| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing-Jiu Zhang, Chang-Chun Yang, Song-Yun Zhang, Li-Hui Zhang, Jie L. Alteration of NPY in hypothalamus and its correlation with leptin and ghrelin during the development of T2DM in a rat model. SpringerPlus. vol 5. issue 1. 2020-09-30. PMID:27867820. |
this study aimed to investigate the alteration of neuropeptide y (npy) in the hypothalamus and its correlation with insulin, leptin and ghrelin during the development of a rat model of type 2 diabetes mellitus. |
2020-09-30 |
2023-08-13 |
rat |
| Bárbara de A Rodrigues, Vitor R Muñoz, Gabriel K Kuga, Rafael C Gaspar, Susana C B R Nakandakari, Barbara M Crisol, José D Botezelli, Luciana S S Pauli, Adelino S R da Silva, Leandro P de Moura, Dennys E Cintra, Eduardo R Ropelle, José R Paul. Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29062272. |
furthermore, the obese mice with increased mkp-3 showed an insulin signaling impairment with reduction of insulin-induced foxo1 and erk1/2 phosphorylation in the hypothalamus. |
2020-09-30 |
2023-08-13 |
mouse |
| Takaoki Saneyasu, Satoshi Fukuzo, Ayana Kitashiro, Kanami Nagata, Kazuhisa Honda, Hiroshi Kamisoyam. Central administration of insulin and refeeding lead to the phosphorylation of AKT, but not FOXO1, in the hypothalamus of broiler chicks. Physiology & behavior. vol 210. 2020-09-21. PMID:31398442. |
central administration of insulin and refeeding lead to the phosphorylation of akt, but not foxo1, in the hypothalamus of broiler chicks. |
2020-09-21 |
2023-08-13 |
Not clear |
| Juan Salazar, Mervin Chávez-Castillo, Joselyn Rojas, Angel Ortega, Manuel Nava, José Pérez, Milagros Rojas, Cristobal Espinoza, Maricarmen Chacin, Yaneth Herazo, Lissé Angarita, Diana Marcela Rojas, Luis D'Marco, Valmore Bermude. Is "Leptin Resistance" Another Key Resistance to Manage Type 2 Diabetes? Current diabetes reviews. vol 16. issue 7. 2020-09-11. PMID:31886750. |
modulators of insulin sensitivity have been tested in animal models and small clinical trials with promising results, especially in combination with agents such as amylin and glp-1 analogs, in particular, due to their central activity in the hypothalamus. |
2020-09-11 |
2023-08-13 |
Not clear |
| Stephanie Kullmann, Vera Valenta, Robert Wagner, Otto Tschritter, Jürgen Machann, Hans-Ulrich Häring, Hubert Preissl, Andreas Fritsche, Martin Hen. Brain insulin sensitivity is linked to adiposity and body fat distribution. Nature communications. vol 11. issue 1. 2020-07-24. PMID:32296068. |
cross-sectionally, strong insulin responsiveness of the hypothalamus associates with less visceral fat, while subcutaneous fat is unrelated. |
2020-07-24 |
2023-08-13 |
Not clear |
| Zhigang Shi, Ding Zhao, Priscila A Cassaglia, Virginia L Brook. Sites and sources of sympathoexcitation in obese male rats: role of brain insulin. American journal of physiology. Regulatory, integrative and comparative physiology. vol 318. issue 3. 2020-07-17. PMID:31967846. |
here, we investigate insulin, via an action in the arcuate nucleus (arcn), and downstream neuropathways, including melanocortin receptor 3/4 (mc3/4r) in the hypothalamic paraventricular nucleus (pvn) and dorsal medial hypothalamus (dmh). |
2020-07-17 |
2023-08-13 |
rat |
| Mariana Rosolen Tavares, Simone Ferreira Lemes, Thais de Fante, Cristina Saenz de Miera, Isadora Carolina Betim Pavan, Rosangela Maria Neves Bezerra, Patricia Oliveira Prada, Marcio Alberto Torsoni, Carol Fuzeti Elias, Fernando Moreira Simabuc. Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism. The Journal of endocrinology. vol 244. issue 1. 2020-07-13. PMID:31557728. |
