| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gisele Castro, Maria Fernanda C Areias, Lais Weissmann, Paula G F Quaresma, Carlos K Katashima, Mario J A Saad, Patricia O Prad. Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats. FEBS open bio. vol 3. 2013-11-19. PMID:24251109. |
insulin acts in the hypothalamus, decreasing food intake (fi) by the ir/pi3k/akt pathway. |
2013-11-19 |
2023-08-12 |
rat |
| J Benzler, G K Ganjam, K Legler, S Stöhr, M Krüger, J Steger, A Tup. Acute inhibition of central c-Jun N-terminal kinase restores hypothalamic insulin signalling and alleviates glucose intolerance in diabetic mice. Journal of neuroendocrinology. vol 25. issue 5. 2013-09-25. PMID:23301857. |
the hypothalamus has been identified as a main insulin target tissue for regulating normal body weight and glucose metabolism. |
2013-09-25 |
2023-08-12 |
mouse |
| Claudia Lindtner, Thomas Scherer, Elizabeth Zielinski, Nika Filatova, Martin Fasshauer, Nicholas K Tonks, Michelle Puchowicz, Christoph Buettne. Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Science translational medicine. vol 5. issue 170. 2013-09-25. PMID:23363978. |
rats that had consumed alcohol exhibited impaired hypothalamic insulin action, defined as the ability of insulin infused into the mediobasal hypothalamus to suppress hepatic glucose production and white adipose tissue lipolysis. |
2013-09-25 |
2023-08-12 |
human |
| Claudia Lindtner, Thomas Scherer, Elizabeth Zielinski, Nika Filatova, Martin Fasshauer, Nicholas K Tonks, Michelle Puchowicz, Christoph Buettne. Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Science translational medicine. vol 5. issue 170. 2013-09-25. PMID:23363978. |
insulin signaling in the hypothalamus, as assessed by insulin receptor and akt phosphorylation, decreased after binge drinking. |
2013-09-25 |
2023-08-12 |
human |
| Y Ichihara, T Wada, Y Soeda, Y Ishii, M Sasahara, H Tsuneki, T Sasaok. SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice. Journal of neuroendocrinology. vol 25. issue 4. 2013-09-16. PMID:23286299. |
sh2-containing inositol 5'-phosphatase 2 (ship2) is a lipid phosphatase that negatively regulates the metabolic signalling of insulin in peripheral tissues; however, the expression of ship2 in the hypothalamus and its functional roles are largely unknown. |
2013-09-16 |
2023-08-12 |
mouse |
| Y Ichihara, T Wada, Y Soeda, Y Ishii, M Sasahara, H Tsuneki, T Sasaok. SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice. Journal of neuroendocrinology. vol 25. issue 4. 2013-09-16. PMID:23286299. |
to clarify the significance of the increased expression of ship2 in the hypothalamus, we examined the central effects of insulin and leptin in transgenic mice overexpressing ship2 (ship2-tg). |
2013-09-16 |
2023-08-12 |
mouse |
| Y Ichihara, T Wada, Y Soeda, Y Ishii, M Sasahara, H Tsuneki, T Sasaok. SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice. Journal of neuroendocrinology. vol 25. issue 4. 2013-09-16. PMID:23286299. |
injection of insulin, were attenuated in ship2-tg compared to wild-type mice, whereas leptin-induced phosphorylation of signal transducer and activator of transcription 3 in the hypothalamus was comparable between them. |
2013-09-16 |
2023-08-12 |
mouse |
| Y Ichihara, T Wada, Y Soeda, Y Ishii, M Sasahara, H Tsuneki, T Sasaok. SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice. Journal of neuroendocrinology. vol 25. issue 4. 2013-09-16. PMID:23286299. |
these results suggest that ship2 contributes to the regulation of food intake mainly via the attenuation of insulin signalling in the hypothalamus of mice. |
2013-09-16 |
2023-08-12 |
mouse |
| Qian Zhang, Junjie Yu, Bin Liu, Ziquan Lv, Tingting Xia, Fei Xiao, Shanghai Chen, Feifan Gu. Central activating transcription factor 4 (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve. Diabetes. vol 62. issue 7. 2013-09-09. PMID:23454693. |
recent studies have revealed that the central nervous system, particularly the hypothalamus, is critical for regulating insulin sensitivity in peripheral tissues. |
2013-09-09 |
2023-08-12 |
mouse |
| Qian Zhang, Junjie Yu, Bin Liu, Ziquan Lv, Tingting Xia, Fei Xiao, Shanghai Chen, Feifan Gu. Central activating transcription factor 4 (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve. Diabetes. vol 62. issue 7. 2013-09-09. PMID:23454693. |
