| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyriaki Gerozissis, Gerozissis Kyriak. Brain insulin: regulation, mechanisms of action and functions. Cellular and molecular neurobiology. vol 23. issue 1. 2003-05-20. PMID:12701881. |
glucose and serotonin regulate insulin directly in the hypothalamus and may be of importance for its biological effects. |
2003-05-20 |
2023-08-12 |
Not clear |
| Kevin D Niswender, Michael W Schwart. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Frontiers in neuroendocrinology. vol 24. issue 1. 2003-04-17. PMID:12609497. |
the adipocyte-derived hormone leptin and the pancreatic beta cell-derived hormone insulin each function as afferent signals to the hypothalamus in an endocrine feedback loop that regulates body adiposity. |
2003-04-17 |
2023-08-12 |
Not clear |
| Kevin D Niswender, Christopher D Morrison, Deborah J Clegg, Ryan Olson, Denis G Baskin, Martin G Myers, Randy J Seeley, Michael W Schwart. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes. vol 52. issue 2. 2003-04-07. PMID:12540590. |
in the hypothalamus, insulin functions with leptin as an afferent adiposity signal important for the regulation of body fat stores and hepatic glucose metabolism. |
2003-04-07 |
2023-08-12 |
Not clear |
| Kevin D Niswender, Christopher D Morrison, Deborah J Clegg, Ryan Olson, Denis G Baskin, Martin G Myers, Randy J Seeley, Michael W Schwart. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes. vol 52. issue 2. 2003-04-07. PMID:12540590. |
these findings support the hypothesis that the irs-pi3k pathway is a mediator of insulin action in the arcuate nucleus and, combined with recent evidence that leptin activates pi3k signaling in the hypothalamus, provide a plausible mechanism for neuronal cross-talk between insulin and leptin signaling. |
2003-04-07 |
2023-08-12 |
Not clear |
| C Ruibal, J L Soengas, M Aldegund. Brain serotonin and the control of food intake in rainbow trout (Oncorhynchus mykiss): effects of changes in plasma glucose levels. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 188. issue 6. 2003-02-05. PMID:12122466. |
intraperitoneal treatment with bovine insulin (4 mg kg(-1)) decreased the 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio in hypothalamus after 1 h. intraperitoneal administration of fenfluramine (3 mg kg(-1)) caused a depression in food intake coincident with a significant decrease of the hypothalamic 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio. |
2003-02-05 |
2023-08-12 |
cattle |
| Adrian K Hewson, Loraine Y C Tung, David W Connell, Laura Tookman, Suzanne L Dickso. The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin, and a ghrelin mimetic. Diabetes. vol 51. issue 12. 2002-12-20. PMID:12453894. |
these data provide evidence that the ghrelin-sensitive circuits in the hypothalamus are dynamically regulated by central insulin and leptin action. |
2002-12-20 |
2023-08-12 |
rat |
| Daniel Porte, Denis G Baskin, Michael W Schwart. Leptin and insulin action in the central nervous system. Nutrition reviews. vol 60. issue 10 Pt 2. 2002-12-18. PMID:12403080. |
this review summarizes old and recent data implicating insulin and leptin as key circulating signals to the central nervous system, particularly the ventral hypothalamus, in communicating the size and the distribution of body fat stores. |
2002-12-18 |
2023-08-12 |
Not clear |
| Pu-Qing Yuan, Hong Yan. Neuronal activation of brain vagal-regulatory pathways and upper gut enteric plexuses by insulin hypoglycemia. American journal of physiology. Endocrinology and metabolism. vol 283. issue 3. 2002-09-23. PMID:12169436. |
insulin hypoglycemia significantly induced fos expression in the paraventricular nucleus of the hypothalamus, locus coeruleus, dorsal motor nucleus of the vagus (dmn), and nucleus tractus solitarii (nts), as well as in the gastric/duodenal myenteric/submucosal plexuses. |
2002-09-23 |
2023-08-12 |
rat |
| J E McMinn, D G Baskin, M W Schwart. Neuroendocrine mechanisms regulating food intake and body weight. Obesity reviews : an official journal of the International Association for the Study of Obesity. vol 1. issue 1. 2002-07-26. PMID:12119644. |
this review describes a neuroanatomically based model in which leptin and insulin signalling in the hypothalamus governs long-term regulation of energy balance via mechanisms that are integrated with satiety hormone signalling in the brainstem. |
2002-07-26 |
2023-08-12 |
Not clear |
| Silvana Obici, Zhaohui Feng, George Karkanias, Denis G Baskin, Luciano Rossett. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nature neuroscience. vol 5. issue 6. 2002-06-19. PMID:12021765. |
