| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Braak, K Del Tredic. [A new look at the corticostriatal-thalamocortical circuit in sporadic Parkinson's disease]. Der Nervenarzt. vol 79. issue 12. 2009-04-20. PMID:18726081. |
in the classic model, major emphasis is placed on the dopamine deficiency in the dorsal striatum that occurs as a result of neuronal loss in the substantia nigra of the midbrain. |
2009-04-20 |
2023-08-12 |
Not clear |
| B Gronie. Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18801415. |
involvement of glutamate neurotransmission and n-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-ht1a receptor agonists: an electrophysiological study in the rat. |
2009-04-14 |
2023-08-12 |
rat |
| B Gronie. Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18801415. |
these results show that activation of midbrain dopamine neurons by the systemic administration of 5-ht1a agonists does involve the inactivation of a tonic gabaergic tone, involving mainly the gabab receptors, probably leading to the stimulation of a glutamatergic excitatory drive from the pfc to the vta and an increase in glutamate release. |
2009-04-14 |
2023-08-12 |
rat |
| Tianran Song, Guian Chen, Yue Wang, Genhong Mao, Yanxia Wang, Haiyan Ba. Chemically defined sequential culture media for TH+ cell derivation from human embryonic stem cells. Molecular human reproduction. vol 14. issue 11. 2009-04-10. PMID:18922848. |
during the past few years several differentiation protocols to derive midbrain dopamine (da) neurons from human embryonic stem (hes) cells have been developed, but the production of sufficient amounts of the 'right' therapeutic da cells has not yet been accomplished. |
2009-04-10 |
2023-08-12 |
human |
| Jaan-Olle Andressoo, Mart Saarm. Signalling mechanisms underlying development and maintenance of dopamine neurons. Current opinion in neurobiology. vol 18. issue 3. 2009-04-09. PMID:18678254. |
majority of the brain dopamine (da) neurons reside in a distinct area in the midbrain and project axons into the striatum and frontal cortex to control central nervous system (cns) functions such as movement, motivation and mood. |
2009-04-09 |
2023-08-12 |
Not clear |
| David H Zald, Ronald L Cowan, Patrizia Riccardi, Ronald M Baldwin, M Sib Ansari, Rui Li, Evan S Shelby, Clarence E Smith, Maureen McHugo, Robert M Kessle. Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 53. 2009-04-09. PMID:19118170. |
rodent models of temperament indicate that high novelty responding is associated with decreased inhibitory autoreceptor control of midbrain dopamine neurons. |
2009-04-09 |
2023-08-12 |
human |
| David H Zald, Ronald L Cowan, Patrizia Riccardi, Ronald M Baldwin, M Sib Ansari, Rui Li, Evan S Shelby, Clarence E Smith, Maureen McHugo, Robert M Kessle. Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 53. 2009-04-09. PMID:19118170. |
we speculate that the lower midbrain (auto)receptor availability seen in high novelty seekers leads to accentuated dopaminergic responses to novelty and other conditions that induce dopamine release. |
2009-04-09 |
2023-08-12 |
human |
| Kavita Prasad, Eric K Richfiel. Sporadic midbrain dopamine neuron abnormalities in laboratory mice. Neurobiology of disease. vol 32. issue 2. 2009-04-08. PMID:18687402. |
sporadic midbrain dopamine neuron abnormalities in laboratory mice. |
2009-04-08 |
2023-08-12 |
mouse |
| Corey B Puryear, Sheri J Y Mizumor. Reward prediction error signals by reticular formation neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 15. issue 12. 2009-04-08. PMID:19050161. |
as a key part of the brain's reward system, midbrain dopamine neurons are thought to generate signals that reflect errors in the prediction of reward. |
2009-04-08 |
2023-08-12 |
rat |
| Bin Pan, Cecilia J Hillard, Qing-song Li. D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 52. 2009-04-08. PMID:19109485. |
d2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of gabaergic synaptic transmission in midbrain dopamine neurons via camp-protein kinase a signaling. |
