| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Al Massadi, M Quiñones, P Lear, C Dieguez, R Nogueira. The brain: a new organ for the metabolic actions of SIRT1. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 45. issue 13. 2014-08-18. PMID:23950036. |
recent studies have shown that sirt1 controls glucose and lipid metabolism in both liver and muscle, promotes fat mobilization, stimulates remodeling of white to brown fat, controls insulin secretion in the pancreas, and senses nutrient availability in the hypothalamus. |
2014-08-18 |
2023-08-12 |
Not clear |
| Qiyi Chen, Wenkui Yu, Jiangliang Shi, Juanhong Shen, Tao Gao, Juanjuan Zhang, Fengchan Xi, Jieshou Li, Ning L. Insulin alleviates the inflammatory response and oxidative stress injury in cerebral tissues in septic rats. Journal of inflammation (London, England). vol 11. 2014-08-05. PMID:25093012. |
after 6 hours of insulin therapy, we found that the cytokine concentrations notably decreased and oxidative stress injuries in the cortex, hypothalamus, and hippocampus were alleviated in septic rats. |
2014-08-05 |
2023-08-13 |
rat |
| Magdalena Wierucka-Rybak, Ewa Bojanowsk. Bacteria, viruses, and hypothalamic inflammation: potential new players in obesity. Postepy higieny i medycyny doswiadczalnej (Online). vol 68. 2014-07-21. PMID:24662795. |
studies on the pathomechanisms related to the pathogenesis of obesity indicated that a high-fat diet triggers the inflammatory response in the hypothalamus, an event that promotes weight gain and further defends elevated body weight through the initiation of central leptin and insulin resistance and impairment of regenerative capacity of hypothalamic neurons. |
2014-07-21 |
2023-08-12 |
human |
| G Mithieu. Influence of diabetes surgery on a gut-brain-liver axis regulating food intake and internal glucose production. Nutricion hospitalaria. vol 28 Suppl 2. 2014-06-30. PMID:23834054. |
it has long been known that the brain, especially the hypothalamus, can modulate both insulin secretion and hepatic glucose fluxes, via the modulation of the sympathetic system (promoting glycogen breakdown) and the parasympathetic system (stimulating glycogen deposition). |
2014-06-30 |
2023-08-12 |
mouse |
| Hyoungil Oh, Stephane Boghossian, David A York, Miejung Park-Yor. The effect of high fat diet and saturated fatty acids on insulin signaling in the amygdala and hypothalamus of rats. Brain research. vol 1537. 2014-06-25. PMID:24076449. |
the effect of high fat diet and saturated fatty acids on insulin signaling in the amygdala and hypothalamus of rats. |
2014-06-25 |
2023-08-12 |
rat |
| Hyoungil Oh, Stephane Boghossian, David A York, Miejung Park-Yor. The effect of high fat diet and saturated fatty acids on insulin signaling in the amygdala and hypothalamus of rats. Brain research. vol 1537. 2014-06-25. PMID:24076449. |
cea insulin also induced an increase in akt phosphorylation in the hypothalamus but had no effect on hypothalamic mtor phosphorylation. |
2014-06-25 |
2023-08-12 |
rat |
| Satya P Kalr. Should leptin replace insulin as a lifetime monotherapy for diabetes type 1 and 2? Indian journal of endocrinology and metabolism. vol 17. issue Suppl 1. 2014-06-24. PMID:24251168. |
in view of the relentless challenges posed by the worldwide epidemic of diabetes and soaring treatment costs, taken together with the well-known shortcomings of therapies based on restoring insulin signaling, it is highly critical and timely to undertake new clinical trials that ascertain appropriate dosage and route of leptin delivery to the hypothalamus capable of safely sustaining stable glycemia for lifetime. |
2014-06-24 |
2023-08-12 |
Not clear |
| Jenny Ha, Jessica I Cohen, Aziz Tirsi, Antonio Convi. Association of obesity-mediated insulin resistance and hypothalamic volumes: possible sex differences. Disease markers. vol 35. issue 4. 2014-06-20. PMID:24344399. |
there was a significant interaction between insulin resistance and sex on hypothalamus volume; obese females with significant insulin resistance have smaller hypothalamic volumes than obese males. |
2014-06-20 |
2023-08-12 |
human |
| Wei Zhang, Lindsay H Sumners, Paul B Siegel, Mark A Cline, Elizabeth R Gilber. Quantity of glucose transporter and appetite-associated factor mRNA in various tissues after insulin injection in chickens selected for low or high body weight. Physiological genomics. vol 45. issue 22. 2014-05-30. PMID:24046279. |
to evaluate if there are differences in appetite-regulatory factor and glucose transporter (glut) mrna that are accentuated by hypoglycemia, blood glucose was measured, and hypothalamus, liver, pectoralis major, and abdominal fat collected at 90 days of age from female hws and lws chickens, and reciprocal crosses, hl and lh, at 60 min after intraperitoneal injection of insulin. |
2014-05-30 |
2023-08-12 |
Not clear |
| Beatrice M Filippi, Aria Bassiri, Mona A Abraham, Frank A Duca, Jessica T Y Yue, Tony K T La. Insulin signals through the dorsal vagal complex to regulate energy balance. Diabetes. vol 63. issue 3. 2014-04-24. PMID:24270985. |
insulin signaling in the hypothalamus regulates food intake and hepatic glucose production in rodents. |
2014-04-24 |
2023-08-12 |
rat |
