| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandros Tsompanidis, Elizabeth Vafiadaki, Susann Blüher, Georgia Kalozoumi, Despina Sanoudou, Christos S Mantzoro. Ciliary neurotrophic factor upregulates follistatin and Pak1, causes overexpression of muscle differentiation related genes and downregulation of established atrophy mediators in skeletal muscle. Metabolism: clinical and experimental. vol 65. issue 6. 2017-05-26. PMID:27173470. |
the ciliary neurotrophic factor (cntf) is a pluripotent cytokine with anorexigenic actions in the hypothalamus that improves insulin sensitivity, increases energy expenditure and induces weight loss. |
2017-05-26 |
2023-08-13 |
Not clear |
| Maitrayee Sahu, Prashanth Anamthathmakula, Abhiram Sah. Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice. Neuroendocrinology. vol 104. issue 2. 2017-05-09. PMID:27002827. |
insulin action in the hypothalamus plays a critical role in the regulation of energy homeostasis, yet the intracellular signaling mechanisms mediating insulin action are incompletely understood. |
2017-05-09 |
2023-08-13 |
mouse |
| Maitrayee Sahu, Prashanth Anamthathmakula, Abhiram Sah. Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice. Neuroendocrinology. vol 104. issue 2. 2017-05-09. PMID:27002827. |
although phosphodiesterase 3b (pde3b) mediates insulin action in the adipose tissue and it is highly expressed in the hypothalamic areas implicated in energy homeostasis, its role, if any, in mediating insulin action in the hypothalamus is unknown. |
2017-05-09 |
2023-08-13 |
mouse |
| Maitrayee Sahu, Prashanth Anamthathmakula, Abhiram Sah. Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice. Neuroendocrinology. vol 104. issue 2. 2017-05-09. PMID:27002827. |
we tested the hypothesis that insulin action in the hypothalamus is mediated by pde3b. |
2017-05-09 |
2023-08-13 |
mouse |
| Weiyi Chen, Eglantine Balland, Michael A Cowle. Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis. Neuroendocrinology. vol 104. issue 4. 2017-05-01. PMID:28122381. |
in recent years, accumulating evidence has demonstrated the existence of insulin resistance within the hypothalamus. |
2017-05-01 |
2023-08-13 |
Not clear |
| Masahiro Ohsawa, Tomoyasu Murakami, Kazuhiko Kum. Possible Involvement of Insulin Resistance in the Progression of Cancer Cachexia in Mice. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 136. issue 5. 2017-04-06. PMID:27150920. |
the signaling protein in the insulin cascade was attenuated in the skeletal muscle and hypothalamus from tumor-bearing mice. |
2017-04-06 |
2023-08-13 |
mouse |
| Isabel Arrieta-Cruz, Roger Gutiérrez-Juáre. The Role of Insulin Resistance and Glucose Metabolism Dysregulation in the Development of Alzheimer´s Disease. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. vol 68. issue 2. 2017-02-10. PMID:27103040. |
in this article, we review the potential toxic effects of β-amyloid in the hypothalamus, a brain center involved in the control of insulin action and glucose metabolism. |
2017-02-10 |
2023-08-13 |
Not clear |
| C A Woods, Z R Guttman, D Huang, R A Kolaric, A I Rabinowitsch, K T Jones, S Cabeza de Vaca, A Sclafani, K D Car. Insulin receptor activation in the nucleus accumbens reflects nutritive value of a recently ingested meal. Physiology & behavior. vol 159. 2016-12-27. PMID:26988281. |
with respect to feeding, insulin is typically thought of as a satiety hormone, acting in the hypothalamus to limit ingestive behavior. |
2016-12-27 |
2023-08-13 |
rat |
| Christophe Magnan, Serge Luque. [Role of fatty acids in the nervous control of energy balance]. Biologie aujourd'hui. vol 209. issue 4. 2016-12-13. PMID:27021049. |
fatty acid (fa)-sensitive neurons are present in the brain, especially the hypothalamus, and play a key role in the neural control of energy and glucose homeostasis including feeding behavior, insulin secretion and action. |
2016-12-13 |
2023-08-13 |
human |
| Hiroshi Inou. Central insulin-mediated regulation of hepatic glucose production [Review]. Endocrine journal. vol 63. issue 1. 2016-11-11. PMID:26447084. |
it has become evident that nutrients such as glucose, fatty acids, and amino acids act upon the hypothalamus together with insulin, affecting hgp. |
2016-11-11 |
2023-08-13 |
human |
| Hiroshi Inou. Central insulin-mediated regulation of hepatic glucose production [Review]. Endocrine journal. vol 63. issue 1. 2016-11-11. PMID:26447084. |
