| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Johanna Duda, Michael Fauler, Jan Gründemann, Birgit Lis. Cell-Specific RNA Quantification in Human SN DA Neurons from Heterogeneous Post-mortem Midbrain Samples by UV-Laser Microdissection and RT-qPCR. Methods in molecular biology (Clifton, N.J.). vol 1723. 2019-01-16. PMID:29344870. |
all these issues were considered for comparative gene expression analysis in dopamine (da) midbrain neurons of the substantia nigra (sn) from controls and parkinson's disease (pd) specimens, as the preferential degeneration of sn da neurons in the pathological hallmark of pd. |
2019-01-16 |
2023-08-13 |
human |
| Eleanor C Sandhu, Anushka B P Fernando, Elaine E Irvine, Kyoko Tossell, Michelle Kokkinou, Justyna Glegola, Mark A Smith, Oliver D Howes, Dominic J Withers, Mark A Ungles. Phasic Stimulation of Midbrain Dopamine Neuron Activity Reduces Salt Consumption. eNeuro. vol 5. issue 2. 2019-01-11. PMID:29766048. |
phasic stimulation of midbrain dopamine neuron activity reduces salt consumption. |
2019-01-11 |
2023-08-13 |
mouse |
| Ray Luo, Akira Uematsu, Adam Weitemier, Luca Aquili, Jenny Koivumaa, Thomas J McHugh, Joshua P Johanse. A dopaminergic switch for fear to safety transitions. Nature communications. vol 9. issue 1. 2019-01-11. PMID:29950562. |
we report that when an expected aversive outcome does not occur, activity in midbrain dopamine neurons is necessary to extinguish behavioral fear responses and engage molecular signaling events in extinction learning circuits. |
2019-01-11 |
2023-08-13 |
Not clear |
| Brooks G Robinson, James R Bunzow, Jonathan B Grimm, Luke D Lavis, Joshua T Dudman, Jennifer Brown, Kim A Neve, John T William. Desensitized D2 autoreceptors are resistant to trafficking. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28663556. |
this study used tagged d2 receptors to identify the localization and distribution of these receptors in living midbrain dopamine neurons. |
2019-01-10 |
2023-08-13 |
Not clear |
| Sarah Kishinevsky, Tai Wang, Anna Rodina, Sun Young Chung, Chao Xu, John Philip, Tony Taldone, Suhasini Joshi, Mary L Alpaugh, Alexander Bolaender, Simon Gutbier, Davinder Sandhu, Faranak Fattahi, Bastian Zimmer, Smit K Shah, Elizabeth Chang, Carmen Inda, John Koren, Nathalie G Saurat, Marcel Leist, Steven S Gross, Venkatraman E Seshan, Christine Klein, Mark J Tomishima, Hediye Erdjument-Bromage, Thomas A Neubert, Ronald C Henrickson, Gabriela Chiosis, Lorenz Stude. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nature communications. vol 9. issue 1. 2019-01-08. PMID:30341316. |
hsp90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. |
2019-01-08 |
2023-08-13 |
human |
| Sarah Kishinevsky, Tai Wang, Anna Rodina, Sun Young Chung, Chao Xu, John Philip, Tony Taldone, Suhasini Joshi, Mary L Alpaugh, Alexander Bolaender, Simon Gutbier, Davinder Sandhu, Faranak Fattahi, Bastian Zimmer, Smit K Shah, Elizabeth Chang, Carmen Inda, John Koren, Nathalie G Saurat, Marcel Leist, Steven S Gross, Venkatraman E Seshan, Christine Klein, Mark J Tomishima, Hediye Erdjument-Bromage, Thomas A Neubert, Ronald C Henrickson, Gabriela Chiosis, Lorenz Stude. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nature communications. vol 9. issue 1. 2019-01-08. PMID:30341316. |
environmental and genetic risk factors contribute to parkinson's disease (pd) pathogenesis and the associated midbrain dopamine (mda) neuron loss. |
2019-01-08 |
2023-08-13 |
human |
