| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clifford M Cassidy, Fabio A Zucca, Ragy R Girgis, Seth C Baker, Jodi J Weinstein, Madeleine E Sharp, Chiara Bellei, Alice Valmadre, Nora Vanegas, Lawrence S Kegeles, Gary Brucato, Un Jung Kang, David Sulzer, Luigi Zecca, Anissa Abi-Dargham, Guillermo Horg. Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 11. 2019-05-06. PMID:30796187. |
here, we validated that nm-mri signal intensity in postmortem midbrain specimens correlated with regional nm concentration even in the absence of neurodegeneration, a prerequisite for its use as a proxy for dopamine function. |
2019-05-06 |
2023-08-13 |
human |
| Ana Canseco-Alba, Norman Schanz, Branden Sanabria, Juan Zhao, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaiv. Behavioral effects of psychostimulants in mutant mice with cell-type specific deletion of CB2 cannabinoid receptors in dopamine neurons. Behavioural brain research. vol 360. 2019-05-02. PMID:30508607. |
the deletion of cb2rs in dopamine neurons modified the levels of tyrosine hydroxylase, and reduced the expression of dopamine transporter gene expression in dat-cnr2 cko midbrain region. |
2019-05-02 |
2023-08-13 |
mouse |
| Hao Liu, Lin Zhong, Chunling Zhao, Xiaolei Tang, Jun Yang, Lei Gon. Quantitative analysis on secretion level of CDNF regulated by two key α-helices in CDNF protein. Cell biology international. vol 43. issue 2. 2019-04-30. PMID:30548741. |
cerebral dopamine neurotrophic factor (cdnf) has been considered as potent candidates for the therapy of parkinson's disease (pd) for which can promote the survival of midbrain dopaminergic neurons. |
2019-04-30 |
2023-08-13 |
Not clear |
| Robert A McCutcheon, Anissa Abi-Dargham, Oliver D Howe. Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms. Trends in neurosciences. vol 42. issue 3. 2019-04-26. PMID:30621912. |
the mesolimbic hypothesis has been a central dogma of schizophrenia for decades, positing that aberrant functioning of midbrain dopamine projections to limbic regions causes psychotic symptoms. |
2019-04-26 |
2023-08-13 |
Not clear |
| Linfang Chen, Liujun Xue, Jinlong Zheng, Xiangyang Tian, Yingdong Zhang, Qiang Ton. PPARß/δ agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson's disease. Behavioural brain research. vol 356. 2019-04-16. PMID:29885849. |
our results show that gw501516 reduced movement impairment in pd mice; furthermore, it attenuated dopaminergic neurodegeneration in the midbrain and the depletion of dopamine in the striatum and it inhibited inflammatory reactions and nlrp3 inflammasome activation in the midbrain of pd mice. |
2019-04-16 |
2023-08-13 |
mouse |
| I L Kovalenko, D A Smagin, A G Galyamina, Yu L Orlov, N N Kudryavtsev. [Changes in the Expression of Dopaminergic Genes in Brain Structures of Male Mice Exposed to Chronic Social Defeat Stress: An RNA-seq Study]. Molekuliarnaia biologiia. vol 50. issue 1. 2019-04-11. PMID:27028825. |
whole-transcriptome analysis (rna-seq) has been used to analyze changes in the expression of dopaminergic genes that encode proteins involved in the synthesis, inactivation, and neurotransmission of dopamine in the striatum, ventral tegmental area, raphe nuclei of the midbrain, hypothalamus, and hippocampus of male mice subjected to chronic social defeat. |
2019-04-11 |
2023-08-13 |
mouse |
| Katarína Tiklová, Åsa K Björklund, Laura Lahti, Alessandro Fiorenzano, Sara Nolbrant, Linda Gillberg, Nikolaos Volakakis, Chika Yokota, Markus M Hilscher, Thomas Hauling, Fredrik Holmström, Eliza Joodmardi, Mats Nilsson, Malin Parmar, Thomas Perlman. Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development. Nature communications. vol 10. issue 1. 2019-04-10. PMID:30718509. |
single-cell rna sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development. |
2019-04-10 |
2023-08-13 |
mouse |
| Katarína Tiklová, Åsa K Björklund, Laura Lahti, Alessandro Fiorenzano, Sara Nolbrant, Linda Gillberg, Nikolaos Volakakis, Chika Yokota, Markus M Hilscher, Thomas Hauling, Fredrik Holmström, Eliza Joodmardi, Mats Nilsson, Malin Parmar, Thomas Perlman. Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development. Nature communications. vol 10. issue 1. 2019-04-10. PMID:30718509. |
midbrain dopamine (mda) neurons constitute a heterogenous group of cells that have been intensely studied, not least because their degeneration causes major symptoms in parkinson's disease. |
2019-04-10 |
2023-08-13 |
mouse |
| Ruiming Zhu, Qian Bu, Dengqi Fu, Xue Shao, Linhong Jiang, Wei Guo, Bo Chen, Bin Liu, Zhengtao Hu, Jingwei Tian, Yinglan Zhao, Xiaobo Ce. Toll-like receptor 3 modulates the behavioral effects of cocaine in mice. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29571298. |
the nucleus accumbens in the midbrain dopamine limbic system plays a key role in cocaine addiction. |
2019-04-08 |
2023-08-13 |
mouse |
| Marta Cherubini, Richard Wade-Martin. Convergent pathways in Parkinson's disease. Cell and tissue research. vol 373. issue 1. 2019-04-01. PMID:29063175. |
