| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P N Eswar Shankar, Anu Joseph, C S Paulos. Decreased [3H] YM-09151-2 binding to dopamine D2 receptors in the hypothalamus, brainstem and pancreatic islets of streptozotocin-induced diabetic rats. European journal of pharmacology. vol 557. issue 2-3. 2007-05-04. PMID:17174299. |
thus our results suggest that the decreased dopamine d2 receptor function in the hypothalamus, brainstem and pancreas affects insulin secretion in diabetic rats, which has immense clinical relevance to the management of diabetes. |
2007-05-04 |
2023-08-12 |
rat |
| Lewis Landsber. Feast or famine: the sympathetic nervous system response to nutrient intake. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16705481. |
diet-induced changes in sns activity are regulated by insulin-mediated glucose uptake and metabolism in central neurons sensitive to insulin and located anatomically in the ventro-medial hypothalamus. |
2007-04-24 |
2023-08-12 |
Not clear |
| Olga Hrytsenko, James R Wright, Carol M Morrison, Bill Pohajda. Insulin expression in the brain and pituitary cells of tilapia (Oreochromis niloticus). Brain research. vol 1135. issue 1. 2007-04-05. PMID:17196948. |
the highest level of insulin mrna was found in the hypothalamus. |
2007-04-05 |
2023-08-12 |
Not clear |
| Olga Hrytsenko, James R Wright, Carol M Morrison, Bill Pohajda. Insulin expression in the brain and pituitary cells of tilapia (Oreochromis niloticus). Brain research. vol 1135. issue 1. 2007-04-05. PMID:17196948. |
the level of insulin transcription in the pituitary gland was 6-fold higher than that in the brain and 4.6-fold higher than that in the hypothalamus. |
2007-04-05 |
2023-08-12 |
Not clear |
| Lício A Vellos. [The hypothalamic control of feeding and thermogenesis: implications on the development of obesity]. Arquivos brasileiros de endocrinologia e metabologia. vol 50. issue 2. 2007-03-08. PMID:16767283. |
it will be focused on the actions of leptin and insulin in the hypothalamus and will explore the hypothesis that hypothalamic resistance to the action of these hormones may play a role in the development of obesity and may act as a molecular link between obesity, type 2 diabetes mellitus and other clinical conditions on which insulin resistance plays an important pathogenetic role. |
2007-03-08 |
2023-08-12 |
Not clear |
| Mario Luís Ribeiro Cesaretti, Osvaldo Kohlmann Junio. [Experimental models of insulin resistance and obesity: lessons learned]. Arquivos brasileiros de endocrinologia e metabologia. vol 50. issue 2. 2007-03-08. PMID:16767285. |
experimental obesity and insulin resistance can be due to a deficient response to leptin, secondary to hypoleptinemia and/or mutations on leptin receptor, by modifications on insulin receptor, deletion or diminished insulin signal transduction, enhancement of the effects of orexigen peptides and/or diminution of anorexigen peptides actions on hypothalamus, as well as secondary to arterial hypertension, as in the spontaneously hypertension. |
2007-03-08 |
2023-08-12 |
Not clear |
| Mario Luís Ribeiro Cesaretti, Osvaldo Kohlmann Junio. [Experimental models of insulin resistance and obesity: lessons learned]. Arquivos brasileiros de endocrinologia e metabologia. vol 50. issue 2. 2007-03-08. PMID:16767285. |
obesity and insulin resistance can also be induced by glucocorticoid excess, frutose enriched and cafeteria diet and due to hypothalamus lesions induced by neonatal administration of monossodium glutamate. |
2007-03-08 |
2023-08-12 |
Not clear |
| Stephen C Woods, Thomas A Lutz, Nori Geary, Wolfgang Langhan. Pancreatic signals controlling food intake; insulin, glucagon and amylin. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 361. issue 1471. 2007-02-15. PMID:16815800. |
insulin acts directly at the liver to suppress the synthesis and secretion of glucose, and some plasma insulin is transported into the brain and especially the mediobasal hypothalamus where it elicits a net catabolic response, particularly reduced food intake and loss of body weight. |
2007-02-15 |
2023-08-12 |
Not clear |
| Andreas Plagemann, Helga Davidowa, Thomas Harder, Joachim W Dudenhause. Developmental programming of the hypothalamus: a matter of insulin. A comment on: Horvath, T. L., Bruning, J. C.: Developmental programming of the hypothalamus: a matter of fat. Nat. Med. (2006) 12: 52-53. Neuro endocrinology letters. vol 27. issue 1-2. 2007-01-17. PMID:16648802. |
developmental programming of the hypothalamus: a matter of insulin. |
2007-01-17 |
2023-08-12 |
Not clear |
| Daniela F Bertelli, Eliana P Araújo, Maristela Cesquini, Graziela R Stoppa, Miriam Gasparotto-Contessotto, Marcos H Toyama, Jorge V C Felix, José B Carvalheira, Lisete C Michelini, Silvana Chiavegatto, Antonio C Boschero, Mario J A Saad, Iscia Lopes-Cendes, Licio A Vellos. Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology. vol 147. issue 11. 2006-11-20. PMID:16916951. |
the enzyme phosphatidylinositol 3-kinase (pi3-kinase) exerts an important role in the transduction of the anorexigenic and thermogenic signals delivered by insulin and leptin to first-order neurons of the arcuate nucleus in the hypothalamus. |