| Claude Rouillard, Joanie Baillargeon, Brigitte Paquet, Michel St-Hilaire, Jérôme Maheux, Catherine Lévesque, Noémie Darlix, Simon Majeur, Daniel Lévesqu. Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's disease. Experimental neurology. vol 304. 2019-01-07. PMID:29530712. |
parkinson's disease (pd) is an idiopathic progressive neurodegenerative disorder characterized by the loss of midbrain dopamine neurons. |
2019-01-07 |
2023-08-13 |
rat |
| N Torquet, F Marti, C Campart, S Tolu, C Nguyen, V Oberto, M Benallaoua, J Naudé, S Didienne, N Debray, S Jezequel, L Le Gouestre, B Hannesse, J Mariani, A Mourot, P Faur. Social interactions impact on the dopaminergic system and drive individuality. Nature communications. vol 9. issue 1. 2019-01-07. PMID:30082725. |
we further show that the phenotypic divergence in individual behaviors was mirrored by developing differences in midbrain dopamine neuron firing properties. |
2019-01-07 |
2023-08-13 |
mouse |
| Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jérémie Naudé, Thibaut d'Izarny-Gargas, Stéphanie Pons, Uwe Maskos, Dirk Trauner, Richard H Kramer, Philippe Faure, Alexandre Mouro. Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors. eLife. vol 7. 2019-01-07. PMID:30176987. |
manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors. |
2019-01-07 |
2023-08-13 |
mouse |
| Sebastian P Fernandez, Loïc Broussot, Fabio Marti, Thomas Contesse, Xavier Mouska, Mariano Soiza-Reilly, Hélène Marie, Philippe Faure, Jacques Bari. Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors. Nature communications. vol 9. issue 1. 2019-01-07. PMID:30361503. |
mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors. |
2019-01-07 |
2023-08-13 |
Not clear |
| Federica Bono, Paola Savoia, Adele Guglielmi, Massimo Gennarelli, Giovanna Piovani, Sandra Sigala, Damiana Leo, Stefano Espinoza, Raul R Gainetdinov, Paola Devoto, PierFranco Spano, Cristina Missale, Chiara Fiorentin. Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28092083. |
role of dopamine d2/d3 receptors in development, plasticity, and neuroprotection in human ipsc-derived midbrain dopaminergic neurons. |
2019-01-01 |
2023-08-13 |
human |
| Federica Bono, Paola Savoia, Adele Guglielmi, Massimo Gennarelli, Giovanna Piovani, Sandra Sigala, Damiana Leo, Stefano Espinoza, Raul R Gainetdinov, Paola Devoto, PierFranco Spano, Cristina Missale, Chiara Fiorentin. Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28092083. |
the role of dopamine d2 and d3 receptors (d2r/d3r), located on midbrain dopaminergic (da) neurons, in the regulation of da synthesis and release and in da neuron homeostasis has been extensively investigated in rodent animal models. |
2019-01-01 |
2023-08-13 |
human |
| Ting Zhou, Tae Wan Kim, Chi Nok Chong, Lei Tan, Sadaf Amin, Zohreh Sadat Badieyan, Suranjit Mukherjee, Zaniar Ghazizadeh, Hui Zeng, Min Guo, Miguel Crespo, Tuo Zhang, Reyn Kenyon, Christopher L Robinson, Effie Apostolou, Hui Wang, Jenny Zhaoying Xiang, Todd Evans, Lorenz Studer, Shuibing Che. A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. Nature communications. vol 9. issue 1. 2018-12-19. PMID:30446643. |
screening a panel of diverse hpsc-derived cell types we extended this observation to a similar susceptibility in midbrain dopamine neurons, a cell type affected in parkinson's disease. |
2018-12-19 |
2023-08-13 |
human |
| Layal Maatouk, Anne-Claire Compagnion, Maria-Angeles Carrillo-de Sauvage, Alexis-Pierre Bemelmans, Sabrina Leclere-Turbant, Vincent Cirotteau, Mira Tohme, Allen Beke, Michaël Trichet, Virginie Bazin, Bobby N Trawick, Richard M Ransohoff, François Tronche, Bénédicte Manoury, Sheela Vya. TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons. Nature communications. vol 9. issue 1. 2018-12-17. PMID:29934589. |
