| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paty Karoll Picardi, Andrea Moro Caricilli, Lélia Lelis Ferreira de Abreu, José Barreto Campello Carvalheira, Lício Augusto Velloso, Mário José Abdalla Saa. Modulation of hypothalamic PTP1B in the TNF-alpha-induced insulin and leptin resistance. FEBS letters. vol 584. issue 14. 2010-07-27. PMID:20576518. |
the icv infusion of tnf-alpha-induced an increase in ptp1b protein expression and activity, and attenuated insulin and leptin sensitivity and signaling in the hypothalamus. |
2010-07-27 |
2023-08-12 |
rat |
| Paty Karoll Picardi, Andrea Moro Caricilli, Lélia Lelis Ferreira de Abreu, José Barreto Campello Carvalheira, Lício Augusto Velloso, Mário José Abdalla Saa. Modulation of hypothalamic PTP1B in the TNF-alpha-induced insulin and leptin resistance. FEBS letters. vol 584. issue 14. 2010-07-27. PMID:20576518. |
in addition, our data also show that other mechanisms of insulin and leptin resistance are activated in the hypothalamus by tnf-alpha. |
2010-07-27 |
2023-08-12 |
rat |
| Bengt F Belgardt, Tomoo Okamura, Jens C Brünin. Hormone and glucose signalling in POMC and AgRP neurons. The Journal of physiology. vol 587. issue Pt 22. 2010-07-26. PMID:19770186. |
thus, this review attempts to offer an integrative overview about how peripheral signals, particularly leptin, insulin and glucose, converge on a molecular level in pomc and agrp neurons of the arcuate nucleus of the hypothalamus to control energy homeostasis. |
2010-07-26 |
2023-08-12 |
Not clear |
| Tsutomu Sasaki, Hye-Jin Kim, Masaki Kobayashi, Yukari-Ido Kitamura, Hiromi Yokota-Hashimoto, Tetsuya Shiuchi, Yasuhiko Minokoshi, Tadahiro Kitamur. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology. vol 151. issue 6. 2010-06-30. PMID:20375183. |
insulin and leptin signaling regulate food intake by controlling the expression of orexigenic and anorexigenic neuropeptides in the arcuate nucleus of the hypothalamus via forkhead box o (foxo)-1 and signal transducer and activator of transcription-3. |
2010-06-30 |
2023-08-12 |
mouse |
| Tsutomu Sasaki, Hye-Jin Kim, Masaki Kobayashi, Yukari-Ido Kitamura, Hiromi Yokota-Hashimoto, Tetsuya Shiuchi, Yasuhiko Minokoshi, Tadahiro Kitamur. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology. vol 151. issue 6. 2010-06-30. PMID:20375183. |
forced expression of wild-type sirt1 in the mediobasal hypothalamus by adenovirus microinjection suppressed foxo1-induced hyperphagia, a model for central insulin resistance. |
2010-06-30 |
2023-08-12 |
mouse |
| H Tsuneki, T Wada, T Sasaok. Role of orexin in the regulation of glucose homeostasis. Acta physiologica (Oxford, England). vol 198. issue 3. 2010-06-14. PMID:19489767. |
these suggest that hyperglycaemia due to insulin insensitivity during ageing or by habitual consumption of a high-fat diet leads to the reduction in orexin expression in the hypothalamus, thereby further exacerbating peripheral insulin resistance. |
2010-06-14 |
2023-08-12 |
mouse |
| Prajakta V Belsare, Milind G Watve, Saroj S Ghaskadbi, Dattatraya S Bhat, Chittaranjan S Yajnik, Maithili Jo. Metabolic syndrome: aggression control mechanisms gone out of control. Medical hypotheses. vol 74. issue 3. 2010-05-07. PMID:19800745. |
further chronically elevated serotonin signalling in the hypothalamus induces peripheral insulin resistance. |
2010-05-07 |
2023-08-12 |
Not clear |
| George Boukouvalas, Kyriaki Gerozissis, Efthimia Kitrak. Fat feeding of rats during pubertal growth leads to neuroendocrine alterations in adulthood. Cellular and molecular neurobiology. vol 30. issue 1. 2010-04-13. PMID:19649701. |
the neuroendocrine endpoints studied were the levels of circulating leptin, insulin and corticosterone, as well as their receptors in the hypothalamus and hippocampus. |
2010-04-13 |
2023-08-12 |
rat |
| Joshua P Thaler, Sun Ju Choi, Michael W Schwartz, Brent E Wiss. Hypothalamic inflammation and energy homeostasis: resolving the paradox. Frontiers in neuroendocrinology. vol 31. issue 1. 2010-04-08. PMID:19822168. |
on the other hand, numerous recent studies implicate inflammatory activation within the hypothalamus as a key factor whereby high-fat diets--and saturated fats in particular--cause central leptin and insulin resistance and thereby promote the defense of elevated body weight. |
2010-04-08 |
2023-08-12 |
Not clear |
| Kevin W Williams, Lisandra O Margatho, Charlotte E Lee, Michelle Choi, Syann Lee, Michael M Scott, Carol F Elias, Joel K Elmquis. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 7. 2010-03-19. PMID:20164331. |
several studies have described a "cross talk" between leptin and insulin within the mediobasal hypothalamus via the intracellular enzyme, phosphoinositol-3-kinase (pi3k). |
2010-03-19 |
2023-08-12 |
Not clear |