thus, insulin receptors in discrete areas of the hypothalamus have a physiological role in the control of food intake, fat mass and hepatic action of insulin. |
2002-06-19 |
2023-08-12 |
rat |
| M Taouis, S Dridi, S Cassy, Y Benomar, N Raver, N Rideau, M Picard, J Williams, A Gertle. Chicken leptin: properties and actions. Domestic animal endocrinology. vol 21. issue 4. 2002-04-23. PMID:11872323. |
chicken leptin receptor is expressed in the hypothalamus but also in other tissues such as pancreas, where leptin inhibits insulin secretion and thus may have a key role in regulating nutrient utilization in this species. |
2002-04-23 |
2023-08-12 |
chicken |
| P Shizgal, S Fulton, B Woodsid. Brain reward circuitry and the regulation of energy balance. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 25 Suppl 5. 2002-04-05. PMID:11840209. |
the rewarding effect produced by stimulating the perifornical region of the hypothalamus is modulated by body weight and is attenuated both by leptin and insulin. |
2002-04-05 |
2023-08-12 |
Not clear |
| H Dhillon, S P Kalra, P S Kalr. Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus. Molecular therapy : the journal of the American Society of Gene Therapy. vol 4. issue 2. 2001-12-04. PMID:11482985. |
our studies show for the first time that increased availability of leptin within the hypothalamus through central leptin gene therapy dose-dependently decreases weight gain, adiposity, and serum insulin by increasing energy expenditure and decreasing fi. |
2001-12-04 |
2023-08-12 |
rat |
| T A Lennie, M D Wortman, R J Seele. Activity of body energy regulatory pathways in inflammation-induced anorexia. Physiology & behavior. vol 73. issue 4. 2001-10-04. PMID:11495655. |
specifically, the effect of a 12% prior reduction in body weight on serum leptin, insulin, and corticosterone; levels of interleukin-1 (il-1), interleukin-6 (il-6) in the serum, liver, and spleen; neuropeptide y (npy) and pomc mrna levels in the arcuate nucleus (arc) of the hypothalamus were examined 8 h after induction of acute inflammation. |
2001-10-04 |
2023-08-12 |
rat |
| J B Carvalheira, R M Siloto, I Ignacchitti, S L Brenelli, C R Carvalho, A Leite, L A Velloso, J A Gontijo, M J Saa. Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS letters. vol 500. issue 3. 2001-08-09. PMID:11445068. |
insulin modulates leptin-induced stat3 activation in rat hypothalamus. |
2001-08-09 |
2023-08-12 |
rat |
| J B Carvalheira, R M Siloto, I Ignacchitti, S L Brenelli, C R Carvalho, A Leite, L A Velloso, J A Gontijo, M J Saa. Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS letters. vol 500. issue 3. 2001-08-09. PMID:11445068. |
here, we present evidence for the integration of leptin and insulin signals in the hypothalamus. |
2001-08-09 |
2023-08-12 |
rat |
| A Sainsbury, H Herzo. Inhibitory effects of central neuropeptide Y on the somatotropic and gonadotropic axes in male rats are independent of adrenal hormones. Peptides. vol 22. issue 3. 2001-07-19. PMID:11287103. |
neuropeptide y (npy) in the hypothalamus exerts multiple physiological functions including stimulation of adipogenic pathways such as feeding and insulin secretion as well as inhibition of the somatotropic and gonadotropic axes. |
2001-07-19 |
2023-08-12 |
rat |
| J Wang, V G Yuen, J H McNeil. Effect of vanadium on insulin sensitivity and appetite. Metabolism: clinical and experimental. vol 50. issue 6. 2001-07-05. PMID:11398143. |
because insulin may inhibit hypothalamic neuropeptide y (npy), which is known to be related to appetite, and increase leptin secretion in adipose tissue, we studied the possibility that the changes in appetite produced by vanadium may be linked to altered npy levels in the hypothalamus. |
2001-07-05 |
2023-08-12 |
rat |
| J Wang, V G Yuen, J H McNeil. Effect of vanadium on insulin sensitivity and appetite. Metabolism: clinical and experimental. vol 50. issue 6. 2001-07-05. PMID:11398143. |
these data indicate that bmov may increase insulin sensitivity in adipose tissue and decrease appetite and body fat by decreasing npy levels in the hypothalamus. |
2001-07-05 |
2023-08-12 |
rat |
| S G Krylova, O N Konovalova, E P Zuev. [Correction by common sea buckthorn bark and sprout extracts of hormonal and metabolic disturbances during stress in rats]. Eksperimental'naia i klinicheskaia farmakologiia. vol 63. issue 4. 2000-10-31. PMID:11022314. |
the drug administration led to normalization of the altered functional activity indices of the neuro-endocrine system (disturbed adrenocorticotropin, 11-deoxycortisol, insulin, urea, and glucose levels) by affecting the production of glucocorticoids and increasing the hypothalamus sensitivity with respect to regulatory signals. |
2000-10-31 |
2023-08-12 |
rat |