| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Marcus, G G Nomikos, T H Svensso. Effects of atypical antipsychotic drugs on dopamine output in the shell and core of the nucleus accumbens: role of 5-HT(2A) and alpha(1)-adrenoceptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 4. 2000-09-14. PMID:10871706. |
the effects of acute intravenous administration of several new, atypical antipsychotic drugs (apds): olanzapine (0.05 and 1.0 mg/kg), sertindole (0.1 and 1.0 mg/kg) and quetiapine (0.25 and 2.5 mg/kg), a selective 5-ht(2a) receptor antagonist, m100907 (0.03 and 0.3 mg/kg), and an alpha(1)-adrenoceptor antagonist, prazosin (0.3 mg/kg), on regional dopamine output were examined in the two subdivisions of the nucleus accumbens (nac), the core and shell, which seem associated with motor control and limbic functions, respectively, by using in vivo differential normal pulse voltammetry in anaesthetised, pargyline-pretreated rats. |
2000-09-14 |
2023-08-12 |
rat |
| M S Todtenkopf, K R De Leon, J R Stella. Repeated cocaine treatment alters tyrosine hydroxylase in the rat nucleus accumbens. Brain research bulletin. vol 52. issue 5. 2000-09-14. PMID:10922520. |
after 2 or 14 days of withdrawal, sections of the nucleus accumbens (nac) were processed for tyrosine hydroxylase and the number of immunoreactive varicosities in the core and shell were quantified. |
2000-09-14 |
2023-08-12 |
rat |
| W Hauber, I Bohn, C Giertle. NMDA, but not dopamine D(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934279. |
the present study sought to explore whether signals transmitted via the nmda subtype of glutamate receptors and via dopamine d(2) receptors in the nucleus accumbens (nac) are critical for the determination of reaction times (rts) of instrumental responses by the expectancy of future reward. |
2000-08-31 |
2023-08-12 |
rat |
| M P De Parada, M A Parada, P Rada, L Hernandez, B G Hoebe. Dopamine-acetylcholine interaction in the rat lateral hypothalamus in the control of locomotion. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880673. |
in experiment 2, the same doses of carbachol proportionately increased exctracellular da in the nucleus accumbens (nac) as monitored by brain microdialysis. |
2000-08-28 |
2023-08-12 |
rat |
| V M Pickel, J Douglas, J Chan, P D Gamp, N W Bunnet. Neurokinin 1 receptor distribution in cholinergic neurons and targets of substance P terminals in the rat nucleus accumbens. The Journal of comparative neurology. vol 423. issue 3. 2000-08-24. PMID:10870089. |
substance p (sp) is the major endogenous ligand for neurokinin 1 (nk1) receptors and, together with acetylcholine, has an important role in motivated behaviors involving the limbic shell and motor core of the nucleus accumbens (nac). |
2000-08-24 |
2023-08-12 |
rat |
| T R Franklin, J P Druha. The retrograde tracer fluoro-gold interferes with the expression of fos-related antigens. Journal of neuroscience methods. vol 98. issue 1. 2000-08-15. PMID:10837865. |
to examine this question, fg was microiontophoresed unilaterally into the nucleus accumbens (nac) of rats and fos-related antigens (fras) were examined in both hemispheres 12 days later. |
2000-08-15 |
2023-08-12 |
rat |
| D Nakahara, M Nakamura, H Furukawa, N Furun. Intracranial self-stimulation increases differentially in vivo hydroxylation of tyrosine but similarly in vivo hydroxylation of tryptophan in rat medial prefrontal cortex, nucleus accumbens and striatum. Brain research. vol 864. issue 1. 2000-08-11. PMID:10793194. |
we have examined using microdialysis the effect of intracranial self-stimulation (icss) on the in vivo hydroxylation rate of tyrosine and tryptophan in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and striatum (str). |
2000-08-11 |
2023-08-12 |
rat |
| T R Franklin, J P Druha. Expression of Fos-related antigens in the nucleus accumbens and associated regions following exposure to a cocaine-paired environment. The European journal of neuroscience. vol 12. issue 6. 2000-08-11. PMID:10886349. |
this study examined whether conditioned hyperactivity measured in a cocaine-paired environment was associated with increased expression of fos-related antigens (fra) within the nucleus accumbens (nac) and associated forebrain regions of rats. |
2000-08-11 |
2023-08-12 |
rat |
| M J Thomas, R C Malenka, A Bonc. Modulation of long-term depression by dopamine in the mesolimbic system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908594. |
recent work suggests that long-term changes in synaptic strength at excitatory synapses in the two major components of this system, the nucleus accumbens (nac) and ventral tegmental area, may be particularly important for the development of drug-induced sensitization, a process that may contribute to addiction, as well as for normal response-reinforcement learning. |
2000-08-10 |
2023-08-12 |
Not clear |
| S M Nicola, S A Deadwyle. Firing rate of nucleus accumbens neurons is dopamine-dependent and reflects the timing of cocaine-seeking behavior in rats on a progressive ratio schedule of reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 14. 2000-08-03. PMID:10884336. |
we recorded neuronal spike activity from cells in the nucleus accumbens (nac) of rats responding on a pr schedule for cocaine reinforcement. |
2000-08-03 |
2023-08-12 |
rat |
