| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sunmin Park, Da Sol Kim, James W Dail. Central infusion of ketone bodies modulates body weight and hepatic insulin sensitivity by modifying hypothalamic leptin and insulin signaling pathways in type 2 diabetic rats. Brain research. vol 1401. 2012-05-14. PMID:21652033. |
long-term infusion of bhb potentiated leptin and insulin signaling in the hypothalamus to slightly decrease body weight in px rats. |
2012-05-14 |
2023-08-12 |
rat |
| Sunmin Park, Da Sol Kim, James W Dail. Central infusion of ketone bodies modulates body weight and hepatic insulin sensitivity by modifying hypothalamic leptin and insulin signaling pathways in type 2 diabetic rats. Brain research. vol 1401. 2012-05-14. PMID:21652033. |
in conclusion, mild ketosis by central infusion of ketones improves energy and glucose metabolism through the potentiation of leptin and insulin signaling in the hypothalamus of diabetic rats. |
2012-05-14 |
2023-08-12 |
rat |
| Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma, Hironobu Yoshimats. Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22035323. |
this study aimed to determine whether dpp-iv inhibitor-induced elevation of portal glp-1 levels affect insulin secretion and feeding behavior via the vagal afferent nerve and hypothalamus. |
2012-05-03 |
2023-08-12 |
rat |
| Emma Burgos-Ramos, Agueda González-Rodríguez, Sandra Canelles, Eva Baquedano, Laura M Frago, Jesús Revuelta-Cervantes, Javier Gómez-Ambrosi, Gema Frühbeck, Julie A Chowen, Jesús Argente, Angela M Valverde, Vicente Barrio. Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice. Endocrinology. vol 153. issue 3. 2012-04-16. PMID:22210743. |
we analyzed the activation of leptin and insulin targets by western blotting and their association by immunoprecipitation, as well as the mrna levels of neuropeptide y (npy), proopiomelanocortin, and inflammatory markers by real-time pcr and colocalization of forkhead box protein o1 (foxo1) and npy by double immunohistochemistry in the hypothalamus. |
2012-04-16 |
2023-08-12 |
mouse |
| Hye-Jin Kim, Masaki Kobayashi, Tsutomu Sasaki, Osamu Kikuchi, Kosuke Amano, Tomoya Kitazumi, Yong-Soo Lee, Hiromi Yokota-Hashimoto, Vina Yanti Susanti, Yukari Ido Kitamura, Jun Nakae, Tadahiro Kitamur. Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance. Endocrinology. vol 153. issue 2. 2012-03-27. PMID:22186407. |
recent studies have revealed that insulin signaling in pancreatic β-cells and the hypothalamus is critical for maintaining nutrient and energy homeostasis, the failure of which are hallmarks of metabolic syndrome. |
2012-03-27 |
2023-08-12 |
mouse |
| Hye-Jin Kim, Masaki Kobayashi, Tsutomu Sasaki, Osamu Kikuchi, Kosuke Amano, Tomoya Kitazumi, Yong-Soo Lee, Hiromi Yokota-Hashimoto, Vina Yanti Susanti, Yukari Ido Kitamura, Jun Nakae, Tadahiro Kitamur. Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance. Endocrinology. vol 153. issue 2. 2012-03-27. PMID:22186407. |
we previously reported that forkhead transcription factor forkhead box-containing protein of the o subfamily (foxo)1, a downstream effector of insulin signaling, plays important roles in β-cells and the hypothalamus when we investigated the roles of foxo1 independently in the pancreas and hypothalamus. |
2012-03-27 |
2023-08-12 |
mouse |
| Arine M Melo, Priscila Bittencourt, Fernanda S Nakutis, Anna P Silva, Janaina Cursino, Gustavo A Santos, Nicole G Ashino, Licio A Velloso, Adriana S Torsoni, Marcio A Torson. Solidago chilensis Meyen hydroalcoholic extract reduces JNK/IκB pathway activation and ameliorates insulin resistance in diet-induced obesity mice. Experimental biology and medicine (Maywood, N.J.). vol 236. issue 10. 2011-11-29. PMID:21844120. |
akt phosphorylation stimulated by insulin in the liver, hypothalamus and skeletal muscle was higher in schfd as compared with hfd mice. |
2011-11-29 |
2023-08-12 |
mouse |
| Joseph S Marino, Yong Xu, Jennifer W Hil. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends in endocrinology and metabolism: TEM. vol 22. issue 7. 2011-11-08. PMID:21489811. |
this review discusses the neuronal crosstalk between the hypothalamus, autonomic nervous system, and tissues associated with the pathogenesis of type 2 diabetes, and how hypothalamic insulin and leptin signaling are integral to maintaining normal glucose homeostasis. |
2011-11-08 |
2023-08-12 |
Not clear |
| Bethany P Cummings, Ahmed Bettaieb, James L Graham, Kimber L Stanhope, Riva Dill, Gregory J Morton, Fawaz G Haj, Peter J Have. Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 35. 2011-11-08. PMID:21873226. |
these effects coincided with activation of leptin and insulin signaling pathways and down-regulation of the pkr-like endoplasmic reticulum (er) kinase/eukaryotic translation inhibition factor 2α (perk-eif2α) arm of er stress in liver, skeletal muscle, and adipose tissue as well as increased pro-opiomelanocortin and decreased agouti-related peptide in the hypothalamus. |
2011-11-08 |
2023-08-12 |
rat |
