| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristian Gaarn du Jardin, Heidi Kaastrup Müller, Betina Elfving, Elena Dale, Gregers Wegener, Connie Sanche. Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review. Progress in neuro-psychopharmacology & biological psychiatry. vol 71. 2017-08-30. PMID:27262695. |
in line with these prospects, ketamine may increase 5-ht levels in the prefrontal cortex of rats, plausibly via hippocampal nmda receptor inhibition and activation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptors. |
2017-08-30 |
2023-08-13 |
rat |
| Mercedes Erburu, Irene Muñoz-Cobo, Teresa Diaz-Perdigon, Paolo Mellini, Takayoshi Suzuki, Elena Puerta, Rosa M Torder. SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action. Neuropharmacology. vol 117. 2017-08-29. PMID:28185898. |
sirt2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action. |
2017-08-29 |
2023-08-13 |
Not clear |
| Suzana Elena Voiculescu, Diana Le Duc, Adrian Eugen Roșca, Vlad Zeca, Diana Maria Chiţimuș, Andreea Letiţia Arsene, Cristina Manuela Drăgoi, Alina Crenguţa Nicolae, Leon Zăgrean, Torsten Schöneberg, Ana-Maria Zăgrea. Behavioral and molecular effects of prenatal continuous light exposure in the adult rat. Brain research. vol 1650. 2017-08-21. PMID:27566064. |
the serotonin reuptaker slc6a4 displayed a decreased expression in the prefrontal cortex of pcle group. |
2017-08-21 |
2023-08-13 |
rat |
| Yusuf S Althobaiti, Atiah H Almalki, Sujan C Das, Fahad S Alshehri, Youssef Sar. Effects of repeated high-dose methamphetamine and ceftriaxone post-treatments on tissue content of dopamine and serotonin as well as glutamate and glutamine. Neuroscience letters. vol 634. 2017-08-21. PMID:27702628. |
meth induced a significant depletion of dopamine and 5-ht in the nac and pfc. |
2017-08-21 |
2023-08-13 |
rat |
| Javier Del Pino, Paula Moyano, Matilde Ruiz, María José Anadón, María Jesús Díaz, José Manuel García, Elena Labajo-González, María Teresa Frej. Amitraz changes NE, DA and 5-HT biosynthesis and metabolism mediated by alterations in estradiol content in CNS of male rats. Chemosphere. vol 181. 2017-08-04. PMID:28463726. |
oral amitraz exposure (20, 50 and 80 mg/kg bw, 5 days) has been reported to increase serotonin (5-ht), norepinephrine (ne) and dopamine (da) content and to decrease their metabolites and turnover rates in the male rat brain, particularly in the striatum, prefrontal cortex, and hippocampus. |
2017-08-04 |
2023-08-13 |
rat |
| Begoña Fernández-Pastor, Jorge E Ortega, Laura Grandoso, Elena Castro, Luisa Ugedo, Ángel Pazos, J Javier Mean. Chronic citalopram administration desensitizes prefrontal cortex but not somatodendritic α Neuropharmacology. vol 114. 2017-07-11. PMID:27908769. |
chronic citalopram administration desensitizes prefrontal cortex but not somatodendritic α selective serotonin reuptake inhibitors (ssris) regulate brain noradrenergic neurotransmission both at somatodendritic and nerve terminal areas. |
2017-07-11 |
2023-08-13 |
Not clear |
| C D Pandya, N Hoda, A Crider, D Peter, A Kutiyanawalla, S Kumar, A O Ahmed, G Turecki, C M Hernandez, A V Terry, A Pilla. Transglutaminase 2 overexpression induces depressive-like behavior and impaired TrkB signaling in mice. Molecular psychiatry. vol 22. issue 5. 2017-06-29. PMID:27620841. |
significant increases in the levels of type-2 transglutaminase (tg2, which is implicated in transamidation of 5-ht to rac1) are observed in the mouse prefrontal cortex (pfc) following chronic exposure to stress. |
2017-06-29 |
2023-08-13 |
mouse |
