| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
here, by using 6-[(18)f]fluorodopa (fdopa) positron emission tomography (pet) and event-related 3t functional magnetic resonance imaging (fmri) in the same subjects, we directly demonstrate a link between midbrain dopamine synthesis and reward-related prefrontal activity in humans, show that healthy aging induces functional alterations in the reward system, and identify an age-related change in the direction of the relationship (from a positive to a negative correlation) between midbrain dopamine synthesis and prefrontal activity. |
2008-10-24 |
2023-08-12 |
human |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
taken together, our findings provide an important characterization of the interactions between midbrain dopamine function and the reward system in healthy young humans and older subjects, and identify the changes in this regulatory circuit that accompany aging. |
2008-10-24 |
2023-08-12 |
human |
| Soili M Lehto, Tommi Tolmunen, Jyrki Kuikka, Minna Valkonen-Korhonen, Mikko Joensuu, Pirjo I Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Johannes Lehtone. Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. Neuroscience letters. vol 441. issue 3. 2008-10-20. PMID:18588943. |
midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. |
2008-10-20 |
2023-08-12 |
Not clear |
| Soili M Lehto, Tommi Tolmunen, Jyrki Kuikka, Minna Valkonen-Korhonen, Mikko Joensuu, Pirjo I Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Johannes Lehtone. Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. Neuroscience letters. vol 441. issue 3. 2008-10-20. PMID:18588943. |
we examined the striatum dopamine (dat) and midbrain serotonin transporter (sert) binding of [123i] nor-beta-cit in dd patients (n=8) and compared it to that in md patients (n=11) and healthy controls (n=19). |
2008-10-20 |
2023-08-12 |
Not clear |
| Elyssa B Margolis, Jennifer M Mitchell, Junko Ishikawa, Gregory O Hjelmstad, Howard L Field. Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 36. 2008-10-16. PMID:18768684. |
midbrain dopamine neurons: projection target determines action potential duration and dopamine d(2) receptor inhibition. |
2008-10-16 |
2023-08-12 |
Not clear |
| Elyssa B Margolis, Jennifer M Mitchell, Junko Ishikawa, Gregory O Hjelmstad, Howard L Field. Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 36. 2008-10-16. PMID:18768684. |
broad action potentials (aps) and dopamine (da) d(2) receptor (d(2)r)-mediated inhibition are widely used to identify midbrain da neurons. |
2008-10-16 |
2023-08-12 |
Not clear |
| N M Kanaan, J H Kordower, T J Collie. Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration. The European journal of neuroscience. vol 27. issue 12. 2008-10-09. PMID:18598263. |
age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration. |
2008-10-09 |
2023-08-12 |
monkey |
| Jaroslaw Maciaczyk, Ilyas Singec, Donata Maciaczyk, Guido Nikkha. Combined use of BDNF, ascorbic acid, low oxygen, and prolonged differentiation time generates tyrosine hydroxylase-expressing neurons after long-term in vitro expansion of human fetal midbrain precursor cells. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18652826. |
freshly isolated fetal midbrain neural precursor cells (npcs) that maintain the potential to differentiate into dopamine (da) neurons represent a valuable source for cell therapy in parkinson's disease. |
2008-10-08 |
2023-08-12 |
human |
| Pavlos Pissios, Lauren Frank, Adam R Kennedy, Douglas R Porter, Francis E Marino, Fen-Fen Liu, Emmanuel N Pothos, Eleftheria Maratos-Flie. Dysregulation of the mesolimbic dopamine system and reward in MCH-/- mice. Biological psychiatry. vol 64. issue 3. 2008-10-07. PMID:18281019. |
abundant expression of the mch receptor is observed outside the hypothalamus, especially in the dorsal and the ventral striatum, raising the possibility that mch modulates the function of the midbrain dopamine neurons and associated circuitry. |
2008-10-07 |
2023-08-12 |
mouse |
| M Mamunur Rahman, Takashi Ichiyanagi, Tadazumi Komiyama, Shinji Sato, Tetsuya Konish. Effects of anthocyanins on psychological stress-induced oxidative stress and neurotransmitter status. Journal of agricultural and food chemistry. vol 56. issue 16. 2008-10-06. PMID:18662010. |
concomitantly, dopamine neurotransmitter levels were altered in both the midbrain and the brain cortex. |