| Miriam Granado, Cristina García-Cáceres, María Tuda, Laura M Frago, Julie A Chowen, Jesús Argent. Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats. Molecular and cellular endocrinology. vol 337. issue 1-2. 2011-09-26. PMID:21352888. |
insulin and growth hormone-releasing peptide-6 (ghrp-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (stz)-induced diabetic rats. |
2011-09-26 |
2023-08-12 |
rat |
| Miriam Granado, Cristina García-Cáceres, María Tuda, Laura M Frago, Julie A Chowen, Jesús Argent. Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats. Molecular and cellular endocrinology. vol 337. issue 1-2. 2011-09-26. PMID:21352888. |
hence, we analyzed the effect of insulin and gh-releasing peptide 6 (ghrp-6) on diabetes-induced apoptosis in the pituitary, hypothalamus and cerebellum of diabetic rats. |
2011-09-26 |
2023-08-12 |
rat |
| Miriam Granado, Cristina García-Cáceres, María Tuda, Laura M Frago, Julie A Chowen, Jesús Argent. Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats. Molecular and cellular endocrinology. vol 337. issue 1-2. 2011-09-26. PMID:21352888. |
in the hypothalamus, neither insulin nor ghrp-6 decreased diabetes-induced cell death. |
2011-09-26 |
2023-08-12 |
rat |
| Priscila A Cassaglia, Sam M Hermes, Sue A Aicher, Virginia L Brook. Insulin acts in the arcuate nucleus to increase lumbar sympathetic nerve activity and baroreflex function in rats. The Journal of physiology. vol 589. issue Pt 7. 2011-08-24. PMID:21300750. |
we tested the hypotheses that (1) the paraventricular nucleus of the hypothalamus (pvn) and the arcuate nucleus (arcn) are necessary brain sites and (2) insulin initiates its effects directly in the pvn and/or the arcn. |
2011-08-24 |
2023-08-12 |
rat |
| Jun-Ichi Shiraishi, Kouichi Yanagita, Rika Fukumori, Toshihisa Sugino, Masanori Fujita, Shin-Ichi Kawakami, John P McMurtry, Takashi Bung. Comparisons of insulin related parameters in commercial-type chicks: Evidence for insulin resistance in broiler chicks. Physiology & behavior. vol 103. issue 2. 2011-07-15. PMID:21316379. |
secondly, blood and hypothalamus were collected from both chick types under ad libitum feeding and fasting for 24 h. plasma insulin concentration was measured by time-resolved fluoro-immunoassay. |
2011-07-15 |
2023-08-12 |
chicken |
| Dianne P Figlewicz, Jennifer L Bennett-Jay, Sepideh Kittleson, Alfred J Sipols, Aryana Zavos. Sucrose self-administration and CNS activation in the rat. American journal of physiology. Regulatory, integrative and comparative physiology. vol 300. issue 4. 2011-06-16. PMID:21307361. |
we have previously reported that administration of insulin into the arcuate nucleus of the hypothalamus decreases motivation for sucrose, assessed by a self-administration task, in rats. |
2011-06-16 |
2023-08-12 |
rat |
| Thomas Scherer, James O'Hare, Kelly Diggs-Andrews, Martina Schweiger, Bob Cheng, Claudia Lindtner, Elizabeth Zielinski, Prashant Vempati, Kai Su, Shveta Dighe, Thomas Milsom, Michelle Puchowicz, Ludger Scheja, Rudolf Zechner, Simon J Fisher, Stephen F Previs, Christoph Buettne. Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell metabolism. vol 13. issue 2. 2011-05-19. PMID:21284985. |
here, we show that insulin infused into the mediobasal hypothalamus (mbh) of sprague-dawley rats increases wat lipogenic protein expression, inactivates hormone-sensitive lipase (hsl), and suppresses lipolysis. |
2011-05-19 |
2023-08-12 |
mouse |
| Emma Burgos-Ramos, Julie A Chowen, Eduardo Arilla-Ferreiro, Sandra Canelles, Jesús Argente, Vicente Barrio. Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3. Journal of neurochemistry. vol 117. issue 1. 2011-05-16. PMID:21255014. |
leptin and insulin have overlapping intracellular signaling mechanisms and exert anorexigenic actions in the hypothalamus. |
2011-05-16 |
2023-08-12 |
rat |
| Emma Burgos-Ramos, Julie A Chowen, Eduardo Arilla-Ferreiro, Sandra Canelles, Jesús Argente, Vicente Barrio. Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3. Journal of neurochemistry. vol 117. issue 1. 2011-05-16. PMID:21255014. |
we analyzed the activation and interactions of components of the phosphatidylinositol 3-kinase (pi3k)/akt pathway in the hypothalamus of rats treated icv for 14 days with leptin followed by a central injection of insulin and killed 15 min later. |
2011-05-16 |
2023-08-12 |
rat |
| S P S Ghuman, R Morris, J Scherzer, J E Routly, A Mobasheri, R F Smith, H Dobso. Neuronal responses in the brainstem and hypothalamic nuclei following insulin treatment during the late follicular phase in the ewe. Reproduction in domestic animals = Zuchthygiene. vol 46. issue 1. 2011-04-28. PMID:20403131. |
overall, a complex system of neurones in brainstem and hypothalamus is activated following insulin administration during the late follicular phase. |
2011-04-28 |
2023-08-12 |
Not clear |
| Undurti N Das, Gaston Repossi, Alejandro Dain, Aldo Renato Eynar. Is insulin resistance a disorder of the brain? Frontiers in bioscience (Landmark edition). vol 16. 2011-04-21. PMID:21196154. |
there is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. |
2011-04-21 |
2023-08-12 |
Not clear |