| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O V Kornyushin, A A Bakhtyukov, I I Zorina, Y G Toropova, K V Derkach, O M Berko, M N Todosenko, L S Litvinova, A O Shpakov, M M Galagudz. [The effect of different types of bariatric surgery on the metabolic and hormonal parameters in rats with decompensed form of type 2 diabetes mellitus.] Advances in gerontology = Uspekhi gerontologii. vol 32. issue 1-2. 2019-08-28. PMID:31228372. |
in the hypothalamus, the expression of the genes encoding glp-1 receptor, orexigenic agouti-related peptide (agrp), as well as phosphotyrosine phosphatase 1b and socs3, the negative regulators of the leptin and insulin pathways was increased. |
2019-08-28 |
2023-08-13 |
rat |
| Izabela Martina Ramos Ribeiro, Vagner Roberto Antune. The role of insulin at brain-liver axis in the control of glucose production. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 4. 2019-08-16. PMID:29878846. |
insulin has also an important action within the central nervous system, more precisely in the hypothalamus that projects directly to preautonomic nuclei in the brain stem to control hepatic glucose production. |
2019-08-16 |
2023-08-13 |
Not clear |
| Anna Idelevich, Roland Baro. Brain to bone: What is the contribution of the brain to skeletal homeostasis? Bone. vol 115. 2019-07-15. PMID:29777919. |
in particular, the hypothalamus - located at the base of the brain in close proximity to the medial eminence, where the blood-brain-barrier is not as tight as in other regions of the brain but rather "leaky", due to fenestrated capillaries - is exposed to a variety of circulating body cues, such as nutrients (glucose, fatty acids, amino acids), and hormones (insulin, glucagon, leptin, adiponectin) [1-3].information collected from the body via these peripheral cues is integrated by hypothalamic sensing neurons and glial cells [4-7], which express receptors for these nutrients and hormones, transforming these cues into physiological outputs. |
2019-07-15 |
2023-08-13 |
Not clear |
| Erika K Tse, Ashkan Salehi, Matthew N Clemenzi, Denise D Belsha. Role of the saturated fatty acid palmitate in the interconnected hypothalamic control of energy homeostasis and biological rhythms. American journal of physiology. Endocrinology and metabolism. vol 315. issue 2. 2019-07-09. PMID:29631363. |
the brain, specifically the hypothalamus, controls whole body energy and glucose homeostasis through neurons that synthesize specific neuropeptides, whereas hypothalamic dysfunction is linked directly to insulin resistance, obesity, and type 2 diabetes mellitus. |
2019-07-09 |
2023-08-13 |
Not clear |
| Mehala Subramaniapillai, Roger S McIntyr. A review of the neurobiology of obesity and the available pharmacotherapies. CNS spectrums. vol 22. issue S1. 2019-07-08. PMID:29350126. |
peripheral level regulators of appetite, such as leptin, insulin, ghrelin, and cholecystokinin, feed into the appetite center of the brain, which is controlled by the hypothalamus, to maintain homeostasis and energy balance. |
2019-07-08 |
2023-08-13 |
Not clear |
| Hiraku On. Molecular Mechanisms of Hypothalamic Insulin Resistance. International journal of molecular sciences. vol 20. issue 6. 2019-07-03. PMID:30875909. |
insulin exists in the central nervous system, where it executes two important functions in the hypothalamus: the suppression of food intake and the improvement of glucose metabolism. |
2019-07-03 |
2023-08-13 |
Not clear |
| Jan Detka, Joanna Ślusarczyk, Anna Kurek, Mateusz Kucharczyk, Tomasz Adamus, Paweł Konieczny, Marta Kubera, Agnieszka Basta-Kaim, Władysław Lasoń, Bogusława Budziszewsk. Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line. Pharmacological reports : PR. vol 71. issue 2. 2019-06-17. PMID:30831439. |