tlr9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons. |
2018-12-17 |
2023-08-13 |
mouse |
| Limei Zhang, Vito S Hernández, Jerome D Swinny, Anil K Verma, Torsten Giesecke, Andrew C Emery, Kerim Mutig, Luis M Garcia-Segura, Lee E Eide. A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling. Translational psychiatry. vol 8. issue 1. 2018-12-12. PMID:29479060. |
here, we report a cell type in the medial division of the lhb (lhbm) in male rats that is distinguished by: (1) a molecular signature for gabaergic neurotransmission (slc32a1/vgat) and estrogen receptor (esr1/erα) expression, at both mrna and protein levels, as well as the mrna for vesicular glutamate transporter slc17a6/vglut2, which we term the gabaergic estrogen-receptive neuron (gern); (2) its axonal projection patterns, identified by in vivo juxtacellular labeling, to both local lhb and to midbrain modulatory systems; and (3) its somatic expression of receptors for vasopressin, serotonin and dopamine, and mrna for orexin receptor 2. |
2018-12-12 |
2023-08-13 |
rat |
| Limei Zhang, Vito S Hernández, Jerome D Swinny, Anil K Verma, Torsten Giesecke, Andrew C Emery, Kerim Mutig, Luis M Garcia-Segura, Lee E Eide. A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling. Translational psychiatry. vol 8. issue 1. 2018-12-12. PMID:29479060. |
this cell type is anatomically located to receive afferents from midbrain reward (dopamine and serotonin) and hypothalamic water and energy homeostasis (vasopressin and orexin) circuits. |
2018-12-12 |
2023-08-13 |
rat |
| Matthew M Nour, Tarik Dahoun, Philipp Schwartenbeck, Rick A Adams, Thomas H B FitzGerald, Christopher Coello, Matthew B Wall, Raymond J Dolan, Oliver D Howe. Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 43. 2018-12-11. PMID:30297411. |
using pet we show that the neural encoding of meaningful information is negatively related to dopamine-2/3 receptor availability in the midbrain and dexamphetamine-induced dopamine release capacity in the striatum. |
2018-12-11 |
2023-08-13 |
human |
| Benedicte M Babayan, Naoshige Uchida, Samuel J Gershma. Belief state representation in the dopamine system. Nature communications. vol 9. issue 1. 2018-11-27. PMID:29760401. |
reinforcement learning (rl) models have successfully accounted for such learning, relying on reward prediction errors (rpes) signaled by midbrain dopamine neurons. |
2018-11-27 |
2023-08-13 |
mouse |
| Muhammed Khairujjaman Mazumder, Rajib Paul, Banashree Chetia Phukan, Ankumoni Dutta, Jayasree Chakrabarty, Pallab Bhattacharya, Anupom Bora. Garcinol, an effective monoamine oxidase-B inhibitor for the treatment of Parkinson's disease. Medical hypotheses. vol 117. 2018-11-27. PMID:30077198. |
loss of dopamine containing neurons in the substantia nigra pars compacta of midbrain, and resultant depletion of dopamine in the striatum is the cause of parkinson's disease (pd), which is associated with motor abnormalities. |
2018-11-27 |
2023-08-13 |
Not clear |
| Christopher W Tschumi, Michael J Beckstea. Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABA Neuropharmacology. vol 131. 2018-11-19. PMID:29307543. |
neurotensin speeds inhibition of dopamine neurons through temporal modulation of gaba midbrain dopamine neurons play physiological roles in many processes including reward learning and motivated behavior, and are tonically inhibited by γ-aminobutyric acid (gaba)ergic input from multiple brain regions. |
2018-11-19 |
2023-08-13 |
mouse |