| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rafael C Gaspar, Susana C B R Nakandakari, Vitor R Muñoz, Renan F L Vieira, Adelino S R da Silva, Dennys E Cintra, Leandro P de Moura, Eduardo R Ropelle, José Rodrigo Paul. Acute physical exercise increases PI3K-p110α protein content in the hypothalamus of obese mice. Journal of anatomy. vol 238. issue 3. 2021-08-13. PMID:33094520. |
thus, in the current study, we evaluated the role of acute exercise in the leptin and insulin pathways in the hypothalamus, as well as in food intake control in obese mice. |
2021-08-13 |
2023-08-13 |
mouse |
| Silvie R Ruigrok, Nina Stöberl, Kit-Yi Yam, Chiara de Lucia, Paul J Lucassen, Sandrine Thuret, Aniko Koros. Modulation of the Hypothalamic Nutrient Sensing Pathways by Sex and Early-Life Stress. Frontiers in neuroscience. vol 15. 2021-08-10. PMID:34366778. |
the hypothalamus regulates food intake and energy expenditure by sensing the organism's energy state via metabolic hormones (leptin, insulin, ghrelin) and nutrients (glucose, fatty acids). |
2021-08-10 |
2023-08-13 |
mouse |
| Dina Medina-Vera, Juan Antonio Navarro, Rubén Tovar, Cristina Rosell-Valle, Alfonso Gutiérrez-Adan, Juan Carlos Ledesma, Carlos Sanjuan, Francisco Javier Pavón, Elena Baixeras, Fernando Rodríguez de Fonseca, Juan Decar. Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol. Nutrients. vol 13. issue 7. 2021-07-27. PMID:34209137. |
results indicate that the acute administration of dpin induced time-dependent phosphorylation of pi3k/akt and its related substrates within the hypothalamus, indicating an activation of the insulin signaling pathway. |
2021-07-27 |
2023-08-13 |
rat |
| Yirui He, Cheng Zhang, Yong Luo, Jinhua Chen, Mengliu Yang, Ling Li, Harvest F Gu, Gangyi Yang, Xianxiang Zhan. Hypothalamic BMP9 suppresses glucose production by central PI3K/Akt/mTOR pathway. The Journal of endocrinology. vol 248. issue 2. 2021-07-20. PMID:33337347. |
in addition, icv bmp9 promoted the ability of insulin to activate the insulin receptor/phosphoinositide 3-kinase (pi3k)/akt pathway in the hypothalamus. |
2021-07-20 |
2023-08-13 |
mouse |
| Kamil Ziarniak, Monika Dudek, Julia Matuszewska, Łukasz Bijoch, Marek Skrzypski, Jan Celichowski, Joanna H Sliwowsk. Two weeks of moderate intensity locomotor training increased corticosterone concentrations but did not alter the number of adropin-immunoreactive cells in the hippocampus of diabetic type 2 and control rats. Acta histochemica. vol 123. issue 5. 2021-07-16. PMID:34229193. |
we found that: 1) in dm2 animals, running decreased insulin and increased glucose concentrations; 2) in c rats, running decreased insulin concentrations and had no effect on glucose concentration in blood; 3) running increased corticosterone (cort) concentrations in dm2 and c rats; 4) adr-ir cells were detected in the hippocampus and adr-ir fibers in the arcuate nucleus of the hypothalamus, which is a novel location; 5) metabolic status and running, however, did not change number of these cells. |
2021-07-16 |
2023-08-13 |
rat |
| Jin-Ichi Inokuchi, Hirotaka Kanoh, Kei-Ichiro Inamori, Masakazu Nagafuku, Takahiro Nitta, Koichi Fukas. Homeostatic and pathogenic roles of the GM3 ganglioside. The FEBS journal. 2021-07-01. PMID:34125497. |
this review summarizes our long-term studies on the roles of gm3 in insulin resistance and adipogenesis in adipose tissues, cholesterol uptake in intestine, and leptin resistance in hypothalamus. |
2021-07-01 |
2023-08-13 |
Not clear |
| Dominik Pretz, Christelle Le Foll, Mohammed Z Rizwan, Thomas A Lutz, Alexander Tup. Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 2. 2021-06-24. PMID:33230896. |
pro-inflammatory signaling in the hypothalamus is associated with a decrease of central leptin- and insulin action leading to impaired systemic glucose tolerance. |
2021-06-24 |
2023-08-13 |
mouse |
| Teppei Fujikaw. Central regulation of glucose metabolism in an insulin-dependent and -independent manner. Journal of neuroendocrinology. vol 33. issue 4. 2021-06-15. PMID:33599044. |
the available evidence indicates that insulin directly acts on the cns, in particular the hypothalamus, to regulate hepatic glucose production, thereby controlling whole-body glucose metabolism. |
2021-06-15 |
2023-08-13 |
Not clear |
| Jaemeun Lee, Kyungchan Kim, Jae Hyun Cho, Jin Young Bae, Timothy P O'Leary, James D Johnson, Yong Chul Bae, Eun-Kyoung Ki. Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. JCI insight. vol 5. issue 16. 2021-06-11. PMID:32644973. |
insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. |
2021-06-11 |
2023-08-13 |
mouse |
| Jaemeun Lee, Kyungchan Kim, Jae Hyun Cho, Jin Young Bae, Timothy P O'Leary, James D Johnson, Yong Chul Bae, Eun-Kyoung Ki. Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. JCI insight. vol 5. issue 16. 2021-06-11. PMID:32644973. |
evidence has mounted that insulin can be synthesized in various brain regions, including the hypothalamus. |
2021-06-11 |
2023-08-13 |
mouse |
