| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soo Bong Choi, Jin Sun Jang, Sunmin Par. Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats. Brain research bulletin. vol 67. issue 1-2. 2005-12-13. PMID:16140165. |
tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats. |
2005-12-13 |
2023-08-12 |
rat |
| Soo Bong Choi, Jin Sun Jang, Sunmin Par. Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats. Brain research bulletin. vol 67. issue 1-2. 2005-12-13. PMID:16140165. |
glucose utilization of the cerebral cortex and hypothalamus was enhanced by a 4-week-tramadol administration in 90% pancreatectomized rats, in vivo, as assessed by measurement of glucokinase expression and glycogen deposition via activating insulin signaling cascade such as neuronal cells in vitro. |
2005-12-13 |
2023-08-12 |
rat |
| J Ducob. [The endocannabinoid system and the regulation of the metabolism]. Journal de pharmacie de Belgique. vol 60. issue 3. 2005-12-01. PMID:16252509. |
overactivation of the endocannabinoid system is observed in obesity, with stimulation of the appetite in the hypothalamus and fat accumulation in the adipocytes with increase of insulin resistance and decrease of adiponectin. |
2005-12-01 |
2023-08-12 |
Not clear |
| Tadasuke Komori, Yoshihiro Morikawa, Shinobu Tamura, Asako Doi, Kishio Nanjo, Emiko Senb. Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions. Brain research. vol 1049. issue 1. 2005-11-15. PMID:15925330. |
in addition, phosphorylation of irs-1 at ser307 in the hypothalamus of ob/ob mice was higher when compared to that in lean mice, suggesting that insulin signaling is impaired by phosphorylation of irs-1 at ser307 in the hypothalamus of ob/ob mice. |
2005-11-15 |
2023-08-12 |
mouse |
| J M Steinacker, M Brkic, C Simsch, K Nething, A Kresz, O Prokopchuk, Y Li. Thyroid hormones, cytokines, physical training and metabolic control. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 37. issue 9. 2005-11-15. PMID:16175490. |
leptin, insulin, and cytokines such as interleukin 6 (il-6) contribute to the metabolic error signal to the hypothalamus which result in decrease of hypothalamic release hormones and sympathoadrenergic stimulation. |
2005-11-15 |
2023-08-12 |
Not clear |
| Cláudio T De Souza, Eliana P Araujo, Silvana Bordin, Rika Ashimine, Ricardo L Zollner, Antonio C Boschero, Mário J A Saad, Lício A Vellos. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology. vol 146. issue 10. 2005-11-02. PMID:16002529. |
consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. |
2005-11-02 |
2023-08-12 |
rat |
| Cláudio T De Souza, Eliana P Araujo, Silvana Bordin, Rika Ashimine, Ricardo L Zollner, Antonio C Boschero, Mário J A Saad, Lício A Vellos. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology. vol 146. issue 10. 2005-11-02. PMID:16002529. |
both of these parameters are under the tight control of specialized neurons of the hypothalamus that respond to peripheral anorexigenic and adipostatic signals carried by leptin and insulin. |
2005-11-02 |
2023-08-12 |
rat |
| Cláudio T De Souza, Eliana P Araujo, Silvana Bordin, Rika Ashimine, Ricardo L Zollner, Antonio C Boschero, Mário J A Saad, Lício A Vellos. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology. vol 146. issue 10. 2005-11-02. PMID:16002529. |
we conclude that hl feeding induces a local proinflammatory status in the hypothalamus, which results in impaired anorexigenic insulin signaling. |
2005-11-02 |
2023-08-12 |
rat |
| C Broberge. Brain regulation of food intake and appetite: molecules and networks. Journal of internal medicine. vol 258. issue 4. 2005-10-26. PMID:16164570. |
the present review summarizes recent advances in this field including the characterization of peripheral metabolic signals to the brain such as leptin, insulin, peptide yy, ghrelin and lipid mediators as well as the vagus nerve; signalling of the metabolic sensors in the brainstem and hypothalamus via, e.g. |
2005-10-26 |
2023-08-12 |
human |
| Takashi Miki, Susumu Sein. Roles of KATP channels as metabolic sensors in acute metabolic changes. Journal of molecular and cellular cardiology. vol 38. issue 6. 2005-09-14. PMID:15910876. |
the kir6.2-containing k(atp) channels in pancreatic ss-cells and the hypothalamus are essential in the regulation of glucose-induced insulin secretion and hypoglycemia-induced glucagon secretion, respectively, and are involved in glucose uptake in skeletal muscles, thus playing a key role in the maintenance of glucose homeostasis. |
