| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marius Wernig, Jian-Ping Zhao, Jan Pruszak, Eva Hedlund, Dongdong Fu, Frank Soldner, Vania Broccoli, Martha Constantine-Paton, Ole Isacson, Rudolf Jaenisc. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 15. 2008-06-13. PMID:18391196. |
furthermore, ips cells were induced to differentiate into dopamine neurons of midbrain character and were able to improve behavior in a rat model of parkinson's disease upon transplantation into the adult brain. |
2008-06-13 |
2023-08-12 |
mouse |
| E Mengual, J Chan, D Lane, M San Luciano Palenzuela, Y Hara, A Lessard, V M Picke. Neurokinin-1 receptors in cholinergic neurons of the rat ventral pallidum have a predominantly dendritic distribution that is affected by apomorphine when combined with startle-evoking auditory stimulation. Neuroscience. vol 151. issue 3. 2008-06-12. PMID:18178320. |
gating deficits can be produced in rodent models by acute systemic administration of apomorphine, a non-selective dopamine d1 and d2 receptor agonist that also affects trafficking of neurokinin-1 (nk(1)) receptors induced by startle evoking auditory stimulation (as) in midbrain neurons. |
2008-06-12 |
2023-08-12 |
human |
| Xiqun Chen, Lu Xu, Pheona Radcliffe, Baoyong Sun, A William Tan. Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. Molecular pharmacology. vol 73. issue 6. 2008-06-10. PMID:18349104. |
in this study, we test whether activation of the camp signaling pathway regulates th gene expression in two rodent models of midbrain dopamine neurons, ventral midbrain organotypic slice cultures and mn9d cells. |
2008-06-10 |
2023-08-12 |
Not clear |
| Xiqun Chen, Lu Xu, Pheona Radcliffe, Baoyong Sun, A William Tan. Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. Molecular pharmacology. vol 73. issue 6. 2008-06-10. PMID:18349104. |
an understanding of this novel regulatory mechanism may help to explain the control of th gene expression and consequently dopamine biosynthesis in midbrain neurons under different physiological and pathological conditions. |
2008-06-10 |
2023-08-12 |
Not clear |
| Jun Takahash. [Neuromodulation for Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 48. issue 4. 2008-06-10. PMID:18453154. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a progressive loss of midbrain dopaminergic (da) neurons and a subsequent reduction in striatal dopamine. |
2008-06-10 |
2023-08-12 |
human |
| Giovanni Hernandez, Heshmat Rajabi, Jane Stewart, Andreas Arvanitogiannis, Peter Shizga. Dopamine tone increases similarly during predictable and unpredictable administration of rewarding brain stimulation at short inter-train intervals. Behavioural brain research. vol 188. issue 1. 2008-05-19. PMID:18068824. |
unpredicted rewards, but not predicted ones, trigger strong phasic changes in the firing rates of midbrain dopamine (da). |
2008-05-19 |
2023-08-12 |
human |
| Laurent Roybon, Tord Hjalt, Nicolaj S Christophersen, Jia-Yi Li, Patrik Brundi. Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 14. 2008-05-19. PMID:18385323. |
together, we demonstrate that induced overexpression of transcription factor genes has profound and specific effects on the differentiation of rat and human midbrain progenitors, although few dopamine neurons are generated. |
2008-05-19 |
2023-08-12 |
human |
| K S Bankiewicz, R Sanchez-Pernaute, Y Oiwa, M Kohutnicka, A Cummins, J Eberlin. Preclinical models of Parkinson's disease. Current protocols in neuroscience. vol Chapter 9. 2008-05-13. PMID:18428552. |
parkinson's disease is a neurodegenerative disease in which pigmented midbrain neurons progressively die producing a dopamine (da) deficit in the striatum which manifests as an akinetic movement disorder. |
2008-05-13 |
2023-08-12 |
Not clear |
| Leah R Miller, Shyamali Mukherjee, Twum A Ansah, Salil K Da. Cigarette smoke and dopaminergic system. Journal of biochemical and molecular toxicology. vol 21. issue 6. 2008-05-09. PMID:17994575. |
both acute and chronic cs exposure enhanced locomotor behavior and caused a decrease in midbrain dopamine (da) levels and corresponding increase in 3,4-dihydroxyphenylacetic acid (dopac) levels. |
2008-05-09 |
2023-08-12 |
Not clear |
| Gerson Chadi, Camila Silva, Jessica Ruivo Maximino, Kjell Fuxe, Gilberto Ochman da Silv. Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain. Brain research. vol 1190. 2008-05-06. PMID:18086466. |
adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-ohda-induced dopamine degeneration in regions of the ventral midbrain. |
2008-05-06 |
2023-08-12 |
rat |