2009-04-08 |
2023-08-12 |
Not clear |
| Frédéric Brischoux, Subhojit Chakraborty, Daniel I Brierley, Mark A Ungles. Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 12. 2009-04-08. PMID:19261850. |
midbrain dopamine neurons play central roles in reward processing. |
2009-04-08 |
2023-08-12 |
rat |
| Suzanne N Haber, Justin L Brucke. Cognitive and limbic circuits that are affected by deep brain stimulation. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273166. |
additional integral parts of the network include, the amygdala, the midbrain dopamine cells and the serotonergic neurons. |
2009-04-07 |
2023-08-12 |
Not clear |
| Gregory J Quirk, Francisco Sotres-Bayo. Signaling aversive events in the midbrain: worse than expected. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285461. |
in this issue of neuron, jhou and colleagues identify a region in the midbrain tegmentum that signals aversive events and inhibits midbrain dopamine neurons. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas C Jhou, Howard L Fields, Mark G Baxter, Clifford B Saper, Peter C Hollan. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285474. |
the rostromedial tegmental nucleus (rmtg), a gabaergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas C Jhou, Howard L Fields, Mark G Baxter, Clifford B Saper, Peter C Hollan. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285474. |
we show that neurons in the recently identified gabaergic rostromedial tegmental nucleus (rmtg), which receive a major lhb input, project heavily to midbrain dopamine neurons, and show phasic activations and/or fos induction after aversive stimuli (footshocks, shock-predictive cues, food deprivation, or reward omission) and inhibitions after rewards or reward-predictive stimuli. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas C Jhou, Howard L Fields, Mark G Baxter, Clifford B Saper, Peter C Hollan. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285474. |
these findings suggest that aversive inputs from widespread brain regions and stimulus modalities converge onto the rmtg, which opposes reward and motor-activating functions of midbrain dopamine neurons. |
2009-04-01 |
2023-08-12 |
Not clear |
| Michael Y Aksenov, Marina V Aksenova, Janelle M Silvers, Charles F Mactutus, Rosemarie M Booz. Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18606182. |
different effects of selective dopamine uptake inhibitors, gbr 12909 and win 35428, on hiv-1 tat toxicity in rat fetal midbrain neurons. |
2009-03-26 |
2023-08-12 |
rat |
| Michael Y Aksenov, Marina V Aksenova, Janelle M Silvers, Charles F Mactutus, Rosemarie M Booz. Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18606182. |
in this study, we found that the selective inhibitor of dopamine transporter (dat) function, 1-[2-[bis(4-fluorophenyl) methoxy]ethyl]-4-(3-phenylpropyl) piperazine (gbr 12909, vanoxerine), but not the selective inhibitors of serotonin and norepinephrine (sert and net) transporters, sertraline and nizoxetine, emulated cocaine-mediated enhancement of tat neurotoxicity in rat fetal midbrain primary cell cultures. |
2009-03-26 |
2023-08-12 |
rat |
| Ilva Putzier, Paul H M Kullmann, John P Horn, Edwin S Levita. Dopamine neuron responses depend exponentially on pacemaker interval. Journal of neurophysiology. vol 101. issue 2. 2009-03-26. PMID:19073798. |
midbrain dopamine neuron activity results from the integration of the responses to metabo- and ionotropic receptors with the postsynaptic excitability of these intrinsic pacemakers. |
2009-03-26 |
2023-08-12 |
human |
| Florence Sotty, Trine Damgaard, Liliana P Montezinho, Arne Mørk, Christina K Olsen, Christoffer Bundgaard, Henriette Husu. Antipsychotic-like effect of retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098162. |
because psychotic symptoms are believed to be associated with an increased excitability of dopamine (da) cells in the mesencephalon, kcnq channels might represent a new potential target for the treatment of psychosis. |
2009-03-24 |
2023-08-12 |
Not clear |