| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K V Derkach, A A Perminova, D M Buzanakov, A O Shpako. Intranasal Administration of Proinsulin C-Peptide Enhances the Stimulating Effect of Insulin on Insulin System Activity in the Hypothalamus of Diabetic Rats. Bulletin of experimental biology and medicine. vol 167. issue 3. 2020-01-01. PMID:31346872. |
intranasal administration of proinsulin c-peptide enhances the stimulating effect of insulin on insulin system activity in the hypothalamus of diabetic rats. |
2020-01-01 |
2023-08-13 |
rat |
| K V Derkach, A A Perminova, D M Buzanakov, A O Shpako. Intranasal Administration of Proinsulin C-Peptide Enhances the Stimulating Effect of Insulin on Insulin System Activity in the Hypothalamus of Diabetic Rats. Bulletin of experimental biology and medicine. vol 167. issue 3. 2020-01-01. PMID:31346872. |
we studied the effects of single and repeated (over 7 days) individual and combined nasal administration of c-peptide (10 μg/day) and insulin (20 μg/day) on activity of akt kinase and kinase-3β-glycogen synthase (gsk3β), the components of 3-phosphoinositide pathway, in the hypothalamus of intact rats and rats with mild streptozotocin-induced type 1 diabetes mellitus. |
2020-01-01 |
2023-08-13 |
rat |
| b' Sanja Kova\\xc4\\x8devi\\xc4\\x87, Jelena Nestorov, Gordana Mati\\xc4\\x87, Ivana Elakovi\\xc4\\x8. Chronic Stress Combined with a Fructose Diet Reduces Hypothalamic Insulin Signaling and Antioxidative Defense in Female Rats. Neuroendocrinology. vol 108. issue 4. 2019-12-26. PMID:30572328.' |
in the hypothalamus, a crossroad of stress responses and energy balance, insulin and glucocorticoids regulate the expression of orexigenic neuropeptides, neuropeptide y (npy) and agouti-related protein (agrp), and anorexigenic neuropeptides, proopio-melanocortin (pomc) and cocaine- and amphetamine-regulated transcript (cart). |
2019-12-26 |
2023-08-13 |
rat |
| Tetsuhiro Horie, Gyujin Park, Yuka Inaba, Emi Hashiuchi, Takashi Iezaki, Kazuya Tokumura, Kazuya Fukasawa, Takanori Yamada, Manami Hiraiwa, Yuka Kitaguchi, Hikari Kamada, Katsuyuki Kaneda, Tomohiro Tanaka, Hiroshi Inoue, Eiichi Hino. MAPK Erk5 in Leptin Receptor‒Expressing Neurons Controls Body Weight and Systemic Energy Homeostasis in Female Mice. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31555819. |
in the current study, systemic insulin injection significantly induced phosphorylation of erk5 in the hypothalamus. |
2019-12-23 |
2023-08-13 |
mouse |
| Kira Derkach, Irina Zakharova, Inna Zorina, Andrey Bakhtyukov, Irina Romanova, Liubov Bayunova, Alexander Shpako. The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect. PloS one. vol 14. issue 3. 2019-12-12. PMID:30870482. |
in the hypothalamus of obese agouti-mice, the leptin and insulin content was reduced and the expression of the genes encoding leptin receptor (lepr), mc3- and mc4-melanocortin receptors and pro-opiomelanocortin (pomc), the precursor of anorexigenic melanocortin peptides, was increased. |
2019-12-12 |
2023-08-13 |
mouse |
| Kira Derkach, Irina Zakharova, Inna Zorina, Andrey Bakhtyukov, Irina Romanova, Liubov Bayunova, Alexander Shpako. The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect. PloS one. vol 14. issue 3. 2019-12-12. PMID:30870482. |
in the hypothalamus of mf-treated agouti-mice (10 days, 600 mg/kg/day), the leptin and insulin content was restored, akt-kinase activity was increased, and the activities of ampk and stat3 were reduced and did not differ from control mice. |
2019-12-12 |
2023-08-13 |
mouse |
| Ghislaine Poizat, Coralie Alexandre, Sarah Al Rifai, Laure Riffault, Delphine Crepin, Yacir Benomar, Mohammed Taoui. Maternal resistin predisposes offspring to hypothalamic inflammation and body weight gain. PloS one. vol 14. issue 3. 2019-12-03. PMID:30845245. |
at p28, resistin increased the expression of inflammation markers (il6, tnfα and nfκb) and tlr4 in the hypothalamus and decreased both hypothalamic insulin and leptin receptors' expression. |
2019-12-03 |
2023-08-13 |
mouse |
| Marcelo B S Flores, Maria Fernanda A Fernandes, Eduardo R Ropelle, Marcel C Faria, Mirian Ueno, Lício A Velloso, Mario J A Saad, José B C Carvalheir. Statement of Retraction. Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats. Diabetes 2006;55:2554-2561. DOI: 10.2337/db05-1622. Diabetes. vol 65. issue 4. 2019-11-20. PMID:27208025. |
exercise improves insulin and leptin sensitivity in hypothalamus of wistar rats. |
2019-11-20 |
2023-08-13 |
rat |
| Khanh V Doan, Ann W Kinyua, Dong Joo Yang, Chang Mann Ko, Sang Hyun Moh, Ko Eun Shong, Hail Kim, Sang-Kyu Park, Dong-Hoon Kim, Inki Kim, Ji-Hye Paik, Ronald A DePinho, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Yun-Hee Choi, Ki Woo Ki. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nature communications. vol 7. 2019-11-20. PMID:27681312. |
forkhead transcriptional factor o1 (foxo1) in the hypothalamus plays a crucial role in mediation of leptin and insulin function. |
2019-11-20 |
2023-08-13 |
mouse |
| Mina Thon, Toru Hosoi, Koichiro Ozaw. Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis. Frontiers in endocrinology. vol 7. 2019-11-20. PMID:27812350. |
