| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Dobson, R F Smit. What is stress, and how does it affect reproduction? Animal reproduction science. vol 60-61. 2000-08-22. PMID:10844239. |
transport, or insulin, reduce the frequency and amplitude of gonadotrophin-releasing hormone and lh pulses, suggesting that these stressors exert effects at the hypothalamus or higher centres in the brain. |
2000-08-22 |
2023-08-12 |
Not clear |
| M E Malighetti, C Berra, A Secchi, G Pozza, V Di Carlo, L Luz. Persistence of anomalies in the growth hormone-releasing hormone-stimulated growth hormone response in diabetic-uremic patients after combined kidney-pancreas transplantation. Transplantation. vol 69. issue 9. 2000-06-08. PMID:10830243. |
our results indicate that: 1) kidney-pancreas transplantation does not normalize the gh response to gh-rh; 2) gh abnormalities are not due either to the chronic immunosuppressive therapy or to the insulin effect on gh release; 3) gh abnormalities are probably secondary to functional and/or organic complications of the hypothalamus and/or pituitary as a sequela of diabetes mellitus. |
2000-06-08 |
2023-08-12 |
human |
| M Shintani, Y Ogawa, K Naka. [Insulin resistance, role of leptin and leptin receptor]. Nihon rinsho. Japanese journal of clinical medicine. vol 58. issue 2. 2000-06-07. PMID:10707553. |
in in vivo studies, however, leptin has been reported to improve insulin sensitivity and glucose metabolism in normal and obese rodents acting mainly through hypothalamus. |
2000-06-07 |
2023-08-12 |
mouse |
| D G Baskin, D Figlewicz Lattemann, R J Seeley, S C Woods, D Porte, M W Schwart. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain research. vol 848. issue 1-2. 2000-02-25. PMID:10612703. |
future development of this model will incorporate brain pathways for integration of leptin and insulin adiposity signaling to the hypothalamus with meal-related signals that act in the caudal brainstem. |
2000-02-25 |
2023-08-12 |
Not clear |
| F Orzi, C Morisco, V Colangelo, R Di Grezia, G Lemb. Lack of effect of insulin on glucose utilization of the hypothalamus in normotensive and hypertensive rats. Neuroscience letters. vol 278. issue 1-2. 2000-02-22. PMID:10643793. |
lack of effect of insulin on glucose utilization of the hypothalamus in normotensive and hypertensive rats. |
2000-02-22 |
2023-08-12 |
rat |
| F Orzi, C Morisco, V Colangelo, R Di Grezia, G Lemb. Lack of effect of insulin on glucose utilization of the hypothalamus in normotensive and hypertensive rats. Neuroscience letters. vol 278. issue 1-2. 2000-02-22. PMID:10643793. |
hypertension is frequently associated with insulin resistance and enhanced sympathetic activity supposedly mediated by an effect of the hormone on the hypothalamus. |
2000-02-22 |
2023-08-12 |
rat |
| F Orzi, C Morisco, V Colangelo, R Di Grezia, G Lemb. Lack of effect of insulin on glucose utilization of the hypothalamus in normotensive and hypertensive rats. Neuroscience letters. vol 278. issue 1-2. 2000-02-22. PMID:10643793. |
in this study we sought to determine whether insulin modifies the functional activity of the hypothalamus and other brain areas of spontaneously hypertensive (shr) and normotensive wky rats. |
2000-02-22 |
2023-08-12 |
rat |
| F Orzi, C Morisco, V Colangelo, R Di Grezia, G Lemb. Lack of effect of insulin on glucose utilization of the hypothalamus in normotensive and hypertensive rats. Neuroscience letters. vol 278. issue 1-2. 2000-02-22. PMID:10643793. |
the results show that insulin has no effect on any of the brain areas examined including the hypothalamus, of both wky and shr rats. |
2000-02-22 |
2023-08-12 |
rat |
| M S Haque, Y Minokoshi, M Hamai, M Iwai, M Horiuchi, T Shimaz. Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats. Diabetes. vol 48. issue 9. 1999-09-30. PMID:10480598. |
these results appear to indicate that leptin in the hypothalamus enhances glucose uptake in certain peripheral tissues through mediation of a beta-adrenergic mechanism for the sympathetic nerves innervating the tissues and that central leptin and peripheral insulin have a synergistic role in augmenting tissue glucose uptake. |
1999-09-30 |
2023-08-12 |
rat |
| A Cai, J F Hyd. The human growth hormone-releasing hormone transgenic mouse as a model of modest obesity: differential changes in leptin receptor (OBR) gene expression in the anterior pituitary and hypothalamus after fasting and OBR localization in somatotrophs. Endocrinology. vol 140. issue 8. 1999-08-17. PMID:10433218. |
in conclusion, 1) the modest obesity in hghrh transgenic mice is associated with increases in leptin synthesis and secretion as well as insulin secretion; 2) gh and/or ghrh as well as leptin and insulin may differentially contribute to the changes in obr(l) gene expression in the anterior pituitary and the hypothalamus; 3) the response of obr(l) gene expression in the hypothalamus to fasting is absent in the modestly obese hghrh transgenic mice; and 4) somatotrophs are target cells for leptin, and the increase in obr(l) gene expression in the pituitary of hghrh transgenic mice is due at least in part to the increase in the number of cells expressing obr(l). |
