| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clifford J Rosen, Anne Klibansk. Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis. The American journal of medicine. vol 122. issue 5. 2009-05-07. PMID:19375545. |
the hypothalamus modulates fat and bone via the sympathetic nervous system by regulating appetite, insulin sensitivity, energy use, and skeletal remodeling. |
2009-05-07 |
2023-08-12 |
Not clear |
| Marciane Milanski, Giovanna Degasperi, Andressa Coope, Joseane Morari, Raphael Denis, Dennys E Cintra, Daniela M L Tsukumo, Gabriel Anhe, Maria E Amaral, Hilton K Takahashi, Rui Curi, Helena C Oliveira, José B C Carvalheira, Silvana Bordin, Mário J Saad, Lício A Vellos. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 2. 2009-04-08. PMID:19144836. |
in animal models of diet-induced obesity, the activation of an inflammatory response in the hypothalamus produces molecular and functional resistance to the anorexigenic hormones insulin and leptin. |
2009-04-08 |
2023-08-12 |
mouse |
| J E de Leeuw van Weenen, L Hu, K Jansen-Van Zelm, M G de Vries, J T Tamsma, J A Romijn, H Pij. Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice. Brain research. vol 1250. 2009-02-27. PMID:19028458. |
four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of c57bl6 mice. |
2009-02-27 |
2023-08-12 |
mouse |
| J E de Leeuw van Weenen, L Hu, K Jansen-Van Zelm, M G de Vries, J T Tamsma, J A Romijn, H Pij. Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice. Brain research. vol 1250. 2009-02-27. PMID:19028458. |
we show here that short term high fat feeding does not affect dopaminergic neurotransmission in the hypothalamus, whereas it does impair insulin action. |
2009-02-27 |
2023-08-12 |
mouse |
| Lício A Velloso, Eliana P Araújo, Cláudio T de Souz. Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation. vol 15. issue 3. 2009-02-20. PMID:18781083. |
recent studies have revealed that the consumption of fat-rich foods can activate an inflammatory response in the hypothalamus, which disturbs the anorexigenic and thermogenic signals generated by the hormones leptin and insulin, leading in turn to anomalous body mass control. |
2009-02-20 |
2023-08-12 |
Not clear |
| Lício A Velloso, Eliana P Araújo, Cláudio T de Souz. Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation. vol 15. issue 3. 2009-02-20. PMID:18781083. |
here, we present the mechanisms involved in diet-induced resistance to leptin and insulin action in the hypothalamus and discuss some of the potential applications of this knowledge in the therapeutics of obesity. |
2009-02-20 |
2023-08-12 |
Not clear |
| Dianne P Figlewicz, Stephen C Benoi. Insulin, leptin, and food reward: update 2008. American journal of physiology. Regulatory, integrative and comparative physiology. vol 296. issue 1. 2009-02-06. PMID:18945945. |
in a previous review, we described new research demonstrating that, in addition to these direct homeostatic actions at the hypothalamus, cns circuitry that subserves reward and motivation is also a direct and an indirect target for insulin and leptin action. |
2009-02-06 |
2023-08-12 |
Not clear |
| Golnaz Madadi, Prasad S Dalvi, Denise D Belsha. Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1. Biochemical and biophysical research communications. vol 376. issue 4. 2008-11-13. PMID:18809381. |
the insulin cis-regulatory regions differ between the pancreas and the hypothalamus, and glucose and glp-1 regulate the expression of hypothalamic insulin. |
2008-11-13 |
2023-08-12 |
mouse |
| Kyriaki Gerozissi. Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies. European journal of pharmacology. vol 585. issue 1. 2008-10-31. PMID:18407262. |
the action of insulin in the brain is under a multilevel control via metabolic, endocrine and neural signals induced by nutrients, integrated mainly by the hypothalamus. |
2008-10-31 |
2023-08-12 |
Not clear |
| Jun-Ichi Shiraishi, Kouchi Yanagita, Masanori Fujita, Takashi Bung. Micro-opioid receptor agonist diminishes POMC gene expression and anorexia by central insulin in neonatal chicks. Neuroscience letters. vol 439. issue 3. 2008-09-26. PMID:18534752. |
pro-opiomelanocortin (pomc) neurons in the hypothalamus are direct targets of peripheral satiety signals, such as leptin and insulin in mammals. |
2008-09-26 |
2023-08-12 |
Not clear |
| Hiraku Ono, Alessandro Pocai, Yuhua Wang, Hideyuki Sakoda, Tomoichiro Asano, Jonathan M Backer, Gary J Schwartz, Luciano Rossett. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. The Journal of clinical investigation. vol 118. issue 8. 2008-09-25. PMID:18618016. |
extending previous findings that insulin suppresses hepatic glucose production (hgp) partly via its effect in the hypothalamus, we report that this effect was blunted by short-term high-fat diet (hfd) feeding, with concomitant suppression of insulin signaling and activation of s6k in the mediobasal hypothalamus (mbh). |
2008-09-25 |
2023-08-12 |
mouse |
