| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joshua P Thaler, Sun Ju Choi, Mini P Sajan, Kayoko Ogimoto, Hong T Nguyen, Miles Matsen, Stephen C Benoit, Brent E Wisse, Robert V Farese, Michael W Schwart. Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819945. |
immunohistochemistry analysis revealed that apkc is expressed in the arcuate and paraventricular nuclei of the hypothalamus, key sites of leptin, insulin, and lps action. |
2010-01-19 |
2023-08-12 |
Not clear |
| Erika A F R Roman, Daniel Reis, Talita Romanatto, Denis Maimoni, Eduardo A Ferreira, Gustavo A Santos, Adriana S Torsoni, Licio A Velloso, Marcio A Torson. Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Molecular and cellular endocrinology. vol 314. issue 1. 2010-01-11. PMID:19698760. |
thus, a defective leptin signalling pi3k pathway in the hypothalamus may contribute to peripheral resistance to insulin associated to diet-induced obesity. |
2010-01-11 |
2023-08-12 |
rat |
| Hiraku On. The hypothalamus bridges the gap between physiology and biochemistry in high-fat diet-induced hepatic insulin resistance. Cell cycle (Georgetown, Tex.). vol 8. issue 18. 2009-12-30. PMID:19738432. |
the hypothalamus bridges the gap between physiology and biochemistry in high-fat diet-induced hepatic insulin resistance. |
2009-12-30 |
2023-08-12 |
Not clear |
| Hiraku On. The hypothalamus bridges the gap between physiology and biochemistry in high-fat diet-induced hepatic insulin resistance. Cell cycle (Georgetown, Tex.). vol 8. issue 18. 2009-12-30. PMID:19738432. |
there are both direct and indirect pathways by which insulin suppresses hepatic glucose production, and the indirect pathway via the hypothalamus is particularly impaired under relatively short-term overfeeding conditions, which in turn leads to compensatory enhancement of insulin signaling in the liver. |
2009-12-30 |
2023-08-12 |
Not clear |
| Alfonso Abizai. Ghrelin and dopamine: new insights on the peripheral regulation of appetite. Journal of neuroendocrinology. vol 21. issue 9. 2009-12-21. PMID:19523165. |
on the basis of these data as well as the fact that vta dopamine cells respond to other metabolic hormones such as insulin and leptin, it is proposed that vta dopamine cells, similar to cells in the mediobasal hypothalamus, are first-order sensory neurones that regulate appetitive behaviour in response to metabolic and nutritional signals. |
2009-12-21 |
2023-08-12 |
Not clear |
| Stéphane Boghossian, Karalee Lemmon, Miejung Park, David A Yor. High-fat diets induce a rapid loss of the insulin anorectic response in the amygdala. American journal of physiology. Regulatory, integrative and comparative physiology. vol 297. issue 5. 2009-12-03. PMID:19726717. |
cea insulin increased c-fos in multiple brain regions, including the arcuate nucleus/paraventricular nucleus region of the hypothalamus. |
2009-12-03 |
2023-08-12 |
rat |
| T Yamauchi, T Kadowak. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. International journal of obesity (2005). vol 32 Suppl 7. 2009-10-29. PMID:19136982. |
further conclusions are that decreased adiponectin action and increased monocyte chemoattractant protein-1 (mcp-1) form a vicious adipokine network causing obesity-linked insulin resistance and metabolic syndrome; ppargamma upregulates hmw adiponectin and pparalpha upregulates adipors; that dietary osmotin can serve as a naturally occurring adiponectin receptor agonist; and finally, that under starvation conditions, mmw adiponectin activates ampk in hypothalamus, and promotes food intake, and at the same time hmw adiponectin activates ampk in peripheral tissues, such as skeletal muscle, and stimulates fatty-acids combustion. |
2009-10-29 |
2023-08-12 |
Not clear |
| Jonathan German, Francis Kim, Gary J Schwartz, Peter J Havel, Christopher J Rhodes, Michael W Schwartz, Gregory J Morto. Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology. vol 150. issue 10. 2009-10-22. PMID:19574396. |
recent evidence suggests that hormones such as insulin and leptin act in the hypothalamus to regulate energy balance and glucose metabolism. |
2009-10-22 |
2023-08-12 |
rat |
| Stephen C Benoit, Christopher J Kemp, Carol F Elias, William Abplanalp, James P Herman, Stephanie Migrenne, Anne-Laure Lefevre, Céline Cruciani-Guglielmacci, Christophe Magnan, Fang Yu, Kevin Niswender, Boman G Irani, William L Holland, Deborah J Cleg. Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. The Journal of clinical investigation. vol 119. issue 9. 2009-10-02. PMID:19726875. |
cns exposure to palmitic acid via direct infusion or by oral gavage increased the localization of pkc-theta to cell membranes in the hypothalamus, which was associated with impaired hypothalamic insulin and leptin signaling. |
2009-10-02 |
2023-08-12 |
mouse |
| Eduardo R Ropelle, José R Pauli, Patrícia Prada, Dennys E Cintra, Guilherme Z Rocha, Juliana C Moraes, Marisa J S Frederico, Gabrielle da Luz, Ricardo A Pinho, José B C Carvalheira, Licio A Velloso, Mario A Saad, Cláudio T De Souz. Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. The Journal of physiology. vol 587. issue Pt 10. 2009-09-03. PMID:19332486. |
