| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min-Seon Kim, Youngmi K Pak, Pil-Geum Jang, Cherl Namkoong, Yon-Sik Choi, Jong-Chul Won, Kyung-Sup Kim, Seung-Whan Kim, Hyo-Soo Kim, Joong-Yeol Park, Young-Bum Kim, Ki-Up Le. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nature neuroscience. vol 9. issue 7. 2006-09-05. PMID:16783365. |
insulin signaling in the hypothalamus plays a role in maintaining body weight. |
2006-09-05 |
2023-08-12 |
mouse |
| Guoqing Sheng, Guo-qing Chang, John Y Lin, Zhao-Xue Yu, Zhi-Hui Fang, Juan Rong, Stuart A Lipton, Shi-Hua Li, Gang Tong, Sarah F Leibowitz, Xiao-Jiang L. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nature medicine. vol 12. issue 5. 2006-07-18. PMID:16604089. |
the hypothalamus responds to circulating leptin and insulin in the control of food intake and body weight. |
2006-07-18 |
2023-08-12 |
mouse |
| Guoqing Sheng, Guo-qing Chang, John Y Lin, Zhao-Xue Yu, Zhi-Hui Fang, Juan Rong, Stuart A Lipton, Shi-Hua Li, Gang Tong, Sarah F Leibowitz, Xiao-Jiang L. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nature medicine. vol 12. issue 5. 2006-07-18. PMID:16604089. |
here, we report that fasting upregulates the expression of hap1 in the rodent hypothalamus, whereas intracerebroventricular administration of insulin downregulates hap1 by increasing its degradation through ubiquitination. |
2006-07-18 |
2023-08-12 |
mouse |
| Sunmin Park, Jin Sun Jang, Dong Wha Jun, Sang Mee Hon. Exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic rats. Neuroendocrinology. vol 82. issue 5-6. 2006-07-18. PMID:16721034. |
exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic rats. |
2006-07-18 |
2023-08-12 |
rat |
| Sunmin Park, Jin Sun Jang, Dong Wha Jun, Sang Mee Hon. Exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic rats. Neuroendocrinology. vol 82. issue 5-6. 2006-07-18. PMID:16721034. |
the data revealed that the administration of a high dose (0.1 mg/kg body weight/day) of dex (hdex) attenuated insulin signaling in the cerebral cortex and hypothalamus, whereas exercise potentiated their insulin signaling along with induction of irs2 expression. |
2006-07-18 |
2023-08-12 |
rat |
| Sunmin Park, Jin Sun Jang, Dong Wha Jun, Sang Mee Hon. Exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic rats. Neuroendocrinology. vol 82. issue 5-6. 2006-07-18. PMID:16721034. |
in conclusion, exercise improves insulin and leptin signaling in the cerebral cortex and hypothalamus of diabetic rats exacerbated with hdex, contributing to the regulation of body weight and glucose homeostasis. |
2006-07-18 |
2023-08-12 |
rat |
| Kinh-Tung T Nguyen, Panteha Tajmir, Chia Hung Lin, Nicole Liadis, Xu-Dong Zhu, Mohammed Eweida, Gunce Tolasa-Karaman, Fang Cai, Rennian Wang, Tadahiro Kitamura, Denise D Belsham, Michael B Wheeler, Akira Suzuki, Tak W Mak, Minna Wo. Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Molecular and cellular biology. vol 26. issue 12. 2006-07-17. PMID:16738317. |
recently, rodent insulin transcription was also shown in the brain, particularly the hypothalamus. |
2006-07-17 |
2023-08-12 |
mouse |
| Kinh-Tung T Nguyen, Panteha Tajmir, Chia Hung Lin, Nicole Liadis, Xu-Dong Zhu, Mohammed Eweida, Gunce Tolasa-Karaman, Fang Cai, Rennian Wang, Tadahiro Kitamura, Denise D Belsham, Michael B Wheeler, Akira Suzuki, Tak W Mak, Minna Wo. Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Molecular and cellular biology. vol 26. issue 12. 2006-07-17. PMID:16738317. |
the partial deletion of pten in the hypothalamus resulted in significant whole-body growth restriction and increased insulin sensitivity. |
2006-07-17 |
2023-08-12 |
mouse |
| Kenjirou Okamoto, Tetsuya Kakuma, Satoshi Fukuchi, Takayuki Masaki, Toshiie Sakata, Hironobu Yoshimats. Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes. Brain research. vol 1081. issue 1. 2006-07-06. PMID:16554040. |
infusion of 2.0 miu insulin or 3.0 microg leptin into the third cerebroventricle did not affect srebp-1 mrna expression in either hypothalamus or cerebrum. |
2006-07-06 |
2023-08-12 |
mouse |
| Akihiko Wada, Hiroki Yokoo, Toshihiko Yanagita, Hideyuki Kobayash. New twist on neuronal insulin receptor signaling in health, disease, and therapeutics. Journal of pharmacological sciences. vol 99. issue 2. 2006-05-03. PMID:16210778. |
in the hypothalamus, insulin regulates food intake, body weight, peripheral fat deposition, hepatic gluconeogenesis, reproductive endocrine axis, and compensatory secretion of counter-regulatory hormones to hypoglycemia. |
2006-05-03 |
2023-08-12 |
Not clear |