| J M Witkin, J A Monn, D D Schoepp, X Li, C Overshiner, S N Mitchell, G Carter, B Johnson, K Rasmussen, L M Rorick-Keh. The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits. The Journal of pharmacology and experimental therapeutics. vol 358. issue 1. 2017-05-23. PMID:27189960. |
when given acutely, both ketamine and ly341495, but not the selective serotonin reuptake inhibitor (ssri) citalopram, increased the number of spontaneously active dopamine neurons in the ventral tegmental area (vta), increased extracellular levels of dopamine in the nucleus accumbens and prefrontal cortex, and enhanced the locomotor stimulatory effects of the dopamine d2/3 receptor agonist quinpirole. |
2017-05-23 |
2023-08-13 |
mouse |
| Jolien Van Schoors, Johan Viaene, Yannick Van Wanseele, Ilse Smolders, Bieke Dejaegher, Yvan Vander Heyden, Ann Van Eeckhau. An improved microbore UHPLC method with electrochemical detection for the simultaneous determination of low monoamine levels in in vivo brain microdialysis samples. Journal of pharmaceutical and biomedical analysis. vol 127. 2017-05-15. PMID:26809614. |
the sensitive uhplc-ecd assay (lloq of 100pm for na and 150pm for da and 5-ht) with an analysis time of 8min for standard solutions and 20min for in vivo microdialysis samples originating from rat hippocampus, prefrontal cortex and striatum, is validated applying accuracy profiles. |
2017-05-15 |
2023-08-13 |
rat |
| Martin J Brodie, Frank Besag, Alan B Ettinger, Marco Mula, Gabriella Gobbi, Stefano Comai, Albert P Aldenkamp, Bernhard J Steinhof. Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review. Pharmacological reviews. vol 68. issue 3. 2017-04-20. PMID:27255267. |
we review the common neurotransmitter systems and brain regions implicated in both epilepsy and aggression, including the gaba, glutamate, serotonin, dopamine, and noradrenaline systems and the hippocampus, amygdala, prefrontal cortex, anterior cingulate cortex, and temporal lobes. |
2017-04-20 |
2023-08-13 |
Not clear |
| Carlos Borges Filho, Cristiano Ricardo Jesse, Franciele Donato, Lucian Del Fabbro, Marcelo Gomes de Gomes, André Tiago Rossito Goes, Leandro Cattelan Souza, Renata Giacomeli, Michelle Antunes, Cristiane Luchese, Silvane Souza Roman, Silvana Peterini Boeir. Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice. European journal of pharmacology. vol 791. 2017-03-28. PMID:27609609. |
ucs induced the decrease in the 5-ht levels in the hp and the increase in the indoleamine-2,3-dioxygenase, caspase 3 and 9 activities in the pfc and hp. |
2017-03-28 |
2023-08-13 |
mouse |
| Laura Jiménez-Sánchez, Anna Castañé, Laura Pérez-Caballero, Marc Grifoll-Escoda, Xavier López-Gil, Leticia Campa, Mireia Galofré, Esther Berrocoso, Albert Adel. Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 6. 2017-03-06. PMID:26088969. |
we also used in vivo microdialysis to evaluate the release of glutamate, γ-aminobutyric acid, serotonin, dopamine, and noradrenaline in the prefrontal cortex and c-fos immunohistochemistry to determine the brain regions activated by dbs. |
2017-03-06 |
2023-08-13 |
Not clear |
| Laura Jiménez-Sánchez, Anna Castañé, Laura Pérez-Caballero, Marc Grifoll-Escoda, Xavier López-Gil, Leticia Campa, Mireia Galofré, Esther Berrocoso, Albert Adel. Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 6. 2017-03-06. PMID:26088969. |
the activation of prefrontal ampars would result in a stimulation of prefrontal output to the brainstem, thus increasing serotonin, dopamine, and noradrenaline in the prefrontal cortex. |
2017-03-06 |
2023-08-13 |
Not clear |