| H Quesne. Nutritional and lactational effects on follicular development in the pig. Society of Reproduction and Fertility supplement. vol 66. 2010-03-11. PMID:19848276. |
glucose, insulin and leptin are the most likely signals informing the hypothalamus of the metabolic state, yet their roles have not been definitely established. |
2010-03-11 |
2023-08-12 |
Not clear |
| Sunmin Park, Sang Mee Hong, Il Sung Ah. Long-term intracerebroventricular infusion of insulin, but not glucose, modulates body weight and hepatic insulin sensitivity by modifying the hypothalamic insulin signaling pathway in type 2 diabetic rats. Neuroendocrinology. vol 89. issue 4. 2010-03-01. PMID:19176946. |
it has been reported that the short-term injection of insulin and glucose into the hypothalamus modulates body weight and hepatic glucose production in non-diabetic rats. |
2010-03-01 |
2023-08-12 |
rat |
| Ji-Yao Li, Biao-Xin Chai, Weizhen Zhang, Hui Wang, Michael W Mulhollan. Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotype. Endocrinology. vol 151. issue 1. 2010-02-22. PMID:19934378. |
injection of insulin into the third ventricle of the rat brain increased asb-4 mrna expression in the paraventricular nucleus but not in the arc of the hypothalamus, whereas injection of leptin (ip) increased asb-4 expression in both mouse paraventricular nucleus and arc. |
2010-02-22 |
2023-08-12 |
mouse |
| Megan E Bardgett, John J McCarthy, Sean D Stocke. Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia. Hypertension (Dallas, Tex. : 1979). vol 55. issue 2. 2010-02-22. PMID:20065145. |
western blot analysis showed that insulin receptor expression is significantly lower in the rvlm than the hypothalamus, and direct microinjection of insulin into the rvlm did not significantly increase lumbar sna. |
2010-02-22 |
2023-08-12 |
rat |
| Jean-François Tanti, Jennifer Jage. Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Current opinion in pharmacology. vol 9. issue 6. 2010-02-08. PMID:19683471. |
studies with genetically modified mice reveal that these kinases integrate signals from metabolic and inflammatory stresses in adipose tissue, liver, and hypothalamus leading to peripheral and central insulin resistance. |
2010-02-08 |
2023-08-12 |
mouse |
| Satya P Kalr. Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation. Peptides. vol 30. issue 10. 2010-02-01. PMID:19647774. |
in this context various lines of evidence are collated here to show that (1) under the direction of leptin two independent relays emanating from the hypothalamus restrain insulin secretion from the pancreas and mobilize peripheral organs--liver, skeletal muscle and brown adipose tissue--to upregulate glucose disposal, and (2), leptin insufficiency in the hypothalamus produced by either leptinopenia or restriction of leptin transport across the blood brain barrier due to hyperleptinemia of obesity and aging, initiate antecedent pathophysiological sequalae of diabetes type 1 and 2. |
2010-02-01 |
2023-08-12 |
Not clear |
| Satya P Kalr. Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation. Peptides. vol 30. issue 10. 2010-02-01. PMID:19647774. |
further, we document here the efficacy of leptin replenishment in vivo, especially by supplying it to the hypothalamus with the aid of gene therapy, in preventing the antecedent pathophysiological sequalae--hyperinsulinemia, insulin resistance and hyperglycemia--in various animal models and clinical paradigms of diabetes type 1 and 2 with or without attendant obesity. |
2010-02-01 |
2023-08-12 |
Not clear |
| Jong Chul Won, Pil-Geum Jang, Churl Namkoong, Eun Hee Koh, Suk Kyeoug Kim, Joong-Yeol Park, Ki-Up Lee, Min-Seon Ki. Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin. Obesity (Silver Spring, Md.). vol 17. issue 10. 2010-01-26. PMID:19543218. |
leptin and insulin are important anorexigenic hormones acting on the hypothalamus. |
2010-01-26 |
2023-08-12 |
mouse |
| Jong Chul Won, Pil-Geum Jang, Churl Namkoong, Eun Hee Koh, Suk Kyeoug Kim, Joong-Yeol Park, Ki-Up Lee, Min-Seon Ki. Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin. Obesity (Silver Spring, Md.). vol 17. issue 10. 2010-01-26. PMID:19543218. |
icv administration of tg by itself activated signal-transduction-activated-transcript-3 (stat3) and akt in the hypothalamus, but prevented a further activation of hypothalamic stat3 and akt by leptin and insulin. |
2010-01-26 |
2023-08-12 |
mouse |
| Sami Dridi, Mohammed Taoui. Adiponectin and energy homeostasis: consensus and controversy. The Journal of nutritional biochemistry. vol 20. issue 11. 2010-01-19. PMID:19716279. |
despite the disparate data, recent advances in our understanding of the signal transduction mechanisms used by adiponectin in the periphery and in the hypothalamus suggest that intracellular cross-talk between adiponectin, leptin and insulin may occur at several levels. |
2010-01-19 |
2023-08-12 |
Not clear |