| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Henry H Ruiz, Tiffany Chi, Andrew C Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettne. Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 8. 2017-10-06. PMID:26928090. |
insulin signaling within the brain, in particular within the hypothalamus regulates carbohydrate, lipid, and branched chain amino acid (bcaa) metabolism in peripheral organs such as the liver and adipose tissue. |
2017-10-06 |
2023-08-13 |
mouse |
| Henry H Ruiz, Tiffany Chi, Andrew C Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettne. Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 8. 2017-10-06. PMID:26928090. |
we hypothesized that cerebral amyloidosis impairs central nervous system control of metabolism through disruption of insulin signaling in the hypothalamus, which dysregulates glucose and bcaa homeostasis resulting in increased susceptibility to diabetes. |
2017-10-06 |
2023-08-13 |
mouse |
| Yuanqing Gao, Clarita Layritz, Beata Legutko, Thomas O Eichmann, Elise Laperrousaz, Valentine S Moullé, Celine Cruciani-Guglielmacci, Christophe Magnan, Serge Luquet, Stephen C Woods, Robert H Eckel, Chun-Xia Yi, Cristina Garcia-Caceres, Matthias H Tschö. Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity. Diabetes. vol 66. issue 10. 2017-10-02. PMID:28710138. |
intriguingly, astrocytic lpl deficiency also triggered increased ceramide content in the hypothalamus, which may contribute to hypothalamic insulin resistance. |
2017-10-02 |
2023-08-13 |
mouse |
| Beatriz C Borges, Carol F Elias, Lucila L K Elia. PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges. Molecular and cellular endocrinology. vol 438. 2017-09-25. PMID:27389879. |
changes in circulating insulin and cytokines such as leptin, interleukins and tumor necrosis factor, as well as changes in their action in the hypothalamus drive the inhibition of food consumption during inflammation. |
2017-09-25 |
2023-08-13 |
Not clear |
| Mariko Sugiyama, Ryoichi Banno, Akira Mizoguchi, Takashi Tominaga, Taku Tsunekawa, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Hiroshi Arim. PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochemical and biophysical research communications. vol 488. issue 1. 2017-09-21. PMID:28479249. |
in an ex vivo study using hypothalamic organotypic cultures, insulin treatment significantly increased the phosphorylation of both irβ and akt in the hypothalamus of ko mice compared to wt mice, and also significantly decreased agrp mrna expression levels in ko mice. |
2017-09-21 |
2023-08-13 |
mouse |
| Yu-Hong Jing, Lang Zhang, Li-Ping Gao, Chu-Chu Qi, Dan-Dan Lv, Yan-Feng Song, Jie Yin, De-Gui Wan. Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. Neuro endocrinology letters. vol 38. issue 1. 2017-08-29. PMID:28456145. |
the hypothalamus regulates metabolism and feeding behavior by perceiving the levels of peripheral insulin. |
2017-08-29 |
2023-08-13 |
Not clear |
| Yu-Hong Jing, Lang Zhang, Li-Ping Gao, Chu-Chu Qi, Dan-Dan Lv, Yan-Feng Song, Jie Yin, De-Gui Wan. Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. Neuro endocrinology letters. vol 38. issue 1. 2017-08-29. PMID:28456145. |
in this study, we investigated the changes of insulin and autophagy relevant signals of hypothalamus under diabetes mellitus. |
2017-08-29 |
2023-08-13 |
Not clear |
| M van Houten, B I Posne. Cellular basis of direct insulin action in the central nervous system. Diabetologia. vol 20. issue Suppl 1. 2017-08-23. PMID:27942810. |
in the arcuatemedian eminence region of the hypothalamus blood-borne insulin directly interacts with receptive nerve terminals, suggesting that insulin acts to influence the electrical activity of select hypothalamic nerve circuits at the level of synaptic transmission. |
2017-08-23 |
2023-08-13 |
Not clear |
| Y Oomura, H Kit. Insulin acting as a modulator of feeding through the hypothalamus. Diabetologia. vol 20. issue Suppl 1. 2017-08-23. PMID:27942814. |
insulin acting as a modulator of feeding through the hypothalamus. |
2017-08-23 |
2023-08-13 |
rat |
| Y Oomura, H Kit. Insulin acting as a modulator of feeding through the hypothalamus. Diabetologia. vol 20. issue Suppl 1. 2017-08-23. PMID:27942814. |
2) specific binding sites of insulin in the brain were most abundant in the hypothalamus and olfactory bulb. |
2017-08-23 |
2023-08-13 |
rat |
| T L Powley, W Laughto. Neural pathways involved in the hypothalamic integration of autonomic responses. Diabetologia. vol 20. issue Suppl 1. 2017-08-23. PMID:27942825. |
these nodes, the basomedial hypothalamus and the vagal complex of the medulla, seem to share similar biochemical specializations reflected in susceptibility to goldthioglucose toxicity, specific insulin binding, and susceptibility to alloxan diabetes. |
2017-08-23 |
2023-08-13 |
Not clear |
| A B Steffen. The modulatory effect of the hypothalamus on glucagon and insulin secretion in the rat. Diabetologia. vol 20. issue Suppl 1. 2017-08-23. PMID:27942829. |
