| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David H Root, Hui-Ling Wang, Bing Liu, David J Barker, László Mód, Péter Szocsics, Afonso C Silva, Zsófia Maglóczky, Marisela Morale. Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans. Scientific reports. vol 6. 2018-04-19. PMID:27477243. |
glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans. |
2018-04-19 |
2023-08-13 |
human |
| David H Root, Hui-Ling Wang, Bing Liu, David J Barker, László Mód, Péter Szocsics, Afonso C Silva, Zsófia Maglóczky, Marisela Morale. Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans. Scientific reports. vol 6. 2018-04-19. PMID:27477243. |
the demonstration that midbrain dopamine neurons are intermixed with glutamate or glutamate-dopamine neurons from rodents to humans offers new opportunities for translational studies towards analyzing the roles that each of these neurons play in human behavior and in midbrain-associated illnesses such as addiction, depression, schizophrenia, and parkinson's disease. |
2018-04-19 |
2023-08-13 |
human |
| James A Duce, Bruce X Wong, Hannah Durham, Jean-Christophe Devedjian, David P Smith, David Devo. Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28592304. |
the primary clinical feature of progressively impaired motor control is caused by a loss of midbrain substantia nigra dopamine neurons that have a high α-synuclein (α-syn) and iron content. |
2018-04-17 |
2023-08-13 |
Not clear |
| Alicia J Avelar, Jianjing Cao, Amy Hauck Newman, Michael J Beckstea. Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons. Neuropharmacology. vol 123. 2018-04-17. PMID:28625719. |
atypical dopamine transporter inhibitors r-modafinil and jhw 007 differentially affect d2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons. |
2018-04-17 |
2023-08-13 |
mouse |
| Thomas Viereckel, Sylvie Dumas, Casey J A Smith-Anttila, Bianca Vlcek, Zisis Bimpisidis, Malin C Lagerström, Åsa Konradsson-Geuken, Åsa Wallén-Mackenzi. Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease. Scientific reports. vol 6. 2018-04-16. PMID:27762319. |
midbrain gene screening identifies a new mesoaccumbal glutamatergic pathway and a marker for dopamine cells neuroprotected in parkinson's disease. |
2018-04-16 |
2023-08-13 |
mouse |
| Timothy J Collier, Nicholas M Kanaan, Jeffrey H Kordowe. Aging and Parkinson's disease: Different sides of the same coin? Movement disorders : official journal of the Movement Disorder Society. vol 32. issue 7. 2018-04-16. PMID:28520211. |
we present evidence from our work on midbrain dopamine neurons of aging nonhuman primates that demonstrates that markers of known correlates of dopamine neuron degeneration in pd, including impaired proteasome/lysosome function, oxidative/nitrative damage, and inflammation, all increase with advancing age and are exaggerated in the ventral tier substantia nigra dopamine neurons most vulnerable to degeneration in pd. |
2018-04-16 |
2023-08-13 |
Not clear |
| YongXin Hao, Aref Shabanpoor, Gerlinde A Met. Stress and corticosterone alter synaptic plasticity in a rat model of Parkinson's disease. Neuroscience letters. vol 651. 2018-03-26. PMID:28473257. |
midbrain mrna expression assessments included markers of dopamine function and neuroplasticity, such as tyrosine hydroxylase (th), synaptophysin (syn), calcyon, and glucocorticoid receptor (gr). |
2018-03-26 |
2023-08-13 |
rat |
| Norihiro Takakuwa, Rikako Kato, Peter Redgrave, Tadashi Is. Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys. eLife. vol 6. 2018-03-26. PMID:28628005. |
responses of midbrain dopamine (da) neurons reflecting expected reward from sensory cues are critical for reward-based associative learning. |
2018-03-26 |
2023-08-13 |
monkey |
| Eva Hedlund, Laure Belnoue, Spyridon Theofilopoulos, Carmen Salto, Chris Bye, Clare Parish, Qiaolin Deng, Banafsheh Kadkhodaei, Johan Ericson, Ernest Arenas, Thomas Perlmann, András Simo. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Scientific reports. vol 6. 2018-03-23. PMID:27246266. |
degeneration of dopamine neurons in the midbrain causes symptoms of the movement disorder, parkinson disease. |
2018-03-23 |
2023-08-13 |
Not clear |
| Eva Hedlund, Laure Belnoue, Spyridon Theofilopoulos, Carmen Salto, Chris Bye, Clare Parish, Qiaolin Deng, Banafsheh Kadkhodaei, Johan Ericson, Ernest Arenas, Thomas Perlmann, András Simo. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Scientific reports. vol 6. 2018-03-23. PMID:27246266. |
dopamine neurons are generated from proliferating progenitor cells localized in the embryonic ventral midbrain. |
2018-03-23 |
2023-08-13 |
Not clear |
