| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanjie Yu, Dan Lv, Mengxin Shen, Yanhua Zhang, Dongsheng Zhou, Zhongming Chen, Chuang Wan. BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. Psychiatry research. vol 271. 2019-04-15. PMID:30529315. |
in addition, the reserpine-induced decreases in serotonin transporter (5-htt), brain-derived neurotrophic factor (bdnf) and tryptophan hydroxylase 1 (tph1) in mouse hippocampus and prefrontal cortex (pfc) were significantly reversed by scopolamine. |
2019-04-15 |
2023-08-13 |
mouse |
| Zhi-Kun Qiu, Guan-Hua Zhang, De-Sheng Zhong, Jia-Li He, Xu Liu, Ji-Sheng Chen, Da-Nian We. Puerarin ameliorated the behavioral deficits induced by chronic stress in rats. Scientific reports. vol 7. issue 1. 2019-04-10. PMID:28740098. |
in addition, enzyme linked immunosorbent assay (elisa) and high performance liquid chromatography-electrochemical detection (hplc-ecd) showed that chronic treatment of puerarin (60 and 120 mg/kg, i.g) reversed the decreased levels of progesterone, allopregnanolone, serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) in prefrontal cortex and hippocampus of post-cus rats. |
2019-04-10 |
2023-08-13 |
rat |
| Zhi-Kun Qiu, Jia-Li He, Xu Liu, Jia Zeng, Wei Xiao, Qing-Hong Fan, Xiao-Meng Chai, Wei-Hai Ye, Ji-Sheng Che. Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder. Metabolic brain disease. vol 33. issue 4. 2019-04-01. PMID:29633071. |
moreover, the decreased levels of serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) in prefrontal cortex and hippocampus were reversed by pf (10 and 20 mg/kg, i.p. |
2019-04-01 |
2023-08-13 |
rat |
| Girdhari Lal Gupta, Joneth Fernande. Protective effect of Convolvulus pluricaulis against neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551424. |
furthermore, a one-week treatment of cpe (50 and 100 mg/kg) or fluoxetine also remarkably restored the serotonin and noradrenaline levels in the hippocampus as well as in the prefrontal cortex of the cums-exposed rats. |
2019-04-01 |
2023-08-13 |
rat |
| Dool-Ri Oh, Yujin Kim, Ara Jo, Eun Jin Choi, Kyo-Nyeo Oh, Jaeyong Kim, Huwon Kang, Young Ran Kim, Chul Yung Cho. Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABA Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551479. |
furthermore, pcpa treatment alone decreased serotonin (5-ht) levels in the hc (p < 0.05) and the prefrontal cortex (pfc; p < 0.05), while vbfw plus pcpa significantly increased the 5-ht levels in both the hc and the pfc (p < 0.05). |
2019-04-01 |
2023-08-13 |
mouse |
| Rulan Lu, Chengliang Zhang, Yanyan Liu, Linxiao Wang, Xia Chen, Xianju Zho. The effect of bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor and serotonin in patients with generalized anxiety disorder. Neuroscience letters. vol 684. 2019-02-20. PMID:30008380. |
the effect of bilateral low-frequency rtms over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor and serotonin in patients with generalized anxiety disorder. |
2019-02-20 |
2023-08-13 |
Not clear |
| Rulan Lu, Chengliang Zhang, Yanyan Liu, Linxiao Wang, Xia Chen, Xianju Zho. The effect of bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor and serotonin in patients with generalized anxiety disorder. Neuroscience letters. vol 684. 2019-02-20. PMID:30008380. |
to investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rtms) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (bdnf) and serotonin (5-ht) in patients with generalized anxiety disorders (gad). |
2019-02-20 |
2023-08-13 |
Not clear |
| Julien Volle, Tatiana Bregman, Brian Scott, Mustansir Diwan, Roger Raymond, Paul J Fletcher, José N Nobrega, Clement Haman. Deep brain stimulation and fluoxetine exert different long-term changes in the serotonergic system. Neuropharmacology. vol 135. 2019-02-04. PMID:29505786. |
both selective serotonin reuptake inhibitors (ssris) and ventromedial prefrontal cortex (vmpfc) deep brain stimulation (dbs) modulate serotonergic activity. |
2019-02-04 |
2023-08-13 |
rat |
| J J Dimatelis, A Mtintsilana, V Naidoo, D J Stein, V A Russel. Chronic light exposure alters serotonergic and orexinergic systems in the rat brain and reverses maternal separation-induced increase in orexin receptors in the prefrontal cortex. Metabolic brain disease. vol 33. issue 2. 2019-01-31. PMID:29039077. |
enzyme-linked immunosorbent assays were employed to measure 5-hydroxytryptamine (5-ht) levels in the hypothalamus and prefrontal cortex (pfc). |
2019-01-31 |
2023-08-13 |
rat |
| J J Dimatelis, A Mtintsilana, V Naidoo, D J Stein, V A Russel. Chronic light exposure alters serotonergic and orexinergic systems in the rat brain and reverses maternal separation-induced increase in orexin receptors in the prefrontal cortex. Metabolic brain disease. vol 33. issue 2. 2019-01-31. PMID:29039077. |
however, ccl increased hypothalamic 5-ht and reduced 5-ht levels in the pfc. |
2019-01-31 |
2023-08-13 |
rat |
| Zhi-Kun Qiu, De-Sheng Zhong, Jia-Li He, Xu Liu, Ji-Sheng Chen, Hong Ni. The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29101599. |
