| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tsutomu Sasaki, Tadahiro Kitamur. Roles of FoxO1 and Sirt1 in the central regulation of food intake. Endocrine journal. vol 57. issue 11. 2011-04-11. PMID:21048357. |
foxo1 is a downstream effecter of insulin signaling and sirt1 is an nad(+)-dependent deacetylase, both of which have been reported to play important roles in the regulation of metabolism in various organs including liver, pancreas, muscle, adipose tissue and hypothalamus. |
2011-04-11 |
2023-08-12 |
Not clear |
| Emily J Gallagher, Derek Leroith, Eddy Karniel. Insulin resistance in obesity as the underlying cause for the metabolic syndrome. The Mount Sinai journal of medicine, New York. vol 77. issue 5. 2011-04-07. PMID:20960553. |
insulin signaling in the brain decreases appetite and prevents glucose production by the liver through neuronal signals from the hypothalamus. |
2011-04-07 |
2023-08-12 |
Not clear |
| Marta Conde-Sieira, Maria J Agulleiro, Ariel J Aguilar, Jesús M Míguez, José M Cerdá-Reverter, José L Soenga. Effect of different glycaemic conditions on gene expression of neuropeptides involved in control of food intake in rainbow trout; interaction with stress. The Journal of experimental biology. vol 213. issue Pt 22. 2011-02-24. PMID:21037065. |
to assess mechanisms relating to food intake and glucosensing in fish, and their interaction with stress, we evaluated changes in the expression of orexigenic (npy) and anorexigenic (pomc, cart and crf) peptides in central glucosensing areas (hypothalamus and hindbrain) of rainbow trout subjected to normoglycaemic (control), hypoglycaemic (4 mg insulin kg(-1)) or hyperglycaemic (500 mg glucose kg(-1)) conditions for 6 h under normal stocking density (nsd; 10 kg fish mass m(-3)) or under stress conditions induced by high stocking density (hsd; 70 kg fish mass m(-3)). |
2011-02-24 |
2023-08-12 |
Not clear |
| Laura J Fick, Denise D Belsha. Nutrient sensing and insulin signaling in neuropeptide-expressing immortalized, hypothalamic neurons: A cellular model of insulin resistance. Cell cycle (Georgetown, Tex.). vol 9. issue 16. 2011-01-18. PMID:20697199. |
these two interrelated diseases are typified by perturbed insulin signaling in the hypothalamus. |
2011-01-18 |
2023-08-12 |
Not clear |
| Lucilla Posto. Developmental programming and diabetes - The human experience and insight from animal models. Best practice & research. Clinical endocrinology & metabolism. vol 24. issue 4. 2011-01-07. PMID:20832735. |
animal models demonstrate that maternal hyperglycaemia leads to persistent disorders of offspring pancreatic β cell secretory capacity, abnormal insulin signaling in insulin-sensitive tissues and abnormal development of the hypothalamus, associated with aberrant control of energy regulation and obesity in adult life. |
2011-01-07 |
2023-08-12 |
human |
| Christiane Koch, Rachael A Augustine, Juliane Steger, Goutham K Ganjam, Jonas Benzler, Corinna Pracht, Chrishanthi Lowe, Michael W Schwartz, Peter R Shepherd, Greg M Anderson, David R Grattan, Alexander Tup. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 48. 2011-01-06. PMID:21123564. |
unlike insulin, however, the anti-diabetic effect of leptin occurred independently of phospho-akt, a major downstream target of pi3k, and instead involved enhanced sensitivity of the hypothalamus to insulin action upstream of pi3k, through modulation of irs1 (insulin receptor substrate 1) phosphorylation. |
2011-01-06 |
2023-08-12 |
mouse |
| Eduardo R Ropelle, Marcelo B Flores, Dennys E Cintra, Guilherme Z Rocha, José R Pauli, Joseane Morari, Claudio T de Souza, Juliana C Moraes, Patrícia O Prada, Dioze Guadagnini, Rodrigo M Marin, Alexandre G Oliveira, Taize M Augusto, Hernandes F Carvalho, Lício A Velloso, Mario J A Saad, José B C Carvalheir. IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS biology. vol 8. issue 8. 2010-12-13. PMID:20808781. |
overnutrition caused by overeating is associated with insulin and leptin resistance through ikkbeta activation and endoplasmic reticulum (er) stress in the hypothalamus. |
2010-12-13 |
2023-08-12 |
mouse |
| Eduardo R Ropelle, Marcelo B Flores, Dennys E Cintra, Guilherme Z Rocha, José R Pauli, Joseane Morari, Claudio T de Souza, Juliana C Moraes, Patrícia O Prada, Dioze Guadagnini, Rodrigo M Marin, Alexandre G Oliveira, Taize M Augusto, Hernandes F Carvalho, Lício A Velloso, Mario J A Saad, José B C Carvalheir. IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS biology. vol 8. issue 8. 2010-12-13. PMID:20808781. |
hence, inflammatory signaling in the hypothalamus links beneficial physiological effects of exercise to the central action of insulin and leptin. |
2010-12-13 |
2023-08-12 |
mouse |
| A Tups, G M Anderson, M Rizwan, R A Augustine, C Chaussade, P R Shepherd, D R Gratta. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of neuroendocrinology. vol 22. issue 6. 2010-11-01. PMID:20236230. |
both p110alpha and p110beta isoforms of phosphatidylinositol 3-oh-kinase are required for insulin signalling in the hypothalamus. |
2010-11-01 |
2023-08-12 |
