| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela F Bertelli, Andressa Coope, Andrea M Caricilli, Patricia O Prada, Mario J Saad, Licio A Velloso, Eliana P Arauj. Inhibition of 72 kDa inositol polyphosphate 5-phosphatase E improves insulin signal transduction in diet-induced obesity. The Journal of endocrinology. vol 217. issue 2. 2013-06-19. PMID:23349329. |
the reduction of 72k-5ptase expression in the hypothalamus results in improved hypothalamic insulin signal transduction and reduction of food intake and body mass. |
2013-06-19 |
2023-08-12 |
mouse |
| Xiaoling L. SIRT1 and energy metabolism. Acta biochimica et biophysica Sinica. vol 45. issue 1. 2013-06-04. PMID:23257294. |
recent studies have shown that sirt1 controls both glucose and lipid metabolism in the liver, promotes fat mobilization and stimulates brown remodeling of the white fat in white adipose tissue, controls insulin secretion in the pancreas, senses nutrient availability in the hypothalamus, influences obesity-induced inflammation in macrophages, and modulates the activity of circadian clock in metabolic tissues. |
2013-06-04 |
2023-08-12 |
Not clear |
| Simone van de Sande-Lee, Licio A Vellos. [Hypothalamic dysfunction in obesity]. Arquivos brasileiros de endocrinologia e metabologia. vol 56. issue 6. 2013-05-17. PMID:22990637. |
the control of energy balance in animals and humans is performed by the central nervous system (cns) by means of neuroendocrine connections, in which circulating peripheral hormones, such as leptin and insulin, provide signals to specialized neurons of the hypothalamus reflecting body fat stores, and induce appropriate responses to maintain the stability of these stores. |
2013-05-17 |
2023-08-12 |
human |
| Simone van de Sande-Lee, Licio A Vellos. [Hypothalamic dysfunction in obesity]. Arquivos brasileiros de endocrinologia e metabologia. vol 56. issue 6. 2013-05-17. PMID:22990637. |
in experimental animals, high-fat diets can induce an inflammatory process in the hypothalamus, which impairs leptin and insulin intracellular signaling pathways, and results in hyperphagia, decreased energy expenditure and, ultimately, obesity. |
2013-05-17 |
2023-08-12 |
human |
| Lynda M William. Hypothalamic dysfunction in obesity. The Proceedings of the Nutrition Society. vol 71. issue 4. 2013-04-04. PMID:22954151. |
a growing number of studies have shown that a diet high in long chain sfa and/or obesity cause profound changes to the energy balance centres of the hypothalamus which results in the loss of central leptin and insulin sensitivity. |
2013-04-04 |
2023-08-12 |
Not clear |
| Lynda M William. Hypothalamic dysfunction in obesity. The Proceedings of the Nutrition Society. vol 71. issue 4. 2013-04-04. PMID:22954151. |
the importance of nutritional activation of the toll-like receptor 4 and the inhibitor of nf-κb kinase subunit β/nk-κb and c-jun amino-terminal kinase 1 inflammatory pathways in linking a high-fat diet to obesity and insulin insensitivity via the hypothalamus is now widely recognised. |
2013-04-04 |
2023-08-12 |
Not clear |
| Yacir Benomar, Arieh Gertler, Pamela De Lacy, Delphine Crépin, Hassina Ould Hamouda, Laure Riffault, Mohammed Taoui. Central resistin overexposure induces insulin resistance through Toll-like receptor 4. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22961082. |
taken together, our findings clearly identify tlr4 as the binding site for resistin in the hypothalamus and bring new insight into the molecular mechanisms involved in resistin-induced inflammation and insulin resistance in the whole animal. |
2013-03-08 |
2023-08-12 |
rat |
| Sebastian Beck Jorgensen, Hayley M O'Neill, Lykke Sylow, Jane Honeyman, Kimberly A Hewitt, Rengasamy Palanivel, Morgan D Fullerton, Lisa Öberg, Anudharan Balendran, Sandra Galic, Chris van der Poel, Ian A Trounce, Gordon S Lynch, Jonathan D Schertzer, Gregory R Steinber. Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22961088. |
socs3 inhibits leptin signaling in the hypothalamus and insulin signal transduction in adipose tissue and the liver. |
2013-03-08 |
2023-08-12 |
mouse |
| Patrícia O Prada, Paula G F Quaresma, Andrea M Caricilli, Andressa C Santos, Dioze Guadagnini, Joseane Morari, Laís Weissmann, Eduardo R Ropelle, José Barreto C Carvalheira, Lício A Velloso, Mario J A Saa. Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22966070. |
inhibition of tub expression in hypothalamus by aso increased food intake, fasting blood glucose, and hepatic glucose output, decreased o(2) consumption, and blunted the effect of insulin or leptin on proopiomelanocortin, thyroid-releasing hormone, melanin-concentrating hormone, and orexin expression. |
2013-03-08 |
2023-08-12 |
mouse |
| Beatrice M Filippi, Clair S Yang, Christine Tang, Tony K T La. Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production. Cell metabolism. vol 16. issue 4. 2013-03-07. PMID:23040071. |
