| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Shannahoff-Khalsa, B Kennedy, F E Yates, M G Ziegle. Low-frequency ultradian insulin rhythms are coupled to cardiovascular, autonomic, and neuroendocrine rhythms. The American journal of physiology. vol 272. issue 3 Pt 2. 1997-04-28. PMID:9087661. |
these results suggest that insulin secretion has a common pacemaker (the hypothalamus) or a mutually entrained pacemaker with the autonomic, cardiovascular, and neuroendocrine systems. |
1997-04-28 |
2023-08-12 |
human |
| T Partone. Possible pathophysiological mechanisms regulating food intake in seasonal affective disorder. Medical hypotheses. vol 47. issue 3. 1997-03-10. PMID:8898322. |
reduced insulin sensitivity may increase the transcriptional activity of the neuropeptide y gene in the medial basal hypothalamus and subsequent ingestion of food. |
1997-03-10 |
2023-08-12 |
Not clear |
| A P Jones, D H Olster, B State. Maternal insulin manipulations in rats organize body weight and noradrenergic innervation of the hypothalamus in gonadally intact male offspring. Brain research. Developmental brain research. vol 97. issue 1. 1997-02-27. PMID:8946050. |
maternal insulin manipulations in rats organize body weight and noradrenergic innervation of the hypothalamus in gonadally intact male offspring. |
1997-02-27 |
2023-08-12 |
rat |
| M W Schwartz, R J Seele. The new biology of body weight regulation. Journal of the American Dietetic Association. vol 97. issue 1. 1997-02-05. PMID:8990418. |
these include the circulating signals, leptin (the hormone encoded by the ob gene that is secreted by fat cells) and the pancreatic hormone insulin; and brain peptides such as neuropeptide y, which is released from nerve terminals in the hypothalamus to elicit changes in feeding behavior and energy expenditure that mediate adaptive changes in energy balance. |
1997-02-05 |
2023-08-12 |
human |
| J L Marks, K Wait. Some acute effects of intracerebroventricular neuropeptide Y on insulin secretion and glucose metabolism in the rat. Journal of neuroendocrinology. vol 8. issue 7. 1996-12-30. PMID:8843019. |
acute administration of neuropeptide y(npy) into the hypothalamus and cerebral ventricles can stimulate insulin secretion in the absence of available food. |
1996-12-30 |
2023-08-12 |
rat |
| G Wol. Leptin: the weight-reducing plasma protein encoded by the obese gene. Nutrition reviews. vol 54. issue 3. 1996-12-26. PMID:8935220. |
leptin release is stimulated by insulin; leptin appears to act on the hypothalamus by inhibiting the release of the neuropeptide y. |
1996-12-26 |
2023-08-12 |
mouse |
| R J Seeley, C A Matson, M Chavez, S C Woods, M F Dallman, M W Schwart. Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding. The American journal of physiology. vol 271. issue 3 Pt 2. 1996-12-05. PMID:8853408. |
during overfeeding, plasma insulin and corticotropin-releasing hormone (crh) mrna in the paraventricular nucleus of the hypothalamus were elevated compared with controls and with overfed rats allowed 3 days to recover from the overfeeding regimen such that body weight returned to the level of controls. |
1996-12-05 |
2023-08-12 |
rat |
| R J Seeley, C A Matson, M Chavez, S C Woods, M F Dallman, M W Schwart. Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding. The American journal of physiology. vol 271. issue 3 Pt 2. 1996-12-05. PMID:8853408. |
in contrast, rats that were not overfed but were pair-fed to the low spontaneous food intake of previously overfed rats lost weight and had significantly reduced plasma insulin and elevated mrna for neuropeptide y (npy) in the arcuate nucleus of the hypothalamus. |
1996-12-05 |
2023-08-12 |
rat |
| A E RABKIN. [EFFECT OF INSULIN ON THE RESTORATION OF CHANGES IN THE STRUCTURE AND NEUROSECRETION OF THE HYPOTHALAMUS IN ALLOXAN DIABETES]. Problemy endokrinologii i gormonoterapii. vol 10. 1996-12-01. PMID:14210097. |
[effect of insulin on the restoration of changes in the structure and neurosecretion of the hypothalamus in alloxan diabetes]. |
1996-12-01 |
2023-08-12 |
Not clear |
| M C Moore, A D Cherringto. Regulation of net hepatic glucose uptake: interaction of neural and pancreatic mechanisms. Reproduction, nutrition, development. vol 36. issue 4. 1996-11-21. PMID:8878357. |
the change in the afferent firing rate is processed in the hypothalamus and instigates a change in the efferent firing rate in the hepatic and pancreatic branches of the vagus (with corresponding increases in insulin secretion and net hepatic glucose uptake). |
1996-11-21 |
2023-08-12 |
Not clear |