| Gerson Chadi, Camila Silva, Jessica Ruivo Maximino, Kjell Fuxe, Gilberto Ochman da Silv. Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain. Brain research. vol 1190. 2008-05-06. PMID:18086466. |
and that 6-ohda injected in the ventral midbrain upregulates fgf-2 synthesis in reactive astrocytes in the ascending dopamine pathways [chadi, g., cao, y., pettersson, r.f., fuxe, k., 1994. |
2008-05-06 |
2023-08-12 |
rat |
| Gerson Chadi, Camila Silva, Jessica Ruivo Maximino, Kjell Fuxe, Gilberto Ochman da Silv. Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain. Brain research. vol 1190. 2008-05-06. PMID:18086466. |
seven days after the dopamine lesion, western blot analysis showed a decreased level of tyrosine hydroxylase in the lesioned side of the midbrain, an event that was not altered by adx or corticosterone replacement. |
2008-05-06 |
2023-08-12 |
rat |
| Gerson Chadi, Camila Silva, Jessica Ruivo Maximino, Kjell Fuxe, Gilberto Ochman da Silv. Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain. Brain research. vol 1190. 2008-05-06. PMID:18086466. |
in conclusion, bilateral adx counteracted the increased astroglial fgf-2 synthesis in the dopamine regions of the ventral midbrain following a 6-ohda-induced local lesion and interfered with fgf receptor regulation around injury. |
2008-05-06 |
2023-08-12 |
rat |
| Lu Wen, Wei Wei, Wenchao Gu, Peng Huang, Xi Ren, Zheng Zhang, Zuoyan Zhu, Shuo Lin, Bo Zhan. Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish. Developmental biology. vol 314. issue 1. 2008-04-29. PMID:18164283. |
the gfp positive neurons include the large and pear-shaped tyrosine hydroxylase positive neurons (th populations 2 and 4) in the posterior tuberculum of ventral diencephalon (pt neurons), which are thought to be equivalent to the midbrain dopamine neurons in mammals. |
2008-04-29 |
2023-08-12 |
zebrafish |
| S Wonnacot. Gates and filters: unveiling the physiological roles of nicotinic acetylcholine receptors in dopaminergic transmission. British journal of pharmacology. vol 153 Suppl 1. 2008-04-28. PMID:18246098. |
in his review, maskos posits that in midbrain dopamine neurons, somatodendritic nachrs activated by cholinergic inputs from the pedunculopontine tegmental nucleus (pptg) and laterodorsal tegmental nucleus (ldtg) serve as a 'gate' that facilitates the switch to burst firing. |
2008-04-28 |
2023-08-12 |
Not clear |
| Chang-Hwan Park, Jin Sun Kang, Eun-Hye Yoon, Jae-Won Shim, Haeyoung Suh-Kim, Sang-Hun Le. Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro. FEBS letters. vol 582. issue 5. 2008-04-24. PMID:18242186. |
roles of nurr1 and neurogenin 2 (ngn2) have been shown in midbrain dopamine (da) neuron development. |
2008-04-24 |
2023-08-12 |
mouse |
| Li-Xing Liu, Wen-Fang Chen, Jun-Xia Xie, Man-Sau Won. Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease. Neuroscience research. vol 60. issue 2. 2008-04-18. PMID:18054104. |
the reverse transcription-pcr results also confirmed that the mptp-induced downregulation of th, dopamine transporter (dat) and bcl-2 mrna expression in the midbrain could be restored by genistein or estrogen pretreatment. |
2008-04-18 |
2023-08-12 |
mouse |
| Theodora Papanikolaou, Jessica B Lennington, Adrienne Betz, Cristina Figueiredo, John D Salamone, Joanne C Conove. In vitro generation of dopaminergic neurons from adult subventricular zone neural progenitor cells. Stem cells and development. vol 17. issue 1. 2008-04-18. PMID:18248323. |
here, we investigate the plasticity of anscs in vitro, in particular, their ability to generate a specific neuronal lineage, midbrain dopamine neurons. |
2008-04-18 |
2023-08-12 |
mouse |
| Theodora Papanikolaou, Jessica B Lennington, Adrienne Betz, Cristina Figueiredo, John D Salamone, Joanne C Conove. In vitro generation of dopaminergic neurons from adult subventricular zone neural progenitor cells. Stem cells and development. vol 17. issue 1. 2008-04-18. PMID:18248323. |
however, these neurons exhibited characteristics of forebrain dopamine neurons and also expressed low levels of midbrain transcription factors. |
2008-04-18 |
2023-08-12 |
mouse |
| G K Murray, P R Corlett, L Clark, M Pessiglione, A D Blackwell, G Honey, P B Jones, E T Bullmore, T W Robbins, P C Fletche. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Molecular psychiatry. vol 13. issue 3. 2008-04-17. PMID:17684497. |
recent theoretical interest has been directed at relating the known role of midbrain dopamine neurons in reinforcement learning, motivational salience and prediction error to explain the abnormal mental experience of psychosis. |
2008-04-17 |
2023-08-12 |
human |