| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kamal Rahmouni, Donald A Morgan, Gina M Morgan, Xuebo Liu, Curt D Sigmund, Allyn L Mark, William G Hayne. Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. The Journal of clinical investigation. vol 114. issue 5. 2004-10-14. PMID:15343383. |
ex vivo biochemical studies of mediobasal hypothalamic tissue revealed that insulin stimulated the association of insulin receptor substrate-1 with the p85alpha subunit of pi3k and also tyrosine phosphorylation of p42 and p44 subunits of mapk in the hypothalamus. |
2004-10-14 |
2023-08-12 |
rat |
| Christophe Perrin, Claude Knauf, Rémy Burceli. Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis. Endocrinology. vol 145. issue 9. 2004-09-28. PMID:15192044. |
importantly, the cerebral injections of aicar, insulin, and glucose were associated with variations in the phosphorylation state of the amp-activated kinase in the hypothalamus. |
2004-09-28 |
2023-08-12 |
mouse |
| Shin-Ichi Gorogawa, Yoshio Fujitani, Hideaki Kaneto, Yoji Hazama, Hirotaka Watada, Yasuhide Miyamoto, Kiyoshi Takeda, Shizuo Akira, Mark A Magnuson, Yoshimitsu Yamasaki, Yoshitaka Kajimoto, Masatsugu Hor. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochemical and biophysical research communications. vol 319. issue 4. 2004-08-02. PMID:15194489. |
the mice showed partial leptin resistance, suggesting that expression of the rip (rat insulin promoter)-cre transgene in hypothalamus partially inhibited the appetite-regulating system. |
2004-08-02 |
2023-08-12 |
mouse |
| J B C Carvalheira, E B Ribeiro, E P Araújo, R B Guimarães, M M Telles, M Torsoni, J A R Gontijo, L A Velloso, M J A Saa. Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats. Diabetologia. vol 46. issue 12. 2004-07-21. PMID:14600817. |
selective impairment of insulin signalling in the hypothalamus of obese zucker rats. |
2004-07-21 |
2023-08-12 |
rat |
| J B C Carvalheira, E B Ribeiro, E P Araújo, R B Guimarães, M M Telles, M Torsoni, J A R Gontijo, L A Velloso, M J A Saa. Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats. Diabetologia. vol 46. issue 12. 2004-07-21. PMID:14600817. |
however, little is known with regard to insulin signalling in the hypothalamus in insulin-resistant states. |
2004-07-21 |
2023-08-12 |
rat |
| Dana K Sindelar, Linda Ste Marie, Grant I Miura, Richard D Palmiter, Julie E McMinn, Gregory J Morton, Michael W Schwart. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15064281. |
a role for npy in glucoprivic feeding is further supported by our finding that npy mrna content (measured by real-time pcr) increased 2.4-fold in the hypothalamus of npy+/+ mice by 7 h after insulin injection. |
2004-07-14 |
2023-08-12 |
mouse |
| S U Devaska. Neurohumoral regulation of body weight gain. Pediatric diabetes. vol 2. issue 3. 2004-06-30. PMID:15016196. |
while various neuropeptides in the central nervous system (cns), particularly in the hypothalamus, maintain the necessary harmony between hyperphagia and anorexia, peripheral signals arising from the gastrointestinal tract (cholecystokinin-8 [cck-8], amylin), pancreas (insulin) and adipose tissue (leptin) provide the necessary stimuli or a feedback inhibition for the synthesis and secretion of these hypothalamic neuropeptides. |
2004-06-30 |
2023-08-12 |
Not clear |
| Abhiram Sah. Minireview: A hypothalamic role in energy balance with special emphasis on leptin. Endocrinology. vol 145. issue 6. 2004-06-24. PMID:15044360. |
within the hypothalamus, neurons residing in the arc (arcuate nucleus)-pvn (paraventricular)-pf/lh (perifornical/lateral hypothalamus) axis communicate among each other and are subjected to the influence of several peripheral factors, including leptin and insulin. |
2004-06-24 |
2023-08-12 |
Not clear |
| Gregory S Fraley, Jarrad M Scarlett, Issei Shimada, Dawit N Teklemichael, Blake V Acohido, Donald K Clifton, Robert A Steine. Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat. Diabetes. vol 53. issue 5. 2004-06-24. PMID:15111492. |
effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat. |
2004-06-24 |
2023-08-12 |
rat |
| Fumiko Isoda, Laura Shiry, Jeffrey Abergel, Geoffry Allan, Charles Mobb. D-chiro-Inositol enhances effects of hypothalamic toxin gold-thioglucose. Brain research. vol 993. issue 1-2. 2004-02-12. PMID:14642843. |
d-chiro-inositol (dci) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. |
2004-02-12 |
2023-08-12 |
mouse |
| Miklós Palkovit. Hypothalamic regulation of food intake. Ideggyogyaszati szemle. vol 56. issue 9-10. 2004-01-20. PMID:14608950. |
circulating substances carrying signals connected to changes in body food homeostasis and energy balance (leptin, ghrelin, insulin, glucose) enter the hypothalamus mainly through the arcuate nucleus. |