current study was aimed at investigating the influence of prenatal stress (ps) on insulin, glp-1 and their receptor (ir and glp-1r) levels in the hypothalamus. |
2019-06-17 |
2023-08-13 |
Not clear |
| K V Derkach, I B Sukhov, V M Bondareva, A O Shpako. [The effect of Metformin on metabolic parameters and hypothalamic signaling systems in rats with obesity induced by a high-carbohydrate/high-fat diet.] Advances in gerontology = Uspekhi gerontologii. vol 31. issue 1. 2019-06-11. PMID:29860743. |
at the same time, the differences in the activity of the leptin and insulin systems and the ratio of anorexigenic and orexigenic factors in the hypothalamus of the rat groups ob and obm were insignificant. |
2019-06-11 |
2023-08-13 |
rat |
| Marion Soto, Weikang Cai, Masahiro Konishi, C Ronald Kah. Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 13. 2019-05-20. PMID:30765523. |
previous studies have shown that insulin and igf-1 signaling in the brain, especially the hypothalamus, is important for regulation of systemic metabolism. |
2019-05-20 |
2023-08-13 |
mouse |
| Ragitha Chruvattil, Shreya Banerjee, Sarmi Nath, Jatin Machhi, Gitika Kharkwal, Mange Ram Yadav, Sarita Gupt. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Molecular neurobiology. vol 54. issue 9. 2019-05-08. PMID:27822713. |
immunoblotting of insulin receptor (insr)-pi3kinase-akt demonstrated reduced insulin signaling in hypothalamus but no change in hippocampus, cortex, and cerebellum in dexamethasone-treated rats as compared to vehicle-treated rats, signifying the diversity of distribution and function of insulin in different brain regions. |
2019-05-08 |
2023-08-13 |
rat |
| Ragitha Chruvattil, Shreya Banerjee, Sarmi Nath, Jatin Machhi, Gitika Kharkwal, Mange Ram Yadav, Sarita Gupt. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Molecular neurobiology. vol 54. issue 9. 2019-05-08. PMID:27822713. |
graphical abstract reduced insulin signaling as well as elevated glucocorticoid levels in hypothalamus modulates the key appetite regulating neuropeptides, neurotransmitters, and nutrient sensors resulting into reduced appetite and bodyweight. |
2019-05-08 |
2023-08-13 |
rat |
| Tamara Dakic, Tanja Jevdjovic, Iva Lakic, Sinisa F Djurasevic, Jelena Djordjevic, Predrag Vujovi. Food For Thought: Short-Term Fasting Upregulates Glucose Transporters in Neurons and Endothelial Cells, But Not in Astrocytes. Neurochemical research. vol 44. issue 2. 2019-05-07. PMID:30460639. |
our group previously reported that 6-h fasting increased both insulin ii mrna expression and insulin level in rat hypothalamus. |
2019-05-07 |
2023-08-13 |
rat |
| Tamara Dakic, Tanja Jevdjovic, Iva Lakic, Sinisa F Djurasevic, Jelena Djordjevic, Predrag Vujovi. Food For Thought: Short-Term Fasting Upregulates Glucose Transporters in Neurons and Endothelial Cells, But Not in Astrocytes. Neurochemical research. vol 44. issue 2. 2019-05-07. PMID:30460639. |
given that insulin effects on central glucose metabolism are insufficiently understood, we wanted to examine if the centrally produced insulin affects expression and/or regional distribution of glucose transporters, and glycogen stores in the hypothalamus during short-term fasting. |
2019-05-07 |
2023-08-13 |
rat |
| K V Derkach, V M Bondareva, A O Shpako. [Co-administration of intranasally delivered insulin and proinsulin C-peptide to rats with the types 1 and 2 diabetes mellitus restores their metabolic parameters.] Advances in gerontology = Uspekhi gerontologii. vol 30. issue 6. 2019-04-30. PMID:29608829. |