| Jaemeun Lee, Kyungchan Kim, Jae Hyun Cho, Jin Young Bae, Timothy P O'Leary, James D Johnson, Yong Chul Bae, Eun-Kyoung Ki. Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. JCI insight. vol 5. issue 16. 2021-06-11. PMID:32644973. |
herein, we show that in the mouse hypothalamus, the perikarya of insulin-positive neurons are located in the paraventricular nucleus (pvn) and their axons project to the median eminence; these findings define parvocellular neurosecretory pvn insulin neurons. |
2021-06-11 |
2023-08-13 |
mouse |
| Sandra Aparecida Benite-Ribeiro, Valkíria Alves de Lima Rodrigues, Mônica Rodrigues Ferreira Machad. Food intake in early life and epigenetic modifications of pro-opiomelanocortin expression in arcuate nucleus. Molecular biology reports. vol 48. issue 4. 2021-06-09. PMID:33877530. |
the control of food intake is performed by neurons of the arcuate nucleus of the hypothalamus (arc), which secret orexigenic and anorexigenic neuropeptides, such as proopiomelanocortin (pomc), under stimulation of, e.g., ghrelin, insulin, and leptin. |
2021-06-09 |
2023-08-13 |
Not clear |
| Kristina Wardelmann, Michaela Rath, José Pedro Castro, Sabine Blümel, Mareike Schell, Robert Hauffe, Fabian Schumacher, Tanina Flore, Katrin Ritter, Andreas Wernitz, Toru Hosoi, Koichiro Ozawa, Burkhard Kleuser, Jürgen Weiß, Annette Schürmann, André Kleinridder. Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants (Basel, Switzerland). vol 10. issue 5. 2021-05-27. PMID:33946318. |
central acting hsp10 regulates mitochondrial function, fatty acid metabolism, and insulin sensitivity in the hypothalamus. |
2021-05-27 |
2023-08-13 |
mouse |
| Kristina Wardelmann, Michaela Rath, José Pedro Castro, Sabine Blümel, Mareike Schell, Robert Hauffe, Fabian Schumacher, Tanina Flore, Katrin Ritter, Andreas Wernitz, Toru Hosoi, Koichiro Ozawa, Burkhard Kleuser, Jürgen Weiß, Annette Schürmann, André Kleinridder. Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants (Basel, Switzerland). vol 10. issue 5. 2021-05-27. PMID:33946318. |
recently, we demonstrated that a dysregulated mitochondrial stress response (msr) with reduced chaperone expression in the hypothalamus is an early event in obesity development due to insufficient insulin signaling. |
2021-05-27 |
2023-08-13 |
mouse |
| Ali Al-Yasari, Shaima Jabbar, Miguel A Cabrera, Benedicte Rousseau, Dipak K Sarka. Preconception Alcohol Exposure Increases the Susceptibility to Diabetes in the Offspring. Endocrinology. vol 162. issue 1. 2021-05-14. PMID:33057655. |
these rats also showed increased levels of inflammatory cytokines and cellular apoptosis in the pancreas, altered insulin production and actions in the liver, and a reduced number of proopiomelanocortin neurons in the hypothalamus. |
2021-05-14 |
2023-08-13 |
rat |
| Ritchel B Gannaban, Cherl NamKoong, Henry H Ruiz, Hyung Jin Choi, Andrew C Shi. Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons. Diabetes. vol 70. issue 1. 2021-05-10. PMID:33115827. |
here we show that insulin signaling in the mediobasal hypothalamus (mbh) of rats is mandatory for lowering plasma bcaas, most probably by inducing hepatic bcaa catabolism. |
2021-05-10 |
2023-08-13 |
mouse |
| Takashi Matsu. Exhaustive endurance exercise activates brain glycogen breakdown and lactate production more than insulin-induced hypoglycemia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 4. 2021-05-10. PMID:33533310. |
glycogen in the hypothalamus and cerebellum decreased similarly with the insulin challenge and exhaustive exercise; however, glycogen in the cortex, hippocampus, and brainstem of the exercise group were lower compared with the insulin group. |
2021-05-10 |
2023-08-13 |
rat |
| Takashi Matsu. Exhaustive endurance exercise activates brain glycogen breakdown and lactate production more than insulin-induced hypoglycemia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 4. 2021-05-10. PMID:33533310. |
brain lactate and camp levels in the hypothalamus and cerebellum increased similarly with the insulin challenge and exhaustive exercise, but those in the cortex, hippocampus, and brainstem of the exercise group were higher compared with the insulin group. |
2021-05-10 |
2023-08-13 |
rat |
| Takashi Matsu. Exhaustive endurance exercise activates brain glycogen breakdown and lactate production more than insulin-induced hypoglycemia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 4. 2021-05-10. PMID:33533310. |
blood glucose correlated positively with brain glycogen, but the slope of regression lines was greater in the exercise group compared with the insulin group in the cortex, hippocampus, and brainstem, but not the hypothalamus and cerebellum. |
2021-05-10 |
2023-08-13 |
rat |
| Nicola J Lee, Herbert Herzo. Coordinated regulation of energy and glucose homeostasis by insulin and the NPY system. Journal of neuroendocrinology. vol 33. issue 4. 2021-04-19. PMID:33427385. |
in particular, npy neurones in the arcuate nucleus of the hypothalamus are critical control centres for insulin's central action on control energy homeostasis, as well as glucose homeostasis regulation. |
2021-04-19 |
2023-08-13 |
Not clear |