| S Puglisi-Allegra, S Cabib, T Pascucci, R Ventura, F Cali, V Roman. Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuria. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817622. |
results indicated a significant reduction of 5-ht levels and metabolism in prefrontal cortex (pfc), cingulate cortex (cg), nucleus accumbens (nac), caudate putamen (cp), hippocampus (hip) and amygdala (amy). |
2000-07-17 |
2023-08-12 |
mouse |
| M F Salvatore, A Garcia-Espana, M Goldstein, A Y Deutch, J W Haycoc. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854265. |
the striatum (str), substantia nigra (sn), nucleus accumbens (nac), and ventral tegmental area (vta) from sprague-dawley rats were harvested 30-40 min after a single injection of either vehicle, haloperidol (2 mg/kg), raclopride (2 mg/kg), clozapine (30 mg/kg), or sch23390 (0.5 mg/kg). |
2000-07-17 |
2023-08-12 |
rat |
| M M Iravani, D Asari, J Patel, W J Wieczorek, Z L Kru. Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices. Synapse (New York, N.Y.). vol 36. issue 4. 2000-06-06. PMID:10819905. |
we examined the effects of pressure ejected 3, 4-methylenedioxymethamphetamine (mdma) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-ht) or dopamine (da) release in the caudate putamen (cpu), nucleus accumbens (nac), substantia nigra pars reticulata (snr), and the dorsal raphé nucleus (drn) brain slices of rat, using fast cyclic voltammetry (fcv). |
2000-06-06 |
2023-08-12 |
rat |
| D B Carr, S R Sesac. Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 10. 2000-05-25. PMID:10804226. |
to address whether pfc afferents innervate different populations of vta neurons that project to the nucleus accumbens (nac) or to the pfc, a triple labeling method was used that combined peroxidase markers for anterograde and retrograde tract-tracing with pre-embedding immunogold-silver labeling for either tyrosine hydroxylase (th) or gaba. |
2000-05-25 |
2023-08-12 |
rat |
| M F Olive, K K Mehmert, C W Hodg. Microdialysis in the mouse nucleus accumbens: a method for detection of monoamine and amino acid neurotransmitters with simultaneous assessment of locomotor activity. Brain research. Brain research protocols. vol 5. issue 1. 2000-05-24. PMID:10719261. |
microdialysis has been extensively used to characterize the effects of drugs of abuse on extracellular levels of various neurotransmitters in nucleus accumbens (nac) of the rat brain. |
2000-05-24 |
2023-08-12 |
mouse |
| M F Olive, K K Mehmert, C W Hodg. Microdialysis in the mouse nucleus accumbens: a method for detection of monoamine and amino acid neurotransmitters with simultaneous assessment of locomotor activity. Brain research. Brain research protocols. vol 5. issue 1. 2000-05-24. PMID:10719261. |
while an earlier study has shown the feasibility of measuring monoamines in the nac of behaving transgenic mice [i. sillaber, a. montkowski, r. landgraf, n. barden, f. holsboer, r. spanagel, enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type ii) receptor function: influence of long-term treatment with the antidepressant moclobemide, neuroscience, 85 (1998) 415-425 [16] ], in this protocol we demonstrate a method for measuring both monoamine and amino neurotransmitters from the nac of freely moving mice combined with open field locomotor activity monitoring. |
2000-05-24 |
2023-08-12 |
mouse |
| D W Johnson, P Eodice, H Winterbottom, D J Mokle. Decreased accumbens dopamine release after cocaine challenge in behaviorally sensitized female rats. Pharmacology, biochemistry, and behavior. vol 65. issue 4. 2000-05-10. PMID:10764919. |
the effects of the competitive nmda receptor antagonist cpp on the initiation of behavioral sensitization to acute cocaine and basal and acute cocaine-induced dopamine (da) release in the nucleus accumbens (nac) were assessed in female sprague-dawley rats. |
2000-05-10 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens. Brain research. vol 858. issue 2. 2000-04-24. PMID:10708676. |
serotonin (5-ht)(1a) receptor agonism may be of interest in regard to both the antipsychotic action and extrapyramidal symptoms (eps) of antipsychotic drugs (apd) based, in part, on the effect of 5-ht(1a) receptor stimulation on the release of dopamine (da) in the nucleus accumbens (nac) and striatum (str), respectively. |
2000-04-24 |
2023-08-12 |
rat |
| W K Schiffer, M R Gerasimov, R A Bermel, J D Brodie, S L Dewe. Stereoselective inhibition of dopaminergic activity by gamma vinyl-GABA following a nicotine or cocaine challenge: a PET/microdialysis study. Life sciences. vol 66. issue 13. 2000-04-11. PMID:10737423. |
elevation of endogenous gaba by the racemic mixture of gamma vinyl-gaba (gvg, vigabatrin) decreases extracellular nucleus accumbens (nac) dopamine (da) levels and diminishes the response to many drugs of abuse known to elevate da in the mesocorticolimbic system. |
2000-04-11 |
2023-08-12 |
Not clear |
| S Ikemoto, N E Goeder. Intra-medial prefrontal cortex injections of scopolamine increase instrumental responses for cocaine: an intravenous self-administration study in rats. Brain research bulletin. vol 51. issue 2. 2000-03-30. PMID:10709961. |
the present experiments examined the effects of muscarinic cholinergic receptor blockade in the nucleus accumbens (nac) and medial prefrontal cortex (mpc) on intravenous cocaine self-administration. |
2000-03-30 |
2023-08-12 |
rat |