| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sophie Erhardt, Lilly Schwieler, Linda Nilsson, Klas Linderholm, Göran Engber. The kynurenic acid hypothesis of schizophrenia. Physiology & behavior. vol 92. issue 1-2. 2007-12-06. PMID:17573079. |
thus, pharmacologically elevated levels of kynurenic acid, in similarity to systemic administration of phencyclidine or ketamine, were associated with increased firing rate and burst firing activity of midbrain dopamine neurons, indicating per se that elevated levels of brain kynurenic acid is associated with psychotomimetic effects. |
2007-12-06 |
2023-08-12 |
Not clear |
| Sara Lindholm, Asa Rosin, Ingrid Dahlin, Jeanette Georgieva, Johan Franc. Ethanol alters the effect of kappa receptor ligands on dopamine release in the nucleus accumbens. Physiology & behavior. vol 92. issue 1-2. 2007-12-06. PMID:17610914. |
repeated exposure to ethanol has previously been shown to induce alterations in both midbrain dopamine and dynorphin systems. |
2007-12-06 |
2023-08-12 |
rat |
| Vineeta Singh, Melissa Carman, Jochen Roeper, Antonello Bonc. Brief ischemia causes long-term depression in midbrain dopamine neurons. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17880389. |
brief ischemia causes long-term depression in midbrain dopamine neurons. |
2007-11-20 |
2023-08-12 |
rat |
| Giovanni Hernandez, Eric Haines, Heshmat Rajabi, Jane Stewart, Andreas Arvanitogiannis, Peter Shizga. Predictable and unpredictable rewards produce similar changes in dopamine tone. Behavioral neuroscience. vol 121. issue 5. 2007-11-20. PMID:17907821. |
unpredicted rewards trigger more vigorous phasic responses in midbrain dopamine (da) neurons than predicted rewards. |
2007-11-20 |
2023-08-12 |
rat |
| Jeremy J Day, Mitchell F Roitman, R Mark Wightman, Regina M Carell. Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens. Nature neuroscience. vol 10. issue 8. 2007-11-07. PMID:17603481. |
dopamine neurons in the midbrain encode such stimulus-reward relationships in a manner consistent with contemporary learning models, but it is unclear how encoding this translates into actual dopamine release in target regions. |
2007-11-07 |
2023-08-12 |
rat |
| Richard D Palmite. Is dopamine a physiologically relevant mediator of feeding behavior? Trends in neurosciences. vol 30. issue 8. 2007-11-06. PMID:17604133. |
midbrain dopamine neurons have long been implicated in mediating reward behavior and the motivational aspects of feeding behavior. |
2007-11-06 |
2023-08-12 |
Not clear |
| Bruce E McKay, Andon N Placzek, John A Dan. Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17689497. |
recent advances have revealed roles of nachrs in the regulation of synaptic transmission and synaptic plasticity, particularly in the hippocampus and midbrain dopamine centers. |
2007-11-06 |
2023-08-12 |
Not clear |
| Christina H L Teh, Chin Chieh Loh, Kevin K Y Lam, Jia Min Loo, Tie Yan, Tit Meng Li. Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17457889. |
dopamine is the main neurotransmitter present in dopaminergic neurons of the ventral midbrain, where dysfunction of these neurons can lead to parkinson's disease and schizophrenia. |
2007-11-05 |
2023-08-12 |
mouse |
| Hirohide Sawada, Ryohei Hishida, Yoko Hirata, Kenji Ono, Hiromi Suzuki, Shin-ichi Muramatsu, Imaharu Nakano, Toshiharu Nagatsu, Makoto Sawad. Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17469135. |
tyrosine hydroxylase (th) activity, the levels of dopamine and 3,4-dihydroxyphenylacetic acid (dopac), and the levels of pro-inflammatory cytokines il-1beta and il-6 in the midbrain were elevated in the neonates treated with lps and mptp. |
2007-11-05 |
2023-08-12 |
mouse |
| Daniel B Putterman, Adam C Munhall, Laura B Kozell, John K Belknap, Steven W Johnso. Evaluation of levodopa dose and magnitude of dopamine depletion as risk factors for levodopa-induced dyskinesia in a rat model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. vol 323. issue 1. 2007-11-05. PMID:17660384. |
varied concentrations of 6-hydroxy-dopamine were injected into the midbrain to produce wide ranges of dopamine depletion in striatum. |
2007-11-05 |
2023-08-12 |
rat |
| Hideko Yamamoto, Etsuko Kamegaya, Yoko Hagino, Kazuhide Imai, Akihiro Fujikawa, Kohei Tamura, Tomoyuki Enokiya, Toshifumi Yamamoto, Takao Takeshima, Hisashi Koga, George R Uhl, Kazutaka Ikeda, Ichiro Sor. Genetic deletion of vesicular monoamine transporter-2 (VMAT2) reduces dopamine transporter activity in mesencephalic neurons in primary culture. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17664021. |
