| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brenda Diaz, Lizeth Fuentes-Mera, Armando Tovar, Teresa Montiel, Lourdes Massieu, Herminia Guadalupe Martínez-Rodríguez, Alberto Camach. Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells. Brain research. vol 1627. 2016-08-17. PMID:26410780. |
our data indicate that saturated lipids modulate mtf2 expression in hypothalamus coordinating the er stress response and the susceptibility to insulin resistance. |
2016-08-17 |
2023-08-13 |
mouse |
| Y A Panko. [Adipogenic function and other biologic effects of insulin]. Biomeditsinskaia khimiia. vol 62. issue 1. 2016-06-17. PMID:26973181. |
insulin microinjections in the brain, in the cerebral ventricle 4 (icv) and mediobasal hypothalamus (mbh) did not affect the insulin levels in the general circulation, but effectively activated lipogenesis and inhibited lipolysis in adipose tissue. |
2016-06-17 |
2023-08-13 |
mouse |
| M Librán-Pérez, C Velasco, C Otero-Rodiño, M A López-Patiño, J M Míguez, J L Soenga. Effects of insulin treatment on the response to oleate and octanoate of food intake and fatty acid-sensing systems in rainbow trout. Domestic animal endocrinology. vol 53. 2016-06-07. PMID:26226227. |
we hypothesized that food intake and the response of fatty acid (fa)-sensing systems in hypothalamus, liver, and brockmann bodies of rainbow trout to raised levels of oleate (ol) or octanoate (oct) is modified by insulin treatment. |
2016-06-07 |
2023-08-13 |
cattle |
| Melissa A Stouffer, Catherine A Woods, Jyoti C Patel, Christian R Lee, Paul Witkovsky, Li Bao, Robert P Machold, Kymry T Jones, Soledad Cabeza de Vaca, Maarten E A Reith, Kenneth D Carr, Margaret E Ric. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nature communications. vol 6. 2016-05-11. PMID:26503322. |
insulin activates insulin receptors (insrs) in the hypothalamus to signal satiety after a meal. |
2016-05-11 |
2023-08-13 |
rat |
| S Kullmann, M Heni, A Fritsche, H Preiss. Insulin action in the human brain: evidence from neuroimaging studies. Journal of neuroendocrinology. vol 27. issue 6. 2016-03-01. PMID:25594822. |
thus, the action of insulin can be detected within all eating behaviour relevant regions, which include regions deeply located within the brain, such as the hypothalamus, midbrain and brainstem, as well as regions within the striatum. |
2016-03-01 |
2023-08-13 |
human |
| Li Zhang, Haiyan Song, Yingli Ge, Guang Ji, Zemin Ya. Temporal relationship between diet-induced steatosis and onset of insulin/leptin resistance in male Wistar rats. PloS one. vol 10. issue 2. 2016-01-13. PMID:25658428. |
the aim of the current study is to determine the temporal relationships between the development of hepatic steatosis and the onset of insulin and leptin resistance in hypothalamus and liver in male wistar rats (six weeks of age) fed chow or hfhs diet for up to 8 weeks. |
2016-01-13 |
2023-08-13 |
rat |
| Li Zhang, Haiyan Song, Yingli Ge, Guang Ji, Zemin Ya. Temporal relationship between diet-induced steatosis and onset of insulin/leptin resistance in male Wistar rats. PloS one. vol 10. issue 2. 2016-01-13. PMID:25658428. |
hyperinsulinemia, hyperglycemia, dyslipidemia, and increased homeostasis model assessment of basal insulin resistance occurred 1-week after hfhs dieting, coinciding with upregulation of suppressor of cytokine signalling 3 in both hypothalamus and liver. |
2016-01-13 |
2023-08-13 |
rat |
| Li Zhang, Haiyan Song, Yingli Ge, Guang Ji, Zemin Ya. Temporal relationship between diet-induced steatosis and onset of insulin/leptin resistance in male Wistar rats. PloS one. vol 10. issue 2. 2016-01-13. PMID:25658428. |
lowered insulin sensitivity (shown by decreased insulin receptor substrate 1 and protein kinase b phosphorylation) occurred approximately 2 weeks prior to leptin resistance (shown by impaired signal transducer and activator of transcription 3 activation) in both the liver and hypothalamus. |
2016-01-13 |
2023-08-13 |
rat |
| Giuseppe Daniele, Patricia Iozzo, Marjorie Molina-Carrion, Jack Lancaster, Demetrio Ciociaro, Eugenio Cersosimo, Devjit Tripathy, Curtis Triplitt, Peter Fox, Nicolas Musi, Ralph DeFronzo, Amalia Gastaldell. Exenatide Regulates Cerebral Glucose Metabolism in Brain Areas Associated With Glucose Homeostasis and Reward System. Diabetes. vol 64. issue 10. 2016-01-04. PMID:26116695. |
exenatide increased cmrglu in areas of the brain related to glucose homeostasis, appetite, and food reward, despite lower plasma insulin concentrations, but reduced glucose uptake in the hypothalamus. |
2016-01-04 |
2023-08-13 |
human |
| Tetsumori Yamashim. Dual effects of the non-esterified fatty acid receptor 'GPR40' for human health. Progress in lipid research. vol 58. 2015-12-24. PMID:25615413. |
since a substantial expression of gpr40 is also seen in the hypothalamus, 'brain-lipid sensing' might be involved in the control of insulin secretion and energy balance. |
2015-12-24 |
2023-08-13 |
