| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Su, Jing Wu, Weifang Liu, Chaojun Duan, Sai Zhang, Can'e Tang, Fanyan Lu. [Expression change of SH2B1, SOCS3, PTP1B and NPY in mice hypothalamus and its relation with obesity]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 39. issue 1. 2015-09-08. PMID:24473384. |
to investigate the expression pattern of adapter protein with a src-homology 2 domain (sh2b1), the suppressor of cytokine signaling-3 (socs3), protein-tyrosine phosphatase 1b (ptp1b) and neturopetide y (npy) in obese and normal mice hypothalamus and its relation with serum leptin and insulin levels. |
2015-09-08 |
2023-08-12 |
mouse |
| Karine Badonnel, Marie-Christine Lacroix, Didier Durieux, Régine Monnerie, Monique Caillol, Christine Bal. Rat strains with different metabolic statuses differ in food olfactory-driven behavior. Behavioural brain research. vol 270. 2015-08-14. PMID:24837744. |
these metabolic and behavioral changes were partly associated with variations in the transcription profiles of leptin, insulin and orexin and their receptors in the hypothalamus and olfactory system. |
2015-08-14 |
2023-08-13 |
rat |
| Sandeep Dhindsa, Gurkiran Dhindsa, Rama Chemitigant. Comment on Heni et al. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes 2014;63:4083-4088. Diabetes. vol 64. issue 6. 2015-07-21. PMID:25999544. |
central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. |
2015-07-21 |
2023-08-13 |
Not clear |
| Martin Heni, Robert Wagner, Stephanie Kullmann, Hubert Preissl, Andreas Fritsch. Response to Comment on Heni et al. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes 2014;63:4083-4088. Diabetes. vol 64. issue 6. 2015-07-21. PMID:25999545. |
central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. |
2015-07-21 |
2023-08-13 |
Not clear |
| MieJung Park-York, Stéphane Boghossian, Hyoungil Oh, David A Yor. PKCθ over expression in the central nucleus of the amygdala or hypothalamus has differential effects on energy balance and peripheral glucose homeostasis. Brain research. vol 1498. 2015-07-14. PMID:23295188. |
the data suggest that activation of pkcθ in the cea and hypothalamus have different effects on energy balance and peripheral metabolism and that insulin signaling in the amygdala regulates peripheral metabolism. |
2015-07-14 |
2023-08-12 |
rat |
| Sarah K Baisley, Brian A Bald. Amylin receptor signaling in the nucleus accumbens negatively modulates μ-opioid-driven feeding. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:24957819. |
amylin is a peptide co-secreted with insulin that penetrates into the brain, and produces satiation-like effects via actions in the brainstem, hypothalamus, and mesencephalon. |
2015-07-07 |
2023-08-13 |
rat |
| Fei Xiao, Tingting Xia, Ziquan Lv, Qian Zhang, Yuzhong Xiao, Junjie Yu, Hao Liu, Jiali Deng, Yajie Guo, Chunxia Wang, Kai Li, Bin Liu, Shanghai Chen, Feifan Gu. Central prolactin receptors (PRLRs) regulate hepatic insulin sensitivity in mice via signal transducer and activator of transcription 5 (STAT5) and the vagus nerve. Diabetologia. vol 57. issue 10. 2015-07-06. PMID:25064125. |
recent studies have revealed the crucial role of the central nervous system (cns), especially the hypothalamus, in the regulation of insulin sensitivity in peripheral tissues. |
2015-07-06 |
2023-08-13 |
mouse |
| Mona A Abraham, Beatrice M Filippi, Gil Myoung Kang, Min-Seon Kim, Tony K T La. Insulin action in the hypothalamus and dorsal vagal complex. Experimental physiology. vol 99. issue 9. 2015-07-02. PMID:24972836. |
insulin action in the hypothalamus and dorsal vagal complex. |
2015-07-02 |
2023-08-13 |
Not clear |
| Mona A Abraham, Beatrice M Filippi, Gil Myoung Kang, Min-Seon Kim, Tony K T La. Insulin action in the hypothalamus and dorsal vagal complex. Experimental physiology. vol 99. issue 9. 2015-07-02. PMID:24972836. |
in addition to the classical view that insulin resistance in the liver, muscle and fat disrupts glucose homeostasis, studies in the past decade have illustrated that insulin resistance in the hypothalamus dysregulates hepatic glucose production and food intake, leading to type 2 diabetes and obesity. |
2015-07-02 |
2023-08-13 |
Not clear |
| Mona A Abraham, Beatrice M Filippi, Gil Myoung Kang, Min-Seon Kim, Tony K T La. Insulin action in the hypothalamus and dorsal vagal complex. Experimental physiology. vol 99. issue 9. 2015-07-02. PMID:24972836. |
this invited review argues that in addition to the hypothalamus, insulin signalling in the dorsal vagal complex regulates hepatic glucose production and food intake. |
2015-07-02 |
2023-08-13 |
