| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marjan Nikbakhtzadeh, Hoda Ranjbar, Khadijeh Moradbeygi, Elham Zahedi, Mahnaz Bayat, Monavareh Soti, Mohammad Shaban. Cross-talk between the HPA axis and addiction-related regions in stressful situations. Heliyon. vol 9. issue 4. 2023-05-08. PMID:37151697. |
first, we will provide an overview of changes in the hypothalamus-pituitary-adrenal (hpa) axis component following stress, which impact reward-related regions including the ventral tegmental area (vta) and nucleus accumbens (nac). |
2023-05-08 |
2023-08-14 |
Not clear |
| Cristina E Maria-Rios, Geoffrey G Murphy, Jonathan D Morro. Subregional Differences in Medium Spiny Neuron Intrinsic Excitability Properties between Nucleus Accumbens Core and Shell in Male Rats. eNeuro. 2023-05-08. PMID:37156609. |
the nucleus accumbens (nac) is known for its central role in reward and motivation (day and carelli, 2007; floresco, 2015; salgado and kaplitt, 2015). |
2023-05-08 |
2023-08-14 |
rat |
| Parth Bhatia, Lite Yang, Jay X J Luo, Mengyi Xu, William Rentha. Epigenomic profiling of mouse nucleus accumbens at single-cell resolution. Molecular and cellular neurosciences. 2023-05-03. PMID:37137383. |
the nucleus accumbens (nac) is a key brain region involved in reward processing and is linked to multiple neuropsychiatric conditions such as substance use disorder, depression, and chronic pain. |
2023-05-03 |
2023-08-14 |
mouse |
| Saurabh S Kokane, Robert D Cole, Bogdan Bordieanu, Chevin M Ray, Ishraq A Haque, James M Otis, Jacqueline F McGint. Increased Excitability and Synaptic Plasticity of Drd1- and Drd2- expressing Prelimbic Neurons Projecting to Nucleus Accumbens after Heroin Abstinence are Reversed by Cue-induced Relapse and Protein Kinase A Inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-04-24. PMID:37094933. |
dysregulation of the input from the prefrontal cortex (pfc) to the nucleus accumbens (nac) contributes to cue-induced opioid seeking but the heterogeneity in, and regulation of, prelimbic (pl)-pfc to nac (pl->nac) neurons that are altered has not been comprehensively explored. |
2023-04-24 |
2023-08-14 |
Not clear |
| Michał Sobstyl, Angelika Stapińska-Synie. Deep brain stimulation of the medial forebrain bundle for treatment-resistant depression - a narrative literature review. Postepy psychiatrii neurologii. vol 30. issue 3. 2023-04-21. PMID:37082768. |
the main nucleus of the reward circuit is the nucleus accumbens (nac), which plays a critical role in reward-seeking behavior, motivation, and addiction. |
2023-04-21 |
2023-08-14 |
Not clear |
| Tadaaki Nishioka, Suthinee Attachaipanich, Kosuke Hamaguchi, Michael Lazarus, Alban de Kerchove d'Exaerde, Tom Macpherson, Takatoshi Hikid. Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice. Nature communications. vol 14. issue 1. 2023-04-21. PMID:37085502. |
the encoding of such cue-outcome associations, as well as the performance of cue-guided choice behavior, is thought to involve dopamine d1 and d2 receptor-expressing medium spiny neurons (d1-/d2-msns) of the nucleus accumbens (nac). |
2023-04-21 |
2023-08-14 |
mouse |
| Yanqin Hu, Chaoqi Zhao, Houfeng Zhao, Juan Qia. Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder. BMC psychiatry. vol 23. issue 1. 2023-04-21. PMID:37085792. |
the nucleus accumbens (nac) is a crucial brain region in the pathophysiology of major depressive disorder (mdd) patients with anhedonia. |
2023-04-21 |
2023-08-14 |
Not clear |
| Stephanie Puig, Xiangning Xue, Ryan Salisbury, Micah A Shelton, Sam-Moon Kim, Mariah A Hildebrand, Jill R Glausier, Zachary Freyberg, George C Tseng, Anastasia K Yocum, David A Lewis, Marianne L Seney, Matthew L MacDonald, Ryan W Loga. Uncovering circadian rhythm disruptions of synaptic proteome signaling in prefrontal cortex and nucleus accumbens associated with opioid use disorder. bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066169. |
in human subjects with oud, previous transcriptomics work implicated a role for circadian regulation of synaptic processes in key cognitive- and reward-related brain regions, dorsolateral prefrontal cortex (dlpfc) and nucleus accumbens (nac). |
2023-04-17 |
2023-08-14 |
human |
| Ahmet Yardimci, Nazife Ulker Ertugrul, Aslisah Ozgen, Gulendam Ozbeg, Mehmet Ridvan Ozdede, Eda Coban Ercan, Sinan Canpola. Effects of chronic irisin treatment on brain monoamine levels in the hypothalamic and subcortical nuclei of adult male and female rats: An HPLC-ECD study. Neuroscience letters. 2023-04-15. PMID:37061025. |
in nucleus accumbens (nac), irisin significantly reduced 5-hydroxyindoleacetic acid (5-hiaa) levels (p<0.05), which are implicated in autism spectrum disorder (asd) physiopathology. |
2023-04-15 |
2023-08-14 |
rat |