here, we show that overexpression of atf4 in the hypothalamus resulting from intracerebroventricular injection of adenovirus expressing atf4 induces hepatic insulin resistance in mice and that inhibition of hypothalamic atf4 by intracerebroventricular adenovirus expressing a dominant-negative atf4 variant has the opposite effect. |
2013-09-09 |
2023-08-12 |
mouse |
| Teresa C Delgad. Glutamate and GABA in Appetite Regulation. Frontiers in endocrinology. vol 4. 2013-08-22. PMID:23966982. |
within the hypothalamus, several peripheral signals have been shown to modulate the activity of these neurons, including the orexigenic peptide ghrelin and the anorexigenic hormones insulin and leptin. |
2013-08-22 |
2023-08-12 |
mouse |
| B Chai, J-Y Li, D Fritze, W Zhang, Z Xia, M W Mulhollan. A novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signalling. Journal of neuroendocrinology. vol 25. issue 3. 2013-08-12. PMID:22935015. |
a novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signalling. |
2013-08-12 |
2023-08-12 |
human |
| K Gotoh, T Masaki, S Chiba, H Ando, K Fujiwara, T Shimasaki, K Mitsutomi, I Katsuragi, T Kakuma, T Sakata, H Yoshimats. Hypothalamic brain-derived neurotrophic factor regulates glucagon secretion mediated by pancreatic efferent nerves. Journal of neuroendocrinology. vol 25. issue 3. 2013-08-12. PMID:23157205. |
we investigate whether: (i) the central infusion of bdnf stimulates glucagon and/or insulin secretion via the pancreatic efferent nerve from the hypothalamus; (ii) the intraportal infusion of glp-1 regulates glucose metabolism via the central and peripheral nervous system; and (iii) bdnf receptor and/or bdnf-positive fibres are localised near α cells of islets. |
2013-08-12 |
2023-08-12 |
human |
| Patricia I Mighiu, Jessica T Y Yue, Beatrice M Filippi, Mona A Abraham, Madhu Chari, Carol K L Lam, Clair S Yang, Nikita R Christian, Maureen J Charron, Tony K T La. Hypothalamic glucagon signaling inhibits hepatic glucose production. Nature medicine. vol 19. issue 6. 2013-08-05. PMID:23685839. |
continuous intravenous infusion of insulin, however, inhibits glucose production through its sustained actions in both the liver and the mediobasal hypothalamus (mbh). |
2013-08-05 |
2023-08-12 |
mouse |
| Brittany S Luckett, Jennifer L Frielle, Lawrence Wolfgang, Sean D Stocke. Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin. American journal of physiology. Heart and circulatory physiology. vol 304. issue 11. 2013-07-29. PMID:23542919. |
accumulating evidence suggests that insulin acts within the hypothalamus to alter sympathetic nerve activity (sna) and baroreflex function. |
2013-07-29 |
2023-08-12 |
rat |
| Brittany S Luckett, Jennifer L Frielle, Lawrence Wolfgang, Sean D Stocke. Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin. American journal of physiology. Heart and circulatory physiology. vol 304. issue 11. 2013-07-29. PMID:23542919. |
although insulin receptors are widely expressed across the hypothalamus, recent evidence suggests that neurons of the arcuate nucleus (arc) play an important role in the sympathoexcitatory response to insulin. |
2013-07-29 |
2023-08-12 |
rat |
| A Sahu, K Koshinaka, M Sah. Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967108. |
although, in the insulin signalling pathway, pi3k is known to be an upstream regulator of pde3b in non-neuronal tissues, it is still unknown whether this is also the case for leptin signalling in the hypothalamus. |
2013-07-12 |
2023-08-12 |
rat |
| A Sahu, K Koshinaka, M Sah. Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967108. |
leptin on p-akt levels in the hypothalamus and compared them with the known stimulatory effect of insulin on p-akt. |
2013-07-12 |
2023-08-12 |
rat |
| A Sahu, K Koshinaka, M Sah. Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967108. |
we observed that insulin increased p-akt levels but leptin failed to do so, although it increased p-stat3 levels, in the rat hypothalamus. |
2013-07-12 |
2023-08-12 |
rat |
| Mohammed Seed Ahmed, Abraham Kovoor, Sofia Nordman, Norhashimah Abu Seman, Tianwei Gu, Suad Efendic, Kerstin Brismar, Claes-Göran Östenson, Harvest F G. Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis. Islets. vol 4. issue 5. 2013-06-25. PMID:23018249. |
the present study thus provides the first evidence that ac3 is overexpressed in the regions of striatum and hypothalamus of brain, and similarly in pancreatic islets of gk rats suggesting that ac3 plays a role in regulation of glucose homeostasis via cns and insulin secretion. |
2013-06-25 |
2023-08-12 |
rat |