| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eliana P Araújo, Cláudio T De Souza, Mirian Ueno, Dennys E Cintra, Manoel B Bertolo, José B Carvalheira, Mário J Saad, Lício A Vellos. Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes. Endocrinology. vol 148. issue 12. 2008-06-17. PMID:17761768. |
in addition, the clinical outcomes were accompanied by improved insulin signal transduction in muscle, liver, and hypothalamus, as determined by the evaluation of insulin-induced insulin receptor, insulin receptor substrate-1, and receptor substrate-2 tyrosine phosphorylation and akt and forkhead box protein o1 serine phosphorylation. |
2008-06-17 |
2023-08-12 |
mouse |
| Isabel Matias, Anna Valeria Vergoni, Stefania Petrosino, Alessandra Ottani, Alessandro Pocai, Alfio Bertolini, Vincenzo Di Marz. Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17675101. |
here we investigated in the rat if insulin, which is known to exert fundamental actions at the level of the mediobasal hypothalamus (mbh), and the melanocortin system, namely alpha-melanocyte stimulating hormone (alpha-msh) and melanocortin receptor-4 (mcr-4), also regulate hypothalamic endocannabinoid levels, measured by isotope-dilution liquid chromatography coupled to mass spectrometry. |
2008-04-18 |
2023-08-12 |
rat |
| Satya P Kalr. Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides. vol 29. issue 1. 2008-04-07. PMID:18053615. |
furthermore, the leptin insufficiency syndrome delineates a novel role of leptin in the hypothalamus in restraining rhythmic pancreatic insulin secretion while concomitantly enhancing glucose metabolism and non-shivering thermogenic energy expenditure, sequelae that would otherwise promote fat accrual to store excess energy resulting from consumption of energy-enriched diets. |
2008-04-07 |
2023-08-12 |
Not clear |
| C A Grillo, K L Tamashiro, G G Piroli, S Melhorn, J T Gass, R J Newsom, L R Reznikov, A Smith, S P Wilson, R R Sakai, L P Reaga. Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. Physiology & behavior. vol 92. issue 4. 2008-01-29. PMID:17585961. |
to further examine the role of irs in the central actions of insulin, we designed an ir antisense lentiviral vector (lv-iras) and injected this vector into the third ventricle to selectively decrease ir expression in the rat hypothalamus. |
2008-01-29 |
2023-08-12 |
rat |
| Attila Juhász, Evelin Katona, Eva Csongrádi, György Parag. [The regulation of body mass and its relation to the development of obesity]. Orvosi hetilap. vol 148. issue 39. 2007-12-21. PMID:17890170. |
body mass--strictly speaking: the adipose tissue mass--is regulated in a feed-back system by the hypothalamus and brainstem, where adiposity signals (leptin, insulin, amylin) and intestinal peptides (ghrelin, pyy, pp, glp-1, oxm, cck) and the vagal nerve provide afferent information to the central controller on the size of white adipose tissue and the actual nutritional state, respectively. |
2007-12-21 |
2023-08-12 |
Not clear |
| Neel S Singhal, Mitchell A Lazar, Rexford S Ahim. Central resistin induces hepatic insulin resistance via neuropeptide Y. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 47. 2007-12-18. PMID:18032666. |
central resistin induces hepatic insulin resistance via neuropeptide y. sensing of peripheral hormones and nutrients by the hypothalamus plays an important role in maintaining peripheral glucose homeostasis. |
2007-12-18 |
2023-08-12 |
mouse |
| Stéphane Boghossian, Michael G Dube, Rita Torto, Pushpa S Kalra, Satya P Kalr. Hypothalamic clamp on insulin release by leptin-transgene expression. Peptides. vol 27. issue 12. 2007-12-06. PMID:16962683. |
the effects of sustained leptin action locally in the hypothalamus on the functional link between fat accrual and insulin secretion after chronic high fat diet (hfd) consumption in leptin-deficient ob/ob mice, and on the post-prandial insulin response in rats consuming regular chow diet (rcd), was examined in this study. |
2007-12-06 |
2023-08-12 |
mouse |
| Stéphane Boghossian, Michael G Dube, Rita Torto, Pushpa S Kalra, Satya P Kalr. Hypothalamic clamp on insulin release by leptin-transgene expression. Peptides. vol 27. issue 12. 2007-12-06. PMID:16962683. |
thus, the efficacy of increased leptin afferent signaling in the hypothalamus to persistently restrain pancreatic insulin release and insulin resistance can be explored as an adjunct therapeutic modality to alleviate pathophysiological derrangements that confer type 2 diabetes. |
2007-12-06 |
2023-08-12 |
mouse |
| M Osto, P Y Wielinga, B Alder, N Walser, T A Lut. Modulation of the satiating effect of amylin by central ghrelin, leptin and insulin. Physiology & behavior. vol 91. issue 5. 2007-11-28. PMID:17481674. |
the adiposity signals leptin and insulin act in the hypothalamus to influence feeding. |
2007-11-28 |
2023-08-12 |
rat |
| David W Miller, Joanne L Harrison, Ellen J Bennett, Patricia A Findlay, Clare L Ada. Nutritional influences on reproductive neuroendocrine output: insulin, leptin, and orexigenic neuropeptide signaling in the ovine hypothalamus. Endocrinology. vol 148. issue 11. 2007-11-27. PMID:17702844. |