possible integrative actions of leptin and insulin signaling in the hypothalamus targeting energy homeostasis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Undurti N Da. Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus? Frontiers in endocrinology. vol 8. 2019-11-20. PMID:28824543. |
roux-en-y gastric bypass and similar surgeries ameliorate type 2 dm, partly by restoring to normal: gut hormones, hypothalamic neurotransmitters, eno, vagal activity, gut microbiota, bioactive lipids, bdnf production in the gut and hypothalamus, concentrations of cytokines and free radicals that results in resetting glucose-stimulated insulin production by pancreatic β cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| J B C Carvalheira, E B Ribeiro, E P Araújo, R B Guimarães, M M Telles, M Torsoni, J A R Gontijo, L A Velloso, M J A Saa. Expression of Concern: Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats. Diabetologia. 2019-11-20. PMID:28913539. |
expression of concern: selective impairment of insulin signalling in the hypothalamus of obese zucker rats. |
2019-11-20 |
2023-08-13 |
rat |
| Ramavat Ravindhar Naik, Praveen Kumar Munipally, Turlapati Nagaraj. Andrographolide reorganise hyperglycaemia and distorted antioxidant profile in streptozotocin-induced diabetic rats. Cardiovascular & hematological agents in medicinal chemistry. 2019-11-20. PMID:29076435. |
andrographolide (2.5 mg/kg b.w) was administered orally to diabetic rats and glibenclamide (25mg/kg b.w) as control for 30 days to assess its effects on blood glucose, insulin, insulin resistance and antioxidant profiles such as superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation in various regions of brain namely hypothalamus, cerebellum, hippocampus and brain cerebral cortex. |
2019-11-20 |
2023-08-13 |
rat |
| Elena Prodi, Giovanna Demuro, Silvana Obic. How the hypothalamus controls glucose production: an update. Expert review of endocrinology & metabolism. vol 1. issue 5. 2019-11-20. PMID:30754102. |
the hypothalamus senses and integrates signals of fuel abundance, such as circulating macronutrients (glucose and fatty acids) and nutrient-induced hormones (insulin and leptin). |
2019-11-20 |
2023-08-13 |
Not clear |
| M Seo, S A Islam, S-S Moo. Acute anti-obesity effects of intracerebroventricular 11β-HSD1 inhibitor administration in diet-induced obese mice. Journal of neuroendocrinology. vol 30. issue 3. 2019-10-16. PMID:29418022. |
in conclusion, acute 11β-hsd1 inhibition in the hypothalamus could reduce food intake by decreasing er stress and increasing insulin, leptin, and mammalian target of rapamycin complex 1 (mtorc1) signalling. |
2019-10-16 |
2023-08-13 |
mouse |
| Warren T Yacawych, Alexandra L Palmer, Megan A Docz. Insulin receptor localization in the embryonic avian hypothalamus. Neuroscience letters. vol 698. 2019-10-07. PMID:30615976. |
while insulin signaling in the post-hatch chicken has been shown to mirror that of mammals, the developmental role of insulin in the avian embryonic hypothalamus remains largely unexplored. |
2019-10-07 |
2023-08-13 |
chicken |
| Warren T Yacawych, Alexandra L Palmer, Megan A Docz. Insulin receptor localization in the embryonic avian hypothalamus. Neuroscience letters. vol 698. 2019-10-07. PMID:30615976. |
our research provides evidence for the earliest known embryonic expression of insr protein in the avian hypothalamus and may suggest a developmental role for insulin signaling in the early patterning of metabolic pathways in the central nervous system. |
2019-10-07 |
2023-08-13 |
chicken |
| Chun-Ling Dai, Jin-Hua Gu, Fei Liu, Khalid Iqbal, Cheng-Xin Gon. Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance. Neurobiology of aging. vol 70. 2019-09-27. PMID:29944994. |
these phenotype changes were accompanied by marked elevation of serum insulin and leptin levels and neuronal cell death, including the loss of leptin receptor-expressing neurons, in the hypothalamus. |
2019-09-27 |
2023-08-13 |
mouse |
| Zeynep Oşar Siva, Derya Uluduz, Fatma Ela Keskin, Feyza Erenler, Huriye Balcı, Uğur Uygunoğlu, Sabahattin Saip, Baki Göksan, Aksel Siv. Determinants of glucose metabolism and the role of NPY in the progression of insulin resistance in chronic migraine. Cephalalgia : an international journal of headache. vol 38. issue 11. 2019-09-23. PMID:29260593. |
the hypothalamus may play a role in the progression of insulin resistance in chronic migraine through the regulation of orexigenic peptides such as neuropeptide y. insulin resistance may lead to increased risk of future type 2 diabetes mellitus in patients with chronic migraine, which is more likely to occur if other pathogenetic defects of type 2 diabetes mellitus, such as impaired pancreatic β-cell functions and defects in intestinal glucagon-like peptide-1 secretion after meals. |
2019-09-23 |
2023-08-13 |
Not clear |
| Cristina Contreras, Marcos F Fondevila, Miguel Lópe. Hypothalamic GRP78, a new target against obesity? Adipocyte. vol 7. issue 1. 2019-09-09. PMID:29261404. |
we recently described that over-expression of grp78 specifically in the ventromedial nucleus of the hypothalamus (vmh) releases hypothalamic er stress in rodent obese models leading to weight loss, reduced hepatic steatosis and improved insulin and leptin sensitivity. |
2019-09-09 |
2023-08-13 |
Not clear |