| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Pocai, Tony K T Lam, Roger Gutierrez-Juarez, Silvana Obici, Gary J Schwartz, Joseph Bryan, Lydia Aguilar-Bryan, Luciano Rossett. Hypothalamic K(ATP) channels control hepatic glucose production. Nature. vol 434. issue 7036. 2005-05-03. PMID:15846348. |
finally, the infusion of a k(atp) blocker within the mediobasal hypothalamus, or the surgical resection of the hepatic branch of the vagus nerve, negates the effects of central insulin and halves the effects of systemic insulin on hepatic glucose production. |
2005-05-03 |
2023-08-12 |
mouse |
| Manfred Hallschmid, Christian Benedict, Jan Born, Horst-Lorenz Fehm, Werner Ker. Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man. Physiology & behavior. vol 83. issue 1. 2005-04-19. PMID:15501491. |
the peripheral adiposity signals insulin and leptin convey information on the amount of energy stored as body fat to the arcuate nucleus of the hypothalamus, where anabolic/orexigenic and catabolic/anorexigenic pathways interact to regulate food intake and energy expenditure. |
2005-04-19 |
2023-08-12 |
human |
| Z A Archer, S M Rhind, P A Findlay, C E Kyle, M C Barber, C L Ada. Hypothalamic responses to peripheral glucose infusion in food-restricted sheep are influenced by photoperiod. The Journal of endocrinology. vol 184. issue 3. 2005-04-18. PMID:15749810. |
nutritional feedback provided by systemic hormones, such as insulin and leptin, influences reproductive neuroendocrine output within the hypothalamus, yet the mechanisms and their interaction with photoperiodic cues remain unresolved in seasonal species. |
2005-04-18 |
2023-08-12 |
Not clear |
| Kohtaro Minami, Takashi Miki, Takashi Kadowaki, Susumu Sein. Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice. Diabetes. vol 53 Suppl 3. 2005-04-14. PMID:15561908. |
analysis of kir6.2 null mice has shown that kir6.2/sur1 channels in pancreatic beta-cells and the hypothalamus are essential in glucose-induced insulin secretion and hypoglycemia-induced glucagon secretion, respectively, and that kir6.2/sur2 channels are involved in glucose uptake in skeletal muscles. |
2005-04-14 |
2023-08-12 |
mouse |
| Patrícia Oliveira Prada, Henrique Gottardello Zecchin, Alessandra Lia Gasparetti, Márcio Alberto Torsoni, Mirian Ueno, Aparecida Emiko Hirata, Maria Esméria Corezola do Amaral, Nelci Fenalti Höer, Antonio Carlos Boschero, Mario José Abdalla Saa. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology. vol 146. issue 3. 2005-04-04. PMID:15591151. |
the mechanisms by which diet-induced obesity is associated with insulin resistance are not well established, and no study has until now integrated, in a temporal manner, functional insulin action data with insulin signaling in key insulin-sensitive tissues, including the hypothalamus. |
2005-04-04 |
2023-08-12 |
rat |
| Patrícia Oliveira Prada, Henrique Gottardello Zecchin, Alessandra Lia Gasparetti, Márcio Alberto Torsoni, Mirian Ueno, Aparecida Emiko Hirata, Maria Esméria Corezola do Amaral, Nelci Fenalti Höer, Antonio Carlos Boschero, Mario José Abdalla Saa. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology. vol 146. issue 3. 2005-04-04. PMID:15591151. |
in this study, we evaluated the regulation of insulin sensitivity by hyperinsulinemic-euglycemic clamp procedures and insulin signaling, c-jun n-terminal kinase (jnk) activation and insulin receptor substrate (irs)-1(ser307) phosphorylation in liver, muscle, adipose tissue, and hypothalamus, by immunoprecipitation and immunoblotting, in rats fed on a western diet (wd) or control diet for 10 or 30 d. wd increased visceral adiposity, serum triacylglycerol, and insulin levels and reduced whole-body glucose use. |
2005-04-04 |
2023-08-12 |
rat |
| Patrícia Oliveira Prada, Henrique Gottardello Zecchin, Alessandra Lia Gasparetti, Márcio Alberto Torsoni, Mirian Ueno, Aparecida Emiko Hirata, Maria Esméria Corezola do Amaral, Nelci Fenalti Höer, Antonio Carlos Boschero, Mario José Abdalla Saa. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology. vol 146. issue 3. 2005-04-04. PMID:15591151. |
after 10 d of wd (wd10) there was a decrease in irs-1/phosphatidylinositol 3-kinase/protein kinase b pathway in hypothalamus and muscle, associated with an attenuation of the anorexigenic effect of insulin in the former and reduced glucose transport in the latter. |
2005-04-04 |
2023-08-12 |
rat |
| Patrícia Oliveira Prada, Henrique Gottardello Zecchin, Alessandra Lia Gasparetti, Márcio Alberto Torsoni, Mirian Ueno, Aparecida Emiko Hirata, Maria Esméria Corezola do Amaral, Nelci Fenalti Höer, Antonio Carlos Boschero, Mario José Abdalla Saa. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology. vol 146. issue 3. 2005-04-04. PMID:15591151. |
in summary, the insulin resistance induced by wd is tissue specific and installs first in hypothalamus and muscle and later in liver, accompanied by activation of jnk and irs-1(ser307) phosphorylation. |
2005-04-04 |
2023-08-12 |
rat |
| Matthew T Scharf, Rexford S Ahim. Gut peptides and other regulators in obesity. Seminars in liver disease. vol 24. issue 4. 2005-03-18. PMID:15605302. |
the long-term regulation of energy stores is mediated primarily through the actions of adiposity hormones, such as leptin and insulin, in the hypothalamus and other neuronal circuits in the brain. |
2005-03-18 |
2023-08-12 |
Not clear |