the modulatory effect of the hypothalamus on glucagon and insulin secretion in the rat. |
2017-08-23 |
2023-08-13 |
rat |
| Priscila A Cassaglia, Zhigang Shi, Virginia L Brook. Insulin increases sympathetic nerve activity in part by suppression of tonic inhibitory neuropeptide Y inputs into the paraventricular nucleus in female rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 311. issue 1. 2017-07-24. PMID:27122366. |
following binding to receptors in the arcuate nucleus (arcn), insulin increases sympathetic nerve activity (sna) and baroreflex control of sna via a pathway that includes the paraventricular nucleus of the hypothalamus (pvn). |
2017-07-24 |
2023-08-13 |
rat |
| Ghazaleh Nameni, Ghazaleh Hajiluian, Parviz Shahabi, Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Mohammad-Reza Hemmati, Seyed Mahdi Vatandous. The Impact of Vitamin D Supplementation on Neurodegeneration, TNF-α Concentration in Hypothalamus, and CSF-to-Plasma Ratio of Insulin in High-Fat-Diet-Induced Obese Rats. Journal of molecular neuroscience : MN. vol 61. issue 2. 2017-06-27. PMID:27921254. |
the impact of vitamin d supplementation on neurodegeneration, tnf-α concentration in hypothalamus, and csf-to-plasma ratio of insulin in high-fat-diet-induced obese rats. |
2017-06-27 |
2023-08-13 |
rat |
| Ghazaleh Nameni, Ghazaleh Hajiluian, Parviz Shahabi, Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Mohammad-Reza Hemmati, Seyed Mahdi Vatandous. The Impact of Vitamin D Supplementation on Neurodegeneration, TNF-α Concentration in Hypothalamus, and CSF-to-Plasma Ratio of Insulin in High-Fat-Diet-Induced Obese Rats. Journal of molecular neuroscience : MN. vol 61. issue 2. 2017-06-27. PMID:27921254. |
insulin deficiency in the brain especially in the hypothalamus region has neurodegenerative and obesity-promoting effects. |
2017-06-27 |
2023-08-13 |
rat |
| Ghazaleh Nameni, Ghazaleh Hajiluian, Parviz Shahabi, Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Mohammad-Reza Hemmati, Seyed Mahdi Vatandous. The Impact of Vitamin D Supplementation on Neurodegeneration, TNF-α Concentration in Hypothalamus, and CSF-to-Plasma Ratio of Insulin in High-Fat-Diet-Induced Obese Rats. Journal of molecular neuroscience : MN. vol 61. issue 2. 2017-06-27. PMID:27921254. |
because of the anti-inflammatory and neuroprotective effects of vitamin d, in the current experimental study, we aimed to investigate the effects of vitamin d supplementation on neurodegeneration, tnf-α concentration in the hypothalamus, and cerebrospinal fluid (csf) to serum ratio of insulin in high-fat-diet-induced obese rats. |
2017-06-27 |
2023-08-13 |
rat |
| Ghazaleh Nameni, Ghazaleh Hajiluian, Parviz Shahabi, Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Mohammad-Reza Hemmati, Seyed Mahdi Vatandous. The Impact of Vitamin D Supplementation on Neurodegeneration, TNF-α Concentration in Hypothalamus, and CSF-to-Plasma Ratio of Insulin in High-Fat-Diet-Induced Obese Rats. Journal of molecular neuroscience : MN. vol 61. issue 2. 2017-06-27. PMID:27921254. |
csf samples were also collected to measure insulin concentrations, and the hypothalamus was dissected to determine tnf-α concentration. |
2017-06-27 |
2023-08-13 |
rat |
| Cesar L Moreno, Linda Yang, Penny A Dacks, Fumiko Isoda, Jan M A van Deursen, Charles V Mobb. Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates. PloS one. vol 11. issue 11. 2017-06-21. PMID:27832201. |
in addition, these changes are accompanied by molecular evidence in the hypothalamus for impaired leptin and insulin signaling, a shift from glucose to lipid metabolism, and decreased pomc mrna, with no effect on locomotion. |
2017-06-21 |
2023-08-13 |
human |
| Wilfredo Rosario, Inderroop Singh, Arnaud Wautlet, Christa Patterson, Jonathan Flak, Thomas C Becker, Almas Ali, Natalia Tamarina, Louis H Philipson, Lynn W Enquist, Martin G Myers, Christopher J Rhode. The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions. Diabetes. vol 65. issue 9. 2017-06-05. PMID:27207534. |
they also demonstrate that distinct regions of the hypothalamus differentially control insulin and glucagon secretion, potentially in partnership to help maintain glucose homeostasis and guard against hypoglycemia. |
2017-06-05 |
2023-08-13 |
Not clear |
| Stephanie R Sisley, Deanna M Arble, Adam P Chambers, Ruth Gutierrez-Aguilar, Yanlin He, Yong Xu, David Gardner, David D Moore, Randy J Seeley, Darleen A Sandova. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. vol 65. issue 9. 2017-06-05. PMID:27217488. |
indeed, we found that small doses of active vitamin d, 1α,25-dihydroxyvitamin d3 (1,25d3) (calcitriol), into the third ventricle of the brain improved glucose tolerance and markedly increased hepatic insulin sensitivity, an effect that is dependent upon vdr within the paraventricular nucleus of the hypothalamus. |
2017-06-05 |
2023-08-13 |
Not clear |