in the hypothalamus, mtor/s6ks axis mediates the action of leptin and insulin and can modulate the expression of neuropeptides. |
2020-07-13 |
2023-08-13 |
mouse |
| Gregory N Ruegsegger, Shankarappa Manjunatha, Priska Summer, Srinivas Gopala, Piotr Zabeilski, Surendra Dasari, Patrick M Vanderboom, Ian R Lanza, Katherine A Klaus, K Sreekumaran Nai. Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 3. 2020-05-11. PMID:30676773. |
we show that insulin deficiency in streptozotocin-induced diabetic mice decreased mitochondrial atp production and/or citrate synthase and cytochrome oxidase activities in the cerebrum, hypothalamus, and hippocampus. |
2020-05-11 |
2023-08-13 |
mouse |
| Travis McMurphy, Wei Huang, Xianglan Liu, Jason J Siu, Nicholas J Queen, Run Xiao, Lei Ca. Hypothalamic gene transfer of BDNF promotes healthy aging in mice. Aging cell. vol 18. issue 2. 2020-04-20. PMID:30585393. |
bdnf gene transfer prevented the development of aging-associated metabolic declines characterized by: preventing aging-associated weight gain, reducing adiposity, reversing the decline of brown fat activity, increasing adiponectin while reducing leptin and insulin in circulation, improving glucose tolerance, increasing energy expenditure, alleviating hepatic steatosis, and suppressing inflammatory genes in the hypothalamus and adipose tissues. |
2020-04-20 |
2023-08-13 |
mouse |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
this study evaluated the effects of adx on icv (lateral ventricle) injection of insulin-induced changes on food intake, mrna expression of hypothalamic neuropeptides (insulin receptor (insr), proopiomelanocortin, cocaine and amphetamine-regulated transcript (cart), agouti-related protein, neuropeptide y (npy) in the arcuate nucleus of the hypothalamus (arc), corticotrophin-releasing factor in the paraventricular nucleus of the hypothalamus) and hypothalamic protein content of insulin signaling-related molecules (insulin receptor substrate (irs) 1, protein kinase b (akt), extracellular-signal-regulated kinase (erk1/2), c-jun n-terminal kinase (jnk), protein tyrosine phosphatase-1b (ptp1b) and t cell protein tyrosine phosphatase (tcptp)) compared with sham animals, adx increased the hypothalamic content of pjnk/jnk, ptp1b and tcptp, as well as decreased mrna expression of insr, and corticosterone (b) treatment reversed these effects. |
2020-04-06 |
2023-08-13 |
rat |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
these data demonstrate that adx reduces the expression of insr and increases insulin counter-regulators in the hypothalamus, as well as adx abolishes hypophagia, activation of hypothalamic akt pathway and changes in cart and npy mrna expression in the arc induced by insulin. |
2020-04-06 |
2023-08-13 |
rat |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
thus, the higher levels of insulin counter-regulatory proteins and lower expression of insr in the hypothalamus are likely to underlie impaired insulin-induced hypophagia and responses in the hypothalamus after adx. |
2020-04-06 |
2023-08-13 |
rat |
| Allison B Reiss, Daniel S Glass, Eric Lam, Amy D Glass, Joshua De Leon, Lora J Kasselma. Oxytocin: Potential to mitigate cardiovascular risk. Peptides. vol 117. 2020-04-02. PMID:31112739. |
the neuropeptide hormone oxytocin, synthesized in the brain hypothalamus, is worthy of consideration as a cvd ancillary treatment because it moderates factors directly linked to atherosclerotic cvd such as inflammation, weight gain, food intake and insulin resistance. |
2020-04-02 |
2023-08-13 |
human |