we examined mesencephalon dopaminergic cultures prepared from vmat2 wild-type, heterozygous or homozygous knockout (ko) 14-day-old mouse fetuses to determine the number of tyrosine hydroxylase (th)-positive cells and dopamine transporter activity. |
2007-10-25 |
2023-08-12 |
mouse |
| S Karakaya, M Kipp, C Beye. Oestrogen regulates the expression and function of dopamine transporters in astrocytes of the nigrostriatal system. Journal of neuroendocrinology. vol 19. issue 9. 2007-10-23. PMID:17680883. |
using neonatal striatal and midbrain astrocyte cultures, we could demonstrate that astrocytes possess a specific dopamine uptake machinery and express dat at considerable levels. |
2007-10-23 |
2023-08-12 |
Not clear |
| S Karakaya, M Kipp, C Beye. Oestrogen regulates the expression and function of dopamine transporters in astrocytes of the nigrostriatal system. Journal of neuroendocrinology. vol 19. issue 9. 2007-10-23. PMID:17680883. |
functionally, oestrogen exposure inhibited the clearance of dopamine from the extracellular space by 45% and 35% compared to controls in midbrain and striatal astroglia, respectively. |
2007-10-23 |
2023-08-12 |
Not clear |
| B Behrouz, R E Drolet, Z A Sayed, K J Lookingland, J L Goudrea. Unique responses to mitochondrial complex I inhibition in tuberoinfundibular dopamine neurons may impart resistance to toxic insult. Neuroscience. vol 147. issue 3. 2007-10-19. PMID:17583437. |
tuberoinfundibular dopamine (tida) neurons are spared in parkinson's disease (pd), a disorder that causes degeneration of midbrain nigrostriatal dopamine (nsda) and mesolimbic dopamine (mlda) neurons. |
2007-10-19 |
2023-08-12 |
mouse |
| Yan-Na Wu, Steven W Johnso. Rotenone potentiates NMDA currents in substantia nigra dopamine neurons. Neuroscience letters. vol 421. issue 2. 2007-09-28. PMID:17560718. |
we used whole-cell patch pipettes to investigate actions of rotenone on currents evoked by n-methyl-d-aspartate (nmda) in dopamine neurons in slices of rat midbrain. |
2007-09-28 |
2023-08-12 |
rat |
| Matthew B Lassen, J Elliott Brown, Sarah H Stobbs, Seth H Gunderson, Levi Maes, C Fernando Valenzuela, Andrew P Ray, Steven J Henriksen, Scott C Steffense. Brain stimulation reward is integrated by a network of electrically coupled GABA neurons. Brain research. vol 1156. 2007-09-21. PMID:17524371. |
notwithstanding the difficulties in identifying the neuronal integrator of bsr, the mesocorticolimbic dopamine (da) system originating in the ventral tegmental area (vta) of the midbrain has been implicated. |
2007-09-21 |
2023-08-12 |
rat |
| Wolfram Schult. Multiple dopamine functions at different time courses. Annual review of neuroscience. vol 30. 2007-09-21. PMID:17600522. |
many lesion studies report an amazing variety of deficits in behavioral functions that cannot possibly be encoded in great detail by the relatively small number of midbrain dopamine neurons. |
2007-09-21 |
2023-08-12 |
Not clear |
| Michela Giustizieri, Maria Letizia Cucchiaroni, Ezia Guatteo, Giorgio Bernardi, Nicola B Mercuri, Nicola Berrett. Memantine inhibits ATP-dependent K+ conductances in dopamine neurons of the rat substantia nigra pars compacta. The Journal of pharmacology and experimental therapeutics. vol 322. issue 2. 2007-09-20. PMID:17496164. |
besides inhibition of nmda receptor-mediated currents, memantine (30 and 100 microm) increased the spontaneous firing rate of whole-cell recorded dopamine neurons in a midbrain slice preparation. |
2007-09-20 |
2023-08-12 |
rat |
| Stephen Bennett, Benjamin Gronie. Effects of antipsychotic treatments and D-serine supplementation on the electrophysiological activation of midbrain dopamine neurons induced by the noncompetitive NMDA antagonist MK 801. Synapse (New York, N.Y.). vol 61. issue 8. 2007-09-12. PMID:17523181. |
effects of antipsychotic treatments and d-serine supplementation on the electrophysiological activation of midbrain dopamine neurons induced by the noncompetitive nmda antagonist mk 801. |
2007-09-12 |
2023-08-12 |
human |
| Jongpil Kim, Keiichi Inoue, Jennifer Ishii, William B Vanti, Sergey V Voronov, Elizabeth Murchison, Gregory Hannon, Asa Abeliovic. A MicroRNA feedback circuit in midbrain dopamine neurons. Science (New York, N.Y.). vol 317. issue 5842. 2007-09-11. PMID:17761882. |
a microrna feedback circuit in midbrain dopamine neurons. |
2007-09-11 |
2023-08-12 |
Not clear |