| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jon Stoess. Potential therapeutic targets for Parkinson's disease. Expert opinion on therapeutic targets. vol 12. issue 4. 2008-04-17. PMID:18348679. |
the cardinal features are related to dopamine deficiency, arising from loss of neurons projecting from the substantia nigra in the midbrain to the striatum. |
2008-04-17 |
2023-08-12 |
human |
| Clare L Parish, Gonçalo Castelo-Branco, Nina Rawal, Jan Tonnesen, Andreas Toft Sorensen, Carmen Salto, Merab Kokaia, Olle Lindvall, Ernest Arena. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. The Journal of clinical investigation. vol 118. issue 1. 2008-04-14. PMID:18060047. |
wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. |
2008-04-14 |
2023-08-12 |
mouse |
| R Laguna Goya, P Tyers, R A Barke. The search for a curative cell therapy in Parkinson's disease. Journal of the neurological sciences. vol 265. issue 1-2. 2008-04-11. PMID:17936303. |
possible cell sources for replacement range from autologous grafts of dopamine secreting cells to allografts of fetal ventral mesencephalon and neural precursor cells derived from fetal tissue or embryonic stem cells. |
2008-04-11 |
2023-08-12 |
human |
| Oscar Arias-Carrión, Ernst Pŏppe. Dopamine, learning, and reward-seeking behavior. Acta neurobiologiae experimentalis. vol 67. issue 4. 2008-04-09. PMID:18320725. |
dopaminergic neurons of the midbrain are the main source of dopamine (da) in the brain. |
2008-04-09 |
2023-08-12 |
Not clear |
| Arthur C Riegel, John T William. CRF facilitates calcium release from intracellular stores in midbrain dopamine neurons. Neuron. vol 57. issue 4. 2008-04-08. PMID:18304485. |
crf facilitates calcium release from intracellular stores in midbrain dopamine neurons. |
2008-04-08 |
2023-08-12 |
Not clear |
| Arthur C Riegel, John T William. CRF facilitates calcium release from intracellular stores in midbrain dopamine neurons. Neuron. vol 57. issue 4. 2008-04-08. PMID:18304485. |
this study investigates the regulation of cytosolic calcium by corticotropin-releasing factor (crf) in midbrain dopamine neurons. |
2008-04-08 |
2023-08-12 |
Not clear |
| Stephan Lammel, Andrea Hetzel, Olga Häckel, Ian Jones, Birgit Liss, Jochen Roepe. Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron. vol 57. issue 5. 2008-04-08. PMID:18341995. |
in contrast, well-described conventional slow-firing dopamine midbrain neurons only project to the lateral shell of the nucleus accumbens and the dorsolateral striatum. |
2008-04-08 |
2023-08-12 |
Not clear |
| Stephan Lammel, Andrea Hetzel, Olga Häckel, Ian Jones, Birgit Liss, Jochen Roepe. Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron. vol 57. issue 5. 2008-04-08. PMID:18341995. |
among this dual dopamine midbrain system defined in this study by converging anatomical, electrophysiological, and molecular properties, mesoprefrontal dopaminergic neurons are unique, as only they do not possess functional somatodendritic girk2-coupled dopamine d2 autoreceptors. |
2008-04-08 |
2023-08-12 |
Not clear |
| Elisabet Berglöf, Stefan Plantman, Saga Johansson, Ingrid Strömber. Inhibition of proteoglycan synthesis affects neuronal outgrowth and astrocytic migration in organotypic cultures of fetal ventral mesencephalon. Journal of neuroscience research. vol 86. issue 1. 2008-04-04. PMID:17868150. |
this study was performed to evaluate the role of pgs in dopamine nerve fiber formation in organotypic slice cultures of fetal ventral mesencephalon. |
2008-04-04 |
2023-08-12 |
Not clear |
| D Rodaros, D A Caruana, S Amir, J Stewar. Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area. Neuroscience. vol 150. issue 1. 2008-03-28. PMID:17961928. |
crf is released in the ventral tegmental area (vta), the cell body region of the mesocorticolimbic dopaminergic neurons, in response to acute stress and plays a role in stress-activation of appetitive behavior [wang b, shaham y, zitzman d, azari s, wise ra, you zb (2005) cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. |