| María Paz Hernández-Cáceres, Lilian Toledo-Valenzuela, Francisco Díaz-Castro, Yenniffer Ávalos, Paulina Burgos, Carla Narro, Daniel Peña-Oyarzun, Jasson Espinoza-Caicedo, Flavia Cifuentes-Araneda, Fernanda Navarro-Aguad, Cecilia Riquelme, Rodrigo Troncoso, Alfredo Criollo, Eugenia Morsell. Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:30972025. |
previous studies indicate that pa accumulates in the hypothalamus following consumption of hfds; in addition, hfds consumption inhibits autophagy and reduces insulin sensitivity. |
2020-02-25 |
2023-08-13 |
Not clear |
| María Paz Hernández-Cáceres, Lilian Toledo-Valenzuela, Francisco Díaz-Castro, Yenniffer Ávalos, Paulina Burgos, Carla Narro, Daniel Peña-Oyarzun, Jasson Espinoza-Caicedo, Flavia Cifuentes-Araneda, Fernanda Navarro-Aguad, Cecilia Riquelme, Rodrigo Troncoso, Alfredo Criollo, Eugenia Morsell. Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:30972025. |
these results reveal a novel cellular mechanism linking pa-rich diets to decreased insulin sensitivity in the hypothalamus and suggest that hypothalamic autophagy might represent a target for future t2dm therapies. |
2020-02-25 |
2023-08-13 |
Not clear |
| Kartik T Nakhate, Nishikant K Subhedar, Dadasaheb M Kokar. Involvement of neuropeptide CART in the central effects of insulin on feeding and body weight. Pharmacology, biochemistry, and behavior. vol 181. 2020-02-25. PMID:31054945. |
the present study was undertaken to reveal the functional interaction between cocaine- and amphetamine-regulated transcript (cart), a well-known anorexic peptide, and insulin within the framework of hypothalamus in the regulation of feeding behavior and body weight. |
2020-02-25 |
2023-08-13 |
rat |
| Kartik T Nakhate, Nishikant K Subhedar, Dadasaheb M Kokar. Involvement of neuropeptide CART in the central effects of insulin on feeding and body weight. Pharmacology, biochemistry, and behavior. vol 181. 2020-02-25. PMID:31054945. |
we suggest that increased cart contents in the hypothalamus may be causally linked with anorexia and weight loss induced by insulin. |
2020-02-25 |
2023-08-13 |
rat |
| Lynda Saber Cherif, Grégory Pourié, Andréa Geoffroy, Amélia Julien, Déborah Helle, Aurélie Robert, Rémy Umoret, Jean-Louis Guéant, Carine Bossenmeyer-Pourié, Jean-Luc Dava. Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus. International journal of molecular sciences. vol 20. issue 20. 2020-02-21. PMID:31615150. |
at weaning, a predominance of the anorexigenic pathway was observed in deficient pups, with increased plasma peptide yy and increased hypothalamic pro-opiomelanocortin (pomc) mrna, in line with abnormal leptin, ghrelin, and insulin secretion and/or signaling during critical periods of fetal and/or postnatal development of the hypothalamus. |
2020-02-21 |
2023-08-13 |
rat |
| Eglantine Balland, Weiyi Chen, Garron T Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A Cowle. Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice. Cell reports. vol 26. issue 2. 2020-02-14. PMID:30625317. |
insulin action in the hypothalamus results in the suppression of hepatic glucose production (hgp). |
2020-02-14 |
2023-08-13 |
mouse |
| Eglantine Balland, Weiyi Chen, Garron T Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A Cowle. Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice. Cell reports. vol 26. issue 2. 2020-02-14. PMID:30625317. |
overall, our findings indicate that obesity-induced increases in ptp1b diminish insulin action in the hypothalamus, resulting in unconstrained hgp and contributing to hyperglycemia in obesity. |
2020-02-14 |
2023-08-13 |
mouse |