| Eva Hedlund, Laure Belnoue, Spyridon Theofilopoulos, Carmen Salto, Chris Bye, Clare Parish, Qiaolin Deng, Banafsheh Kadkhodaei, Johan Ericson, Ernest Arenas, Thomas Perlmann, András Simo. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Scientific reports. vol 6. 2018-03-23. PMID:27246266. |
we show here that cells expressing lmx1a and other progenitor markers remain in the midbrain aqueductal zone beyond the major dopamine neurogenic period. |
2018-03-23 |
2023-08-13 |
Not clear |
| Eva Hedlund, Laure Belnoue, Spyridon Theofilopoulos, Carmen Salto, Chris Bye, Clare Parish, Qiaolin Deng, Banafsheh Kadkhodaei, Johan Ericson, Ernest Arenas, Thomas Perlmann, András Simo. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Scientific reports. vol 6. 2018-03-23. PMID:27246266. |
these cells express dopamine receptors, are located in regions heavily innervated by midbrain dopamine fibres and their proliferation can be stimulated by antagonizing dopamine receptors, ultimately leading to increased neurogenesis in vivo. |
2018-03-23 |
2023-08-13 |
Not clear |
| Eva Hedlund, Laure Belnoue, Spyridon Theofilopoulos, Carmen Salto, Chris Bye, Clare Parish, Qiaolin Deng, Banafsheh Kadkhodaei, Johan Ericson, Ernest Arenas, Thomas Perlmann, András Simo. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Scientific reports. vol 6. 2018-03-23. PMID:27246266. |
altogether our results indicate a potential for reactivation of resident midbrain cells with dopamine progenitor potential beyond the normal period of dopamine neurogenesis. |
2018-03-23 |
2023-08-13 |
Not clear |
| Julie L Fudge, Emily A Kelly, Ria Pal, Joseph L Bedont, Lydia Park, Brian H. Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 8. 2018-03-23. PMID:28220796. |
cea inputs to the midbrain dopamine (da) system are positioned to influence striatal functions through mesolimbic da-striatal pathways. |
2018-03-23 |
2023-08-13 |
Not clear |
| Yuanzhong Xu, Yungang Lu, Pingwen Xu, Leandra R Mangieri, Elsa Isingrini, Yong Xu, Bruno Giros, Qingchun Ton. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. eNeuro. vol 4. issue 3. 2018-03-20. PMID:28560316. |
the midbrain neurons release a variety of neurotransmitters including dopamine (da), glutamate and gaba. |
2018-03-20 |
2023-08-13 |
mouse |
| Colton R Zwart, Jennifer T Lambert. Not all dopamine neurons are created equal: Functional heterogeneity of midbrain dopamine axons. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 10. 2018-03-19. PMID:27643922. |
not all dopamine neurons are created equal: functional heterogeneity of midbrain dopamine axons. |
2018-03-19 |
2023-08-13 |
Not clear |
| David A Carte. Molecular phenotyping of transient postnatal tyrosine hydroxylase neurons in the rat bed nucleus of the stria terminalis. Journal of chemical neuroanatomy. vol 82. 2018-03-19. PMID:28419831. |
in addition, the bnstli neurons had low, primarily cytoplasmic, expression of nr4a2/nurr1, an orphan nuclear receptor that is critical for adult maintenance of midbrain dopamine neurons. |
2018-03-19 |
2023-08-13 |
rat |
| Margaret I Davis, Jill R Crittenden, Austin Y Feng, David A Kupferschmidt, Alipi Naydenov, Nephi Stella, Ann M Graybiel, David M Lovinge. The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra. PloS one. vol 13. issue 2. 2018-03-13. PMID:29466446. |
these data suggest a role for cb1-rs in caudal dorsolateral striosome collaterals and striosome-dendron bouquet projections to lateral substantia nigra, where they are anatomically poised to mediate presynaptic disinhibition of both striosomal msns and midbrain dopamine neurons in response to endocannabinoids and cannabinomimetics. |
2018-03-13 |
2023-08-13 |
mouse |
| John Pierce Wise, Jason Canno. From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models. Toxicological sciences : an official journal of the Society of Toxicology. vol 153. issue 2. 2018-03-09. PMID:27473339. |
for the first time, we show that optn is enriched in dopamine neurons in the midbrain, and its expression is modulated by rotenone treatment in vivo here, animals were sampled at time-points both prior to overt neurodegeneration and after severe behavioral deficits, where a lesion to the nigrostriatal dopamine system is present. |
2018-03-09 |
2023-08-13 |
rat |
| Peter J Vento, Nathan W Burnham, Courtney S Rowley, Thomas C Jho. Learning From One's Mistakes: A Dual Role for the Rostromedial Tegmental Nucleus in the Encoding and Expression of Punished Reward Seeking. Biological psychiatry. vol 81. issue 12. 2018-03-02. PMID:27931744. |
the recently identified rostromedial tegmental nucleus (rmtg) encodes a wide variety of aversive stimuli and sends robust inhibitory projections to midbrain dopamine neurons, leading to the hypothesis that the rmtg provides a brake to reward signaling in response to aversive costs. |
2018-03-02 |
2023-08-13 |
Not clear |