human |
| V N Tito. [THE BIOLOGICAL FUNCTION OF NUTRITION, BIOLOGICAL REACTION OF EXOTROPHY, DEPOSITING AND ENDOTROPHY. THE VISCERAL FATTY CELLS AND ADIPOCYTES - PHYLOGENETICALLY, FUNCTIONALLY AND REGULATORY DIFFERENT POOLS OF FATTY TISSUE]. Klinicheskaia laboratornaia diagnostika. vol 60. issue 8. 2015-12-08. PMID:26596041. |
the phylogenetically later paracrin cenosises are regulated by insulin and nuclei of hypothalamus. |
2015-12-08 |
2023-08-13 |
Not clear |
| Wei Zhang, Sungwon Kim, Robert Settlage, Wyatt McMahon, Lindsay H Sumners, Paul B Siegel, Benjamin J Dorshorst, Mark A Cline, Elizabeth R Gilber. Hypothalamic differences in expression of genes involved in monoamine synthesis and signaling pathways after insulin injection in chickens from lines selected for high and low body weight. Neurogenetics. vol 16. issue 2. 2015-11-25. PMID:25582322. |
ninety-day-old female lws and hws chickens were injected with either vehicle or insulin and hypothalamus collected at 1 h postinjection. |
2015-11-25 |
2023-08-13 |
chicken |
| Danilo Alves Moraes, Daniel Paulino Venancio, Deborah Sucheck. Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats. Hormones and behavior. vol 66. issue 5. 2015-11-17. PMID:25304978. |
this study aimed to investigate the daily change of 96 h of psd-induced food intake, body weight, blood glucose, plasma insulin and leptin concentrations and the expression of their receptors in the hypothalamus of wistar rats. |
2015-11-17 |
2023-08-13 |
rat |
| Beiying Qiu, Xiaohe Shi, Qiling Zhou, Hui Shan Chen, Joy Lim, Weiping Han, Vinay Tergaonka. Hypothalamic NUCKS regulates peripheral glucose homoeostasis. The Biochemical journal. vol 469. issue 3. 2015-11-10. PMID:26205492. |
considering the pivotal roles of insulin signalling in the brain, especially in the hypothalamus, we examined the functions of hypothalamic nucks in the regulation of peripheral glucose metabolism. |
2015-11-10 |
2023-08-13 |
mouse |
| Beiying Qiu, Xiaohe Shi, Qiling Zhou, Hui Shan Chen, Joy Lim, Weiping Han, Vinay Tergaonka. Hypothalamic NUCKS regulates peripheral glucose homoeostasis. The Biochemical journal. vol 469. issue 3. 2015-11-10. PMID:26205492. |
insulin signalling in the hypothalamus was impaired in the nko mice when insulin was delivered through intracerebroventricular injection. |
2015-11-10 |
2023-08-13 |
mouse |
| Jeremie Z Lindeque, Peet J Jansen van Rensburg, Roan Louw, Francois H van der Westhuizen, Sergi Florit, Lorena Ramírez, Mercedes Giralt, Juan Hidalg. Obesity and metabolomics: metallothioneins protect against high-fat diet-induced consequences in metallothionein knockout mice. Omics : a journal of integrative biology. vol 19. issue 2. 2015-10-23. PMID:25683887. |
considering the expression profiles of the mt isoforms and similarity in brain metabolic variation in the knockout strains, it appears that they promote mitochondrial function in the hypothalamus, thereby limiting weight gain and insulin resistance. |
2015-10-23 |
2023-08-13 |
mouse |
| Jennifer L Steiner, Megan E Bardgett, Lawrence Wolfgang, Charles H Lang, Sean D Stocke. Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. Journal of neurophysiology. vol 112. issue 10. 2015-10-19. PMID:25185805. |
western blot analysis indicates insulin produced similar activation of akt ser(473) and rps6 ser(240/244) in the ventral hypothalamus of control and dexamethasone-treated rats. |
2015-10-19 |
2023-08-13 |
rat |
| T C Adam, S Tsao, K A Page, H Hu, R E Hasson, M I Gora. Insulin sensitivity and brain reward activation in overweight Hispanic girls: a pilot study. Pediatric obesity. vol 10. issue 1. 2015-09-29. PMID:24357646. |
in addition to its role as an energy regulatory signal to the hypothalamus, insulin also modulates food reward. |
2015-09-29 |
2023-08-12 |
Not clear |
| Maria Fernanda Condes Areias, Patricia Oliveira Prad. Mechanisms of insulin resistance in the amygdala: influences on food intake. Behavioural brain research. vol 282. 2015-09-21. PMID:25601576. |
similar to the hypothalamus the anorexigenic effect of insulin is mediated via pi3k (phosphoinositide 3-kinase)/akt (protein kinase b) pathway in the amygdala. |
2015-09-21 |
2023-08-13 |
human |
| Kenia Pereira Bispo, Letícia de Oliveira Rodrigues, Érica da Silva Soares de Souza, Daniela Mucci, Maria das Graças Tavares do Carmo, Kelse Tibau de Albuquerque, Fatima Lucia de Carvalho Sardinh. Trans and interesterified fat and palm oil during the pregnancy and lactation period inhibit the central anorexigenic action of insulin in adult male rat offspring. The journal of physiological sciences : JPS. vol 65. issue 1. 2015-09-15. PMID:25398547. |
this study investigated whether the maternal consumption of normolipidic diets containing these lipids affects the insulin receptor and akt/protein kinase b (pkb) contents in the hypothalamus and the hypophagic effect of centrally administered insulin in 3-month-old male offspring. |
2015-09-15 |
2023-08-13 |
rat |