| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun Austin Changou, Reni Ajoy, Szu-Yi Cho. Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy. Journal of visualized experiments : JoVE. issue 130. 2018-06-19. PMID:29286405. |
the hypothalamus in the central nervous system (cns) is the control center for energy and insulin signal response regulation. |
2018-06-19 |
2023-08-13 |
mouse |
| Bárbara de Almeida Rodrigues, Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Mariana Rosolen Tavares, José Diego Botezelli, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Fernando Moreira Simabuco, Eduardo Rochete Ropelle, José Rodrigo Paul. Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus. Neuroscience letters. vol 659. 2018-05-24. PMID:28866049. |
when dephosphorylated and translocated to the nuclei, foxo1 can promote the transcription of orexigenic neuropeptides (npy/agrp) in the hypothalamus, whereas insulin signaling is responsible for the disruption of this process. |
2018-05-24 |
2023-08-13 |
mouse |
| Szu-Yi Chou, Reni Ajoy, Chun Austin Changou, Ya-Ting Hsieh, Yang-Kao Wang, Barry Hoffe. CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5. Scientific reports. vol 6. 2018-05-18. PMID:27898058. |
both ex vivo stimulation and in vitro tissue culture studies demonstrated that the activation of insulin, and pi3k-akt pathways were impaired in ccr5 and ccl5 deficient hypothalamus. |
2018-05-18 |
2023-08-13 |
mouse |
| Eiko Iwakoshi-Ukena, Kenshiro Shikano, Kunihiro Kondo, Shusuke Taniuchi, Megumi Furumitsu, Yuta Ochi, Tsutomu Sasaki, Shiki Okamoto, George E Bentley, Lance J Kriegsfeld, Yasuhiko Minokoshi, Kazuyoshi Uken. Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity. eLife. vol 6. 2018-04-30. PMID:28799896. |
npgl-precursor gene overexpression in the hypothalamus caused increases in food intake, wat, body mass, and circulating insulin when fed a high calorie diet. |
2018-04-30 |
2023-08-13 |
rat |
| Tamara B Dakic, Tanja V Jevdjovic, Mina I Peric, Ivana M Bjelobaba, Milica B Markelic, Bojana S Milutinovic, Iva V Lakic, Nebojsa I Jasnic, Jelena D Djordjevic, Predrag Z Vujovi. Short-term fasting promotes insulin expression in rat hypothalamus. The European journal of neuroscience. vol 46. issue 1. 2018-03-26. PMID:28544147. |
short-term fasting promotes insulin expression in rat hypothalamus. |
2018-03-26 |
2023-08-13 |
rat |
| Tamara B Dakic, Tanja V Jevdjovic, Mina I Peric, Ivana M Bjelobaba, Milica B Markelic, Bojana S Milutinovic, Iva V Lakic, Nebojsa I Jasnic, Jelena D Djordjevic, Predrag Z Vujovi. Short-term fasting promotes insulin expression in rat hypothalamus. The European journal of neuroscience. vol 46. issue 1. 2018-03-26. PMID:28544147. |
in the hypothalamus, insulin takes on many roles involved in energy homoeostasis. |
2018-03-26 |
2023-08-13 |
rat |
| Tamara B Dakic, Tanja V Jevdjovic, Mina I Peric, Ivana M Bjelobaba, Milica B Markelic, Bojana S Milutinovic, Iva V Lakic, Nebojsa I Jasnic, Jelena D Djordjevic, Predrag Z Vujovi. Short-term fasting promotes insulin expression in rat hypothalamus. The European journal of neuroscience. vol 46. issue 1. 2018-03-26. PMID:28544147. |
immunofluorescence and immunohistochemistry were used to determine the distribution of insulin immunopositivity in the hypothalamus. |
2018-03-26 |
2023-08-13 |
rat |
| Tamara B Dakic, Tanja V Jevdjovic, Mina I Peric, Ivana M Bjelobaba, Milica B Markelic, Bojana S Milutinovic, Iva V Lakic, Nebojsa I Jasnic, Jelena D Djordjevic, Predrag Z Vujovi. Short-term fasting promotes insulin expression in rat hypothalamus. The European journal of neuroscience. vol 46. issue 1. 2018-03-26. PMID:28544147. |
these novel findings point to the complexity of mechanisms regulating insulin expression in the cns in general and in the hypothalamus in particular. |
2018-03-26 |
2023-08-13 |
rat |
| Rodrigo Rorato, Beatriz de Carvalho Borges, Ernane Torres Uchoa, José Antunes-Rodrigues, Carol Fuzeti Elias, Lucila Leico Kagohara Elia. LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes. International journal of molecular sciences. vol 18. issue 7. 2018-03-26. PMID:28677618. |
metabolic endotoxemia contributes to low-grade inflammation in obesity, which causes insulin resistance due to the activation of intracellular proinflammatory pathways, such as the c-jun n-terminal kinase (jnk) cascade in the hypothalamus and other tissues. |
2018-03-26 |
2023-08-13 |
rat |
| Rodrigo Rorato, Beatriz de Carvalho Borges, Ernane Torres Uchoa, José Antunes-Rodrigues, Carol Fuzeti Elias, Lucila Leico Kagohara Elia. LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes. International journal of molecular sciences. vol 18. issue 7. 2018-03-26. PMID:28677618. |
the present data suggest that an increased jnk activity in the hypothalamus underlies the development of insulin resistance during prolonged exposure to endotoxins. |
2018-03-26 |
2023-08-13 |
rat |