2008-10-06 |
2023-08-12 |
mouse |
| Garret D Stuber, Marianne Klanker, Bram de Ridder, M Scott Bowers, Ruud N Joosten, Matthijs G Feenstra, Antonello Bonc. Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science (New York, N.Y.). vol 321. issue 5896. 2008-10-02. PMID:18802002. |
reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. |
2008-10-02 |
2023-08-12 |
Not clear |
| Garret D Stuber, Marianne Klanker, Bram de Ridder, M Scott Bowers, Ruud N Joosten, Matthijs G Feenstra, Antonello Bonc. Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science (New York, N.Y.). vol 321. issue 5896. 2008-10-02. PMID:18802002. |
midbrain dopamine neurons are activated by environmental cues that predict rewards, but the cellular mechanisms that underlie this phenomenon remain elusive. |
2008-10-02 |
2023-08-12 |
Not clear |
| Deranda B Lester, Anthony D Miller, Tiffany D Pate, Charles D Blah. Midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release. Neuroreport. vol 19. issue 9. 2008-09-24. PMID:18521007. |
midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release. |
2008-09-24 |
2023-08-12 |
mouse |
| David Engblom, Ainhoa Bilbao, Carles Sanchis-Segura, Lionel Dahan, Stéphanie Perreau-Lenz, Bénédicte Balland, Jan Rodriguez Parkitna, Rafael Luján, Briac Halbout, Manuel Mameli, Rosanna Parlato, Rolf Sprengel, Christian Lüscher, Günther Schütz, Rainer Spanage. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron. vol 59. issue 3. 2008-09-17. PMID:18701074. |
cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of glur1-containing ampa receptors. |
2008-09-17 |
2023-08-12 |
mouse |
| Rosario Sanchez-Pernaute, Hyojin Lee, Michaela Patterson, Casper Reske-Nielsen, Takahito Yoshizaki, Kai C Sonntag, Lorenz Studer, Ole Isacso. Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669499. |
using a parthenogenetic primate embryonic stem cell line, we have generated dopamine neurons that display persistent expression of midbrain regional and cell-specific transcription factors, which establish their proper identity and allow for their survival. |
2008-09-15 |
2023-08-12 |
rat |
| Yajie Liang, Shurong Li, Can Wen, Yanling Zhang, Qiang Guo, Hanzhi Wang, Bingyin S. Intrastriatal injection of colchicine induces striatonigral degeneration in mice. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18564367. |
recent studies from environmental toxicology and molecular genetics demonstrate that midbrain dopamine (da) neurons are particularly vulnerable to microtubule depolymerizing agents, indicating the involvement of microtubule dysfunction in the pathogenesis of parkinson's disease. |
2008-09-12 |
2023-08-12 |
mouse |
| Y S Levy, M Bahat-Stroomza, R Barzilay, A Burshtein, S Bulvik, Y Barhum, H Panet, E Melamed, D Offe. Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease. Cytotherapy. vol 10. issue 4. 2008-09-09. PMID:18574767. |
the purpose of this study was to assess the developmental potential of hmsc to replace the midbrain dopamine neurons selectively lost in parkinson's disease. |
2008-09-09 |
2023-08-12 |
human |
| Can Ozan Tan, Eric Anderson, Mark Dranias, Daniel Bulloc. Can the apparent adaptation of dopamine neurons' mismatch sensitivities be reconciled with their computation of reward prediction errors? Neuroscience letters. vol 438. issue 1. 2008-09-08. PMID:18482798. |
according to modern reinforcement learning theories, midbrain dopamine (da) neurons are part of an adaptive system within which learned expectations filter reward-related signals to enable computation of reward prediction errors (rpes). |
2008-09-08 |
2023-08-12 |
Not clear |
| Franziska Marschinke, Ingrid Strömber. Dual effects of TNFalpha on nerve fiber formation from ventral mesencephalic organotypic tissue cultures. Brain research. vol 1215. 2008-09-04. PMID:18482714. |
dopamine nerve fiber outgrowth in organotypic cultures of fetal ventral mesencephalon occurs in two waves. |
2008-09-04 |
2023-08-12 |
Not clear |
| Adriana Galvan, Thomas Wichman. Pathophysiology of parkinsonism. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 119. issue 7. 2008-08-20. PMID:18467168. |
this knowledge has contributed significantly to our understanding of the link between the degeneration of dopamine neurons in the midbrain and the development of parkinsonism. |
2008-08-20 |
2023-08-12 |
Not clear |