| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thijs Beuming, Julie Kniazeff, Marianne L Bergmann, Lei Shi, Luis Gracia, Klaudia Raniszewska, Amy Hauck Newman, Jonathan A Javitch, Harel Weinstein, Ulrik Gether, Claus J Lolan. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature neuroscience. vol 11. issue 7. 2008-09-19. PMID:18568020. |
cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (dat). |
2008-09-19 |
2023-08-12 |
Not clear |
| Thijs Beuming, Julie Kniazeff, Marianne L Bergmann, Lei Shi, Luis Gracia, Klaudia Raniszewska, Amy Hauck Newman, Jonathan A Javitch, Harel Weinstein, Ulrik Gether, Claus J Lolan. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature neuroscience. vol 11. issue 7. 2008-09-19. PMID:18568020. |
our models suggest that the binding site for cocaine and cocaine analogs is deeply buried between transmembrane segments 1, 3, 6 and 8, and overlaps with the binding sites for the substrates dopamine and amphetamine, as well as for benztropine-like dat inhibitors. |
2008-09-19 |
2023-08-12 |
Not clear |
| Chunyang Jin, Hernán A Navarro, Kevin Page, F Ivy Carrol. Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes. Bioorganic & medicinal chemistry. vol 16. issue 14. 2008-09-11. PMID:18556210. |
the 2beta-[3'-(substituted benzyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes (3a-h) showed high binding affinities for the dopamine transporter (dat). |
2008-09-11 |
2023-08-12 |
Not clear |
| S A McDougall, C M Reichel, C M Farley, M M Flesher, T Der-Ghazarian, A M Cortez, J J Wacan, C E Martinez, F A Varela, A E Butt, C A Crawfor. Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18485605. |
on pd 90, dopamine transporter (dat) immunoreactivity and [3h]dopamine uptake were assayed in the striatum and nucleus accumbens, while in vivo microdialysis was used to measure dopamine efflux in the same brain regions. |
2008-08-29 |
2023-08-12 |
rat |
| S A McDougall, C M Reichel, C M Farley, M M Flesher, T Der-Ghazarian, A M Cortez, J J Wacan, C E Martinez, F A Varela, A E Butt, C A Crawfor. Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18485605. |
results showed that postnatal mn exposure caused persistent declines in dat protein expression and [3h]dopamine uptake in the striatum and nucleus accumbens, as well as long-term reductions in striatal dopamine efflux. |
2008-08-29 |
2023-08-12 |
rat |
| Jan Booij, Paul Kem. Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs. European journal of nuclear medicine and molecular imaging. vol 35. issue 2. 2008-08-26. PMID:17968545. |
[(123)i]n-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([(123)i]fp-cit) single photon emission computed tomography (spect) is a frequently and routinely used technique to detect or exclude dopaminergic degeneration by imaging the dopamine transporter (dat) in parkinsonian and demented patients. |
2008-08-26 |
2023-08-12 |
Not clear |
| Heather L Kimmel, S Stevens Negus, Kristin M Wilcox, Sarah B Ewing, Jeffrey Stehouwer, Mark M Goodman, John R Votaw, Nancy K Mello, F Ivy Carroll, Leonard L Howel. Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18468667. |
although inhibition of dopamine transporters (dat) and the subsequent increase in dopamine clearly play a role in the effects of psychomotor stimulants, the reinforcing effectiveness of dat inhibitors varies. |
2008-08-25 |
2023-08-12 |
monkey |
| Gang Zhao, Zhi-Hua Jiang, Xiang-Wei Zheng, Shao-Yun Zang, Li-He Gu. Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18485464. |
the present study assessed whether fq is effective in dopamine transporter (dat) regulation and antiparkinsonism by utilizing in vitro and in vivo assays, respectively. |
2008-08-25 |
2023-08-12 |
mouse |
| Gang Zhao, Zhi-Hua Jiang, Xiang-Wei Zheng, Shao-Yun Zang, Li-He Gu. Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18485464. |
fq at concentrations of 1-1000 microg/ml concentration-dependently inhibited dopamine uptake by chinese hamster ovary (cho) cells stably expressing dat (d8 cells) and by synaptosomes. |
2008-08-25 |
2023-08-12 |
mouse |
| Leah Aluisio, Brian Lord, Ann J Barbier, Ian C Fraser, Sandy J Wilson, Jamin Boggs, Lisa K Dvorak, Michael A Letavic, Bruce E Maryanoff, Nicholas I Carruthers, Pascal Bonaventure, Timothy W Lovenber. In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18499098. |
triple reuptake inhibitors, which block the serotonin transporter (sert), norepinephrine transporter (net) and dopamine transporter (dat) in the central nervous system have been described as therapeutic alternatives for classical selective serotonin reuptake inhibitors, with advantages due to their multiple mechanisms of action. |
2008-08-25 |
2023-08-12 |
mouse |
| Michael R Tilley, Howard H G. Dopamine transporter inhibition is required for cocaine-induced stereotypy. Neuroreport. vol 19. issue 11. 2008-08-25. PMID:18596615. |