| Katharina Timper, Jens C Brünin. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Disease models & mechanisms. vol 10. issue 6. 2018-03-23. PMID:28592656. |
distinct neuronal cell populations, particularly within the arcuate nucleus of the hypothalamus, sense the nutrient status of the organism and integrate signals from peripheral hormones including pancreas-derived insulin and adipocyte-derived leptin to regulate calorie intake, glucose metabolism and energy expenditure. |
2018-03-23 |
2023-08-13 |
human |
| Stephanie Kullmann, Andreas Fritsche, Robert Wagner, Sophia Schwab, Hans-Ulrich Häring, Hubert Preissl, Martin Hen. Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans. Physiology & behavior. vol 176. 2018-03-08. PMID:28347723. |
activity of the hypothalamus - the major brain area controlling peripheral metabolism - is specifically modulated by insulin. |
2018-03-08 |
2023-08-13 |
Not clear |
| Maria Cernea, Rebecca Phillips, Vasantha Padmanabhan, Lique M Coolen, Michael N Lehma. Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti-related peptide neurons of the adult ewe. The European journal of neuroscience. vol 44. issue 8. 2018-02-01. PMID:27543746. |
insulin serves as a link between the metabolic and reproductive systems, communicating energy availability to the hypothalamus and enabling reproductive mechanisms. |
2018-02-01 |
2023-08-13 |
Not clear |
| Min-Xuan Xu, Yan-Fang Zhu, Hsiao-Feng Chang, Ying Lian. Nanoceria restrains PM2.5-induced metabolic disorder and hypothalamus inflammation by inhibition of astrocytes activation related NF-κB pathway in Nrf2 deficient mice. Free radical biology & medicine. vol 99. 2018-01-02. PMID:27554971. |
present results found that, indeed, pm2.5 challenges results in glucose tolerance, insulin resistance, dysarteriotony, peripheral inflammation, nerve injury and hypothalamus oxidative stress through astrocytes activation related nf-κb pathway in nrf2 deficient mice. |
2018-01-02 |
2023-08-13 |
mouse |
| María Sol Kruse, Lucas Gabriel Suarez, Héctor Coirin. Regulation of the expression of LXR in rat hypothalamic and hippocampal explants. Neuroscience letters. vol 639. 2017-12-19. PMID:28038938. |
here, we further characterized the effects of glucose, insulin, cholesterol and cholic acid on the expression of lxrα and lxrβ in hypothalamus and hippocampus explants as in vitro models. |
2017-12-19 |
2023-08-13 |
rat |
| María Sol Kruse, Lucas Gabriel Suarez, Héctor Coirin. Regulation of the expression of LXR in rat hypothalamic and hippocampal explants. Neuroscience letters. vol 639. 2017-12-19. PMID:28038938. |
in contrast, insulin treatment decreased lxrβ in the hypothalamus while having no effects on the hippocampus. |
2017-12-19 |
2023-08-13 |
rat |
| Sharon R Ladyman, David R Gratta. Region-Specific Suppression of Hypothalamic Responses to Insulin To Adapt to Elevated Maternal Insulin Secretion During Pregnancy. Endocrinology. vol 158. issue 12. 2017-12-18. PMID:29029017. |
in conclusion, these results demonstrate region-specific changes in responsiveness to insulin in the hypothalamus during pregnancy that may represent an adaptive response to minimize the impact of elevated circulating insulin on the maternal brain. |
2017-12-18 |
2023-08-13 |
rat |
| E P S Conceição, A R Kaezer, N Peixoto-Silva, I Felzenszwalb, E de Oliveira, E G Moura, P C Lisbo. Effects of Ilex paraguariensis (yerba mate) on the hypothalamic signalling of insulin and leptin and liver dysfunction in adult rats overfed during lactation. Journal of developmental origins of health and disease. vol 8. issue 1. 2017-11-21. PMID:27609670. |
leptin and insulin signalling in the hypothalamus measured by western blotting was reduced only in the eo group. |
2017-11-21 |
2023-08-13 |
rat |
| Kentaro Kaneko, Pingwen Xu, Elizabeth L Cordonier, Siyu S Chen, Amy Ng, Yong Xu, Alexei Morozov, Makoto Fukud. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions. Cell reports. vol 16. issue 11. 2017-11-13. PMID:27626668. |
genetic ablation of cns rap1 protects mice from dietary obesity, glucose imbalance, and insulin resistance in the periphery and from hfd-induced neuropathological changes in the hypothalamus, including diminished cellular leptin sensitivity and increased endoplasmic reticulum (er) stress and inflammation. |
2017-11-13 |
2023-08-13 |
mouse |
| Nathan L Price, Carlos Fernández-Hernand. miRNA regulation of white and brown adipose tissue differentiation and function. Biochimica et biophysica acta. vol 1861. issue 12 Pt B. 2017-10-19. PMID:26898181. |
mirnas have been shown to be dysregulated in a number of different tissues under conditions of obesity and insulin resistance, and have been demonstrated to be important regulators of a number of critical metabolic functions, including insulin secretion in the pancreas, lipid and glucose metabolism in the liver, and nutrient signaling in the hypothalamus. |
2017-10-19 |
2023-08-13 |
Not clear |