| Merly C Vogt, Lars Paeger, Simon Hess, Sophie M Steculorum, Motoharu Awazawa, Brigitte Hampel, Susanne Neupert, Hayley T Nicholls, Jan Mauer, A Christine Hausen, Reinhard Predel, Peter Kloppenburg, Tamas L Horvath, Jens C Brünin. Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell. vol 156. issue 3. 2014-04-23. PMID:24462248. |
abrogating insulin action in pomc neurons of the offspring prevents altered pomc projections to the preautonomic paraventricular nucleus of the hypothalamus (pvh), pancreatic parasympathetic innervation, and impaired glucose-stimulated insulin secretion in response to maternal overnutrition. |
2014-04-23 |
2023-08-12 |
mouse |
| K Zhao, Y Ao, R M Harper, V L W Go, H Yan. Food-intake dysregulation in type 2 diabetic Goto-Kakizaki rats: hypothesized role of dysfunctional brainstem thyrotropin-releasing hormone and impaired vagal output. Neuroscience. vol 247. 2014-03-18. PMID:23701881. |
fasting (48h) and refeeding (2h)-associated changes in serum ghrelin, insulin, peptide yy, pancreatic polypeptide and leptin, and the concomitant changes in orexigenic or anorexigenic peptide expression in the brainstem and hypothalamus, all apparent in wistar rats, were absent or markedly reduced in gk rats, with hormone release stimulated by vagal activation, such as ghrelin and pancreatic polypeptide, decreased substantially. |
2014-03-18 |
2023-08-12 |
rat |
| Ricardo Zanuto, Mário A Siqueira-Filho, Luciana C Caperuto, Reury F P Bacurau, Emiko Hirata, Rodrigo A Peliciari-Garcia, Fernanda Gaspar do Amaral, Anderson C Marçal, Luciene M Ribeiro, João P G Camporez, Angelo Rafael Carpinelli, Silvana Bordin, José Cipolla-Neto, Carla R O Carvalh. Melatonin improves insulin sensitivity independently of weight loss in old obese rats. Journal of pineal research. vol 55. issue 2. 2014-03-17. PMID:23565768. |
the aim of the present work was to evaluate, in male old obese wistar rats, the effect of melatonin supplementation in the isp, analyzing the total protein amount and the phosphorylated status (immunoprecipitation and immunoblotting) of the insulin cascade components in the rat hypothalamus, liver, skeletal muscle, and periepididymal adipose tissue. |
2014-03-17 |
2023-08-12 |
rat |
| Mona A Abraham, Jessica T Y Yue, Mary P LaPierre, Guy A Rutter, Peter E Light, Beatrice M Filippi, Tony K T La. Hypothalamic glucagon signals through the KATP channels to regulate glucose production. Molecular metabolism. vol 3. issue 2. 2014-03-17. PMID:24634823. |
insulin, leptin and glp-1 signal in the mediobasal hypothalamus (mbh) to lower hepatic glucose production (gp). |
2014-03-17 |
2023-08-12 |
Not clear |
| André Kleinridders, Hans P M M Lauritzen, Siegfried Ussar, Jane H Christensen, Marcelo A Mori, Peter Bross, C Ronald Kah. Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. The Journal of clinical investigation. vol 123. issue 11. 2014-02-20. PMID:24084737. |
targeted acute downregulation of hsp60 in the hypothalamus also induced insulin resistance, indicating that mitochondrial dysfunction can cause insulin resistance in the hypothalamus. |
2014-02-20 |
2023-08-12 |
mouse |
| André Kleinridders, Hans P M M Lauritzen, Siegfried Ussar, Jane H Christensen, Marcelo A Mori, Peter Bross, C Ronald Kah. Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. The Journal of clinical investigation. vol 123. issue 11. 2014-02-20. PMID:24084737. |
these data indicate that leptin plays an important role in mitochondrial function and insulin sensitivity in the hypothalamus by regulating hsp60. |
2014-02-20 |
2023-08-12 |
mouse |
| Jim R Fadel, Corinne G Jolivalt, Lawrence P Reaga. Food for thought: the role of appetitive peptides in age-related cognitive decline. Ageing research reviews. vol 12. issue 3. 2014-01-21. PMID:23416469. |
through their well described actions in the hypothalamus, appetitive peptides such as insulin, orexin and leptin are recognized as important regulators of food intake, body weight and body composition. |
2014-01-21 |
2023-08-12 |
Not clear |
| Jim R Fadel, Corinne G Jolivalt, Lawrence P Reaga. Food for thought: the role of appetitive peptides in age-related cognitive decline. Ageing research reviews. vol 12. issue 3. 2014-01-21. PMID:23416469. |
collectively, these studies support the hypothesis that leptin and insulin resistance, concepts normally associated with the hypothalamus, are also applicable to the hippocampus. |
2014-01-21 |
2023-08-12 |
Not clear |
| Byoung-Seob Ko, Da Sol Kim, Suna Kang, Jin Ah Ryuk, Sunmin Par. Prunus mume and Lithospermum erythrorhizon Extracts Synergistically Prevent Visceral Adiposity by Improving Energy Metabolism through Potentiating Hypothalamic Leptin and Insulin Signalling in Ovariectomized Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-12-09. PMID:24319483. |
pma+les prevented the attenuation of leptin and insulin signaling by increasing the expression of leptin receptor in the hypothalamus in ovx rats. |
2013-12-09 |
2023-08-12 |
rat |
| P Brandimarti, J M Costa-Júnior, S M Ferreira, A O Protzek, G J Santos, E M Carneiro, A C Boschero, L F Rezend. Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing. The Journal of endocrinology. vol 219. issue 2. 2013-12-03. PMID:23959080. |
we then isolated pancreatic islets for ex vivo glucose-stimulated insulin secretion as well as liver, gastrocnemius, visceral adipose tissue, and hypothalamus for subsequent protein analysis by western blot and determination of mrna levels by real-time rt-pcr. |
2013-12-03 |
2023-08-12 |
mouse |