2008-03-28 |
2023-08-12 |
rat |
| Dali Yang, Zhi-Jian Zhang, Michael Oldenburg, Melvin Ayala, Su-Chun Zhan. Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Stem cells (Dayton, Ohio). vol 26. issue 1. 2008-03-25. PMID:17951220. |
although the donor cells contained forebrain and midbrain dopamine neurons, the dopamine neurons present in the graft mainly exhibited a midbrain, or nigra, phenotype, suggesting the importance of midbrain dopamine neurons in functional repair. |
2008-03-25 |
2023-08-12 |
human |
| Klas R Linderholm, Alexandra Andersson, Sara Olsson, Elin Olsson, Ralph Snodgrass, Göran Engberg, Sophie Erhard. Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: a pharmacological analysis. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:17959203. |
previous studies have shown that elevated levels of endogenous kyna are associated with an increased firing of midbrain dopamine (da) neurons. |
2008-03-21 |
2023-08-12 |
rat |
| Colin Davidson, Qiang Chen, Xiuwn Zhang, Xueying Xiong, Cindy Lazarus, Tong H Lee, Everett H Ellinwoo. Deprenyl treatment attenuates long-term pre- and post-synaptic changes evoked by chronic methamphetamine. European journal of pharmacology. vol 573. issue 1-3. 2008-03-13. PMID:17651730. |
tyrosine hydroxylase immunostaining in the midbrain was unaffected by methamphetamine, suggesting that dopamine neurotoxicity was localized to the caudate. |
2008-03-13 |
2023-08-12 |
rat |
| Qian Gao, Tamas L Horvat. Neuronal control of energy homeostasis. FEBS letters. vol 582. issue 1. 2008-03-12. PMID:18061579. |
various hypothalamic neuronal circuits (which include the hypothalamic melanocortin, midbrain dopamine reward and caudal brainstem autonomic feeding systems) control energy intake and expenditure to maintain body weight within a narrow range for long periods of a life span. |
2008-03-12 |
2023-08-12 |
Not clear |
| J Russel Keath, Michael P Iacoviello, Lindy E Barrett, Huibert D Mansvelder, Daniel S McGehe. Differential modulation by nicotine of substantia nigra versus ventral tegmental area dopamine neurons. Journal of neurophysiology. vol 98. issue 6. 2008-03-05. PMID:17942622. |
midbrain dopamine (da) neurons are found in two nuclei, the substantia nigra pars compacta (snc) and ventral tegmental area (vta). |
2008-03-05 |
2023-08-12 |
Not clear |
| Paul D Shepard, Carmen C Canavier, Edwin S Levita. Ether-a-go-go-related gene potassium channels: what's all the buzz about? Schizophrenia bulletin. vol 33. issue 6. 2008-02-27. PMID:17905786. |
recently, it has been discovered that the same channels are present in the brain, including midbrain dopamine neurons. |
2008-02-27 |
2023-08-12 |
Not clear |
| Satoshi Ikemot. Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain research reviews. vol 56. issue 1. 2008-02-26. PMID:17574681. |
dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. |
2008-02-26 |
2023-08-12 |
rat |
| Satoshi Ikemot. Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain research reviews. vol 56. issue 1. 2008-02-26. PMID:17574681. |
a review of the literature suggests that (1) the midbrain has corresponding zones for the accumbens core and medial shell; (2) the striatal portion of the olfactory tubercle is a ventral extension of the nucleus accumbens shell; and (3) a model of two dopamine projection systems from the ventral midbrain to the ventral striatum is useful for understanding reward function. |
2008-02-26 |
2023-08-12 |
rat |
| Frederic Boyer, Jean-Luc Dreye. Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats. The European journal of neuroscience. vol 26. issue 10. 2008-02-25. PMID:18001274. |
alpha-synuclein levels are elevated in midbrain dopamine neurons of chronic cocaine abusers, and its expression is increased in psychostimulant-treated animals [m.s. |
2008-02-25 |
2023-08-12 |
rat |
| Bin Pan, Cecilia J Hillard, Qing-song Li. Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 6. 2008-02-25. PMID:18256258. |
endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. |
2008-02-25 |
2023-08-12 |
Not clear |