insulin signalling in the hypothalamus plays a role in maintaining body weight. |
2009-09-03 |
2023-08-12 |
rat |
| Eduardo R Ropelle, José R Pauli, Patrícia Prada, Dennys E Cintra, Guilherme Z Rocha, Juliana C Moraes, Marisa J S Frederico, Gabrielle da Luz, Ricardo A Pinho, José B C Carvalheira, Licio A Velloso, Mario A Saad, Cláudio T De Souz. Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. The Journal of physiology. vol 587. issue Pt 10. 2009-09-03. PMID:19332486. |
the forkhead transcription factor foxo1 is an important mediator of insulin signalling in the hypothalamus. |
2009-09-03 |
2023-08-12 |
rat |
| José M Carrascosa, Manuel Ros, Antonio Andrés, Teresa Fernández-Agulló, Carmen Arriba. Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging. Experimental gerontology. vol 44. issue 1-2. 2009-08-05. PMID:18572339. |
here we review the mechanisms of action of leptin and insulin in the hypothalamus and how these mechanisms are altered during aging in rat models. |
2009-08-05 |
2023-08-12 |
rat |
| José M Carrascosa, Manuel Ros, Antonio Andrés, Teresa Fernández-Agulló, Carmen Arriba. Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging. Experimental gerontology. vol 44. issue 1-2. 2009-08-05. PMID:18572339. |
moreover, leptin and insulin signaling are decreased in hypothalamus from aged rats. |
2009-08-05 |
2023-08-12 |
rat |
| José M Carrascosa, Manuel Ros, Antonio Andrés, Teresa Fernández-Agulló, Carmen Arriba. Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging. Experimental gerontology. vol 44. issue 1-2. 2009-08-05. PMID:18572339. |
more studies are necessary to clarify the role of the hypothalamus in the development of age-associated obesity and insulin resistance. |
2009-08-05 |
2023-08-12 |
rat |
| Juliana C Moraes, Andressa Coope, Joseane Morari, Dennys E Cintra, Erika A Roman, José R Pauli, Talita Romanatto, José B Carvalheira, Alexandre L R Oliveira, Mario J Saad, Licio A Vellos. High-fat diet induces apoptosis of hypothalamic neurons. PloS one. vol 4. issue 4. 2009-07-14. PMID:19340313. |
in rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic signaling in the hypothalamus by a mechanism dependent on the in situ activation of inflammation. |
2009-07-14 |
2023-08-12 |
Not clear |
| Juliana C Moraes, Andressa Coope, Joseane Morari, Dennys E Cintra, Erika A Roman, José R Pauli, Talita Romanatto, José B Carvalheira, Alexandre L R Oliveira, Mario J Saad, Licio A Vellos. High-fat diet induces apoptosis of hypothalamic neurons. PloS one. vol 4. issue 4. 2009-07-14. PMID:19340313. |
in diet-induced inflammation of the hypothalamus, tlr4 exerts a dual function, on one side activating pro-inflammatory pathways that play a central role in the development of resistance to leptin and insulin, and on the other side restraining further damage by controlling the apoptotic activity. |
2009-07-14 |
2023-08-12 |
Not clear |
| Malathi Srinivasan, Paul Mitrani, Gigani Sadhanandan, Catherine Dodds, Suhad Shbeir-ElDika, Shanthie Thamotharan, Hussam Ghanim, Paresh Dandona, Sherin U Devaskar, Mulchand S Pate. A high-carbohydrate diet in the immediate postnatal life of rats induces adaptations predisposing to adult-onset obesity. The Journal of endocrinology. vol 197. issue 3. 2009-07-07. PMID:18492820. |
further investigation of insulin signaling in the hypothalamus of hc rats indicated significant decreases in the proximal signaling components (insulin receptor substrate proteins 1 and 2 and phosphotidylinositol 3-kinase) in 100-day-old hc rats. |
2009-07-07 |
2023-08-12 |
rat |
| Mariona Palou, Juana Sánchez, Ana M Rodríguez, Teresa Priego, Catalina Picó, Andreu Palo. Induction of NPY/AgRP orexigenic peptide expression in rat hypothalamus is an early event in fasting: relationship with circulating leptin, insulin and glucose. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 23. issue 1-3. 2009-06-16. PMID:19255506. |
induction of npy/agrp orexigenic peptide expression in rat hypothalamus is an early event in fasting: relationship with circulating leptin, insulin and glucose. |
2009-06-16 |
2023-08-12 |
rat |
| Kent K Ishihara, Samuel C Haywood, Dorit Daphna-Iken, Erwin C Puente, Simon J Fishe. Brain insulin infusion does not augment the counterregulatory response to hypoglycemia or glucoprivation. Metabolism: clinical and experimental. vol 58. issue 6. 2009-06-10. PMID:19375131. |
we hypothesized that a direct infusion of insulin into the third ventricle and/or the mediobasal hypothalamus (mbh) would amplify the sympathoadrenal response to hypoglycemia. |
2009-06-10 |
2023-08-12 |
rat |
| Sophie M Banas, Claude Rouch, Nadim Kassis, Eirini M Markaki, Kyriaki Gerozissi. A dietary fat excess alters metabolic and neuroendocrine responses before the onset of metabolic diseases. Cellular and molecular neurobiology. vol 29. issue 2. 2009-05-08. PMID:18773289. |
the release of serotonin, which is closely associated with the actions of insulin and leptin, was measured, by electrochemical detection following reverse-phase liquid chromatography (hplc), in the extracellular space of the medial hypothalamus and the dorsal hippocampus in samples obtained from non-anesthetized animals, by microdialysis. |
2009-05-08 |
2023-08-12 |
rat |