| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hisae Ando, Koro Gotoh, Kansuke Fujiwara, Manabu Anai, Seiichi Chiba, Takayuki Masaki, Tetsuya Kakuma, Hirotaka Shibat. Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats. Scientific reports. vol 7. issue 1. 2019-02-20. PMID:28717164. |
chronic glp-1 (7-36) administration to hfd-induced obese rats elevated c-fos expression and bdnf content in the hypothalamus, followed by a reduction in pancreatic β-cell hyperplasia and insulin content, thus resulting in improved glucose tolerance. |
2019-02-20 |
2023-08-13 |
rat |
| Baile Wang, Kenneth King-Yip Chen. Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance. International journal of molecular sciences. vol 19. issue 11. 2019-02-11. PMID:30423881. |
although activation of ampk in peripheral tissues is able to promote fatty acid oxidation and insulin sensitivity, its chronic activation in the hypothalamus causes obesity by inducing hyperphagia in both humans and rodents. |
2019-02-11 |
2023-08-13 |
Not clear |
| Mélanie Campana, Lara Bellini, Claude Rouch, Latif Rachdi, Nicolas Coant, Noémie Butin, Cécile L Bandet, Erwann Philippe, Kelly Meneyrol, Nadim Kassis, Julien Dairou, Eric Hajduch, Benoit Colsch, Christophe Magnan, Hervé Le Stunf. Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Molecular metabolism. vol 8. 2019-01-29. PMID:29233519. |
inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese zucker rats. |
2019-01-29 |
2023-08-13 |
rat |
| Mélanie Campana, Lara Bellini, Claude Rouch, Latif Rachdi, Nicolas Coant, Noémie Butin, Cécile L Bandet, Erwann Philippe, Kelly Meneyrol, Nadim Kassis, Julien Dairou, Eric Hajduch, Benoit Colsch, Christophe Magnan, Hervé Le Stunf. Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Molecular metabolism. vol 8. 2019-01-29. PMID:29233519. |
here, we aimed to determine the role of de novo ceramide synthesis in hypothalamus on the onset of central insulin resistance and the dysregulation of glucose homeostasis induced by obesity. |
2019-01-29 |
2023-08-13 |
rat |
| Lan Xiang, Jing Li, Qian Wang, Ruiqi Tang, Jianhua Q. Leptin Gene Transfer Improves Symptoms of Type 2 Diabetic Mice by Regulating Leptin Signaling Pathway and Insulin Resistance of Peripheral Tissues. Human gene therapy. vol 29. issue 1. 2019-01-28. PMID:28622065. |
the mrna expression levels of adiponectin receptor 1 (adr1), glucose transporter 4 (glut4), glucose-6-phosphase, and peroxisome proliferator-activated receptor γ in the liver, leptin, adiponectin, and hormone-sensitive lipase in adipose tissue, leptin, leptin-receptor, adr1 in the hypothalamus, and adr1, glut4, and insulin 1 in the gastrocnemius significantly increased. |
2019-01-28 |
2023-08-13 |
mouse |
| Bong-Hoi Choi, Zhen Jin, Chin-Ok Yi, Juhong Oh, Eun Ae Jeong, Jong Youl Lee, Kyung-Ah Park, Kyung Eun Kim, Jung Eun Lee, Hyun-Jin Kim, Jong Ryeal Hahm, Gu Seob Ro. Effects of lobeglitazone on insulin resistance and hepatic steatosis in high-fat diet-fed mice. PloS one. vol 13. issue 7. 2019-01-08. PMID:29979770. |
despite improving leptin signaling in the hypothalamus and enhancing insulin sensitivity in hfd-fed mice, lobe increased body weight and steatosis. |
2019-01-08 |
2023-08-13 |
mouse |
| Stephanie Kullmann, Martin Heni, Ralf Veit, Klaus Scheffler, Jürgen Machann, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preiss. Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger. Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28487570. |
insulin compared to placebo administration resulted in increased functional connectivity between the prefrontal regions of the default-mode network and the hippocampus as well as the hypothalamus. |
2018-12-11 |
2023-08-13 |
human |
| Mateusz Maciejczyk, Ewa Żebrowska, Anna Zalewska, Adrian Chabowsk. Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet-Induced Insulin Resistance. Oxidative medicine and cellular longevity. vol 2018. 2018-12-11. PMID:30271528. |
redox balance, antioxidant defense, and oxidative damage in the hypothalamus and cerebral cortex of rats with high fat diet-induced insulin resistance. |
2018-12-11 |
2023-08-13 |
rat |
| Sara Carmo-Silva, Cláudia Cavada. Hypothalamic Dysfunction in Obesity and Metabolic Disorders. Advances in neurobiology. vol 19. 2018-11-01. PMID:28933062. |
all these observations occur at the same time and it is still difficult to discern whether inflammatory processes are the main drivers of these cellular dysfunctions or if the hypothalamic hormone resistance (insulin, leptin, and ghrelin) can be pinpointed as the source of several of these events.understanding the mechanisms that underlie the pathophysiology of obesity in the hypothalamus is crucial for the development of strategies that can prevent or attenuate the deleterious effects of obesity. |
2018-11-01 |
2023-08-13 |
Not clear |
| Wen-Ya Huang, Xin Zou, Fu-Er Lu, Hao Su, Chu Zhang, Yan-Lin Ren, Ke Fang, Li-Jun Xu, Kai-Fu Wang, Qing-Jie Chen, Hui Don. Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats. Current medical science. vol 38. issue 4. 2018-10-31. PMID:30128882. |
meanwhile, the mrna expression of inflammatory markers, activity of nuclear factor kappa b (nf-κb) p65 protein, as well as the expression levels of insulin signaling pathway proteins in hypothalamus, adipose and liver tissues were measured. |