2004-01-20 |
2023-08-12 |
Not clear |
| Jing-Ning Huan, Ji Li, Yiping Han, Ke Chen, Nancy Wu, Allan Z Zha. Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12925533. |
despite a normal level of leptin receptors in the hypothalamus and normal food intake, mutant mice developed increased adiposity, decreased body temperature, hyperinsulinemia, hypertriglyceridemia, impaired glucose tolerance and insulin sensitivity, as well as elevated hepatic and skeletal muscle triglyceride levels. |
2003-12-24 |
2023-08-12 |
mouse |
| Naruhiro Fujita, Hiroyuki Sakamaki, Shigeo Uotani, Ryoko Takahashi, Hironaga Kuwahara, Atsushi Kita, Katsuya Oshima, Hironori Yamasaki, Yoshihiko Yamaguchi, Katsumi Eguch. Intracerebroventricular administration of insulin and glucose inhibits the anorectic action of leptin in rats. Experimental biology and medicine (Maywood, N.J.). vol 228. issue 10. 2003-12-23. PMID:14610254. |
to elucidate the mechanism of this paradox, the effects of insulin and glucose on the anorectic action of leptin in the hypothalamus were examined. |
2003-12-23 |
2023-08-12 |
human |
| Márcio A Torsoni, José B Carvalheira, Márcio Pereira-Da-Silva, Marco A de Carvalho-Filho, Mário J A Saad, Lício A Vellos. Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. American journal of physiology. Endocrinology and metabolism. vol 285. issue 1. 2003-07-18. PMID:12644444. |
molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. |
2003-07-18 |
2023-08-12 |
rat |
| Márcio A Torsoni, José B Carvalheira, Márcio Pereira-Da-Silva, Marco A de Carvalho-Filho, Mário J A Saad, Lício A Vellos. Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. American journal of physiology. Endocrinology and metabolism. vol 285. issue 1. 2003-07-18. PMID:12644444. |
insulin and leptin act in the hypothalamus, providing robust anorexigenic signals. |
2003-07-18 |
2023-08-12 |
rat |
| Márcio A Torsoni, José B Carvalheira, Márcio Pereira-Da-Silva, Marco A de Carvalho-Filho, Mário J A Saad, Lício A Vellos. Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. American journal of physiology. Endocrinology and metabolism. vol 285. issue 1. 2003-07-18. PMID:12644444. |
however, after an acute, peripheral infusion of exogenous insulin, significantly lower increases of ir and irs-2 tyrosine phosphorylation were detected in the hypothalamus of cold-exposed rats. |
2003-07-18 |
2023-08-12 |
rat |
| Márcio A Torsoni, José B Carvalheira, Márcio Pereira-Da-Silva, Marco A de Carvalho-Filho, Mário J A Saad, Lício A Vellos. Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. American journal of physiology. Endocrinology and metabolism. vol 285. issue 1. 2003-07-18. PMID:12644444. |
to test the hypothesis of functional impairment of insulin signaling in the hypothalamus, intracerebroventricularly cannulated rats were acutely treated with insulin, and food ingestion was measured over a period of 12 h. cold-exposed animals presented a significantly lower insulin-induced reduction in food consumption compared with animals maintained at room temperature. |
2003-07-18 |
2023-08-12 |
rat |
| Márcio A Torsoni, José B Carvalheira, Márcio Pereira-Da-Silva, Marco A de Carvalho-Filho, Mário J A Saad, Lício A Vellos. Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. American journal of physiology. Endocrinology and metabolism. vol 285. issue 1. 2003-07-18. PMID:12644444. |
hence, the present studies reveal that animals exposed to cold are resistant, both at the molecular and the functional level, to the actions of insulin in the hypothalamus. |
2003-07-18 |
2023-08-12 |
rat |
| Robert Gros, Xiaomang You, Laurie L Baggio, M Golam Kabir, Al Muktafi Sadi, Imran N Mungrue, Thomas G Parker, Qingling Huang, Daniel J Drucker, Mansoor Husai. Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology. vol 144. issue 6. 2003-06-25. PMID:12746281. |
the defective cardiovascular response to insulin was not attributable to a generalized defect in the stress response, because glp-1r(-/-) mice responded appropriately to insulin with increased c-fos expression in the hypothalamus and increased circulating levels of glucagon and epinephrine. |
2003-06-25 |
2023-08-12 |
mouse |
| Paul A Rushin. Central amylin signaling and the regulation of energy homeostasis. Current pharmaceutical design. vol 9. issue 10. 2003-06-10. PMID:12678881. |
like leptin and insulin, amylin is not synthesized within the brain, but is rapidly and efficiently transported across the blood-brain barrier (bbb) to a variety of discrete brain regions, including the hypothalamus, where populations of amylin binding sites are found. |
2003-06-10 |
2023-08-12 |
mouse |