| M Niimi, M Sato, M Tamaki, Y Wada, J Takahara, K Kawanish. Induction of Fos protein in the rat hypothalamus elicited by insulin-induced hypoglycemia. Neuroscience research. vol 23. issue 4. 1996-05-03. PMID:8602275. |
the induction of fos protein was maximum after the first injection of insulin for 3 h. this induction was found in the parvocellular division of paraventricular nucleus (pvn), the periventricular, dorsomedial and arcuate nuclei and the lateral hypothalamic area of the hypothalamus. |
1996-05-03 |
2023-08-12 |
rat |
| A Sahu, M G Dube, C P Phelps, C A Sninsky, P S Kalra, S P Kalr. Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: a putative hypothalamic site for energy homeostasis. Endocrinology. vol 136. issue 12. 1995-12-28. PMID:7588328. |
to establish the site of interaction between the hypothalamus and the pancreas, we examined the effects of insulin on npy release in vivo and in vitro from hypothalamic sites known to be involved in feeding behavior. |
1995-12-28 |
2023-08-12 |
rat |
| M Berelowitz, Y Xu, J Song, J F Brun. Regulation of somatostatin receptor mRNA expression. Ciba Foundation symposium. vol 190. 1995-12-06. PMID:7587642. |
sstr5 mrna is reduced by 70% in the pituitary and by 30% in the hypothalamus with restoration of both by insulin treatment. |
1995-12-06 |
2023-08-12 |
rat |
| H M Frankish, S Dryden, D Hopkins, Q Wang, G William. Neuropeptide Y, the hypothalamus, and diabetes: insights into the central control of metabolism. Peptides. vol 16. issue 4. 1995-11-30. PMID:7479313. |
the arc-pvn projection is also stimulated in rat models of obesity +/- non-insulin diabetes, possibly because the hypothalamus is resistant to inhibition by insulin; in these animals, enhanced activity of arc npy neurons could cause hyperphagia, reduced energy expenditure, and obesity, and perhaps contribute to hyperinsulinemia and altered pituitary secretion. |
1995-11-30 |
2023-08-12 |
human |
| A P D'Costa, X Xu, R L Ingram, W E Sonnta. Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats. Neuroscience. vol 65. issue 3. 1995-08-17. PMID:7609879. |
male brown norway rats (5-7 and 27-28 months old) were used to determine (1) whether in vivo protein synthesis in cortex, hippocampus, hypothalamus and cerebellum decreases with age and (2) whether these deficiencies are associated with age-related alterations in response to insulin-like growth factor-1, des (1-3) igf-1 or insulin. |
1995-08-17 |
2023-08-12 |
rat |
| C Livingstone, H Lyall, G W Goul. Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism? Molecular and cellular endocrinology. vol 107. issue 1. 1995-08-03. PMID:7796936. |
the recent finding that glut 4 is also expressed in the hypothalamus suggests that this brain region, which is outside the blood-brain barrier and therefore sensitive to circulating insulin, may experience stimulation of glucose uptake in response to insulin. |
1995-08-03 |
2023-08-12 |
Not clear |
| C Livingstone, H Lyall, G W Goul. Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism? Molecular and cellular endocrinology. vol 107. issue 1. 1995-08-03. PMID:7796936. |
we propose that this may allow regions of the hypothalamus to respond directly to elevated blood glucose, constituting a form of metabolic regulation by allowing circulating glucose (and therefore insulin) in concert with other mechanisms to maintain blood glucose homeostasis. |
1995-08-03 |
2023-08-12 |
Not clear |
| R H Ra. Effect of systemic glucagon administration on ACTH secretion in anaesthetized rats. The Journal of endocrinology. vol 145. issue 1. 1995-08-03. PMID:7798030. |
it is postulated that glucagon may inhibit acth secretion either by a direct effect on the hypothalamus or indirectly through insulin, which is known to stimulate endogenous somatostatin release. |
1995-08-03 |
2023-08-12 |
rat |
| Y F Yang, M T Li. Brain serotonin depletion attenuates diabetogenic effects of streptozotocin. The American journal of physiology. vol 268. issue 5 Pt 1. 1995-06-29. PMID:7762635. |
at four days after stz administration, vehicle-treated rats displayed hyperglycemia, polydipsia, polyphagia, decreased plasma insulin level, derangement of islet morphology (few insulin cells, accumulation of glucagon cells), and elevated 5-ht release in the hypothalamus. |
1995-06-29 |
2023-08-12 |
rat |
| M S Muntzel, E A Anderson, A K Johnson, A L Mar. Mechanisms of insulin action on sympathetic nerve activity. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 17. issue 1-2. 1995-06-08. PMID:7735284. |
previous studies employing norepinephrine turnover have suggested that insulin causes sympathoexcitation by acting in the hypothalamus. |
1995-06-08 |
2023-08-12 |
rat |