2005-09-14 |
2023-08-12 |
mouse |
| B S Mühlhäusler, C L Adam, E M Marrocco, P A Findlay, C T Roberts, J R McFarlane, K G Kauter, I C McMille. Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation. The Journal of physiology. vol 565. issue Pt 1. 2005-08-16. PMID:15661821. |
these findings demonstrate that increased circulating glucose and insulin regulate gene expression of the neuropeptides within the fetal hypothalamus that are part of the neural network regulating energy balance in adult life. |
2005-08-16 |
2023-08-12 |
Not clear |
| W R Crowley, G Ramoz, K A Keefe, R Torto, S P Kalra, G R Hanso. Differential effects of methamphetamine on expression of neuropeptide Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum-fed and schedule-fed rats. Neuroscience. vol 132. issue 1. 2005-07-20. PMID:15780475. |
in a separate study, al and sf animals were killed just prior to expected food presentation, and expression of npy, agrp and pomc mrnas in hypothalamus was determined using in situ hybridisation; concentrations of leptin, insulin and ghrelin in serum were determined with radioimmunoassays. |
2005-07-20 |
2023-08-12 |
rat |
| Roger D Con. Anatomy and regulation of the central melanocortin system. Nature neuroscience. vol 8. issue 5. 2005-07-08. PMID:15856065. |
it is likely to be involved in integrating long-term adipostatic signals from leptin and insulin, primarily received by the hypothalamus, with acute signals regulating hunger and satiety, primarily received by the brainstem. |
2005-07-08 |
2023-08-12 |
Not clear |
| David Carlin. AMP-activated protein kinase: balancing the scales. Biochimie. vol 87. issue 1. 2005-06-28. PMID:15733742. |
in the hypothalamus, ampk is inhibited by leptin and insulin, hormones which suppress feeding, whilst ghrelin, a hormone that increases food intake, activates ampk. |
2005-06-28 |
2023-08-12 |
rat |
| José B C Carvalheira, Márcio A Torsoni, Mirian Ueno, Maria E Amaral, Eliana P Araújo, Lício A Velloso, José A R Gontijo, Mario J A Saa. Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obesity research. vol 13. issue 1. 2005-06-23. PMID:15761162. |
cross-talk between the insulin and leptin signaling systems in rat hypothalamus. |
2005-06-23 |
2023-08-12 |
rat |
| José B C Carvalheira, Márcio A Torsoni, Mirian Ueno, Maria E Amaral, Eliana P Araújo, Lício A Velloso, José A R Gontijo, Mario J A Saa. Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obesity research. vol 13. issue 1. 2005-06-23. PMID:15761162. |
to investigate whether insulin and leptin share common intracellular signal transduction pathways and to determine whether these hormonal signaling systems modulate each other's action in rat hypothalamus. |
2005-06-23 |
2023-08-12 |
rat |
| Jason W Mastaitis, Elisa Wurmbach, Hui Cheng, Stuart C Sealfon, Charles V Mobb. Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia. Diabetes. vol 54. issue 4. 2005-06-03. PMID:15793232. |
to clarify these mechanisms, we examined gene expression in hypothalamus, cortex, and liver 3 h after induction of mild hypoglycemia by a single injection of insulin, using cdna microarray analysis and quantitative real-time pcr. |
2005-06-03 |
2023-08-12 |
Not clear |
| Tracy L Breen, Irene M Conwell, Sharon L Wardla. Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Brain research. vol 1032. issue 1-2. 2005-05-12. PMID:15680952. |
effects of fasting, leptin, and insulin on agrp and pomc peptide release in the hypothalamus. |
2005-05-12 |
2023-08-12 |
rat |
| Tracy L Breen, Irene M Conwell, Sharon L Wardla. Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Brain research. vol 1032. issue 1-2. 2005-05-12. PMID:15680952. |
agouti-related protein (agrp) and proopiomelanocortin (pomc) have opposing effects on melanocortin receptor (mc-r) signaling and energy balance, and are important targets for leptin and insulin in the hypothalamus. |
2005-05-12 |
2023-08-12 |
rat |
| Tracy L Breen, Irene M Conwell, Sharon L Wardla. Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Brain research. vol 1032. issue 1-2. 2005-05-12. PMID:15680952. |
here we have examined the effects of fasting, leptin, and insulin on the release of agrp and the pomc-derived peptide gamma(3)-msh from the perifused rat hypothalamus in vitro. |
2005-05-12 |
2023-08-12 |
rat |