the signaling systems sensitive to insulin in the hypothalamus and other brain areas are among the targets of insulin. |
2019-04-30 |
2023-08-13 |
human |
| Samuel E Jones, Jacqueline M Lane, Andrew R Wood, Vincent T van Hees, Jessica Tyrrell, Robin N Beaumont, Aaron R Jeffries, Hassan S Dashti, Melvyn Hillsdon, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Seth A Sharp, Yingjie Jie, William D Thompson, Jamie W Harrison, Amy Dawes, Enda M Byrne, Henning Tiemeier, Karla V Allebrandt, Jack Bowden, David W Ray, Rachel M Freathy, Anna Murray, Diego R Mazzotti, Philip R Gehrman, Debbie A Lawlor, Timothy M Frayling, Martin K Rutter, David A Hinds, Richa Saxena, Michael N Weedo. Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature communications. vol 10. issue 1. 2019-04-15. PMID:30696823. |
the loci are enriched for genes involved in circadian regulation, camp, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. |
2019-04-15 |
2023-08-13 |
human |
| Francisco García-Carrizo, Catalina Picó, Ana María Rodríguez, Andreu Palo. High-Esterified Pectin Reverses Metabolic Malprogramming, Improving Sensitivity to Adipostatic/Adipokine Hormones. Journal of agricultural and food chemistry. vol 67. issue 13. 2019-04-15. PMID:30855142. |
we focused on the study of the sensitivity to the main adipostatic/adipokine hormones, i.e., leptin, insulin, and adiponectin, at both peripheral (liver and circulating parameters) and central (hypothalamus) levels. |
2019-04-15 |
2023-08-13 |
rat |
| Carlos Kiyoshi Katashima, Vagner Ramon Rodrigues Silva, Luciene Lenhare, Rodrigo Miguel Marin, José Barreto Campello Carvalheir. iNOS promotes hypothalamic insulin resistance associated with deregulation of energy balance and obesity in rodents. Scientific reports. vol 7. issue 1. 2019-04-11. PMID:28835706. |
thus, in the present study we aimed to evaluate the effects of s-nitrosation in insulin signaling pathway in the hypothalamus of rodents. |
2019-04-11 |
2023-08-13 |
Not clear |
| Chao Chen, Hong-Cai Wang, Xu Zhai, Feng Huang, Dong Wu, Pei-Jing Ron. [Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 9. 2019-04-08. PMID:30232872. |
results showed that acupuncture intervention can relieve dm by 1) reducing body weight through up-regulating leptin level, suppressing insulin resistance and appetite to reduce food intake possibly by way of down-regulating expression of neuropeptide y in the hypothalamus, retarding gastric emptying velocity, increasing small intestinal peristalsis, raising plasma levels of glucagon-like peptide-1 (glp-1) and peptide yy, etc. |
2019-04-08 |
2023-08-13 |
Not clear |
| Hannah Mathew, V Daniel Castracane, Christos Mantzoro. Adipose tissue and reproductive health. Metabolism: clinical and experimental. vol 86. 2019-03-13. PMID:29155136. |
leptin, the "satiety hormone" primarily acts on the hypothalamus via pro-opiomelanocortin (pomc), neuropeptide y (npy), and agouti-related peptide (agrp) neurons to translate acute changes in nutrition and energy expenditure, as well as chronic adipose accumulation into changes in appetite and potentially mediate insulin resistance via shared pathway and notably impacting reproductive health via influence on gnrh secreting neurons. |
2019-03-13 |
2023-08-13 |
Not clear |
| Keisha Harrison, Stephanie Sisle. Vitamin D and the paraventricular nucleus: Relevance for type 2 diabetes. The Journal of steroid biochemistry and molecular biology. vol 177. 2019-03-12. PMID:28993246. |
specifically, we focus on the role of insulin and inflammation in the hypothalamus and how these may be modified through vitamin d action. |
2019-03-12 |
2023-08-13 |
Not clear |