| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asif Iqbal, Abdul Hamid, Syed Muzzammil Ahmad, Kabirullah Lutf. The Role of Mu Opioid Receptors in High Fat Diet-Induced Reward and Potentiation of the Rewarding Effect of Oxycodone. Life (Basel, Switzerland). vol 13. issue 3. 2023-03-29. PMID:36983775. |
excessive high fat diet (hfd) consumption can induce food addiction, which is believed to involve the communication between the hypothalamus and mesolimbic dopaminergic neurons, originating in the ventral tegmental area (vta) and projecting to the nucleus accumbens (nac). |
2023-03-29 |
2023-08-14 |
mouse |
| Alysha A Sultan, Mikaela K Dimick, Clement C Zai, James L Kennedy, Bradley J MacIntosh, Benjamin I Goldstei. The association of CNR1 genetic variants with resting-state functional connectivity in youth bipolar disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 71. 2023-03-27. PMID:36972648. |
regions-of-interests in seed-to-voxel analyses included: bilateral amygdala, hippocampus, nucleus accumbens (nac), and orbitofrontal cortex (ofc). |
2023-03-27 |
2023-08-14 |
human |
| Robert A Phillips, Jennifer J Tuscher, N Dalton Fitzgerald, Ethan Wan, Morgan E Zipperly, Corey G Duke, Lara Ianov, Jeremy J Da. Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine. Molecular and cellular neurosciences. 2023-03-25. PMID:36965548. |
drugs of abuse increase extracellular concentrations of dopamine in the nucleus accumbens (nac), resulting in transcriptional alterations that drive long-lasting cellular and behavioral adaptations. |
2023-03-25 |
2023-08-14 |
rat |
| Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C Nairn, Paul Greengard, Marc Flajolet, Denis Herv, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Giraul. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945487. |
these effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (nac). |
2023-03-22 |
2023-08-14 |
Not clear |
| Weiwei Bao, Jiahui Ding, Shan Jiang, Zhen Yao, Weimin Qu, Wenxian Li, Zhili Huang, Yuan Ha. Selective Activation of NAc D1R-VP/LH Circuits Promotes Reanimation From Sevoflurane Anesthesia in Mice. Anesthesia and analgesia. 2023-03-21. PMID:36944111. |
emerging evidence has uncovered a vital role of nucleus accumbens (nac) neurons that express the dopamine d1 receptor (d1r) and its upstream neural circuit in general anesthesia (ga) regulation. |
2023-03-21 |
2023-08-14 |
mouse |
| Kai Wen Xi, De Duo Chen, Xin Geng, Yan Bian, Min Xin Wang, Hui Bia. Calcium/calmodulin-dependent protein kinase II is involved in the transmission and regulation of nociception in naïve and morphine-tolerant rat nucleus accumbens. The Korean journal of pain. 2023-03-20. PMID:36941088. |
this research was conducted to investigate the role of camk ii in the transmission and regulation of nociceptive information within the nucleus accumbens (nac) of naïve and morphine-tolerant rats. |
2023-03-20 |
2023-08-14 |
rat |
| Kyle D Ketchesin, Darius D Becker-Krail, Xiangning Xue, Rashaun S Wilson, TuKiet T Lam, Kenneth R Williams, Angus C Nairn, George C Tseng, Ryan W Loga. Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909659. |
repeated use of substances such as psychostimulants and opioids may lead to significant alterations in molecular rhythms in the nucleus accumbens (nac), a brain region central to reward and motivation. |
2023-03-13 |
2023-08-14 |
mouse |
| Mark D Namba, Megan N Phillips, Peng-Jen Chen, Benjamin E Blass, M Foster Olive, Janet L Neisewande. HIV gp120 impairs nucleus accumbens neuroimmune function and dopamine D3 receptor-mediated inhibition of cocaine seeking in male rats. Addiction neuroscience. vol 5. 2023-03-13. PMID:36909738. |
moreover, postmortem analysis of nucleus accumbens (nac) core neuroimmune function indicated cocaine abstinence- and gp120-induced impairments, and the expression of several immune factors within the nac core significantly correlated with cocaine-seeking behavior. |
2023-03-13 |
2023-08-14 |
human |
| Xiaoying Tan, Elizabeth M Neslund, Zheng-Ming Din. The involvement of dopamine and D2 receptor-mediated transmission in effects of cotinine in male rats. Neuropharmacology. 2023-03-13. PMID:36914092. |
passive administration of cotinine elevated extracellular dopamine levels in the nucleus accumbens (nac) and the d1 receptor antagonist sch23390 attenuated cotinine self-administration. |
2023-03-13 |
2023-08-14 |
rat |
| Yunwanbin Wang, Archana Singh, Guohui Li, Shuwen Yue, Kegan Hertel, Zi-Jun Wan. Opioid induces increased DNA damage in prefrontal cortex and nucleus accumbens. Pharmacology, biochemistry, and behavior. 2023-03-12. PMID:36907467. |
to test our hypothesis, we aim to examine the overall dna damage level in prefrontal cortex (pfc) and nucleus accumbens (nac) after heroin exposure, as well as whether manipulating dna damage levels can alter heroin seeking. |
2023-03-12 |
2023-08-14 |
mouse |
| Zi-Xuan He, Ke Xi, Kai-Jie Liu, Mei-Hui Yue, Yao Wang, Yue-Yue Yin, Lin Liu, Xiao-Xiao He, Hua-Li Yu, Zhen-Kai Xing, Xiao-Juan Zh. A Nucleus Accumbens Tac1 Neural Circuit Regulates Avoidance Responses to Aversive Stimuli. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901777. |