| Mary Gemmel, Ine Rayen, Tiffany Lotus, Eva van Donkelaar, Harry W Steinbusch, Sonsoles De Lacalle, Nikolaos Kokras, Christina Dalla, Jodi L Pawlusk. Developmental fluoxetine and prenatal stress effects on serotonin, dopamine, and synaptophysin density in the PFC and hippocampus of offspring at weaning. Developmental psychobiology. vol 58. issue 3. 2017-01-02. PMID:26477449. |
developmental fluoxetine and prenatal stress effects on serotonin, dopamine, and synaptophysin density in the pfc and hippocampus of offspring at weaning. |
2017-01-02 |
2023-08-13 |
rat |
| Teri M Furlong, Lee S Leavitt, Kristen A Keefe, Jong-Hyun So. Methamphetamine-, d-Amphetamine-, and p-Chloroamphetamine-Induced Neurotoxicity Differentially Effect Impulsive Responding on the Stop-Signal Task in Rats. Neurotoxicity research. vol 29. issue 4. 2016-12-27. PMID:26846719. |
these regimens preferentially reduced da transporter levels in striatum, 5-ht transporter levels in prefrontal cortex, or both, respectively. |
2016-12-27 |
2023-08-13 |
rat |
| Susana Aznar, Mona El-Sayed Hervi. The 5-HT2A serotonin receptor in executive function: Implications for neuropsychiatric and neurodegenerative diseases. Neuroscience and biobehavioral reviews. vol 64. 2016-12-27. PMID:26891819. |
serotonin signalling at serotonin 2a receptors (5-ht2ar) has important effects on these behavioural and cognitive pathways, with the prefrontal cortex (pfc) as the central actor. |
2016-12-27 |
2023-08-13 |
human |
| A L Garcia-Garcia, Q Meng, J Richardson-Jones, A Dranovsky, E D Leonard. Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. Neuroscience. vol 321. 2016-12-13. PMID:26049143. |
the treatment with way 100,635 does not affect adult 5-ht1a expression levels, but leads to increased expression of the serotonin transporter in the raphe, along with enhanced serotonin levels in both the prefrontal cortex and raphe that correlate with the behavioral changes observed in adult mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Yen-Wenn Liu, Wei-Hsien Liu, Chien-Chen Wu, Yi-Chen Juan, Yu-Chen Wu, Huei-Ping Tsai, Sabrina Wang, Ying-Chieh Tsa. Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice. Brain research. vol 1631. 2016-12-13. PMID:26620542. |
furthermore, the dopamine level in the prefrontal cortex (pfc) was significantly increased in ps128 treated els and naïve adult mice whereas serotonin (5-ht) level was increased only in the naïve adult mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Inbar Zohar, Shai Shoham, Marta Weinstoc. Perinatal citalopram does not prevent the effect of prenatal stress on anxiety, depressive-like behaviour and serotonergic transmission in adult rat offspring. The European journal of neuroscience. vol 43. issue 4. 2016-12-13. PMID:26669896. |
citalopram failed to restore the reduction in the expression of serotonin 1a autoreceptors in the prefrontal cortex of males and in corticotropin-releasing factor type 2 receptors in the dorsal raphe nuclei of females induced by prenatal stress. |
2016-12-13 |
2023-08-13 |
rat |
| b' Jan Vevera, Karel Vale\\xc5\\xa1, Zden\\xc4\\x9bk Fi\\xc5\\xa1ar, Jana Hroudov\\xc3\\xa1, Namrata Singh, Ale\\xc5\\xa1 Stuchl\\xc3\\xadk, Petr Ka\\xc4\\x8der, Tereza Nekov\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa. The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model. Physiology & behavior. vol 158. 2016-12-13. PMID:26917054.' |
we have studied selected biologic traits potentially affected by statin treatment - serotonin (5-ht) uptake in platelets, membrane microviscosity in erythrocytes, cholesterol level in the brain (amygdala; hippocampus and prefrontal cortex), as well as behavioral changes in an elevated plus maze and open field test in male long-evans rats, which were treated by simvastatin (30mg/kg per day) for 2 or 4weeks. |
2016-12-13 |
2023-08-13 |
rat |