Not clear |
| Mona A Abraham, Beatrice M Filippi, Gil Myoung Kang, Min-Seon Kim, Tony K T La. Insulin action in the hypothalamus and dorsal vagal complex. Experimental physiology. vol 99. issue 9. 2015-07-02. PMID:24972836. |
a thorough understanding of the physiological and pathophysiological mechanisms of insulin action in the hypothalamus and dorsal vagal complex is necessary in order to identify therapeutic targets for obesity and type 2 diabetes. |
2015-07-02 |
2023-08-13 |
Not clear |
| Hellen Barbosa Farias Silva, Ana Paula Carli de Almeida, Katarine Barbosa Cardoso, Letícia Martins Ignacio-Souza, Silvia Regina de Lima Reis, Marise Auxiliadora de Barros Reis, Márcia Queiroz Latorraca, Marciane Milanski, Vanessa Cristina Arante. Nutritional recovery promotes hypothalamic inflammation in rats during adulthood. Mediators of inflammation. vol 2014. 2015-06-24. PMID:25258479. |
we evaluated whether protein restriction in fetal life alters food intake and glucose homeostasis in adulthood by interfering with insulin signal transduction through proinflammatory mechanisms in the hypothalamus and peripheral tissues. |
2015-06-24 |
2023-08-13 |
rat |
| Andrew Wolfe, Sara Divall, Sheng W. The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1). Frontiers in neuroendocrinology. vol 35. issue 4. 2015-06-16. PMID:24929098. |
the role that insulin and igf-1 play in controlling the hypothalamus and pituitary and their role in regulating puberty and nutritional control of reproduction has been studied extensively. |
2015-06-16 |
2023-08-13 |
human |
| Kenjiro Muta, Donald A Morgan, Kamal Rahmoun. The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice. Endocrinology. vol 156. issue 4. 2015-06-11. PMID:25574706. |
insulin action in the brain particularly the hypothalamus is critically involved in the regulation of several physiological processes, including energy homeostasis and sympathetic nerve activity, but the underlying mechanisms are poorly understood. |
2015-06-11 |
2023-08-13 |
mouse |
| Kenjiro Muta, Donald A Morgan, Kamal Rahmoun. The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice. Endocrinology. vol 156. issue 4. 2015-06-11. PMID:25574706. |
these results demonstrate the importance of mtorc1 pathway in the hypothalamus in mediating the action of insulin to regulate energy homeostasis and sympathetic nerve traffic. |
2015-06-11 |
2023-08-13 |
mouse |
| Qing-Yu Zhang, Ying Pan, Rong Wang, Lin-Lin Kang, Qiao-Chu Xue, Xiao-Ning Wang, Ling-Dong Kon. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. The Journal of nutritional biochemistry. vol 25. issue 4. 2015-05-12. PMID:24491314. |
quercetin inhibits ampk/txnip activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. |
2015-05-12 |
2023-08-12 |
rat |
| Qing-Yu Zhang, Ying Pan, Rong Wang, Lin-Lin Kang, Qiao-Chu Xue, Xiao-Ning Wang, Ling-Dong Kon. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. The Journal of nutritional biochemistry. vol 25. issue 4. 2015-05-12. PMID:24491314. |
these results provide in vivo evidence that quercetin-mediated down-regulation of ampk/txnip and subsequent inhibition of nf-κb pathway/nlrp3 inflammasome activation in the hypothalamus of rats may be associated with the reduction of hypothalamic inflammatory lesions, contributing to the improvement of hypothalamic insulin signaling defect in this model. |
2015-05-12 |
2023-08-12 |
rat |
| Brittany B Rice, Wei Zhang, Shiping Bai, Paul B Siegel, Mark A Cline, Elizabeth R Gilber. Insulin-induced hypoglycemia associations with gene expression changes in liver and hypothalamus of chickens from lines selected for low or high body weight. General and comparative endocrinology. vol 208. 2015-04-29. PMID:25157791. |
compared to the vehicle, insulin treatment was associated with an increase in tryptophan hydroxylase 2 mrna in the hypothalamus of both lines (p=0.02). |
2015-04-29 |
2023-08-13 |
Not clear |
| Hiroyuki Takahashi, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Atsushi Yamauchi, Shinya Dohgu, Yasufumi Kataok. Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons. Biochemical and biophysical research communications. vol 457. issue 4. 2015-04-17. PMID:25597994. |
insulin signaling in the hypothalamus plays an important role in food intake and glucose homeostasis. |
2015-04-17 |
2023-08-13 |
mouse |
| Teppei Fujikawa, Roberto Coppar. Living without insulin: the role of leptin signaling in the hypothalamus. Frontiers in neuroscience. vol 9. 2015-04-14. PMID:25870537. |
living without insulin: the role of leptin signaling in the hypothalamus. |
2015-04-14 |
2023-08-13 |
Not clear |