| Kevin D Niswender, Denis G Baskin, Michael W Schwart. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends in endocrinology and metabolism: TEM. vol 15. issue 8. 2005-03-07. PMID:15380807. |
regulation of adiposity occurs through a classical endocrine feedback loop, in which the pancreatic beta-cell-derived hormone insulin and the adipocyte-derived hormone leptin signal the status of body energy stores to the hypothalamus. |
2005-03-07 |
2023-08-12 |
Not clear |
| Kevin D Niswender, Denis G Baskin, Michael W Schwart. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends in endocrinology and metabolism: TEM. vol 15. issue 8. 2005-03-07. PMID:15380807. |
recent advances in our understanding of the signal transduction mechanisms used by insulin and leptin in the hypothalamus to modulate neuronal firing suggest that intracellular cross-talk occurs at several levels and is a potentially important determinant of regulated body weight. |
2005-03-07 |
2023-08-12 |
Not clear |
| Frank Svec, Patrick Robinson, Leslie Michel, Jessica Bradley, Connie Corll, Johnny R Porte. Caloric intake and hypothalamic neurotransmitters in Zucker rats made acutely diabetic with streptozocin. Nutritional neuroscience. vol 7. issue 5-6. 2005-03-03. PMID:15682928. |
it is hypothesized that in the obese zucker rat decrements in food intake are mediated by increase in serotonin turnover in the hypothalamus and these changes are related to changes of insulin levels. |
2005-03-03 |
2023-08-12 |
rat |
| Lorenz Fehm, Werner Kern, Achim Peter. [Body weight regulation through the central nervous system. The development of a pathogenetically based adiposity therapy]. Medizinische Klinik (Munich, Germany : 1983). vol 99. issue 11. 2005-01-31. PMID:15583877. |
the melanocortin neurons in the arcuate nucleus of the hypothalamus are important mediators of the feedback effects of leptin and insulin. |
2005-01-31 |
2023-08-12 |
Not clear |
| R Ramakrishnan, R Sheeladevi, N Suthanthiraraja. PKC-alpha mediated alterations of indoleamine contents in diabetic rat brain. Brain research bulletin. vol 64. issue 2. 2004-11-29. PMID:15342107. |
striatum (st), hippocampus (hc), hypothalamus (ht), midbrain (mb), pons medulla (pm), cerebellum (cb) and cerebral cortex (ccx) of control, untreated diabetic and insulin treated diabetic rats after 30 days. |
2004-11-29 |
2023-08-12 |
rat |
| Xueying Lin, Akiko Taguchi, Sunmin Park, Jake A Kushner, Fan Li, Yedan Li, Morris F Whit. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. The Journal of clinical investigation. vol 114. issue 7. 2004-11-22. PMID:15467829. |
here we show that a conditional knockout of insulin receptor substrate 2 (irs2) in mouse pancreas beta cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. |
2004-11-22 |
2023-08-12 |
mouse |
| J L Soengas, M Aldegund. Brain glucose and insulin: effects on food intake and brain biogenic amines of rainbow trout. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 190. issue 8. 2004-11-15. PMID:15138792. |
the effects of central (intracerebroventricular, 9 microg fish(-1)) and peripheral (intraperitoneal, 4 mg kg(-1)) administration of bovine insulin, as well as the effect of hyperglycemia (oral administration of 1 g glucose fish(-1)) and brain glucodeprivation (intracerebroventricular administration of 2-deoxy-d-glucose) on food intake and levels of brain (telencephalon, preoptic area, and hypothalamus) biogenic amines (serotonin, dopamine, noradrenaline and their metabolites 5-hydroxyindoleacetic acid, and dihydroxyphenylacetic acid) were assessed on rainbow trout ( oncorhynchus mykiss). |
2004-11-15 |
2023-08-12 |
cattle |
| J L Soengas, M Aldegund. Brain glucose and insulin: effects on food intake and brain biogenic amines of rainbow trout. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 190. issue 8. 2004-11-15. PMID:15138792. |
when assessing changes in the levels of biogenic amines after 26 h of central insulin administration, there was a significant increase in the levels of 5-hydroxyindoleacetic acid, and in the ratio of dihydroxyphenylacetic acid/dopamine of insulin-treated fish, in telencephalon and hypothalamus, respectively. |
2004-11-15 |
2023-08-12 |
cattle |
| Jürgen M Steinacker, Werner Lormes, Susanne Reissnecker, Yuefei Li. New aspects of the hormone and cytokine response to training. European journal of applied physiology. vol 91. issue 4. 2004-11-04. PMID:14608461. |
a nutrient-sensing signal of adipose tissue may be represented by leptin which, as for insulin, il-6 and insulin-like growth-factor i (igf-i), has profound effects on the hypothalamus and is involved in the metabolic hormonal regulation of exercise and training. |
2004-11-04 |
2023-08-12 |
Not clear |
| K Gerozissi. Brain insulin and feeding: a bi-directional communication. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094073. |
single meals as well as glucose and serotonin are able to regulate insulin release directly in the hypothalamus and may be of importance for its biological effects. |
2004-11-03 |
2023-08-12 |
Not clear |
| K Gerozissi. Brain insulin and feeding: a bi-directional communication. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094073. |
in the hypothalamus, insulin and leptin share a common signaling pathway involved in food intake, namely the insulin receptor substrate, phosphatidylinositol 3-kinase pathway. |
2004-11-03 |
2023-08-12 |
Not clear |