| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Scherer, Claudia Lindtner, Elizabeth Zielinski, James O'Hare, Nika Filatova, Christoph Buettne. Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis. The Journal of biological chemistry. vol 287. issue 39. 2012-12-07. PMID:22810223. |
overfeeding did not impair insulin signaling in wat, but it abolished the ability of mediobasal hypothalamus insulin to suppress wat lipolysis and hepatic glucose production as assessed by glycerol and glucose flux. |
2012-12-07 |
2023-08-12 |
human |
| O V Chistyakova, I B Sukhov, M L Loshkareva, V N Shipilov, V M Bondareva, A O Shpako. Initial stages of the insulin signaling system in the brain of rats with experimental diabetes mellitus. Bulletin of experimental biology and medicine. vol 153. issue 1. 2012-11-28. PMID:22808485. |
in type 1 diabetes mellitus characterized by acute insulin insufficiency, specific binding of insulin in rat brain increased 2-fold in comparison with the control and irs2-gene expression in rat hypothalamus and cortex 2-4 fold surpassed the normal values. |
2012-11-28 |
2023-08-12 |
rat |
| Andrea M Caricilli, Erica Penteado, Lélia L de Abreu, Paula G F Quaresma, Andressa C Santos, Dioze Guadagnini, Daniella Razolli, Francine C Mittestainer, Jose B Carvalheira, Licio A Velloso, Mario J A Saad, Patricia O Prad. Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice. Endocrinology. vol 153. issue 9. 2012-10-29. PMID:22822160. |
thus, we investigate herein whether short-term tpm treatment alters energy balance by affecting insulin and leptin signaling, action, or neuropeptide expression in the hypothalamus of mice fed with a high-fat diet. |
2012-10-29 |
2023-08-12 |
mouse |
| Jane Yellowlees Douglas, Ashay D Bhatwadekar, Sergio Li Calzi, Lynn C Shaw, Debra Carnegie, Sergio Caballero, Quihong Li, Alan W Stitt, Mohan K Raizada, Maria B Gran. Bone marrow-CNS connections: implications in the pathogenesis of diabetic retinopathy. Progress in retinal and eye research. vol 31. issue 5. 2012-10-04. PMID:22609081. |
the resulting systemic inflammation further impacts the hypothalamus, promoting insulin resistance and diabetes, and initiates an inflammatory cascade that adversely impacts both macrovascular and microvascular complications, including diabetic retinopathy (dr). |
2012-10-04 |
2023-08-12 |
Not clear |
| Jessica T Y Yue, Tony K T La. Lipid sensing and insulin resistance in the brain. Cell metabolism. vol 15. issue 5. 2012-10-03. PMID:22560217. |
here, we discuss the underlying molecular and neuronal mechanisms of lipid sensing and insulin signaling in the hypothalamus and how these mechanisms are affected in response to high-fat feeding. |
2012-10-03 |
2023-08-12 |
Not clear |
| M J McKinley, B J Oldfiel. The brain as an endocrine target for Peptide hormones. Trends in endocrinology and metabolism: TEM. vol 9. issue 9. 2012-10-02. PMID:18406304. |
there are some circulating peptides such as insulin and leptin that are transported from the bloodstream across cerebral blood vessel walls into sites in the hypothalamus that have appropriate neural connections to influence food intake and sympathetic control of brown fat. |
2012-10-02 |
2023-08-12 |
Not clear |
| G A Werther, A Hogg, B J Oldfield, M J McKinley, R Figdor, F A Mendelsoh. Localization and Characterization of Insulin-Like Growth Factor-I Receptors in Rat Brain and Pituitary Gland Using in vitro Autoradiography and Computerized Densitometry* A Distinct Distribution from Insulin Receptors. Journal of neuroendocrinology. vol 1. issue 5. 2012-10-02. PMID:19210430. |
the hypothalamus was more widely labelled with insulin, while in the thalamus the converse was true. |
2012-10-02 |
2023-08-12 |
rat |
| E Bobbioni-Harsch, B Jeanrenau. The hypothalamic origin of an insulin secretion promoting factor present in the plasma of normal rats. Journal of neuroendocrinology. vol 1. issue 2. 2012-10-02. PMID:19210466. |
conversely, the insulin secretion promoting activity is decreased in plasma from rats whose ventral hypothalamus is acutely and electrolytically lesioned. |
2012-10-02 |
2023-08-12 |
rat |
| E Bobbioni-Harsch, B Jeanrenau. The hypothalamic origin of an insulin secretion promoting factor present in the plasma of normal rats. Journal of neuroendocrinology. vol 1. issue 2. 2012-10-02. PMID:19210466. |
these data indicate that, in normal rats, the hypothalamus contains an insulin secretion promoting factor that is releasable in the plasma. |
2012-10-02 |
2023-08-12 |
rat |
| N Nahas, A S Abdul-Ghan. Species-directed variation and non-uniform distribution of glycogen in mammalian brains during starvation, diabetes and anesthesia. Neurochemistry international. vol 14. issue 1. 2012-10-02. PMID:20504394. |
the reduced glycogen concentration in thalamus, hypothalamus and medulla of diabetic rats could be corrected by insulin treatment, indicating that glycogen metabolism in these areas is insulin dependent. |
2012-10-02 |
2023-08-12 |
mouse |