rat |
| A Tups, G M Anderson, M Rizwan, R A Augustine, C Chaussade, P R Shepherd, D R Gratta. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of neuroendocrinology. vol 22. issue 6. 2010-11-01. PMID:20236230. |
both insulin and leptin action in the brain are considered to involve activation of phosphoinositide 3-kinase (pi3k), although the roles of different pi3k isoforms in insulin signalling in the hypothalamus are unknown. |
2010-11-01 |
2023-08-12 |
rat |
| A Tups, G M Anderson, M Rizwan, R A Augustine, C Chaussade, P R Shepherd, D R Gratta. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of neuroendocrinology. vol 22. issue 6. 2010-11-01. PMID:20236230. |
unlike insulin, leptin did not induce phosphorylated akt in the hypothalamus, as detected by immunohistochemistry, and the anorectic effects of leptin were not affected by pre-treatment with a combination of p110alpha and p110beta inhibitors. |
2010-11-01 |
2023-08-12 |
rat |
| A Tups, G M Anderson, M Rizwan, R A Augustine, C Chaussade, P R Shepherd, D R Gratta. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of neuroendocrinology. vol 22. issue 6. 2010-11-01. PMID:20236230. |
the data suggest that p110alpha and p110beta isoforms of pi3k are necessary to mediate insulin action in the hypothalamus. |
2010-11-01 |
2023-08-12 |
rat |
| François P Pralon. Insulin and NPY pathways and the control of GnRH function and puberty onset. Molecular and cellular endocrinology. vol 324. issue 1-2. 2010-10-05. PMID:20138117. |
leptin and insulin are among the metabolic factors signaling the nutritional status of an individual to the hypothalamus, and their role in the overall modulation of the activity of gnrh neurons is increasingly recognized. |
2010-10-05 |
2023-08-12 |
Not clear |
| Joshua P Thaler, Michael W Schwart. Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology. vol 151. issue 9. 2010-10-04. PMID:20573720. |
recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. |
2010-10-04 |
2023-08-12 |
Not clear |
| Kelly A Diggs-Andrews, Xuezhao Zhang, Zhentao Song, Dorit Daphna-Iken, Vanessa H Routh, Simon J Fishe. Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia. Diabetes. vol 59. issue 9. 2010-09-23. PMID:20547974. |
this study tests the hypothesis that insulin acts directly in the brain to regulate critical glucose-sensing neurons in the hypothalamus to mediate the counterregulatory response to hypoglycemia. |
2010-09-23 |
2023-08-12 |
Not clear |
| Sara A Divall, Tameeka R Williams, Sarah E Carver, Linda Koch, Jens C Brüning, C Ronald Kahn, Fredric Wondisford, Sally Radovick, Andrew Wolf. Divergent roles of growth factors in the GnRH regulation of puberty in mice. The Journal of clinical investigation. vol 120. issue 8. 2010-09-02. PMID:20628204. |
anabolic factors that may signal nutritional status to the hypothalamus include the growth factors insulin and igf-1. |
2010-09-02 |
2023-08-12 |
mouse |
| Meng-Jie Yang, Fang Wang, Jiang-Hua Wang, Wen-Ning Wu, Zhuang-Li Hu, Jin Cheng, Dan-Fang Yu, Li-Hong Long, Hui Fu, Na Xie, Jian-Guo Che. PI3K integrates the effects of insulin and leptin on large-conductance Ca2+-activated K+ channels in neuropeptide Y neurons of the hypothalamic arcuate nucleus. American journal of physiology. Endocrinology and metabolism. vol 298. issue 2. 2010-09-01. PMID:19671839. |
the adipocyte-derived hormone leptin and the pancreatic beta-cell-derived hormone insulin function as afferent signals to the hypothalamus in an endocrine feedback loop that regulates body adiposity. |
2010-09-01 |
2023-08-12 |
Not clear |
| Jennifer W Hill, Carol F Elias, Makoto Fukuda, Kevin W Williams, Eric D Berglund, William L Holland, You-Ree Cho, Jen-Chieh Chuang, Yong Xu, Michelle Choi, Danielle Lauzon, Charlotte E Lee, Roberto Coppari, James A Richardson, Jeffrey M Zigman, Streamson Chua, Philipp E Scherer, Bradford B Lowell, Jens C Brüning, Joel K Elmquis. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell metabolism. vol 11. issue 4. 2010-08-17. PMID:20374961. |
circulating leptin and insulin convey information regarding energy stores to the central nervous system, particularly the hypothalamus. |
2010-08-17 |
2023-08-12 |
mouse |
| Ewan C McNay, Cecilia T Ong, Rory J McCrimmon, James Cresswell, Jonathan S Bogan, Robert S Sherwi. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiology of learning and memory. vol 93. issue 4. 2010-07-30. PMID:20176121. |
insulin regulates glucose uptake and storage in peripheral tissues, and has been shown to act within the hypothalamus to acutely regulate food intake and metabolism. |
2010-07-30 |
2023-08-12 |
rat |
| Ewan C McNay, Cecilia T Ong, Rory J McCrimmon, James Cresswell, Jonathan S Bogan, Robert S Sherwi. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiology of learning and memory. vol 93. issue 4. 2010-07-30. PMID:20176121. |
the machinery for transduction of insulin signaling is also present in other brain areas, particularly in the hippocampus, but a physiological role for brain insulin outside the hypothalamus has not been established. |
2010-07-30 |
2023-08-12 |
rat |