the temporal and spatial actions of dopamine by reuptaking this neurotransmitter into the presynaptic neurons. |
2009-02-06 |
2023-08-12 |
mouse |
| Timothy M Fountaine, Lara Lourenco Venda, Nicholas Warrick, Helen C Christian, Patrik Brundin, Keith M Channon, Richard Wade-Martin. The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons. The European journal of neuroscience. vol 28. issue 12. 2009-02-03. PMID:19032594. |
in attempting to understand how this occurred we found that lowering alpha-synuclein levels caused changes to intracellular vesicles, dopamine transporter (dat) and vesicular monoamine transporter (vmat2), each of which is known to be an important component of the early events leading to mpp+ toxicity. |
2009-02-03 |
2023-08-12 |
mouse |
| Paul Crits-Christoph, Andrew Newberg, Nancy Wintering, Karl Ploessl, Mary Beth Connolly Gibbons, Sarah Ring-Kurtz, Robert Gallop, Julie Presen. Dopamine transporter levels in cocaine dependent subjects. Drug and alcohol dependence. vol 98. issue 1-2. 2009-01-23. PMID:18565692. |
cocaine use is a significant problem in the us and it is well established that cocaine binds to the dopamine transporter (dat) in the brain. |
2009-01-23 |
2023-08-12 |
human |
| Jason R Richardson, W Michael Caudle, Min Zheng Wang, E Danielle Dean, Kurt D Pennell, Gary W Mille. Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner. Neurotoxicology. vol 29. issue 5. 2009-01-23. PMID:18577399. |
exposure of pregnant mice to heptachlor led to increased levels of the dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2) levels at both the protein and mrna level in their offspring. |
2009-01-23 |
2023-08-12 |
mouse |
| Jason R Richardson, W Michael Caudle, Min Zheng Wang, E Danielle Dean, Kurt D Pennell, Gary W Mille. Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner. Neurotoxicology. vol 29. issue 5. 2009-01-23. PMID:18577399. |
increased dat and vmat2 levels were accompanied by alterations of mrna levels of nuclear transcription factors that control dopamine neuron development and regulate dat and vmat2 levels in adulthood. |
2009-01-23 |
2023-08-12 |
mouse |