| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tatyana D Sotnikova, Jean-Martin Beaulieu, Raul R Gainetdinov, Marc G Caro. Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter. CNS & neurological disorders drug targets. vol 5. issue 1. 2006-05-22. PMID:16613553. |
the plasma membrane dopamine transporter (dat) tightly regulates the extracellular concentrations of dopamine (da) by re-capturing released neurotransmitter back into the presynaptic neuronal terminals and/or neighboring da projections thereby providing an effective way to regulate synaptic and extrasynaptic da levels. |
2006-05-22 |
2023-08-12 |
mouse |
| Johanna Krause, Christian la Fougere, Klaus-Henning Krause, Manfred Ackenheil, Stefan H Drese. Influence of striatal dopamine transporter availability on the response to methylphenidate in adult patients with ADHD. European archives of psychiatry and clinical neuroscience. vol 255. issue 6. 2006-05-17. PMID:16091862. |
in this study, we investigated whether availability of striatal dopamine transporter (dat) may have an influence on the response of adult patients with attention deficit hyperactivity disorder (adhd) on methylphenidate (mph). |
2006-05-17 |
2023-08-12 |
Not clear |
| Ivan O Medvedev, Raul R Gainetdinov, Tatyana D Sotnikova, Laura M Bohn, Marc G Caron, Linda A Dykstr. Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice. Psychopharmacology. vol 180. issue 3. 2006-05-16. PMID:15719221. |
the dopamine transporter (dat) is thought to play a major role in the rewarding effects of cocaine. |
2006-05-16 |
2023-08-12 |
mouse |
| Habibeh Khoshbouei, Namita Sen, Bipasha Guptaroy, L 'Aurelle Johnson, David Lund, Margaret E Gnegy, Aurelio Galli, Jonathan A Javitc. N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. PLoS biology. vol 2. issue 3. 2006-05-12. PMID:15024426. |
amphetamine (amph) elicits its behavioral effects by acting on the dopamine (da) transporter (dat) to induce da efflux into the synaptic cleft. |
2006-05-12 |
2023-08-12 |
human |
| Robert D Staszewski, Bryan K Yamamot. Methamphetamine-induced spectrin proteolysis in the rat striatum. Journal of neurochemistry. vol 96. issue 5. 2006-05-11. PMID:16417574. |
however, ampa or nmda receptor antagonism did not attenuate the meth-induced depletions of the dopamine transporter (dat). |
2006-05-11 |
2023-08-12 |
rat |
| Xilu Jiao, William P Paré, Shanaz M Tejani-But. Antidepressant drug induced alterations in binding to central dopamine transporter sites in the Wistar Kyoto rat strain. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 1. 2006-05-08. PMID:16091300. |
given the role of the mesolimbic dopamine (da) system in cognitive, emotional and motivational behaviors, we previously examined the distribution of da transporter (dat) sites in the brains of wky compared to wistar (wis) and sprague-dawley (s-d) rats. |
2006-05-08 |
2023-08-12 |
rat |
| Doris J Doudet, Thomas J Ruth, James E Holde. Sequential versus nonsequential measurement of density and affinity of dopamine D2 receptors with [11C]raclopride: 2: effects of DAT inhibitors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 1. 2006-05-03. PMID:15973354. |
sequential versus nonsequential measurement of density and affinity of dopamine d2 receptors with [11c]raclopride: 2: effects of dat inhibitors. |
2006-05-03 |
2023-08-12 |
Not clear |
| D J Speca, N Rabbee, D Chihara, T P Speed, A S Peterso. A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice. Genes, brain, and behavior. vol 5. issue 1. 2006-05-03. PMID:16436185. |
with a genetic background sensitized by a mutation in the dopamine transporter (dat), we used random chemical mutagenesis and screened for mutant mice with locomotor abnormalities. |
2006-05-03 |
2023-08-12 |
mouse |
| D J Speca, N Rabbee, D Chihara, T P Speed, A S Peterso. A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice. Genes, brain, and behavior. vol 5. issue 1. 2006-05-03. PMID:16436185. |
mapping of mutations in these lines identified two loci that alter activity only when dopamine levels are elevated by a dat mutation and thus would only have been uncovered by this type of approach. |
2006-05-03 |
2023-08-12 |
mouse |
| Alessandro Bertolino, Giuseppe Blasi, Valeria Latorre, Valeria Rubino, Antonio Rampino, Lorenzo Sinibaldi, Grazia Caforio, Vittoria Petruzzella, Antonio Pizzuti, Tommaso Scarabino, Marcello Nardini, Daniel R Weinberger, Bruno Dallapiccol. Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 15. 2006-05-02. PMID:16611807. |
functional polymorphisms in the catechol-o-methyltransferase (comt) and the dopamine transporter (dat) genes modulate dopamine inactivation, which is crucial for determining neuronal signal-to-noise ratios in prefrontal cortex during working memory. |
2006-05-02 |
2023-08-12 |
human |