on the other hand, hgp control by central insulin action is impeded in obesity and impeded by insulin resistance due to disturbance of pi3k signaling and inflammation in the hypothalamus or inhibition of stat3 signaling in the liver. |
2016-11-11 |
2023-08-13 |
human |
| Jaemeun Lee, Kyungchan Kim, Seong-Woon Yu, Eun-Kyoung Ki. Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus. Molecular brain. vol 9. 2016-10-14. PMID:26956881. |
wnt3a upregulates brain-derived insulin by increasing neurod1 via wnt/β-catenin signaling in the hypothalamus. |
2016-10-14 |
2023-08-13 |
Not clear |
| Patricia Seoane-Collazo, Johan Fernø, Francisco Gonzalez, Carlos Diéguez, Rosaura Leis, Rubén Nogueiras, Miguel Lópe. Hypothalamic-autonomic control of energy homeostasis. Endocrine. vol 50. issue 2. 2016-09-16. PMID:26089260. |
several key areas such as the hypothalamus and brainstem receive and integrate signals conveying energy status from the periphery, such as leptin, thyroid hormones, and insulin, ultimately leading to modulation of food intake, energy expenditure (ee), and peripheral metabolism. |
2016-09-16 |
2023-08-13 |
Not clear |
| Kazuhisa Honda, Takaoki Saneyasu, Koji Aoki, Tomohiko Shimatani, Takuya Yamaguchi, Hiroshi Kamisoyam. Correlation analysis of hypothalamic mRNA levels of appetite regulatory neuropeptides and several metabolic parameters in 28-day-old layer chickens. Animal science journal = Nihon chikusan Gakkaiho. vol 86. issue 5. 2016-09-12. PMID:25441031. |
various lines of evidence suggest that appetite-related neuropeptides in the hypothalamus are regulated by adiposity signals such as leptin and insulin in mammals. |
2016-09-12 |
2023-08-13 |
Not clear |
| Christophe Magnan, Barry E Levin, Serge Luque. Brain lipid sensing and the neural control of energy balance. Molecular and cellular endocrinology. vol 418 Pt 1. 2016-09-09. PMID:26415589. |
fatty acid (fa) -sensitive neurons are present in the brain, especially the hypothalamus, and play a key role in the neural control of energy and glucose homeostasis including feeding behavior, secretion insulin and action. |
2016-09-09 |
2023-08-13 |
Not clear |
| Sander Kooijman, José K van den Heuvel, Patrick C N Rense. Neuronal Control of Brown Fat Activity. Trends in endocrinology and metabolism: TEM. vol 26. issue 11. 2016-09-06. PMID:26482876. |
given that activated bat has a high capacity to take up and burn fatty acids (fas) and glucose, pharmacological stimulation of brown fat in humans by either targeting the hypothalamus or mimicking outflow of the sympathetic nervous system might help improve glucose metabolism and insulin sensitivity, and also lower body fat. |
2016-09-06 |
2023-08-13 |
Not clear |
| Takeshi Onoue, Motomitsu Goto, Takashi Tominaga, Mariko Sugiyama, Taku Tsunekawa, Daisuke Hagiwara, Ryoichi Banno, Hidetaka Suga, Yoshihisa Sugimura, Hiroshi Arim. Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. Neuroscience letters. vol 619. 2016-08-24. PMID:26968348. |
reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. |
2016-08-24 |
2023-08-13 |
mouse |
| Takeshi Onoue, Motomitsu Goto, Takashi Tominaga, Mariko Sugiyama, Taku Tsunekawa, Daisuke Hagiwara, Ryoichi Banno, Hidetaka Suga, Yoshihisa Sugimura, Hiroshi Arim. Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. Neuroscience letters. vol 619. 2016-08-24. PMID:26968348. |
in the hypothalamus, several reports have implied that ros mediate physiological effects of insulin. |
2016-08-24 |
2023-08-13 |
mouse |
| Onder Celik, Suleyman Aydin, Nilufer Celik, Musa Yilma. Peptides: Basic determinants of reproductive functions. Peptides. vol 72. 2016-08-22. PMID:26074346. |
changes in energy stores produce fluctuations in leptin, insulin, ghrelin and glucose signals that feedback mainly to the hypothalamus to regulate metabolism and fertility. |
2016-08-22 |
2023-08-13 |
Not clear |
| Brenda Diaz, Lizeth Fuentes-Mera, Armando Tovar, Teresa Montiel, Lourdes Massieu, Herminia Guadalupe Martínez-Rodríguez, Alberto Camach. Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells. Brain research. vol 1627. 2016-08-17. PMID:26410780. |
here we determine whether lipotoxic insult induced by saturated lipids decreases mtf2 expression leading to er stress response in hypothalamus and its effects on insulin sensitivity using in vitro and in vivo models. |
2016-08-17 |
2023-08-13 |
mouse |