moreover, the present study also found that consistent with ser, the levels of allopregnanolone and serotonin (5-ht) in the prefrontal cortex and hippocampus were increased by puerarin (60 and 120 mg/kg, i.g. |
2019-01-31 |
2023-08-13 |
Not clear |
| M G Morgese, S Schiavone, E Mhillaj, M Bove, P Tucci, L Trabac. N-3 PUFA diet enrichment prevents amyloid beta-induced depressive-like phenotype. Pharmacological research. vol 129. 2019-01-22. PMID:29203442. |
furthermore, n-3 pufa rich diet exposure reverted also serotonin and neurotrophin level reduction in prefrontal cortex of aβ treated rats. |
2019-01-22 |
2023-08-13 |
rat |
| Han-Fang Wu, Yi-Ju Chen, Ming-Chia Chu, Ya-Ting Hsu, Ting-Yi Lu, I-Tuan Chen, Po See Chen, Hui-Ching Li. Deep Brain Stimulation Modified Autism-Like Deficits via the Serotonin System in a Valproic Acid-Induced Rat Model. International journal of molecular sciences. vol 19. issue 9. 2018-12-18. PMID:30235871. |
deep brain stimulation (dbs) is known to be a promising treatment for resistant depression, which acts via the serotonin (5-hydroxytryptamine, 5-ht) system in the infralimbic prefrontal cortex (ilpfc). |
2018-12-18 |
2023-08-13 |
rat |
| Benneth Ben-Azu, Adegbuyi Oladele Aderibigbe, Aya-Ebi Okubo Eneni, Abayomi Mayowa Ajayi, Solomon Umukoro, Ezekiel O Iwalew. Morin Attenuates Neurochemical Changes and Increased Oxidative/Nitrergic Stress in Brains of Mice Exposed to Ketamine: Prevention and Reversal of Schizophrenia-Like Symptoms. Neurochemical research. vol 43. issue 9. 2018-11-21. PMID:29956036. |
thereafter, the brain levels of dopamine, glutamate, 5-hydroxytryptamine and acetyl-cholinesterase, as well as biomarkers of oxidative/nitrergic stress were measured in the striatum, prefrontal-cortex (pfc) and hippocampus (hc). |
2018-11-21 |
2023-08-13 |
mouse |
| Ryan M Walsh, Erica Y Shen, Rosemary C Bagot, Anthony Anselmo, Yan Jiang, Behnam Javidfar, Gregory J Wojtkiewicz, Jennifer Cloutier, John W Chen, Ruslan Sadreyev, Eric J Nestler, Schahram Akbarian, Konrad Hochedlinge. Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice. Nature communications. vol 8. 2018-11-14. PMID:28485378. |
we further observe misregulation of serotonin signalling within the prefrontal cortex of phf8 deficient mice and identify the serotonin receptors htr1a and htr2a as direct targets of phf8. |
2018-11-14 |
2023-08-13 |
mouse |
| Lei Gao, Shuo Feng, Zhao-Yuan Liu, Jiu-Qiang Wang, Ke-Ke Qi, Kai Wan. A computational network analysis based on targets of antipsychotic agents. Schizophrenia research. vol 193. 2018-11-13. PMID:28755876. |
by historeceptomics analysis, significant brain region specific target-drug interactions were identified in targets of dopamine receptors (drd1-olanzapine in caudate nucleus and pons (p-value<0.005), drd2-bifeprunox in caudate nucleus and pituitary (p-value<0.0005), drd4-loxapine in pineal (p-value<0.00001)) and 5-hydroxytryptamine receptor (htr2a-risperidone in occipital lobe, prefrontal cortex and subthalamic nucleus (p-value<0.0001)). |
2018-11-13 |
2023-08-13 |
Not clear |
| Wu Song, Yan Guo, Shuang Jiang, Lin Wei, Zhi Liu, Xiaoyan Wang, Ying S. Antidepressant Effects of the Ginsenoside Metabolite Compound K, Assessed by Behavioral Despair Test and Chronic Unpredictable Mild Stress Model. Neurochemical research. vol 43. issue 7. 2018-10-15. PMID:29790069. |
to investigate the underlying mechanism, the levels of endogenous noradrenaline, dopamine (da), 5-hydroxytryptamine (5-ht) and their metabolites in the prefrontal cortex (pfc) and hippocampus were detected by hplc coupled with electron detector. |
2018-10-15 |
2023-08-13 |
mouse |
| Gerard J Mare. Interactions of Hallucinogens with the Glutamatergic System: Permissive Network Effects Mediated Through Cortical Layer V Pyramidal Neurons. Current topics in behavioral neurosciences. vol 36. 2018-09-20. PMID:28831734. |
recordings made from layer v (l5) pyramidal cells of the prefrontal cortex (pfc) and neocortex in rodent slice preparations have shown that serotonin (5-hydroxytryptamine, 5-ht) and serotonergic hallucinogens induce an increase in the frequency of spontaneous excitatory postsynaptic currents (epscs) in the apical dendritic field by activating 5-ht |
2018-09-20 |
2023-08-13 |
Not clear |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
additionally, t3 and t4 levels were measured again, and serotonin (5ht), dopamine, and noradrenaline levels were analyzed in the prefrontal cortex and the hippocampus. |
2018-08-20 |
2023-08-13 |
mouse |
| Vandreza Cardoso Bortolotto, Franciane Cabral Pinheiro, Stífani Machado Araujo, Márcia Rósula Poetini, Bianca Santos Bertolazi, Mariane Trindade de Paula, Luana Barreto Meichtry, Francielli Polet de Almeida, Shanda de Freitas Couto, Cristiano Ricardo Jesse, Marina Prigo. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. European journal of pharmacology. vol 822. 2018-08-20. PMID:29355556. |
reduced levels of 5ht and dopamine in the prefrontal cortex and the hippocampus were observed in the hypothyroid mice than in the euthyroid mice. |
2018-08-20 |
2023-08-13 |
mouse |