the primary mechanism by which cocaine induces stereotypy has been difficult to discern because cocaine has three high-affinity targets: the reuptake transporters for dopamine (dat), norepinephrine, and serotonin. |
2008-08-25 |
2023-08-12 |
mouse |
| Christopher H van Dyck, Robert A Avery, Martha G MacAvoy, Kenneth L Marek, Donald M Quinlan, Ronald M Baldwin, John P Seibyl, Robert B Innis, Amy F T Arnste. Striatal dopamine transporters correlate with simple reaction time in elderly subjects. Neurobiology of aging. vol 29. issue 8. 2008-08-21. PMID:17363113. |
this research tested the hypothesis that striatal dopamine transporter (dat) availability in healthy elderly individuals was related to measures of motor performance. |
2008-08-21 |
2023-08-12 |
human |
| Teresa Marie du Bois, Ching-Wen Hsu, Yulin Li, Yean Yeow Tan, Chao Deng, Xu-Feng Huan. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Neurochemical research. vol 33. issue 7. 2008-08-20. PMID:18256931. |
this study examined how perinatal phencyclidine (pcp) treatment would affect dopamine d2 receptor and dopamine transporter (dat) binding at different stages after treatment cessation. |
2008-08-20 |
2023-08-12 |
rat |
| Frederic Boyer, Jean-Luc Dreye. The role of gamma-synuclein in cocaine-induced behaviour in rats. The European journal of neuroscience. vol 27. issue 11. 2008-08-20. PMID:18588534. |
the aim of this study was to investigate the role of gamma-synuclein in the rewarding effects of chronic cocaine administration and its putative interaction with the dopamine transporter (dat). |
2008-08-20 |
2023-08-12 |
rat |
| Christopher D Verrico, Laurie Lynch, Michele A Fahey, Ashley-Kay Fryer, Gregory M Miller, Bertha K Madra. MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. Journal of psychopharmacology (Oxford, England). vol 22. issue 2. 2008-08-18. PMID:18308800. |
we postulated that mdma will compromise executive function in primates and that an inhibitor of the serotonin transporter (sert) and the norepinephrine transporter (net) but not the dopamine (dat) transporter, will prevent impairment. |
2008-08-18 |
2023-08-12 |
human |
| Chunyang Jin, Hernán A Navarro, F Ivy Carrol. Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives. Bioorganic & medicinal chemistry. vol 16. issue 10. 2008-08-18. PMID:18434164. |
all tested compounds were found to exhibit nanomolar or subnanomolar affinity for the dopamine transporter (dat). |
2008-08-18 |
2023-08-12 |
Not clear |
| G J E Schmitt, C la Fougère, S Dresel, T Frodl, K Hahn, H-J Möller, E M Meisenzah. Dual-isotope SPECT imaging of striatal dopamine: first episode, drug naïve schizophrenic patients. Schizophrenia research. vol 101. issue 1-3. 2008-08-13. PMID:18083348. |
the aim of this investigation was to evaluate the usefulness of a dual-isotope spect technique to assess simultaneously striatal dopamine binding structures - presynaptic dopamine transporter (dat) and postsynaptic dopamine d(2) receptor - in first-episode, drug-naive schizophrenic patients compared to healthy control persons. |
2008-08-13 |
2023-08-12 |
Not clear |
| Vishakantha Murthy, Thomas J Martin, Susy Kim, Huw M L Davies, Steven R Childer. In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain. The Journal of pharmacology and experimental therapeutics. vol 326. issue 2. 2008-08-12. PMID:18492949. |
previous studies have shown that the phenylisothiocyanate tropane analog 2-beta-propanoyl-3-beta-(2-naphthyl)-8-[4-isothiocyanato)benzyl]nortropane (hd-205) binds covalently to dopamine and serotonin transporters (dat and sert, respectively) in rat brain membranes (biochem pharmacol 74:336-344, 2007). |
2008-08-12 |
2023-08-12 |
rat |
| Madhu Singh, Anwar J Khan, Parag P Shah, Rakesh Shukla, V K Khanna, Devendra Parma. Polymorphism in environment responsive genes and association with Parkinson disease. Molecular and cellular biochemistry. vol 312. issue 1-2. 2008-08-11. PMID:18327668. |
significant association was observed for monoamine oxidase-b(mao-b) variant allele g and pd, whereas no difference in genotype and allele frequencies was observed for manganese-superoxide dismutase (mnsod), dopamine receptor-d2(drd2), and dopamine transporter (dat) genes between controls and pd cases. |
2008-08-11 |
2023-08-12 |
Not clear |
| Shariq A Syed, Amy H Newman, Ahmed A Othman, Natalie D Eddingto. Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse. Journal of pharmaceutical sciences. vol 97. issue 5. 2008-08-05. PMID:17879975. |
a second generation of n-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]-tropanes (ga 1-69, jhw 005 and jhw 013) binds with high affinity to the dopamine transporter (dat) and are highly selective toward dat compared to muscarinic receptor binding (m1). |
2008-08-05 |
2023-08-12 |
rat |