| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sevki Cetinkalp, Ilgin Y Simsir, Sibel Erte. Insulin resistance in brain and possible therapeutic approaches. Current vascular pharmacology. vol 12. issue 4. 2015-02-20. PMID:23627981. |
excessive caloric intake and high-fat diets initiate insulin and leptin resistance by inducing mitochondrial dysfunction and endoplasmic reticulum stress in the hypothalamus. |
2015-02-20 |
2023-08-12 |
Not clear |
| Joanna H Sliwowska, Chrysanthi Fergani, Monika Gawałek, Bogda Skowronska, Piotr Fichna, Michael N Lehma. Insulin: its role in the central control of reproduction. Physiology & behavior. vol 133. 2015-02-19. PMID:24874777. |
we also review the role that insulin plays in prenatal programming of adult reproduction, and consider specific candidate neurons in the adult hypothalamus by which insulin may act to regulate reproductive function. |
2015-02-19 |
2023-08-13 |
human |
| Martin Heni, Robert Wagner, Stephanie Kullmann, Ralf Veit, Haliza Mat Husin, Katarzyna Linder, Charlotte Benkendorff, Andreas Peter, Norbert Stefan, Hans-Ulrich Häring, Hubert Preissl, Andreas Fritsch. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes. vol 63. issue 12. 2015-01-16. PMID:25028522. |
central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. |
2015-01-16 |
2023-08-13 |
human |
| Lin Zhao, Ku-Peng Jia, Lu Wang, Mei-Ni Chen, Ya-Ping Wang, Yan-Ling Yan. [Expression of orexin-A in insulin induced acute hypoglycemia in rat hypothalamus]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 30. issue 3. 2015-01-15. PMID:25244783. |
[expression of orexin-a in insulin induced acute hypoglycemia in rat hypothalamus]. |
2015-01-15 |
2023-08-13 |
rat |
| Melissa L Borg, Moyra Lemus, Alex Reichenbach, Ahrathy Selathurai, Brian J Oldfield, Zane B Andrews, Matthew J Wat. Hypothalamic neurogenesis is not required for the improved insulin sensitivity following exercise training. Diabetes. vol 63. issue 11. 2014-12-30. PMID:24898143. |
these data suggest that regular exercise training induces significant non-neuronal cell proliferation in the hypothalamus of obese mice, but this proliferation is not required for enhanced insulin action. |
2014-12-30 |
2023-08-13 |
mouse |
| Jung D Kim, Stephanie Leyva, Sabrina Dian. Hormonal regulation of the hypothalamic melanocortin system. Frontiers in physiology. vol 5. 2014-12-24. PMID:25538630. |
within the cns, the hypothalamus is a critical center for monitoring, processing and responding to peripheral signals, including hormones such as ghrelin, leptin, and insulin. |
2014-12-24 |
2023-08-13 |
Not clear |
| Laís Weissmann, Paula G F Quaresma, Andressa C Santos, Alexandre H B de Matos, Vínicius D'Ávila Bittencourt Pascoal, Tamires M Zanotto, Gisele Castro, Dioze Guadagnini, Joelcimar Martins da Silva, Licio A Velloso, Jackson C Bittencourt, Iscia Lopes-Cendes, Mario J A Saad, Patricia O Prad. IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. Diabetes. vol 63. issue 10. 2014-11-18. PMID:24812431. |
ikkε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. |
2014-11-18 |
2023-08-13 |
mouse |
| Laís Weissmann, Paula G F Quaresma, Andressa C Santos, Alexandre H B de Matos, Vínicius D'Ávila Bittencourt Pascoal, Tamires M Zanotto, Gisele Castro, Dioze Guadagnini, Joelcimar Martins da Silva, Licio A Velloso, Jackson C Bittencourt, Iscia Lopes-Cendes, Mario J A Saad, Patricia O Prad. IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. Diabetes. vol 63. issue 10. 2014-11-18. PMID:24812431. |
we demonstrate that ikkε is expressed in neurons and is upregulated in the hypothalamus of obese mice, contributing to insulin and leptin resistance. |
2014-11-18 |
2023-08-13 |
mouse |
| Laís Weissmann, Paula G F Quaresma, Andressa C Santos, Alexandre H B de Matos, Vínicius D'Ávila Bittencourt Pascoal, Tamires M Zanotto, Gisele Castro, Dioze Guadagnini, Joelcimar Martins da Silva, Licio A Velloso, Jackson C Bittencourt, Iscia Lopes-Cendes, Mario J A Saad, Patricia O Prad. IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. Diabetes. vol 63. issue 10. 2014-11-18. PMID:24812431. |
inhibition of ikkε activity, but not tbk1, reduced irs-1(ser307) phosphorylation and insulin and leptin resistance by an improvement of the ir/irs-1/akt and jak2/stat3 pathways in the hypothalamus. |
2014-11-18 |
2023-08-13 |
mouse |
| Laís Weissmann, Paula G F Quaresma, Andressa C Santos, Alexandre H B de Matos, Vínicius D'Ávila Bittencourt Pascoal, Tamires M Zanotto, Gisele Castro, Dioze Guadagnini, Joelcimar Martins da Silva, Licio A Velloso, Jackson C Bittencourt, Iscia Lopes-Cendes, Mario J A Saad, Patricia O Prad. IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. Diabetes. vol 63. issue 10. 2014-11-18. PMID:24812431. |
increased insulin and leptin action/signaling in the hypothalamus may contribute to a decrease in adiposity and hypophagia and an enhancement of energy expenditure accompanied by lower npy and increased pomc mrna levels. |