insulin activates pi3-kinase (pi3k)/akt to regulate glucose homeostasis in the peripheral tissues and the mediobasal hypothalamus (mbh) of rodents. |
2013-03-07 |
2023-08-12 |
mouse |
| Melissa L Borg, Simin Fallah Omran, Jacquelyn Weir, Peter J Meikle, Matthew J Wat. Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice. The Journal of physiology. vol 590. issue 17. 2013-02-11. PMID:22674717. |
lipids known to induce insulin resistance, including ceramide (22%↑), diacylglycerol (25%↑), lysophosphatidylcholine (17%↑), cholesterol esters (60%↑) and dihexosylceramide (33%↑), were increased in the hypothalamus of hfd vs. lfd mice. |
2013-02-11 |
2023-08-12 |
mouse |
| A E Relling, K Lee, S C Loerch, C K Reynold. Effects of glucose, propionate and splanchnic hormones on neuropeptide mRNA concentrations in the ovine hypothalamus. Journal of animal physiology and animal nutrition. vol 96. issue 4. 2013-01-29. PMID:21732994. |
results of the present study are consistent with the concept that effects of propionate on feed intake in ruminants is not mediated through direct effects on the hypothalamus, and that insulin is required for an effect of glucose on hypothalamic pomc expression. |
2013-01-29 |
2023-08-12 |
Not clear |
| Xiaomei Liu, Ying Qi, Hong Gao, Yisheng Jiao, Hui Gu, Jianing Miao, Zhengwei Yua. Maternal protein restriction induces alterations in insulin signaling and ATP sensitive potassium channel protein in hypothalami of intrauterine growth restriction fetal rats. Journal of clinical biochemistry and nutrition. vol 52. issue 1. 2013-01-24. PMID:23341697. |
to investigate the mechanisms behind this "metabolic imprinting" phenomenon, we examined the impact of maternal undernutrition on insulin signaling pathway and the atp sensitive potassium channel expression in the hypothalamus of intrauterine growth restriction fetus. |
2013-01-24 |
2023-08-12 |
rat |
| Xiaomei Liu, Ying Qi, Hong Gao, Yisheng Jiao, Hui Gu, Jianing Miao, Zhengwei Yua. Maternal protein restriction induces alterations in insulin signaling and ATP sensitive potassium channel protein in hypothalami of intrauterine growth restriction fetal rats. Journal of clinical biochemistry and nutrition. vol 52. issue 1. 2013-01-24. PMID:23341697. |
our data suggested that aberrant intrauterine milieu impaired insulin signaling in the hypothalamus, and these alterations early in life might contribute to the predisposition of the intrauterine growth restriction fetus toward the adult metabolic disorders. |
2013-01-24 |
2023-08-12 |
rat |
| Shaona Niu, Hao Wang, Zhenbo Huang, Xiurong Rao, Xiangsheng Cai, Tao Liang, Jing Xu, Xingshun Xu, Guoqing Shen. Expression changes of hypothalamic Ahi1 in mice brain: implication in sensing insulin signaling. Molecular biology reports. vol 39. issue 10. 2013-01-14. PMID:22740139. |
our study provides the evidence for the role of abelson helper integration site 1 (ahi1) protein as a sensor of insulin signaling in the hypothalamus. |
2013-01-14 |
2023-08-12 |
mouse |
| Eva Rother, Bengt F Belgardt, Eva Tsaousidou, Brigitte Hampel, Ari Waisman, Martin G Myers, Jens C Brünin. Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 44. 2013-01-08. PMID:23064638. |
rat insulin promoter (rip)-expressing neurons in the hypothalamus control body weight and energy homeostasis. |
2013-01-08 |
2023-08-12 |
mouse |
| Ji Hee Yu, Min-Seon Ki. Molecular mechanisms of appetite regulation. Diabetes & metabolism journal. vol 36. issue 6. 2013-01-01. PMID:23275931. |
the adipocyte-derived hormone leptin and pancreatic β-cell-derived insulin inform adiposity to the hypothalamus. |
2013-01-01 |
2023-08-12 |
Not clear |
| Ozanna Burnicka-Turek, Belal A Mohamed, Katayoon Shirneshan, Thatchawan Thanasupawat, Sabine Hombach-Klonisch, Thomas Klonisch, Ibrahim M Adha. INSL5-deficient mice display an alteration in glucose homeostasis and an impaired fertility. Endocrinology. vol 153. issue 10. 2012-12-11. PMID:22822165. |
insulin-like factor 5 (insl5), a member of the insulin superfamily, is expressed in the colorectum and hypothalamus. |
2012-12-11 |
2023-08-12 |
mouse |
| Prasad S Dalvi, Frederick D Erbiceanu, David M Irwin, Denise D Belsha. Direct regulation of the proglucagon gene by insulin, leptin, and cAMP in embryonic versus adult hypothalamic neurons. Molecular endocrinology (Baltimore, Md.). vol 26. issue 8. 2012-12-10. PMID:22669740. |
whether leptin, insulin, or camp activation controls proglucagon gene expression in the hypothalamus is not known. |
2012-12-10 |
2023-08-12 |
Not clear |
| Thomas Scherer, Claudia Lindtner, Elizabeth Zielinski, James O'Hare, Nika Filatova, Christoph Buettne. Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis. The Journal of biological chemistry. vol 287. issue 39. 2012-12-07. PMID:22810223. |
rats were studied by euglycemic pancreatic clamps and concomitant infusion of either insulin or vehicle into the mediobasal hypothalamus. |
2012-12-07 |
2023-08-12 |
human |