| Vladimir Strbák, Julius Benicky, Susan E Greer, Zuzana Bacova, Miroslava Najvirtova, Monte A Gree. Cell swelling-induced peptide hormone secretion. Advances in experimental medicine and biology. vol 559. 2008-09-12. PMID:18727251. |
secretion of essentially all so-packaged hormones including those from hypothalamus (thyrotropin-releasing hormone, trh; gonadotropin-releasing hormone, gnrh), pituitary (lh, fsh, acth, msh, tsh, prolactin, beta endorphin), pancreas (insulin, somatostatin, glucagon), heart (atrial natriuretic hormone) and kidney (renin) are stimulated in a concentration-related manner by medium hyposmolarity or isosmolar medium containing permeant molecules such as ethanol or urea (reviewed in ref. |
2008-09-12 |
2023-08-12 |
human |
| Paty Karoll Picardi, Vivian Cristine Calegari, Patricia Oliveira Prada, Patrícia de Oliveira Prada, Juliana Contin Moraes, Eliana Araújo, Maria Cristina Cintra Gomes Marcondes, Miriam Ueno, José Barreto Campello Carvalheira, Licio Augusto Velloso, Mario José Abdalla Saa. Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology. vol 149. issue 8. 2008-08-26. PMID:18467448. |
the selective decrease in hypothalamic ptp1b resulted in decreased food intake, reduced body weight, reduced adiposity after high-fat feeding, improved leptin and insulin action and signaling in hypothalamus, and may also have a role in the improvement in glucose metabolism in diabetes-induced obese rats. |
2008-08-26 |
2023-08-12 |
mouse |
| Otto Tschritter, Anita M Hennige, Hubert Preissl, Katarina Porubska, Silke A Schäfer, Werner Lutzenberger, Fausto Machicao, Niels Birbaumer, Andreas Fritsche, Hans-Ulrich Härin. Cerebrocortical beta activity in overweight humans responds to insulin detemir. PloS one. vol 2. issue 11. 2008-08-21. PMID:18030331. |
this approach is based on studies in mice where we could recently demonstrate increased brain tissue concentrations of insulin and increased insulin signaling in the hypothalamus and cerebral cortex following peripheral injection of insulin detemir. |
2008-08-21 |
2023-08-12 |
mouse |
| H Tsuneki, S Murata, Y Anzawa, Y Soeda, E Tokai, T Wada, I Kimura, M Yanagisawa, T Sakurai, T Sasaok. Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice. Diabetologia. vol 51. issue 4. 2008-08-06. PMID:18256806. |
age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice. |
2008-08-06 |
2023-08-12 |
mouse |
| Andressa Coope, Marciane Milanski, Eliana P Araújo, Marcos Tambascia, Mário J A Saad, Bruno Geloneze, Lício A Vellos. AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS letters. vol 582. issue 10. 2008-07-09. PMID:18394428. |
thus, adiponectin acts in the hypothalamus, activating elements of the canonical insulin and leptin signaling pathways and promoting reduction of food intake. |
2008-07-09 |
2023-08-12 |
Not clear |
| Eliana P Araújo, Cláudio T De Souza, Mirian Ueno, Dennys E Cintra, Manoel B Bertolo, José B Carvalheira, Mário J Saad, Lício A Vellos. Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes. Endocrinology. vol 148. issue 12. 2008-06-17. PMID:17761768. |
in addition, the clinical outcomes were accompanied by improved insulin signal transduction in muscle, liver, and hypothalamus, as determined by the evaluation of insulin-induced insulin receptor, insulin receptor substrate-1, and receptor substrate-2 tyrosine phosphorylation and akt and forkhead box protein o1 serine phosphorylation. |
2008-06-17 |
2023-08-12 |
mouse |
| Isabel Matias, Anna Valeria Vergoni, Stefania Petrosino, Alessandra Ottani, Alessandro Pocai, Alfio Bertolini, Vincenzo Di Marz. Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17675101. |
here we investigated in the rat if insulin, which is known to exert fundamental actions at the level of the mediobasal hypothalamus (mbh), and the melanocortin system, namely alpha-melanocyte stimulating hormone (alpha-msh) and melanocortin receptor-4 (mcr-4), also regulate hypothalamic endocannabinoid levels, measured by isotope-dilution liquid chromatography coupled to mass spectrometry. |
2008-04-18 |
2023-08-12 |
rat |
| Satya P Kalr. Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides. vol 29. issue 1. 2008-04-07. PMID:18053615. |
furthermore, the leptin insufficiency syndrome delineates a novel role of leptin in the hypothalamus in restraining rhythmic pancreatic insulin secretion while concomitantly enhancing glucose metabolism and non-shivering thermogenic energy expenditure, sequelae that would otherwise promote fat accrual to store excess energy resulting from consumption of energy-enriched diets. |
2008-04-07 |
2023-08-12 |
Not clear |
| C A Grillo, K L Tamashiro, G G Piroli, S Melhorn, J T Gass, R J Newsom, L R Reznikov, A Smith, S P Wilson, R R Sakai, L P Reaga. Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. Physiology & behavior. vol 92. issue 4. 2008-01-29. PMID:17585961. |
to further examine the role of irs in the central actions of insulin, we designed an ir antisense lentiviral vector (lv-iras) and injected this vector into the third ventricle to selectively decrease ir expression in the rat hypothalamus. |
2008-01-29 |
2023-08-12 |
rat |