2014-11-18 |
2023-08-13 |
mouse |
| Delphine Crépin, Yacir Benomar, Laure Riffault, Hamza Amine, Arieh Gertler, Mohammed Taoui. The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment. Molecular and cellular endocrinology. vol 384. issue 1-2. 2014-10-27. PMID:24394757. |
the over-expression of mir-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment. |
2014-10-27 |
2023-08-12 |
mouse |
| Chawnshang Chang, Shuyuan Yeh, Soo Ok Lee, Ta-Min Chan. Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells. Nuclear receptor signaling. vol 11. 2014-10-06. PMID:24653668. |
in metabolism, the ars in brain, particularly in the hypothalamus, and the liver appear to participate in regulation of insulin sensitivity and glucose homeostasis. |
2014-10-06 |
2023-08-12 |
mouse |
| Janine J Geerling, Mariëtte R Boon, Sander Kooijman, Edwin T Parlevliet, Louis M Havekes, Johannes A Romijn, Illiana M Meurs, Patrick C N Rense. Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies. Journal of lipid research. vol 55. issue 2. 2014-09-28. PMID:24285857. |
various neuronal populations, such as neuropeptide y (npy)-expressing neurons and melanocortin-expressing neurons, as well as peripherally produced hormones (i.e., glp-1, leptin, and insulin), modulate sympathetic outflow from the hypothalamus toward target organs and thereby influence peripheral tg metabolism. |
2014-09-28 |
2023-08-12 |
Not clear |
| Nihar R Pandey, Xun Zhou, Tariq Zaman, Shelly A Cruz, Zhaohong Qin, Michael Lu, Kianoosh Keyhanian, Jean Michel Brunel, Alexandre F R Stewart, Hsiao-Huei Che. LMO4 is required to maintain hypothalamic insulin signaling. Biochemical and biophysical research communications. vol 450. issue 1. 2014-09-21. PMID:24937445. |
insulin action at the hypothalamus controls glucose homeostasis by suppressing hepatic glucose production and promoting glucose uptake by muscle. |
2014-09-21 |
2023-08-13 |
mouse |
| Nihar R Pandey, Xun Zhou, Tariq Zaman, Shelly A Cruz, Zhaohong Qin, Michael Lu, Kianoosh Keyhanian, Jean Michel Brunel, Alexandre F R Stewart, Hsiao-Huei Che. LMO4 is required to maintain hypothalamic insulin signaling. Biochemical and biophysical research communications. vol 450. issue 1. 2014-09-21. PMID:24937445. |
here, we determined how loss of lmo4 in the hypothalamus would affect central insulin signaling and glucose homeostasis. |
2014-09-21 |
2023-08-13 |
mouse |
| Nihar R Pandey, Xun Zhou, Tariq Zaman, Shelly A Cruz, Zhaohong Qin, Michael Lu, Kianoosh Keyhanian, Jean Michel Brunel, Alexandre F R Stewart, Hsiao-Huei Che. LMO4 is required to maintain hypothalamic insulin signaling. Biochemical and biophysical research communications. vol 450. issue 1. 2014-09-21. PMID:24937445. |
in transgenic mice that have lmo4 in ablated in glutamatergic neurons, we found that insulin signaling is impaired in the hypothalamus as well as in peripheral tissues (liver and skeletal muscle). |
2014-09-21 |
2023-08-13 |
mouse |
| Nihar R Pandey, Xun Zhou, Tariq Zaman, Shelly A Cruz, Zhaohong Qin, Michael Lu, Kianoosh Keyhanian, Jean Michel Brunel, Alexandre F R Stewart, Hsiao-Huei Che. LMO4 is required to maintain hypothalamic insulin signaling. Biochemical and biophysical research communications. vol 450. issue 1. 2014-09-21. PMID:24937445. |
importantly, we found that administration of a selective ptp1b inhibitor trodusquemine to the hypothalamus restored central insulin signaling and improved the response of peripheral tissues to insulin in these lmo4-deficient mice. |
2014-09-21 |
2023-08-13 |
mouse |
| Takashi Sumita, Hiraku Ono, Tokuko Suzuki, Gota Sakai, Kouichi Inukai, Hideki Katagiri, Tomoichiro Asano, Shigehiro Katayama, Takuya Awat. Mediobasal hypothalamic PTEN modulates hepatic insulin resistance independently of food intake in rats. American journal of physiology. Endocrinology and metabolism. vol 307. issue 1. 2014-08-27. PMID:24824654. |
insulin acts in the mediobasal hypothalamus (mbh) to not only suppress food intake and weight gain but also improve glucose metabolism via pi 3-kinase activation. |
2014-08-27 |
2023-08-13 |
rat |
| Katrina Weston-Green, Xu-Feng Huang, Chao Den. Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor. CNS drugs. vol 27. issue 12. 2014-08-26. PMID:24114586. |
olanzapine alters m3r density in discrete nuclei of the hypothalamus and caudal brainstem, regions that regulate glucose homeostasis and insulin secretion through vagal innervation of the pancreas. |
2014-08-26 |
2023-08-12 |
mouse |
| Doan V Khanh, Yun-Hee Choi, Sang Hyun Moh, Ann W Kinyua, Ki Woo Ki. Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system. Frontiers in psychology. vol 5. 2014-08-22. PMID:25147530. |
in addition to the crucial effects on the hypothalamus, emerging evidence suggests that the leptin and insulin signaling can act on other brain regions to mediate the reward value of nutrients. |
2014-08-22 |
2023-08-13 |
Not clear |