nutritional influences on reproductive neuroendocrine output: insulin, leptin, and orexigenic neuropeptide signaling in the ovine hypothalamus. |
2007-11-27 |
2023-08-12 |
Not clear |
| Kazuhisa Honda, Hiroshi Kamisoyama, Takaoki Saneyasu, Kunio Sugahara, Shin Hasegaw. Central administration of insulin suppresses food intake in chicks. Neuroscience letters. vol 423. issue 2. 2007-11-13. PMID:17693022. |
central administration of insulin significantly upregulated mrna levels of proopiomelanocortin (pomc), cocaine- and amphetamine-regulated transcript (cart) and corticotropin-releasing factor (crf), but did not influence mrna levels of neuropeptide y and agouti-related protein in the hypothalamus. |
2007-11-13 |
2023-08-12 |
Not clear |
| Yalda Jamshidi, Theodosios Kyriakou, Sakina B Gooljar, Laura J Collins, Carl A Lane, Harold Snieder, Xiaoling Wang, Tim D Spector, Sandra D O'Del. Common STAT3 variants are not associated with obesity or insulin resistance in female twins. Obesity (Silver Spring, Md.). vol 15. issue 7. 2007-10-26. PMID:17636079. |
in animal models, stat3 action in the hypothalamus and liver appears essential for normal body weight and glucose homeostasis in response to insulin. |
2007-10-26 |
2023-08-12 |
human |
| Nell Marty, Michel Dallaporta, Bernard Thoren. Brain glucose sensing, counterregulation, and energy homeostasis. Physiology (Bethesda, Md.). vol 22. 2007-10-18. PMID:17699877. |
glucose, beside being a nutrient, is also a signal detected by several glucose-sensing units that are located at different anatomical sites and converge to the hypothalamus to cooperate with leptin and insulin in controlling the melanocortin pathway. |
2007-10-18 |
2023-08-12 |
Not clear |
| E L Meyer, C Marcus, E Waldenlin. Nocturnal secretion of growth hormone, noradrenaline, cortisol and insulin in cluster headache remission. Cephalalgia : an international journal of headache. vol 27. issue 8. 2007-10-12. PMID:17645758. |
lipolysis is stimulated by noradrenaline (na), growth hormone (gh) and cortisol, and inhibited by insulin, hormones which are directly or indirectly regulated by the hypothalamus. |
2007-10-12 |
2023-08-12 |
Not clear |
| Z-J Liu, J Bian, J Liu, A Endo. Obesity reduced the gene expressions of leptin receptors in hypothalamus and liver. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 39. issue 7. 2007-09-27. PMID:17611900. |
serum leptin and insulin concentrations were measured and gene expressions of short form of leptin receptor (ob-ra) and long form (ob-rb) in hypothalamus and liver were detected by rt-pcr. |
2007-09-27 |
2023-08-12 |
rat |
| Z-J Liu, J Bian, J Liu, A Endo. Obesity reduced the gene expressions of leptin receptors in hypothalamus and liver. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 39. issue 7. 2007-09-27. PMID:17611900. |
on the other hand, serum insulin levels had no relationship with ob-ra or ob-rb gene expression levels in neither liver nor hypothalamus. |
2007-09-27 |
2023-08-12 |
rat |
| Talita Romanatto, Maristela Cesquini, Maria E Amaral, Erika A Roman, Juliana C Moraes, Márcio A Torsoni, Ariovaldo P Cruz-Neto, Lício A Vellos. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. Peptides. vol 28. issue 5. 2007-08-24. PMID:17459524. |
tnf-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. |
2007-08-24 |
2023-08-12 |
Not clear |
| Talita Romanatto, Maristela Cesquini, Maria E Amaral, Erika A Roman, Juliana C Moraes, Márcio A Torsoni, Ariovaldo P Cruz-Neto, Lício A Vellos. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. Peptides. vol 28. issue 5. 2007-08-24. PMID:17459524. |
in this study, we investigate the capacity of tnf-alpha to activate signal transduction in the hypothalamus through elements of the pathways employed by the anorexigenic hormones insulin and leptin. |
2007-08-24 |
2023-08-12 |
Not clear |
| Talita Romanatto, Maristela Cesquini, Maria E Amaral, Erika A Roman, Juliana C Moraes, Márcio A Torsoni, Ariovaldo P Cruz-Neto, Lício A Vellos. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. Peptides. vol 28. issue 5. 2007-08-24. PMID:17459524. |
in conclusion, tnf-alpha, on a dose-dependent way, modulates insulin and leptin signaling and action in the hypothalamus. |
2007-08-24 |
2023-08-12 |
Not clear |
| Kamlesh V Vavaiya, Sachin A Paranjape, Karen P Brisk. Testicular regulation of neuronal glucose and monocarboxylate transporter gene expression profiles in CNS metabolic sensing sites during acute and recurrent insulin-induced hypoglycemia. Journal of molecular neuroscience : MN. vol 31. issue 1. 2007-07-12. PMID:17416968. |
we investigated whether habituated neuronal reactivity in cns sensing sites to hypoglycemia is correlated with modified monocarboxylate and/or glucose uptake by using quantitative real-time rt-pcr to analyze neuronal monocarboxylate transporter (mct2) and glucose transporter variant (glut and glut4) gene expression profiles in the microdissected lha, ventromedial nucleus hypothalamus (vmh), and dvc after one or multiple insulin injections. |
2007-07-12 |
2023-08-12 |
rat |