| Daniel Ka Leung Cheuk, Susanna Yuk Han Li, Virginia Won. No association between VNTR polymorphisms of dopamine transporter gene and attention deficit hyperactivity disorder in Chinese children. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 2. 2006-05-01. PMID:16402340. |
dopamine transporter (dat) gene is implicated in the pathogenesis of attention deficit hyperactivity disorder (adhd). |
2006-05-01 |
2023-08-12 |
Not clear |
| Peter Klivenyi, Donald Siwek, Gabrielle Gardian, Lichuan Yang, Anatoly Starkov, Carine Cleren, Robert J Ferrante, Neil W Kowall, Asa Abeliovich, M Flint Bea. Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiology of disease. vol 21. issue 3. 2006-04-28. PMID:16298531. |
there was dose-dependent protection against loss of both dopamine in the striatum and dopamine transporter (dat) immunoreactive neurons in the substantia nigra. |
2006-04-28 |
2023-08-12 |
mouse |
| Koenraad Van Laere, Cindy Casteels, Liesbet De Ceuninck, Bert Vanbilloen, Alex Maes, Luc Mortelmans, Wim Vandenberghe, Alfons Verbruggen, René Do. Dual-tracer dopamine transporter and perfusion SPECT in differential diagnosis of parkinsonism using template-based discriminant analysis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 3. 2006-04-27. PMID:16513606. |
we investigated whether combined perfusion and dopamine transporter (dat) imaging can aid in the differential diagnosis of parkinsonian disorders: idiopathic parkinson's disease (ipd), progressive supranuclear palsy (psp), multiple system atrophy (msa), dementia with lewy bodies (lbd), and essential tremor (et). |
2006-04-27 |
2023-08-12 |
Not clear |
| Sami S Zoghbi, H Umesha Shetty, Masanori Ichise, Masahiro Fujita, Masao Imaizumi, Jeih-San Liow, Jay Shah, John L Musachio, Victor W Pike, Robert B Inni. PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 3. 2006-04-27. PMID:16513622. |
18f-2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (18f-fecnt), a pet radioligand for the dopamine transporter (dat), generates a radiometabolite that enters the rat brain. |
2006-04-27 |
2023-08-12 |
human |
| Elisabeth Greiner, Terrence L Boos, Thomas E Prisinzano, Maria G De Martino, Brian Zeglis, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity. Journal of medicinal chemistry. vol 49. issue 5. 2006-04-25. PMID:16509591. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-piperidines and 4-[2-[(bisphenyl)methoxy]ethyl]-piperidines with different types of substituents in the phenylpropyl side-chain were synthesized and examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2006-04-25 |
2023-08-12 |
Not clear |
| Grazyna Bial. [Behavioral and pharmacological characteristics of mice lacking the dopamine transporter]. Postepy higieny i medycyny doswiadczalnej (Online). vol 58. 2006-04-21. PMID:15765018. |
the dopamine transporter (dat) reuptakes the released neurotransmitter into presynaptic terminals. |
2006-04-21 |
2023-08-12 |
mouse |
| Grazyna Bial. [Behavioral and pharmacological characteristics of mice lacking the dopamine transporter]. Postepy higieny i medycyny doswiadczalnej (Online). vol 58. 2006-04-21. PMID:15765018. |
mice lacking the dopamine transporter (dat knock-out mice) display marked changes in an dopamine homeostasis that result in an elevated dopaminergic level and locomotor hyperactivity. |
2006-04-21 |
2023-08-12 |
mouse |
| Grazyna Bial. [Behavioral and pharmacological characteristics of mice lacking the dopamine transporter]. Postepy higieny i medycyny doswiadczalnej (Online). vol 58. 2006-04-21. PMID:15765018. |
the reinforcing potency of amphetamines, cocaine, and morphine maintained in the absence of the dat may suggest that other neurotransmitter systems in addition to dopamine might contribute to the actions of psychostimulants and opioid agonists. |
2006-04-21 |
2023-08-12 |
mouse |
| Luciano Minuzzi, Aage Kristian Olsen, Dirk Bender, Sidse Arnfred, Rebecca Grant, Erik H Danielsen, Paul Cummin. Quantitative autoradiography of ligands for dopamine receptors and transporters in brain of Göttingen minipig: comparison with results in vivo. Synapse (New York, N.Y.). vol 59. issue 4. 2006-04-21. PMID:16385509. |
however, the dopamine transporter (dat) ligand [3h]gbr12935 did not bind in pig brain cryostat sections. |
2006-04-21 |
2023-08-12 |
human |
| Mohamed A Elwan, Jason R Richardson, Thomas S Guillot, W Michael Caudle, Gary W Mille. Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxicology and applied pharmacology. vol 211. issue 3. 2006-04-20. PMID:16005927. |
studies from our laboratory and others have demonstrated that certain pesticides increase levels of the dopamine transporter (dat), an integral component of dopaminergic neurotransmission and a gateway for dopaminergic neurotoxins. |
2006-04-20 |
2023-08-12 |
mouse |