| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. Bioorganic & medicinal chemistry. vol 12. issue 23. 2005-04-13. PMID:15519172. |
both cis and trans 2,4- and 3,6-disubstituted derivatives were synthesized to determine the positional importance of n-substitution on affinity for monoamine transporters, that is the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net) in rat brain. |
2005-04-13 |
2023-08-12 |
rat |
| Yolanda Mateo, Evgeny A Budygin, Carrie E John, Matthew L Banks, Sara R Jone. Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus accumbens. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589348. |
cocaine elevates dopamine (da) in the nucleus accumbens (nac) by blocking the uptake of da through the da transporter (dat). |
2005-04-12 |
2023-08-12 |
mouse |
| Stacey A Lomenzo, Jill B Rhoden, Sari Izenwasser, Dean Wade, Theresa Kopajtic, Jonathan L Katz, Mark L Trudel. Synthesis and biological evaluation of meperidine analogues at monoamine transporters. Journal of medicinal chemistry. vol 48. issue 5. 2005-04-11. PMID:15743177. |
three compounds, the 3,4-dichlorophenyl derivative 7e and the 2-naphthyl analogues 6f and 7f, were identified that were more potent at the dat than meperidine and that exhibited well-defined biphasic dopamine uptake inhibition similar to meperidine. |
2005-04-11 |
2023-08-12 |
Not clear |
| Hidekazu Kawashima, Yasuhiko Iida, Youji Kitamura, Hideo Saj. Binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP+), a metabolite of haloperidol, to synthetic melanin: implications for the dopaminergic neurotoxicity of HPP+. Neurotoxicity research. vol 6. issue 7-8. 2005-04-08. PMID:15639785. |
when hpp+ (approximately 100 microm) was added to primary cultures prepared from rat embryonic mesencephalon for 1 h, the survivability of dopaminergic neurons decreased significantly, and this effect was not inhibited by the dopamine transporter (dat) inhibitor gbr 12909. |
2005-04-08 |
2023-08-12 |
rat |
| Daniel Weintraub, Andrew B Newberg, Mark S Cary, Andrew D Siderowf, Paul J Moberg, Galit Kleiner-Fisman, John E Duda, Matthew B Stern, David Mozley, Ira R Kat. Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 46. issue 2. 2005-04-08. PMID:15695780. |
we studied the correlation of striatal dopamine transporter (dat) imaging with anxiety and depression symptoms in parkinson's disease (pd). |
2005-04-08 |
2023-08-12 |
Not clear |
| Zoltán Szabó, Miklós Argyelán, Balázs Kanyó, László Pávics, Zoltán Jank. [Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 6. issue 2. 2005-04-05. PMID:15787205. |
[change of dopamine transporter activity (dat) during the action of bupropion (in depression)]. |
2005-04-05 |
2023-08-12 |
Not clear |
| Aurelija Jucaite, Elisabeth Fernell, Christer Halldin, Hans Forssberg, Lars Fard. Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity. Biological psychiatry. vol 57. issue 3. 2005-04-01. PMID:15691523. |
the purpose of our study was to examine dopamine transporter (dat) and dopamine d2 receptor (d2r) binding in adolescents with adhd and to search for its relationship with cognitive functions as well as locomotor hyperactivity. |
2005-04-01 |
2023-08-12 |
Not clear |
| Robert Hering, Karsten M Strauss, Xiao Tao, Andreas Bauer, Dirk Woitalla, Eva-Maria Mietz, Slobodanka Petrovic, Peter Bauer, Wilhelm Schaible, Thomas Müller, Ludger Schöls, Christine Klein, Daniela Berg, Philipp T Meyer, Jörg B Schulz, Bernd Wollnik, Liang Tong, Rejko Krüger, Olaf Ries. Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365989. |
in the patient, a substantial reduction of dopamine uptake transporter (dat) binding was found in the striatum using [(18)f]fp-cit and pet, indicating a serious loss of presynaptic dopaminergic afferents. |
2005-03-31 |
2023-08-12 |
Not clear |
| Keun-Ah Cheon, Young-Hoon Ryu, Jae-Won Kim, Dae-Yeon Ch. The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 15. issue 1. 2005-03-29. PMID:15572278. |
the symptoms of attention deficit hyperactivity disorder (adhd) can be treated with methylphenidate (mph), a potent blocker of dopamine transporter (dat). |
2005-03-29 |
2023-08-12 |
human |
| Xuemei Peng, Ao Zhang, Nora S Kula, Ross J Baldessarini, John L Neumeye. Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. Bioorganic & medicinal chemistry letters. vol 14. issue 22. 2005-03-22. PMID:15482938. |
novel compounds were evaluated for affinity and selectivity in competitive radioligand binding assays selective for cerebral serotonin (5-ht), dopamine (da), and norepinephrine (ne) transporters (sert, dat, and net). |
2005-03-22 |
2023-08-12 |
Not clear |
| Varun Rachakonda, Tian Hong Pan, Wei Dong L. Biomarkers of neurodegenerative disorders: how good are they? Cell research. vol 14. issue 5. 2005-03-22. PMID:15538967. |
the followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated beta-amyloid peptide for alzheimer's disease (ad), alpha-synuclein contained lewy bodies and altered dopamine transporter (dat) imaging for parkinson's disease (pd), sod mutations for familial amyotrophic lateral sclerosis (als), and cag repeats resulted from huntington's gene mutations in huntington's disease (hd). |
2005-03-22 |
2023-08-12 |
Not clear |
| Yasuhide Mitsumoto, Atsushi Mori, Satoshi Ohashi, Masami Nakai, Tetsuji Moriizum. Differential effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the olfactory bulb and the striatum in mice. Neuroscience research. vol 51. issue 1. 2005-03-21. PMID:15596247. |
while a small reduction of tyrosine hydroxylase protein level was observed in the ob of mptp-treated mice, dopamine transporter (dat) was undetectable at the protein level in this region. |
2005-03-21 |
2023-08-12 |
mouse |
| Bin Liu, Jun Xia Xie, Dewi Kenneth Rowlands, Yu Lin Gou, Ching Cheong Leung, Yiu Wa Chung, Hsiao Chang Cha. Neuroprotective effects of Bak Foong Pill in 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-induced Parkinson's disease model mice. Biological & pharmaceutical bulletin. vol 27. issue 8. 2005-03-18. PMID:15305030. |
in the present study, we compared the effects of bak foong pill (bfp), a well-known gynaecological tonic in china, and 17beta-estradiol, on dopamine transporter (dat) and tyrosine hydroxylase (th) gene expression patterns in ovariectomized, 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (mptp)-induced parkinson's disease (pd) model mice, using multiplex reverse transcription-polymerase chain reaction (rt-pcr). |
2005-03-18 |
2023-08-12 |
mouse |
| Houbo Jiang, Qian Jiang, Jian Fen. Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. The Journal of biological chemistry. vol 279. issue 52. 2005-03-14. PMID:15492001. |
consistent with this, increased binding sites for dopamine transporter (dat) ligand were observed in sh-sy5y cells overexpressing parkin. |
2005-03-14 |
2023-08-12 |
human |
| Houbo Jiang, Qian Jiang, Jian Fen. Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. The Journal of biological chemistry. vol 279. issue 52. 2005-03-14. PMID:15492001. |
in these cells, parkin enhanced the ubiquitination and degradation of dat, increased its cell surface expression, and augmented dopamine uptake. |
2005-03-14 |
2023-08-12 |
human |
| Houbo Jiang, Qian Jiang, Jian Fen. Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. The Journal of biological chemistry. vol 279. issue 52. 2005-03-14. PMID:15492001. |
because the cell surface expression of functional dat requires its oligomerization, misfolded dat, induced either by the protein glycosylation inhibitor tunicamycin or by its c-terminal truncation, significantly attenuated cell surface expression of native dat and reduced dopamine uptake. |
2005-03-14 |
2023-08-12 |
human |
| Houbo Jiang, Qian Jiang, Jian Fen. Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. The Journal of biological chemistry. vol 279. issue 52. 2005-03-14. PMID:15492001. |
thus, our studies suggest that parkin increases dopamine uptake by enhancing the ubiquitination and degradation of misfolded dat, so as to prevent it from interfering with the oligomerization and cell surface expression of native dat. |
2005-03-14 |
2023-08-12 |
human |
| Tetsurou Ikeda, Masaru Kurosawa, Chiharu Uchikawa, Shigeo Kitayama, Nobuyuki Nukin. Modulation of monoamine transporter expression and function by repetitive transcranial magnetic stimulation. Biochemical and biophysical research communications. vol 327. issue 1. 2005-03-11. PMID:15629452. |
in contrast to the sert changes, increased mrna levels of dopamine transporter (dat) and norepinephrine transporter (net) were observed. |
2005-03-11 |
2023-08-12 |
mouse |
| Karmen K Yoder, Gary D Hutchins, Evan D Morris, Allison Brashear, Chunzi Wang, Anantha Shekha. Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia. Schizophrenia research. vol 71. issue 2-3. 2005-03-01. PMID:15474908. |
striatal dopamine transporter (dat) binding potential (bp) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. |
2005-03-01 |
2023-08-12 |
human |
| Sara A Gardiner, Mary F Morrison, P David Mozley, Lyn Harper Mozley, Colleen Brensinger, Warren Bilker, Andrew Newberg, Michelle Battistin. Pilot study on the effect of estrogen replacement therapy on brain dopamine transporter availability in healthy, postmenopausal women. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 12. issue 6. 2005-02-28. PMID:15545330. |
authors investigated the association between estrogen replacement therapy (ert) and dopamine transporter (dat) availability in women. |
2005-02-28 |
2023-08-12 |
Not clear |