1999-08-17 |
2023-08-12 |
mouse |
| H H Zhang, S Kumar, A H Barnett, M C Egg. Intrinsic site-specific differences in the expression of leptin in human adipocytes and its autocrine effects on glucose uptake. The Journal of clinical endocrinology and metabolism. vol 84. issue 7. 1999-07-26. PMID:10404835. |
leptin, the ob gene product of adipocytes, regulates body weight by actions on the satiety center in the hypothalamus, but it may also have peripheral effects on the metabolic actions of insulin. |
1999-07-26 |
2023-08-12 |
human |
| R J Holde. The role of brain insulin in the neurophysiology of serious mental disorders: review. Medical hypotheses. vol 52. issue 3. 1999-07-22. PMID:10362277. |
it is hypothesized that insulin regulates rcbf either directly, or indirectly via glut4 in the hypothalamus now considered the glucose-sensing, insulin-sensing mechanism of the brain and the body. |
1999-07-22 |
2023-08-12 |
Not clear |
| C B Herath, G W Reynolds, D D MacKenzie, S R Davis, P M Harri. Vagotomy suppresses cephalic phase insulin release in sheep. Experimental physiology. vol 84. issue 3. 1999-07-12. PMID:10362854. |
it is concluded that insulin secretion from the pancreatic -cells in response to either food-related reflex activation of the vagal nuclei in the hypothalamus or direct cervical vagus nerve stimulation is mediated through the vagal efferent fibres carried in the abomasal, pyloric and duodenal branches of the vagus nerves in sheep. |
1999-07-12 |
2023-08-12 |
Not clear |
| A Plagemann, T Harder, A Rake, U Janert, K Melchior, W Rohde, G Dörne. Morphological alterations of hypothalamic nuclei due to intrahypothalamic hyperinsulinism in newborn rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 17. issue 1. 1999-07-06. PMID:10219959. |
for this purpose, on the 8th day of age in wistar rats a long-acting insulin was bilaterally applicated stereotactically into the hypothalamus (12 miu on each side), while in controls the insulin-free agar-vehicle was given only. |
1999-07-06 |
2023-08-12 |
rat |
| H Y Li, L L Wang, R S Ye. Leptin immunoreactivity in the central nervous system in normal and diabetic rats. Neuroreport. vol 10. issue 2. 1999-06-03. PMID:10203350. |
in streptozotocin-treated diabetic rats, leptin-ir was dramatically attenuated only in the hypothalamus, and was restored by insulin treatment. |
1999-06-03 |
2023-08-12 |
rat |
| A Plagemann, T Harder, A Rake, K Melchior, F Rittel, W Rohde, G Dörne. Hypothalamic insulin and neuropeptide Y in the offspring of gestational diabetic mother rats. Neuroreport. vol 9. issue 18. 1999-04-13. PMID:9926849. |
in conclusion, an increase in the number of npyergic neurons in the hypothalamus, possibly due to hypothalamic malformation and/or perinatally acquired hypothalamic insulin resistance, might contribute to the development of obesity and metabolic disturbances in the offspring of diabetic mothers. |
1999-04-13 |
2023-08-12 |
rat |
| R Krysiak, E Obuchowicz, Z S Herma. Interactions between the neuropeptide Y system and the hypothalamic-pituitary-adrenal axis. European journal of endocrinology. vol 140. issue 2. 1999-03-29. PMID:10069655. |
we also describe the effects of glucocorticosteroids on the npy system in the hypothalamus, including interactions between glucocorticosteroids and insulin. |
1999-03-29 |
2023-08-12 |
Not clear |
| B Jeanrenaud, I Cusin, F Rohner-Jeanrenau. [From Claude Bernard to the regulatory system between the hypothalamus and the periphery: implications for homeostasis of body weight and obesity]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 5. 1999-01-28. PMID:9871796. |
released leptin, acting within the hypothalamus, decreases hypothalamic npy levels (probably those of other hypothalamic neuropeptides as well), food intake, insulinemia, insulin sensitivity of white adipose tissue, while increasing that of muscles. |
1999-01-28 |
2023-08-12 |
rat |
| H Yoshitomi, K Yamazaki, S Abe, I Tanak. Differential regulation of mouse uncoupling proteins among brown adipose tissue, white adipose tissue, and skeletal muscle in chronic beta 3 adrenergic receptor agonist treatment. Biochemical and biophysical research communications. vol 253. issue 1. 1999-01-13. PMID:9875224. |
it has been thought that the ucp1 and ucp3 mrna expressions in the bat and wat are mainly controlled by the hypothalamus via the sympathetic nervous system, while the levels of insulin, ffa or both may play important roles in the control of the ucp2 and ucp3 mrna expressions in the skeletal muscle an heart. |
1999-01-13 |
2023-08-12 |
mouse |
| T KUZUY. [Regulation of insulin secretion by the central nervous system. II. The role of the hypothalamus and the pituitary gland upon insulin secretion]. Japanese journal of medical science & biology. vol 51. 1998-11-01. PMID:13927726. |
the role of the hypothalamus and the pituitary gland upon insulin secretion]. |
1998-11-01 |
2023-08-12 |
Not clear |