2006-11-20 |
2023-08-12 |
rat |
| Daniela F Bertelli, Eliana P Araújo, Maristela Cesquini, Graziela R Stoppa, Miriam Gasparotto-Contessotto, Marcos H Toyama, Jorge V C Felix, José B Carvalheira, Lisete C Michelini, Silvana Chiavegatto, Antonio C Boschero, Mario J A Saad, Iscia Lopes-Cendes, Licio A Vellos. Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology. vol 147. issue 11. 2006-11-20. PMID:16916951. |
to evaluate the participation of 5ptase iv in insulin action in hypothalamus, we used a phosphorthioate-modified antisense oligonucleotide specific for this enzyme. |
2006-11-20 |
2023-08-12 |
rat |
| Naohiko Ueno, Akio Inui, Pushpa S Kalra, Satya P Kalr. Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice. Peptides. vol 27. issue 9. 2006-11-07. PMID:16621153. |
these findings endorse the hypothesis that increased leptin action locally in the hypothalamus can impose euglycemia independent of pancreatic insulin, and central leptin reinforcement may serve as a newer adjunct therapy to treat type 1 and type 2 diabetes. |
2006-11-07 |
2023-08-12 |
mouse |
| Anna Wójcik-Gładysz, Krzysztof W Nowak, Krystyna Pierzchała-Koziec, Marta Wańkowska, Tomasz Misztal, Jolanta Polkowska, Magdalena Nowak, Przemysław Kaczmarek, Tatiana Górska, Dawid Szczepankiewicz, Joanna Zube. Aspects of central and peripheral regulation of reproduction in mammals. Reproductive biology. vol 6 Suppl 1. 2006-10-30. PMID:16967091. |
on the other hand, a decrease in leptin receptors mrna content within hypothalamus and pituitary together with unchanged plasma insulin level may suggest that during rat pregnancy leptin resistance was developed in the hypothalamus, pituitary and pancreatic islets. |
2006-10-30 |
2023-08-12 |
rat |
| Marcella Gamba, François P Pralon. Control of GnRH neuronal activity by metabolic factors: the role of leptin and insulin. Molecular and cellular endocrinology. vol 254-255. 2006-10-25. PMID:16757107. |
leptin and insulin are among the metabolic factors signaling the nutritional status of an individual to the hypothalamus, and their role in the overall modulation of the activity of gnrh neurons is increasingly recognized. |
2006-10-25 |
2023-08-12 |
mouse |
| Marcelo B S Flores, Maria Fernanda A Fernandes, Eduardo R Ropelle, Marcel C Faria, Mirian Ueno, Lício A Velloso, Mario J A Saad, José B C Carvalheir. Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes. vol 55. issue 9. 2006-10-24. PMID:16936204. |
exercise improves insulin and leptin sensitivity in hypothalamus of wistar rats. |
2006-10-24 |
2023-08-12 |
rat |
| Marcelo B S Flores, Maria Fernanda A Fernandes, Eduardo R Ropelle, Marcel C Faria, Mirian Ueno, Lício A Velloso, Mario J A Saad, José B C Carvalheir. Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes. vol 55. issue 9. 2006-10-24. PMID:16936204. |
exercise was associated with a markedly increased phosphorylation/activity of several proteins involved in leptin and insulin signal transduction in the hypothalamus. |
2006-10-24 |
2023-08-12 |
rat |
| Marcelo B S Flores, Maria Fernanda A Fernandes, Eduardo R Ropelle, Marcel C Faria, Mirian Ueno, Lício A Velloso, Mario J A Saad, José B C Carvalheir. Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes. vol 55. issue 9. 2006-10-24. PMID:16936204. |
the regulatory role of interleukin (il)-6 in mediating the increase in leptin and insulin sensitivity in hypothalamus was also investigated. |
2006-10-24 |
2023-08-12 |
rat |
| Marcelo B S Flores, Maria Fernanda A Fernandes, Eduardo R Ropelle, Marcel C Faria, Mirian Ueno, Lício A Velloso, Mario J A Saad, José B C Carvalheir. Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes. vol 55. issue 9. 2006-10-24. PMID:16936204. |
the current study provides direct measurements of leptin and insulin signaling in the hypothalamus and documents increased sensitivity to these hormones in the hypothalamus of exercised rats in an il-6-dependent manner. |
2006-10-24 |
2023-08-12 |
rat |
| Fernando Forcada, José-Alfonso Abeci. The effect of nutrition on the seasonality of reproduction in ewes. Reproduction, nutrition, development. vol 46. issue 4. 2006-10-11. PMID:16824445. |
several experimental approaches have elucidated that both high body fat and food intake are able to modify the sensitivity of the hypothalamus to oestradiol negative feedback during seasonal anoestrus, with those effects being associated to a reduced amount of npy mrna and to an increase of plasma insulin, glucose and leptin concentrations, particularly in the late scenario. |
2006-10-11 |
2023-08-12 |
Not clear |
| Korami Dembele, Xing-Hai Yao, Li Chen, B L Grégoire Nyomb. Intrauterine ethanol exposure results in hypothalamic oxidative stress and neuroendocrine alterations in adult rat offspring. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 3. 2006-09-20. PMID:16614051. |
because etoh can induce oxidative stress, which is a putative mechanism of insulin resistance, and because of the central role of the hypothalamus in the regulation of energy homeostasis and insulin action, we investigated whether prenatal etoh exposure causes oxidative damage to the hypothalamus, which may alter its function. |
2006-09-20 |
2023-08-12 |
rat |