| Clare L Adam, Patricia A Findlay, Raymond P Aitken, John S Milne, Jacqueline M Wallac. In vivo changes in central and peripheral insulin sensitivity in a large animal model of obesity. Endocrinology. vol 153. issue 7. 2012-09-20. PMID:22593271. |
here we examined in vivo peripheral and central insulin sensitivity, and whether central insensitivity in terms of the voluntary food intake (vfi) response occurs within the hypothalamus or at blood-brain transfer level, during obesity and after subsequent weight loss. |
2012-09-20 |
2023-08-12 |
Not clear |
| Olivia Osborn, Da Young Oh, Joanne McNelis, Manuel Sanchez-Alavez, Saswata Talukdar, Min Lu, Pingping Li, Lucinda Thiede, Hidetaka Morinaga, Jane J Kim, Jan Heinrichsdorff, Sarah Nalbandian, Jachelle M Ofrecio, Miriam Scadeng, Simon Schenk, John Hadcock, Tamas Bartfai, Jerrold M Olefsk. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. The Journal of clinical investigation. vol 122. issue 7. 2012-09-11. PMID:22653059. |
we found that the orphan gpcr gpr21 was highly expressed in the hypothalamus and macrophages of mice and that whole-body ko of this receptor led to a robust improvement in glucose tolerance and systemic insulin sensitivity and a modest lean phenotype. |
2012-09-11 |
2023-08-12 |
mouse |
| Carina S Solon, Daniel Franci, Letícia M Ignacio-Souza, Talita Romanatto, Erika A Roman, Ana P Arruda, Joseane Morari, Adriana S Torsoni, Everardo M Carneiro, Licio A Vellos. Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats. Amino acids. vol 42. issue 6. 2012-09-10. PMID:21818562. |
taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats. |
2012-09-10 |
2023-08-12 |
rat |
| Carina S Solon, Daniel Franci, Letícia M Ignacio-Souza, Talita Romanatto, Erika A Roman, Ana P Arruda, Joseane Morari, Adriana S Torsoni, Everardo M Carneiro, Licio A Vellos. Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats. Amino acids. vol 42. issue 6. 2012-09-10. PMID:21818562. |
thus, the aminoacid, taurine, exerts a potent anorexigenic action in the hypothalamus and enhances the effect of insulin on the control of food intake. |
2012-09-10 |
2023-08-12 |
rat |
| James A Armitage, Sandra L Burke, Larissa J Prior, Benjamin Barzel, Nina Eikelis, Kyungjoon Lim, Geoffrey A Hea. Rapid onset of renal sympathetic nerve activation in rabbits fed a high-fat diet. Hypertension (Dallas, Tex. : 1979). vol 60. issue 1. 2012-09-07. PMID:22647890. |
increased plasma leptin and insulin may contribute to the initiation of hypertension but are not required for maintenance of mean arterial pressure, which likely lies in alterations in the response of neurons in the hypothalamus. |
2012-09-07 |
2023-08-12 |
Not clear |
| Maricedes Acosta-Martíne. PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction. Frontiers in endocrinology. vol 2. 2012-08-23. PMID:22654843. |
metabolic models known to alter gnrh/lh release such as diabetes, diet-induced obesity, and caloric restriction are also accompanied by impairment of pi3k signaling in insulin and leptin sensitive tissues including the hypothalamus. |
2012-08-23 |
2023-08-12 |
Not clear |
| Dongsheng Cai, Tiewen Li. Inflammatory cause of metabolic syndrome via brain stress and NF-κB. Aging. vol 4. issue 2. 2012-07-11. PMID:22328600. |
this type of nutrition-related molecular inflammation in the central nervous system, particularly in the hypothalamus, can form a common pathogenic basis for the induction of various metabolic syndrome components such as obesity, insulin resistance, and hypertension. |
2012-07-11 |
2023-08-12 |
Not clear |
| Yoshihiro Ito, Ryoichi Banno, Shigeru Hagimoto, Yoshiharu Ozawa, Hiroshi Arima, Yutaka Ois. TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures. Regulatory peptides. vol 174. issue 1-3. 2012-07-03. PMID:22166493. |
these data suggest that tnfα acts on the hypothalamus to increase hypothalamic ptp1b expression and activity via the nfκb pathway, and that tnfα-mediated induction of nfκb in the hypothalamus may cause leptin and insulin resistance in the hypothalamus by increasing hypothalamic ptp1b activity. |
2012-07-03 |
2023-08-12 |
rat |
| Ioannis Papazoglou, Flavien Berthou, Nicolas Vicaire, Claude Rouch, Eirini M Markaki, Danielle Bailbe, Bernard Portha, Mohammed Taouis, Kyriaki Gerozissi. Hypothalamic serotonin-insulin signaling cross-talk and alterations in a type 2 diabetic model. Molecular and cellular endocrinology. vol 350. issue 1. 2012-05-18. PMID:22209745. |
serotonin and insulin are key regulators of homeostatic mechanisms in the hypothalamus. |
2012-05-18 |
2023-08-12 |
rat |
| Ioannis Papazoglou, Flavien Berthou, Nicolas Vicaire, Claude Rouch, Eirini M Markaki, Danielle Bailbe, Bernard Portha, Mohammed Taouis, Kyriaki Gerozissi. Hypothalamic serotonin-insulin signaling cross-talk and alterations in a type 2 diabetic model. Molecular and cellular endocrinology. vol 350. issue 1. 2012-05-18. PMID:22209745. |
we used a diabetic model, the goto kakizaki (gk) rats, to explore insulin receptor expression, insulin and serotonin efficiency in the hypothalamus and liver by means of akt phosphorylation. |
2012-05-18 |
2023-08-12 |
rat |