| Akihiko Wada, Hiroki Yokoo, Toshihiko Yanagita, Hideyuki Kobayash. New twist on neuronal insulin receptor signaling in health, disease, and therapeutics. Journal of pharmacological sciences. vol 99. issue 2. 2006-05-03. PMID:16210778. |
in the hypothalamus, insulin-induced activation of the phosphoinositide 3-kinase pathway followed by opening of atp-sensitive k+ channel has been shown to be related to multiple effects of insulin. |
2006-05-03 |
2023-08-12 |
Not clear |
| Bernard Beck, Rouba Kozak, Kim M Moar, Julian G Merce. Hypothalamic orexigenic peptides are overexpressed in young Long-Evans rats after early life exposure to fat-rich diets. Biochemical and biophysical research communications. vol 342. issue 2. 2006-04-28. PMID:16487482. |
to establish the influence of the macronutrient type on feeding regulatory mechanisms and more particularly on stimulatory pathways (galanin and orexins), we fed female rats on either a high-carbohydrate (hc), a high-fat (hf), or a well-balanced control diet during gestation and lactation, and measured peptide expression in the hypothalamus and important hormones (leptin, insulin) in their pups at weaning. |
2006-04-28 |
2023-08-12 |
rat |
| Jean Girar. Insulin's effect on the liver: "direct or indirect?" continues to be the question. The Journal of clinical investigation. vol 116. issue 2. 2006-03-23. PMID:16453016. |
these data balance previous studies in mice that suggested that indirect effects of insulin via the hypothalamus are the primary determinant of hgp. |
2006-03-23 |
2023-08-12 |
mouse |
| Effiong E Otukonyong, Michael G Dube, Rita Torto, Pushpa S Kalra, Satya P Kalr. Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight. Peptides. vol 26. issue 12. 2006-02-28. PMID:15936848. |
we tested the hypothesis that leptin acts centrally to differentially modulate the ultradian communication of leptin, insulin and ghrelin with the hypothalamus. |
2006-02-28 |
2023-08-12 |
rat |
| A C Heijboer, P J Voshol, E Donga, C G van Eden, L M Havekes, J A Romijn, H Pijl, E P M Corssmi. High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice. Peptides. vol 26. issue 12. 2006-02-28. PMID:15979206. |
the purpose of the present study was to investigate the effects of 2 weeks high fat feeding in wildtype mice on (1) insulin sensitivity and triglyceride accumulation in liver and muscle in relation to (2) mrna expression levels of neuropeptide y (npy), agouti-related protein (agrp), pro-opiomelanocortin (pomc), and cocaine- and amphetamine-regulated transcript (cart) in the hypothalamus. |
2006-02-28 |
2023-08-12 |
mouse |
| A C Heijboer, P J Voshol, E Donga, C G van Eden, L M Havekes, J A Romijn, H Pijl, E P M Corssmi. High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice. Peptides. vol 26. issue 12. 2006-02-28. PMID:15979206. |
this study shows that 2 weeks of high fat feeding in mice does not affect mrna expression levels of npy, agrp, pomc or cart, in the whole hypothalamus, despite induction of hepatic, but not peripheral, insulin resistance. |
2006-02-28 |
2023-08-12 |
mouse |
| J Ducob. [The endocannabinoid system and the regulation of the metabolism]. Revue medicale de Bruxelles. vol 26. issue 3. 2006-02-21. PMID:16038140. |
overactivation of the endocannabinoid system is observed in obesity, with stimulation of the appetite in the hypothalamus and fat accumulation in the adipocytes with increase of insulin resistance and decrease of adiponectin. |
2006-02-21 |
2023-08-12 |
Not clear |
| Satya P Kalra, Pushpa S Kalr. Subjugation of hypothalamic NPY and cohorts with central leptin gene therapy alleviates dyslipidemia, insulin resistance, and obesity for life-time. EXS. issue 95. 2006-02-07. PMID:16383005. |
increasing the supply of the endogenous repressor hormone leptin locally in the hypothalamus with the aid of leptin gene therapy, blocked age-related and dietary obesities, and the sequential development of dyslipidemia, hyperglycemia, and insulin resistance. |
2006-02-07 |
2023-08-12 |
Not clear |
| Yacir Benomar, Sandrine Wetzler, Christiane Larue-Achagiotis, Jean Djiane, Daniel Tomé, Mohammed Taoui. In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus. Molecular and cellular endocrinology. vol 242. issue 1-2. 2006-01-24. PMID:16150536. |
in vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus. |
2006-01-24 |
2023-08-12 |
rat |
| Yacir Benomar, Anne-France Roy, Alain Aubourg, Jean Djiane, Mohammed Taoui. Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line. The Biochemical journal. vol 388. issue Pt 3. 2005-12-13. PMID:15715521. |
leptin and insulin are major signals to the hypothalamus to regulate energy homoeostasis and body adiposity. |
2005-12-13 |
2023-08-12 |
human |