2018-10-31 |
2023-08-13 |
rat |
| Miguel A Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Thomas Jensen, David J Orlicky, Carlos A Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S MacLean, Richard J Johnso. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 12. 2018-09-18. PMID:29507217. |
here we show that high intake of salt activates the aldose reductase-fructokinase pathway in the liver and hypothalamus, leading to endogenous fructose production with the development of leptin resistance and hyperphagia that cause obesity, insulin resistance, and fatty liver. |
2018-09-18 |
2023-08-13 |
mouse |
| Garron T Dodd, Robert S Lee-Young, Jens C Brüning, Tony Tigani. TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding. Diabetes. vol 67. issue 7. 2018-08-16. PMID:29712668. |
insulin receptor (ir) signaling inhibits agrp-expressing neurons in the hypothalamus to contribute to the suppression of hepatic glucose production (hgp) by insulin, whereas agrp neuronal activation attenuates brown adipose tissue (bat) glucose uptake. |
2018-08-16 |
2023-08-13 |
Not clear |
| Hao Hong, Zhen-Zhong Cui, Lu Zhu, Shu-Ping Fu, Mario Rossi, Ying-Hong Cui, Bing-Mei Zh. Central IGF1 improves glucose tolerance and insulin sensitivity in mice. Nutrition & diabetes. vol 7. issue 12. 2018-07-27. PMID:29259155. |
mice that over-expressed central igf1 displayed increased appetite, improved glucose tolerance and insulin sensitivity, decreased pomc levels in the hypothalamus, and increased ucp1 expression in brown fat tissue. |
2018-07-27 |
2023-08-13 |
mouse |
| Sabine Frank-Podlech, Julia von Schnurbein, Ralf Veit, Martin Heni, Jürgen Machann, Jaana M Heinze, Stephanie Kullmann, Jaida Manzoor, Saqib Mahmood, Hans-Ulrich Häring, Hubert Preissl, Martin Wabitsch, Andreas Fritsch. Leptin Replacement Reestablishes Brain Insulin Action in the Hypothalamus in Congenital Leptin Deficiency. Diabetes care. vol 41. issue 4. 2018-07-19. PMID:29367426. |
leptin replacement reestablishes brain insulin action in the hypothalamus in congenital leptin deficiency. |
2018-07-19 |
2023-08-13 |
human |
| Izabelle Dias Benfato, Thaís Ludmilla Moretto, Francine Pereira de Carvalho, Marcela Barthichoto, Sandra Mara Ferreira, José Maria Costa Júnior, Mariana Cruz Lazzarin, Flávia de Oliveira, Carolina Martinez, Carolina Prado de França Carvalho, Camila Aparecida Machado de Oliveir. Spontaneous physical activity and mediators of energy homeostasis in the hypothalamus of mice from 4 to 10 months of age. Experimental physiology. vol 102. issue 11. 2018-07-09. PMID:28786537. |
is the initial decline of spontaneous physical activity (spa) in mice related to impaired insulin and leptin signalling or brain-derived neurotrophic factor expression in the hypothalamus? |
2018-07-09 |
2023-08-13 |
mouse |
| Izabelle Dias Benfato, Thaís Ludmilla Moretto, Francine Pereira de Carvalho, Marcela Barthichoto, Sandra Mara Ferreira, José Maria Costa Júnior, Mariana Cruz Lazzarin, Flávia de Oliveira, Carolina Martinez, Carolina Prado de França Carvalho, Camila Aparecida Machado de Oliveir. Spontaneous physical activity and mediators of energy homeostasis in the hypothalamus of mice from 4 to 10 months of age. Experimental physiology. vol 102. issue 11. 2018-07-09. PMID:28786537. |
age decreases insulin, leptin and brain-derived neurotrophic factor (bdnf) signalling in the hypothalamus, and all have been shown to modulate spontaneous physical activity (spa). |
2018-07-09 |
2023-08-13 |
mouse |
| M Proszkowiec-Weglarz, J Dupont, N Rideau, C Gespach, J Simon, T E Porte. Insulin immuno-neutralization decreases food intake in chickens without altering hypothalamic transcripts involved in food intake and metabolism. Poultry science. vol 96. issue 12. 2018-07-05. PMID:29053815. |
in mammals, insulin regulates blood glucose levels and plays a key regulatory role in appetite via the hypothalamus. |
2018-07-05 |
2023-08-13 |
Not clear |
| Masahiro Konishi, Masaji Sakaguchi, Samuel M Lockhart, Weikang Cai, Mengyao Ella Li, Erica P Homan, Christian Rask-Madsen, C Ronald Kah. Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 40. 2018-06-26. PMID:28923931. |
using mice with endothelial-specific inactivation of the ir gene (endoirko), we find that in response to systemic insulin stimulation, loss of endothelial irs caused delayed onset of insulin signaling in skeletal muscle, brown fat, hypothalamus, hippocampus, and prefrontal cortex but not in liver or olfactory bulb. |
2018-06-26 |
2023-08-13 |
mouse |
| Reni Ajoy, Szu-Yi Cho. Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain. Journal of visualized experiments : JoVE. issue 131. 2018-06-21. PMID:29364220. |
insulin regulates systematic metabolism in the hypothalamus and the peripheral insulin response. |
2018-06-21 |
2023-08-13 |
mouse |
| Reni Ajoy, Szu-Yi Cho. Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain. Journal of visualized experiments : JoVE. issue 131. 2018-06-21. PMID:29364220. |
in addition, ccl5 plays a neuroendocrine role in the hypothalamus by regulating food intake and body temperature, thus, prompting us to investigate its function in hypothalamic insulin signaling and the regulation of peripheral glucose metabolism. |
2018-06-21 |
2023-08-13 |
mouse |