the nucleus accumbens (nac) plays an important role in predicting aversive events and translating motivations into actions. |
2023-03-11 |
2023-08-14 |
Not clear |
| Kelsey Hagan, Nandini Datta, May Stern, Cara Boho. Aberrant reward-related neural activation: Dimensional correlate of binge-eating severity or categorical marker of binge eating? Journal of psychiatric research. vol 161. 2023-03-10. PMID:36898327. |
mean percent signal change within the left and right nucleus accumbens (nac) during anticipation of monetary gain (versus non-gain) was extracted from a priori-defined functional 5 mm spheres and correlated with average weekly be frequency. |
2023-03-10 |
2023-08-14 |
Not clear |
| Wenjuan Hou, Shuying Huang, Zhixiong He, Xing Guo, Lu Li, Shufeng Shang, Ziyan Jia, Lizi Zhang, Yishan Qu, Caihong Huang, Yin Li, Yitong Li, Zijian Lv, Fadao Ta. Oxytocin treatments or activation of the paraventricular nucleus-the shell of nucleus accumbens pathway reduce adverse effects of chronic social defeat stress on emotional and social behaviors in Mandarin voles. Neuropharmacology. 2023-03-09. PMID:36893984. |
repeated ot treatments during csds prevented decrease of oxytocin receptors in nucleus accumbens (nac) in females, but produced no effects on males. |
2023-03-09 |
2023-08-14 |
Not clear |
| Arthur Godino, Marine Salery, Romain Durand-de Cuttoli, Molly S Estill, Leanne M Holt, Rita Futamura, Caleb J Browne, Philipp Mews, Peter J Hamilton, Rachael L Neve, Li Shen, Scott J Russo, Eric J Nestle. Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards. Neuron. 2023-03-08. PMID:36889314. |
in the nucleus accumbens (nac) of male and female mice, we show that although its own expression remains unaltered after cocaine exposure, rxrα controls plasticity- and addiction-relevant transcriptional programs in both dopamine receptor d1- and d2-expressing medium spiny neurons, which in turn modulate intrinsic excitability and synaptic activity of these nac cell types. |
2023-03-08 |
2023-08-14 |
mouse |
| Yajie Jiang, Manshu Zou, Yeqing Wang, Yuhong Wan. Nucleus Accumbens in the Pathogenesis of Major Depressive Disorder: A Brief Review. Brain research bulletin. 2023-03-08. PMID:36889362. |
extensive studies have demonstrated the involvement of nuclei such as the prefrontal cortex (pfc), hippocampus (hip), nucleus accumbens (nac), hypothalamus, etc., in mdd. |
2023-03-08 |
2023-08-14 |
Not clear |
| Lisha Deng, Zheng Chu, Peng Liu, Baijia Li, Gang Lei, Shaofu Li, Yongkang Ma, Yonghui Dan. Effects of brain-derived neurotrophic factor and adeno-associated viral vector on morphine-induced condition through target concentration changes in the ventral tegmental area and nucleus accumbens. Behavioural brain research. 2023-03-08. PMID:36889465. |
the overexpression of bdnf in the ventral tegmental area (vta) caused by bdnf-aav injection decreased the total distance of locomotion in mice who underwent morphine-induced bs and increased the concentrations of bdnf, trkb, and creb in the vta and nucleus accumbens (nac). |
2023-03-08 |
2023-08-14 |
mouse |
| Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior. 2023-03-04. PMID:36870422. |
the present study demonstrated for the first time that acute as well as subchronic (4 days) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3 mg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the β-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). |
2023-03-04 |
2023-08-14 |
rat |
| Soren D Emerson, Maxime Chevée, Philipp Mews, Erin S Calipar. The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system. Molecular and cellular neurosciences. 2023-03-03. PMID:36868542. |
in this study, we utilized rna sequencing to characterize how the transcriptome-wide effects of acute cocaine exposure were altered by a history of cocaine self-administration and long-term withdrawal (30 days) in the ventral tegmental area (vta), nucleus accumbens (nac), and prefrontal cortex (pfc) in male mice. |
2023-03-03 |
2023-08-14 |
mouse |
| Parviz Dousti Kataj, Nasim Vousooghi, Mahmoud Reza Hadjighassem, Maryam Farahmandfar, Somayeh Ebrahimi-Baroug. Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: expression changes of NMDA receptor subunits and NT-3. Behavioural brain research. 2023-02-28. PMID:36854364. |
this study was designed to discover the effect of mscs injection in the nucleus accumbens (nac) on the reinstatement of behavior in morphine-induced conditioned place preference (cpp) in male rats. |
2023-02-28 |
2023-08-14 |
rat |
| Yun Zhou, Qingxiao Hong, Wenjin Xu, Weisheng Chen, Xiaohu Xie, Dingding Zhuang, Miaojun Lai, Dan Fu, Zemin Xu, Majie Wang, Wenhua Zhou, Huifen Li. Differential expression profiling of tRNA-Derived small RNAs and their potential roles in methamphetamine self-administered rats. Frontiers in genetics. vol 14. 2023-02-27. PMID:36845381. |
in this study, we used a combination of small rna sequencing, quantitative reverse transcription-polymerase chain reaction (qrt‒pcr), bioinformatics, and luciferase reporter assays to screen the expression profiles and identify the functional roles of trfs and tirnas in the nucleus accumbens (nac) of methamphetamine self-administration rat models. |
2023-02-27 |
2023-08-14 |
rat |