preferential degeneration of dopamine neurons (dan) in the midbrain represents the principal hallmark of parkinson's disease (pd). |
2019-04-01 |
2023-08-13 |
Not clear |
| Rajib Paul, Ankumoni Dutta, Banashree Chetia Phukan, Muhammed Khairujjaman Mazumder, Arokiasamy Justin-Thenmozhi, Thamilarasan Manivasagam, Pallab Bhattacharya, Anupom Bora. Accumulation of Cholesterol and Homocysteine in the Nigrostriatal Pathway of Brain Contributes to the Dopaminergic Neurodegeneration in Mice. Neuroscience. vol 388. 2019-03-29. PMID:30075243. |
the results highlighted the involvement of mitochondrial complex-i dysfunction with subsequent generation of hydroxyl radicals for the observed loss of midbrain dopamine neurons in animals receiving the combined treatment. |
2019-03-29 |
2023-08-13 |
mouse |
| Moritz Möller, Rafal Bogac. Learning the payoffs and costs of actions. PLoS computational biology. vol 15. issue 2. 2019-03-28. PMID:30818357. |
the basal ganglia include two pathways, which have been associated with approach and avoid behavior respectively and are differentially modulated by dopamine projections from the midbrain. |
2019-03-28 |
2023-08-13 |
Not clear |
| M A Hutchison, X Gu, M F Adrover, M R Lee, T S Hnasko, V A Alvarez, W L. Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular psychiatry. vol 23. issue 5. 2019-03-27. PMID:28194005. |
midbrain dopamine neurons are crucial for many behavioral and cognitive functions. |
2019-03-27 |
2023-08-13 |
mouse |
| I V Ekimova, A R Gazizova, M N Karpenko, D V Plaksin. [Signs of anhedonia and destructive changes in the ventral tegmental area of the midbrain in the model of the preclinical Parkinson's disease stage in experiment]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 9. 2019-03-25. PMID:30335074. |
anhedonia was combined with the death of about one third of dopamine (da)-ergic neurons in the ventral tegmental area of the midbrain and their axons in the ventral striatum; and a decrease of dopamine concentration in the ventral striatum (by 40%) and the tyrosine hydroxylase level in surviving da-ergic neurons. |
2019-03-25 |
2023-08-13 |
rat |
| N Benamer, F Marti, R Lujan, R Hepp, T G Aubier, A A M Dupin, G Frébourg, S Pons, U Maskos, P Faure, Y A Hay, B Lambolez, L Tricoir. GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons. Molecular psychiatry. vol 23. issue 3. 2019-03-12. PMID:28696429. |
based on the known function of its paralog glud2 in cerebellum, we searched for a role of glud1 in slow glutamatergic transmission mediated by metabotropic receptor mglu1 in midbrain dopamine neurons, whose dysfunction is a hallmark of schizophrenia. |
2019-03-12 |
2023-08-13 |
mouse |
| N Benamer, F Marti, R Lujan, R Hepp, T G Aubier, A A M Dupin, G Frébourg, S Pons, U Maskos, P Faure, Y A Hay, B Lambolez, L Tricoir. GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons. Molecular psychiatry. vol 23. issue 3. 2019-03-12. PMID:28696429. |
we then characterized mglu1-dependent currents in dopamine neurons from midbrain slices. |
2019-03-12 |
2023-08-13 |
mouse |
| Ching-Long Lai, Chun-Chung Lu, Hui-Ching Lin, Yueh-Feng Sung, Yi-Pin Wu, Jau-Shyong Hong, Giia-Sheun Pen. Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: A potential role of BDNF up-regulation. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 118. issue 1 Pt 3. 2019-03-12. PMID:30031602. |
the main purpose of this study was to extend previously reported showing potent neuroprotective effect of valproic acid (vpa) in primary midbrain neuro-glial cultures to investigate whether vpa could protect dopamine (da) neurons in vivo against 6-hydroxydopamine (6-ohda)-induced neurodegeneration and to determine the underlying mechanism. |
2019-03-12 |
2023-08-13 |
Not clear |
| Benjamin Pasquereau, Léon Tremblay, Robert S Turne. Local Field Potentials Reflect Dopaminergic and Non-Dopaminergic Activities within the Primate Midbrain. Neuroscience. vol 399. 2019-03-11. PMID:30578975. |
midbrain dopamine neurons are thought to play a crucial role in motivating behaviors toward desired goals. |
2019-03-11 |
2023-08-13 |
monkey |
| Benjamin Pasquereau, Léon Tremblay, Robert S Turne. Local Field Potentials Reflect Dopaminergic and Non-Dopaminergic Activities within the Primate Midbrain. Neuroscience. vol 399. 2019-03-11. PMID:30578975. |
while the activity of dopamine single-units is known to adhere closely to the reward prediction error (rpe) signal hypothesized by learning theory, much less is known about the dynamic coordination of population-level neuronal activities in the midbrain. |
2019-03-11 |
2023-08-13 |
monkey |
| Kai-C Sonntag, Bin Song, Nayeon Lee, Jin Hyuk Jung, Young Cha, Pierre Leblanc, Carolyn Neff, Sek Won Kong, Bob S Carter, Jeffrey Schweitzer, Kwang-Soo Ki. Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects. Progress in neurobiology. vol 168. 2019-03-08. PMID:29653250. |
because motor impairments in pd largely result from loss of midbrain dopamine neurons in the substantia nigra pars compacta, pd has long been considered to be one of the most promising target diseases for cell-based therapy. |
2019-03-08 |
2023-08-13 |
human |