| Lorraine Madur, Christian Ineichen, Giorgio Bergamini, Alexandra Greter, Giulia Poggi, Nagiua Cuomo-Haymour, Hannes Sigrist, Yaroslav Sych, Jean-Charles Paterna, Klaus D Bornemann, Coralie Viollet, Francesc Fernandez-Albert, Gregorio Alanis-Lobato, Bastian Hengerer, Christopher R Pryc. Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice. Communications biology. vol 6. issue 1. 2023-04-15. PMID:37061616. |
glutamate neurons in basal amygdala (ba) project to various regions including nucleus accumbens (nac). |
2023-04-15 |
2023-08-14 |
mouse |
| Liang Wang, Qingfan Wei, Rui Xu, Yaxing Chen, Shu Li, Qian Bu, Ying Zhao, Hongchun Li, Yue Zhao, Linhong Jiang, Yuanyuan Chen, Yanping Dai, Yinglan Zhao, Xiaobo Ce. Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice. ACS chemical neuroscience. 2023-04-12. PMID:37043723. |
the results showed that meth remodeled the mitochondrial lipidome of the hippocampus, nucleus accumbens (nac), and striatum in both models. |
2023-04-12 |
2023-08-14 |
mouse |
| Xin-Gui Guo, Li-Qing Kang, Ning Wang, Jie-Xia Wan. Assessment of nucleus accumbens impairment in a rat model of postoperative cognitive dysfunction using diffusion tensor imaging. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 2023-04-11. PMID:37039137. |
nucleus accumbens (nac) is involved in depression. |
2023-04-11 |
2023-08-14 |
rat |
| Yi He, Junshi Wang, King-Lun Li, Yao Q Wang, Zachary Freyberg, Yan Don. Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-04-11. PMID:37041207. |
expression of incubated cocaine seeking is mediated, in part, by cocaine-induced cellular adaptations in medium spiny neurons (msns) within the nucleus accumbens (nac). |
2023-04-11 |
2023-08-14 |
mouse |
| Alexa R Zimbelman, Benjamin Wong, Conor H Murray, Marina E Wolf, Michael T Stefani. Dopamine D1 and NMDA receptor co-regulation of protein translation in cultured nucleus accumbens neurons. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034633. |
we used nucleus accumbens (nac) medium spiny neurons (msn), co-cultured with cortical neurons to restore excitatory synapses, to examine whether dopamine modulates protein translation in nac msn. |
2023-04-10 |
2023-08-14 |
Not clear |
| Christian M Wood, Laith Alexander, Johan Alsiö, Andrea M Santangelo, Lauren McIver, Gemma J Cockcroft, Angela C Robert. Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets. Science translational medicine. vol 15. issue 690. 2023-04-05. PMID:37018416. |
activation of the neural pathway connecting the scacc-25 to the nucleus accumbens (nac) caused blunting of anticipatory arousal (a form of anhedonia) in marmosets in response to a reward-associated conditioned stimulus in an appetitive pavlovian discrimination test. |
2023-04-05 |
2023-08-14 |
human |
| Linxuan Zhang, Zehao Zeng, Xiaoyu Lu, Mengqing Li, Jiayu Yao, Guangjing Zou, Zhaorong Chen, Qian Li, Changqi Li, Fang L. CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice. Neurotoxicity research. 2023-04-04. PMID:37014368. |
therefore, in the present study, we established mouse models of single and repeated meth exposure and subsequently determined that cntn1 expression in the nucleus accumbens (nac) was upregulated in mice following single or repeated meth exposure, whereas cntn1 expression in the hippocampus was not significantly altered. |
2023-04-04 |
2023-08-14 |
mouse |
| Jae Gon Kim, Ji Yun Ea, Bong-June Yoo. Orexinergic neurons modulate stress coping responses in mice. Frontiers in molecular neuroscience. vol 16. 2023-04-03. PMID:37008783. |
in addition, analyses using pathway-specific optic stimulation revealed that activating orexinergic projections to the medial part of the nucleus accumbens (nac) alone mediated a decrease in anxiety but was not sufficient to induce resilience in the lht. |
2023-04-03 |
2023-08-14 |
mouse |
| Santiago A Forero, Lindsay L Sailer, Aistė Girčytė, Jesus E Madrid, Nicole Sullivan, Alexander G Ophi. Motherhood and DREADD manipulation of the nucleus accumbens weaken established pair bonds in female prairie voles. Hormones and behavior. vol 151. 2023-04-01. PMID:37003159. |
the nucleus accumbens (nac) is known to modulate social valence and is central to mammalian pair bonding. |
2023-04-01 |
2023-08-14 |
Not clear |
| Zahra Ebrahimi, Nazanin Kahvandi, Elahe Shahriari, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Maryam Sharifi, Abdolrahman Sarih. VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Brain research bulletin. 2023-03-30. PMID:36997034. |
nucleus accumbens (nac) neurons appear to be at the hub of the reward circuit. |
2023-03-30 |
2023-08-14 |
rat |
| Zahra Fatahi, Mohammad Fatahi, Mirmohammadali Mirramezani Alizamini, Ahmad Ghorbani, Mohammad Ismail Zibaii, Abbas Haghparas. Exogenous Cannabinoids Impair Effort-Related Decision-Making via Affecting Neural Synchronization between the Anterior Cingulate Cortex and Nucleus Accumbens. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979223. |
the cortical-limbic-striatal pathway mediates endeavor-based choice behavior, including the nucleus accumbens (nac) and the anterior cingulate cortex (acc). |
2023-03-29 |
2023-08-14 |
Not clear |